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Current Medical Science 2024年第1期44卷 232-240页

作者： Zhi-bin ZHU Meng-jie LIU Jing WANG zhou shu Jie CAO Department of Stomatology Chengdu Seventh People's HospitalChengdu 610044China Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis.However,the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain unclear.This study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in vivo.Methods In vitro,HaCaT cells were induced with tumor necrosis factor-alpha(TNF-α,10 ng/mL)to establish an inflammatory injury model,and the expression of nuclear transcription factor-κB(NF-κB)pathway components was measured using qRT-PCR and Western blotting.An in vivo mouse model of imiquimod(IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating psoriasis.Results SC significantly blocked the activation of NF-κB signaling in TNF-α-stimulated HaCaT cells.In addition,systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse model.SC reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin lesions.Conclusion The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis.

关键词： secoemestrin C(SC) psoriasis tumor necrosis factor-alpha(TNF-α) nuclear transcription factor-kB(NF-kB) inflammation

Effects of Aromatherapy on Physical and Mental Health of Cancer Patients Undergoing Radiotherapy and/or Chemotherapy: A Meta-Analysis

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Chinese Journal of Integrative Medicine 2024年第5期30卷 449-457页

作者： XIE shuang-ran MA Liang XU Xin-yu zhou shu XIE Hui-miao XIE Chang-sheng The First Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Medical Oncology Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007China Department of Dermatology the Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Famous Chinese Medicine Clinic the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310005China Department of Medical Oncology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China

Backgroup:Currently,aromatherapy is being increasingly utilized in clinical practice,particularly in managing the side effects associated with radiotherapy and chemoradiotherapy.However,it remains to be established whether aromatherapy can effectively alleviate these symptoms.Objective:To investigate the effects of aromatherapy on the physical and mental health of patients with cancer undergoing radiotherapy and chemotherapy.Methods:Seven databases were researched from inception until September 29,2023,including PubMed,Scopus,and Web of Science,Chinese National Knowledge Infrastructure,Wanfang database,China Biology Medicine disc and VIP Chinese Medical Journal Database.Review Manager version 5.3 was utilized for data analysis.The Cochrane Risk of Bias tool RoB2 was employed to evaluate the quality of the literature included in the study.Evidence quality rating was assessed using the Grading of Recommendations Assessment,Development,and Evaluation(GRADE) approach through the GRADEpro GDT online tool.Results:Nineteen studies involving 1,541 patients were included.Aromatherapy can alleviate nausea [relative risk(RR)=0.64,95% confidence interval(CI):0.53 to 0.78,P<0.05,I^(2)=46%;standardized mean difference(SMD)=-0.86,95% CI:-1.21 to-0.51,P<0.05,I^(2)=64%] and vomiting(RR=0.54,95% CI:0.42 to 0.69,P<0.05,I^(2)=35%;SMD=-1.28,95% CI:-1.52 to-1.03,P<0.05,I^(2)=92%),improve sleep disorders [mean difference(MD)=-3.39,95% CI:-3.95 to-2.84,P<0.05,I^(2)=0%],relieve pain(SMD=-1.58,95% CI:-1.96 to-1.21,P<0.05,I^(2)=0%),mitigate fatigue(SMD=-1.28,95% CI:-2.44 to-0.11,P<0.05,I^(2)=93%) and enhance quality of life(SMD=0.50,95% CI:0.22 to 0.79,P<0.05,I^(2)=0%) in cancer patients after radiotherapy and chemotherapy,but it may not have a significant effect on anxiety.The risk of bias was high in the included studies using the Cochrane Risk of Bias tool RoB2,and no studies were considered to be of high grade according to the GRADE system.Conclusions:Aromatherapy is an efficacious,safe and economic adjunctive therapy for cancer patien

关键词： aromatherapy cancer chemoradiotherapy physical psychological

Physics Informed Neural Network-based High-frequency Modeling of Induction Motors

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Chinese Journal of Electrical Engineering 2022年第4期8卷 30-38页

作者： Zhenyu Zhao Fei Fan Quqin Sun Huamin Jie zhou shu Wensong Wang Kye Yak See School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Science and Technology on Thermal Energy and Power Laboratory Wuhan Second Ship Design and Research InstituteWuhan 430000China

The high-frequency(HF)modeling of induction motors plays a key role in predicting the motor terminal overvoltage and conducted emissions in a motor drive system.In this study,a physics informed neural network-based HF modeling method,which has the merits of high accuracy,good versatility,and simple parameterization,is proposed.The proposed model of the induction motor consists of a three-phase equivalent circuit with eighteen circuit elements per phase to ensure model accuracy.The per phase circuit structure is symmetric concerning its phase-start and phase-end points.This symmetry enables the proposed model to be applicable for both star-and delta-connected induction motors without having to recalculate the circuit element values when changing the motor connection from star to delta and vice versa.Motor physics knowledge,namely per-phase impedances,are used in the artificial neural network to obtain the values of the circuit elements.The parameterization can be easily implemented within a few minutes using a common personal computer(PC).Case studies verify the effectiveness of the proposed HF modeling method.

关键词： Equivalent circuit high-frequency(HF)modeling induction motor parameterization physics informed neural network

Delayed-onset adenosine deaminase deficiency with a novel synonymous mutation and a case series from China

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World Journal of Pediatrics 2023年第7期19卷 687-700页

作者： Yue Zhang Wei Liu zhou shu Yan Li Fei Sun Zhi-Gang Li Tong-Xin Han Hua-Wei Mao Tian-You Wang Department of Immunology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthNo.56 Nan Lishi RoadXicheng DistrictBeijing 100045China Hematology Oncology Center Henan Children's HospitalChildren's Hospital Affiliated of Zhengzhou UniversityZhengzhou Children's HospitalZhengzhouChina Hematologic Disease Laboratory Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Hematology Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthNo.56 Nan Lishi RoadXicheng DistrictBeijing 100045China Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of PediatricsCapital Medical UniversityBeijingChina Key Laboratory of Major Diseases in Children Ministry of EducationBeijingChina

Background Adenosine deaminase(ADA)is a key enzyme in the purine salvage pathway.Genetic defects of the ADA gene can cause a subtype of severe combined immunodeficiency.To date,few Chinese cases have been reported.Methods We retrospectively reviewed the medical records of patients diagnosed with ADA deficiency in Beijing Children's Hospital and summarized the previously published ADA deficiency cases from China in the literature.Results Nine patients were identified with two novel mutations(W272X and Q202=).Early-onset infection,thymic abnor-malities and failure to thrive were the most common manifestations of Chinese ADA-deficient patients.The ADA genotype has a major effect on the clinical phenotype.Notably,a novel synonymous mutation(c.606G>A,p.Q202=)was identified in a delayed-onset patient,which affected pre-mRNA splicing leading to a frameshift and premature truncation of the protein.Furthermore,the patient showed γδT cells expansion with an increased effect or phenotype,which may be associated with the delayed onset of disease.In addition,we reported cerebral aneurysm and intracranial artery stenosis for the first time in ADA deficiency.Five patients died with a median age of four months,while two patients received stem cell transplantation and are alive.Conclusions This study described the first case series of Chinese ADA-deficient patients.Early-onset infection,thymic abnormalities and failure to thrive were the most common manifestations in our patients.We identified a synonymous muta-tion that affected pre-mRNA splicing in the ADA gene,which had never been reported in ADA deficiency.Furthermore,we reported cerebral aneurysm in a delayed-onset patient for the first time.Further study is warranted to investigate the underlying mechanisms.

关键词： Adenosine deaminase deficiency Cerebral aneurysm Gamma delta Severe combined immunodeficiency Synonymous mutation

Impact of Motor Stator Winding Faults on Motor Differential-mode Impedance and Mode Transformation

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Chinese Journal of Electrical Engineering 2022年第3期8卷 12-21页

作者： Fei Fan Zhenyu Zhao Huamin Jie Quqin Sun Pengfei Tu zhou shu Wensong Wang Kye Yak See School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Science and Technology on Thermal Energy and Power Laboratory Wuhan Second Ship Design and Research InstituteWuhan 430000China

Motor impedance and mode transformation have significant effects on the electromagnetic interference(EMI)generated in motor drive systems.Stator winding faults commonly cause motor failure;however,in their early stages,they may not affect the short-term operation of the motor.To date,EMI noise under the influence of premature stator winding faults has not been adequately studied,particularly the differential-mode(DM)noise due to the common-mode(CM)-to-DM transformation.This study investigates and quantifies the influence of stator winding faults on the motor DM impedance and mode transformation.First,the transmission line model of an induction motor is described based on the scattering(S)parameter measurements of each phase of the motor.It offers the flexibility to emulate different types of stator winding faults at specific locations and various severities,such that the impacts of the faults on the motor DM impedance can be easily estimated.Second,a test setup is proposed to quantify the CM-to-DM transformation due to the stator winding faults.The findings of this study reveal that even the early stages of stator winding faults can result in significant changes in the DM noise.

关键词： Differential-mode(DM)impedance DM noise mode transformation motor stator winding faults transmission line model

基于高通量定量PCR与高通量测序技术研究城市湿地公园抗生素抗性基因污染特征

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环境科学 2024年第1期45卷 576-583页

作者：黄福义周曙仡聃潘婷周昕原苏建强张娴中国科学院城市环境研究所城市环境与健康重点实验室福建省流域生态重点实验室厦门361021 中国科学院大学北京100049 中国科学院华南植物园退化生态系统植被恢复与管理重点实验室广州510650

城市湿地公园是城市湿地保护与利用的重要实践,具有重要的生态系统服务价值.抗生素抗性基因(ARGs)作为一种新污染物,在水体环境中普遍存在,是当前环境研究和公众关注热点.基于高通量定量PCR与16S rRNA基因高通量测序技术,深入研究了厦... 详细信息

城市湿地公园是城市湿地保护与利用的重要实践,具有重要的生态系统服务价值.抗生素抗性基因(ARGs)作为一种新污染物,在水体环境中普遍存在,是当前环境研究和公众关注热点.基于高通量定量PCR与16S rRNA基因高通量测序技术,深入研究了厦门城市湿地公园水体环境中抗生素抗性基因的种类、丰度水平和分布特征.结合微生物群落特征和水质理化性质,阐释了城市湿地公园抗生素抗性基因污染的影响因子和驱动机制.结果表明,城市湿地公园水体环境总共发现了217种抗生素抗性基因,丰度水平高达6.48×10^(9)copies·L^(-1),抗性基因呈现出丰度较高、种类多样以及普遍共存的特点,城市湿地公园是抗生素抗性基因分布的重要热区和存储库;Marivivens、NS5_marine_group和Planktomarina等9种微生物是41种抗生素抗性基因的潜在携带者,微生物群落结构对城市湿地公园水体环境抗性基因变化的单独解释量达到了51%,因此微生物群落是城市湿地抗生素抗性基因赋存和演化最重要的驱动力.基于研究结果,暗示着城市湿地公园水体环境抗生素抗性基因具有潜在水生态安全及人类健康风险,应该加强城市湿地公园水体环境微生物污染研究与控制.

关键词：高通量城市湿地抗生素抗性基因(ARGs) 水环境新污染物

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艺术博物馆空间的阈限性与社交潜能

艺术设计研究 2024年第3期 84-93页

作者：周术乔纳森·黑尔烟台大学建筑学院英国诺丁汉大学工程学院建筑与建成环境系

在网络城市公共空间持续阈限和公共生活缺失的现实下,本文以阈限理论为框架,梳理了艺术博物馆从“时间阈限”到“空间阈限”的历史演化过程,及其分别在精神和身体层面的社交潜能。并以三个具有空间阈限性的当代艺术博物馆为例,分析了介... 详细信息

在网络城市公共空间持续阈限和公共生活缺失的现实下,本文以阈限理论为框架,梳理了艺术博物馆从“时间阈限”到“空间阈限”的历史演化过程,及其分别在精神和身体层面的社交潜能。并以三个具有空间阈限性的当代艺术博物馆为例,分析了介于“结构/反结构”“公共/私密”之间的空间布局和形态特征,指出其设计核心是为了弱化物质空间的存在,从而释放新的社交可能性。

关键词：艺术博物馆空间阈限性社交潜能

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基于复杂网络的政府投资基金地理集聚特征研究

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技术经济与管理研究 2024年第3期 69-76页

作者：周代数靳志伟中国科学技术发展战略研究院北京100038 中国财政科学研究院北京100036

基于爬虫等技术获取我国政府投资基金相关数据,并用复杂网络模型考察我国五大城市群政府投资基金的地理集聚特征。研究发现:五大城市群政府投资基金融资网络均具有较强的地理邻近特征,“极化现象”较为明显;政府投资基金的辐射效应不平... 详细信息

基于爬虫等技术获取我国政府投资基金相关数据,并用复杂网络模型考察我国五大城市群政府投资基金的地理集聚特征。研究发现:五大城市群政府投资基金融资网络均具有较强的地理邻近特征,“极化现象”较为明显;政府投资基金的辐射效应不平衡,京津冀城市群、长三角城市群、珠三角城市群的辐射效应显著优于长江中游城市群、成渝城市群;2014—2020年间,五大城市群内部核心城市与外围城市的差距均在缩小,跨区域交叉投资的空间格局也愈发明显。建议进一步发挥资本密集型城市群政府投资基金的辐射效应和欠发达区域政府投资基金“远吸近投”的引导效应,构建跨区域资本网络,打造“以强带弱”的资本流动格局,支持区域协调发展。

关键词：政府投资基金复杂网络资本集聚风险投资地理集聚

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软件运行时配置研究综述

软件学报 2024年第1期35卷 63-86页

作者：周书林李姗姗董威王戟廖湘科国防科技大学计算机学院湖南长沙410073

运行时配置为用户使用软件提供了灵活性和可定制性,但其巨大的规模和复杂的机制也带来了巨大的挑战.大量学者和研究机构针对软件运行时配置展开了研究,以提升软件系统在复杂外部环境中的可用性和适应性.建立运行时配置研究分析框架,从... 详细信息

运行时配置为用户使用软件提供了灵活性和可定制性,但其巨大的规模和复杂的机制也带来了巨大的挑战.大量学者和研究机构针对软件运行时配置展开了研究,以提升软件系统在复杂外部环境中的可用性和适应性.建立运行时配置研究分析框架,从配置分析与理解、配置缺陷检测与故障诊断、配置应用3个阶段对现有研究工作进行归类和分析,总结归纳现有研究的不足和面临的挑战,并对未来的研究趋势进行展望,对下一步研究具有一定的指导意义.

关键词：运行时配置配置理解配置缺陷检测配置故障诊断配置应用

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史料所见唐代县主簿职掌新考

唐山师范学院学报 2024年第1期46卷 61-66页

作者：李澍洲华中师范大学历史文献学研究所湖北武汉430079

对大量墓志材料和传世典籍进行梳理,证明唐代县主簿作为佐贰官之一,其在各地的职掌呈多样化的表现形式,内容涵盖了基层行政、刑狱、教化、邮务、经济以及兼使职而行公事等六大职能,而并不仅限于以往依靠传统典志研究所总结出的基础权责。

关键词：唐代基层县主簿职掌出土文献