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Meta-silencer with designable timbre

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International Journal of Extreme Manufacturing 2023年第2期5卷 230-242页

作者： Nengyin Wang Chengcheng zhou Sheng Qiu Sibo Huang Bin Jia Shanshan Liu Junmei Cao zhiling zhou Hua Ding Jie Zhu Yong Li Institute of Acoustics&MOE Key Laboratory of Advanced Micro-Structured Material School of Physics Science and EngineeringTongji UniversityShanghai 200092People’s Republic of China AECC Commercial Aircraft Engine Co. LTDShanghai 200240People’s Republic of China Department of Electrical Engineering City University of Hong KongHong KongPeople’s Republic of China

Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of ***,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in *** global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre *** proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,*** proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 *** work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.

关键词： designable timbre acoustic metamaterial multi-functional sound silencer resonance modulation

The Practice of Pharmacist-Driven Antimicrobial Stewardship Based on Value-Based Healthcare

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Asian Journal of Social Pharmacy 2021年第2期16卷 180-186页

作者： Sun Yinxiang Xu Chunhua Li Yong Huang Sichao zhou zhiling Cui Min Department of Clinical Pharmacy Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China School of Pharmacy Zunyi Medical UniversityZunyi 563000China Department of Hospital Affairs Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 19000China Department of Pharmacy Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University) Zhuhai 519000China

Objective To evaluate the effect of pharmacist-driven antimicrobial stewardship based on value-based healthcare in a tertiary hospital in *** The application of plan-do-check-action(PDCA)cycle and antimicrobial stewardship(AMS)were respectively used to improve the rational use of antimicrobial agents in prophylactic and *** were collected and the effect was assessed during the management period(2016-2019).Results and Conclusion From 2016(before implementation)to 2019(after implementation),the rational use of antibiotics were obviously enhanced in outpatients,inpatients,and emergency *** instance,the utilization rate in type I incision operation was decreased from 26.42%to 14.60%(P=0.000),the daily doses of antibiotic per 100 patient-days decreased from 49.34±2.97 to 35.89±4.96(P=0.000),and the average antibiotic expenditures dropped from 948.53 yuan to 526.30 yuan(P=0.000).There was no significant change in infection rate,nosocomial mortality rate,and the length of hospital *** the implementation of clinical pharmacist-driven antimicrobial stewardship based on value-based healthcare,the consumption and cost of antibacterial have been greatly ***,the pharmacist-driven antimicrobial stewardship increases its value。

关键词： pharmacist value-based healthcare antimicrobial stewardship antibiotic consumption medical quality

Compact broadband acoustic sink with coherently coupled weak resonances

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Science Bulletin 2020年第5期65卷 373-379页

作者： Sibo Huang zhiling zhou Dongting Li Tuo Liu Xu Wang Jie Zhu Yong Li Institute of Acoustics School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Broadband sound sink/absorber via a structure with deep sub-wavelength thickness is of great and continuing interest in physics and engineering *** intuitive technique extensively used is to combine components(resonators)with quasi-perfect absorption to piece together a broad absorbing band,but the requirement of quasi-perfect absorption substantially places a very strict restriction on the impedance and thickness of the ***,we theoretically and experimentally demonstrate that a compact broadband acoustic sink that quasi-perfectly absorbs broadband arriving sound waves can be achieved with coherently coupled‘‘weak resonances"(resonant sound absorbing systems with low absorption peaks).Although each component exhibits rather low absorption peak alone,via manipulating the coherent coupling effect among the components,they collectively provide a remarkably improved performance over a wide frequency range with a significantly compressed *** illustrate the design principle,a hybrid metasurface utilizing the coaction of parallel and cascade couplings is presented,which possesses an average absorption coefficient of 0.957 in the quasi-perfect band(a>0:9)from 870 to 3224 Hz with a thickness of only 3.9 *** results open new avenues for the development of novel and highly efficient acoustic absorbers against low frequency noise,and more essentially,suggest an efficient approach towards on-demand acoustic impedance engineering in broadband.

关键词： Broadband acoustic sink Acoustic metasurface Coherent coupling Imperfect components

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白蛋白治疗在肝性脑病中的研究进展

中华肝脏病杂志 2024年第9期32卷 861-864页

作者：周志玲张大志重庆医科大学附属第二医院感染科重庆医科大学感染性疾病分子生物学教育部重点实验室重庆医科大学病毒性肝炎研究所重庆401336

肝性脑病是由肝功能不全和/或门体分流引起的脑功能障碍,是肝硬化失代偿期的严重并发症之一,通常表现为从亚临床改变到昏迷的广泛的神经或精神异常。肝性脑病的发病机制复杂,主要与氨中毒有关,氧化应激、炎症和肠道菌群失调等也在其中... 详细信息

肝性脑病是由肝功能不全和/或门体分流引起的脑功能障碍,是肝硬化失代偿期的严重并发症之一,通常表现为从亚临床改变到昏迷的广泛的神经或精神异常。肝性脑病的发病机制复杂,主要与氨中毒有关,氧化应激、炎症和肠道菌群失调等也在其中发挥了重要作用。肝性脑病的治疗缺乏特效药物,目前可使用的药物包括不可吸收的二糖(如乳果糖)、抗生素(如利福昔明)、其他疗法(如口服支链氨基酸、静脉注射L-鸟氨酸-L-天冬氨酸、益生菌)等。近年研究表明人血白蛋白治疗HE安全有效,不仅能改善患者脑功能,而且能提高患者的生活质量。

关键词：白蛋白肝性脑病肝硬化认知功能治疗

The Expression of Hypoxia-regulated MicroRNAs （HRMs） Induced by Hypoxia Preconditioning in hMSCs

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中国药理通讯 2008年第2期25卷 37-38页

作者： ZhiXin Shan Qiu Xiong Lin XiYong Yu XiaoHong Li zhiling zhou Chun YU deng Hong Hong Tan Shu Guang Lin Research Center of Medical Sciences Guangdong Provincial Peoples Hospital Guangzhou 510080

基于模式模拟的苏皖鲁豫交界区典型月份PM_(2.5)来源解析

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环境科学学报 2023年第2期43卷 365-375页

作者：程先富周志凌蔡菁菁安徽师范大学地理与旅游学院芜湖241002 南京市宁海中学南京210024

基于WRF-Chem模式模拟分析了2019年1月、7月苏皖鲁豫交界区本地排放对PM_(2.5)污染水平的贡献以及不同污染源对PM_(2.5)浓度和化学组分的贡献.结果表明:WRF-Chem模式合理地模拟了研究时段内苏皖鲁豫交界区PM_(2.5)的空间分布特征,PM_(2... 详细信息

基于WRF-Chem模式模拟分析了2019年1月、7月苏皖鲁豫交界区本地排放对PM_(2.5)污染水平的贡献以及不同污染源对PM_(2.5)浓度和化学组分的贡献.结果表明:WRF-Chem模式合理地模拟了研究时段内苏皖鲁豫交界区PM_(2.5)的空间分布特征,PM_(2.5)的化学组分中冬季NO3-含量最高,夏季SO42-含量最高.在不同的污染源中,民用源是冬季苏皖鲁豫交界区PM_(2.5)最主要的来源,贡献约为35.87%,农业源和工业源对PM_(2.5)的贡献分别为28.71%、22.17%;工业源是夏季苏皖鲁豫交界区PM_(2.5)最主要的来源,贡献达到50.57%,电力源、农业源和民用源的贡献分别为18.05%、15.14%和12.22%.从各污染源对PM_(2.5)污染贡献量的小时变化上看,工业源和民用源对冬季PM_(2.5)贡献量呈现明显的双峰双谷变化特点,其它污染源对PM_(2.5)贡献量的小时变化特征都不明显.冬季应通过控制民用源和工业源的排放来减轻苏皖鲁豫交界区PM_(2.5)污染,夏季应通过控制工业源和农业源的排放来减轻PM_(2.5)污染.

关键词： WRF-Chem模式 PM_(2.5) 化学组分来源解析苏皖鲁豫交界区

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腹直肌鞘额外卵巢1例并文献复习

中国现代医生 2008年第23期46卷 95-96页

作者：周志凌三峡大学第三临床医学院葛洲坝中心医院病理科湖北宜昌443002

目的探讨腹直肌鞘额外卵巢的临床病理特征。方法收集1例腹直肌鞘额外卵巢的完整临床资料,对其常规光镜下的形态进行观察,复习相关文献,对其临床病理特征及相关疾病进行诊断及鉴别诊断。结果腹直肌鞘横纹肌内见卵巢黄体、白体及卵巢间质... 详细信息

目的探讨腹直肌鞘额外卵巢的临床病理特征。方法收集1例腹直肌鞘额外卵巢的完整临床资料,对其常规光镜下的形态进行观察,复习相关文献,对其临床病理特征及相关疾病进行诊断及鉴别诊断。结果腹直肌鞘横纹肌内见卵巢黄体、白体及卵巢间质。结论临床诊断需与腹壁韧带样纤维瘤病、腹部瘢痕子宫内膜异位症、转移癌及纤维肉瘤进行鉴别。

关键词：额外卵巢诊断鉴别诊断

HPLC-MS／MS检测[18F]FDG中Kryptofix 2．2．2的残留量

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核技术 2012年第2期35卷 121-125页

作者：何山震王淑侠王朋翟创彦周志凌广东省人民医院PET中心广东省医学科学院广州510080 广东省人民医院医学研究中心广州510080

应用高效液相色谱-电喷雾串联质谱(HPLC-MS/MS)测定[18F]FDG示踪剂中残留的Kryptofix 2.2.2浓度,并进行方法学确证。以乙腈40 mmol/L NH4Ac水溶液(50:50,V/V)为流动相,采用ultimate XB-C18(4.6×150 mm,3μm)色谱柱进行分离,流速为0.85 ***–1,通过电喷雾离子化串联质谱,以多反应监测(MRM)方式对[18F]FDG中的K-222残留量进行检测。结果表明,用HPLC-MS/MS法可以在4 min内完成K-222的检测,其线性范围为0.5–120 ***–1,平均回收率在101.3%–106.6%,批内和批间变异均小于9.4%。HPLC-MS/MS方法简单、快速、灵敏,适合于短半衰期[18F]FDG中K-222残留浓度的检测。

关键词：氨基聚醚(K-222) 高效液相色谱质谱串联法电喷雾

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甲砜霉素胶囊含量测定方法的改进

中国药品标准 2005年第6期6卷 35-37页

作者：周志凌梁净安徽省药品检验所合肥230061

目的:改进甲砜霉素胶囊的含量测定方法。方法:采用高效液相色谱法。色谱柱为Kromasil C18柱(150×4．6mm,5μm); 流动相为:水-甲醇-冰醋酸(55:45:0．1);流速:1．0ml／min;检测波长273nm;柱温:室温;结果:甲砜霉素在1．0-10．0μg范围内... 详细信息

目的:改进甲砜霉素胶囊的含量测定方法。方法:采用高效液相色谱法。色谱柱为Kromasil C18柱(150×4．6mm,5μm); 流动相为:水-甲醇-冰醋酸(55:45:0．1);流速:1．0ml／min;检测波长273nm;柱温:室温;结果:甲砜霉素在1．0-10．0μg范围内具有良好的线性关系,平均回收率为100．2％,RSD=0．25％。结论:该法可用于甲砜霉素胶囊中的甲砜霉素含量测定。

关键词：甲砜霉素含量测定高效液相色谱法