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A chromosome-level genome assembly for Chinese plum‘Wushancuili'reveals the molecular basis of its fruit color and susceptibility to rain-cracking

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Horticultural Plant Journal 2024年第3期10卷 672-688页

作者： Kun zhou Jingwen Wang Lin Pan Fang Xiang Yi zhou Wei Xiong Ming Zeng Donald Grierson Wenbin Kong Lingyu Hu Wanpeng Xi College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Southwest UniversityChongqing 400715China Department of Pomology Chongqing Agricultural Technology Extension StationChongqing 401420China Plant and Crop Sciences Division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughborough LE125RDUK Wuxi Economical Crop Technology Extension Station Chongqing 405800China

Chinese plum(Prunus salicina Lindl.)originates from China and makes a large contribution to the global production of *** ***‘Wushancuili'has a green coloration and high fruit quality and is economically important in eliminating poverty and protecting ecology in the Yangtze River Three Gorges ***,rain-induced cracking(rain-cracking,literally skin cracking caused by rain)is a limitation to‘Wushancuili'fruit production and causes severe *** study reported a high-quality‘Wushancuili'genome assembly consisting of a 302.17-Mb sequence with eight pseudo-chromosomes and a contig N50 of 23.59 Mb through the combination of Illumina sequencing,Pacific Biosciences HiFiⅢsequencing,and high-throughput chromosome conformation capture technology.A total of 25109 protein-coding genes are predicted and 54.17%of the genome is composed of repetitive sequences.‘Wushancuili'underwent a remarkable orthoselection during *** identification revealed that loss-of-function in four core MYB10 genes results in the anthocyanin deficiency and absence of red color,revealing the green coloration due to the residual high chlorophyll in fruit ***,the occurrence of cracking is assumed to be closely associated with cell wall modification and frequently rain-induced pathogen enrichment through transcriptomic *** loss of MYB10 genes might render fruit more susceptible to pathogen-mediated cracking by weakening the epidermal strength and reactive oxygen species(ROS)*** findings provided fundamental knowledge regarding fruit coloration and rain-cracking and will facilitate genetic improvement and cultivation management in Chinese plums.

关键词： Chinese plum Fruit coloration Fruit epidermis Genome MYB10 Rain-cracking

Event segmentation in ADHD:neglect of social information and deviant theta activity point to a mechanism underlying ADHD

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General Psychiatry 2024年第3期37卷 431-439页

作者： Astrid Prochnow Xianzhen zhou Foroogh Ghorbani Veit Roessner Bernhard Hommel Christian Beste Cognitive Neurophysiology Department of Child and Adolescent PsychiatryFaculty of MedicineTU DresdenDresdenGermany Faculty of Psychology Shandong Normal UniversityJinanShandongChina

Background Attention-deficit/hyperactivity disorder(ADHD)is one of the most frequently diagnosed psychiatric conditions in children and *** the symptoms appear to be well described,no coherent conceptual mechanistic framework integrates their occurrence and variance and the associated problems that people with ADHD *** The current study proposes that altered event segmentation processes provide a novel mechanistic framework for understanding deficits in *** Adolescents with ADHD and neurotypically developing(NT)peers watched a short movie and were then asked to indicate the boundaries between meaningful segments of the *** recorded electroencephalography(EEG)data were analysed for differences in frequency band activity and effective connectivity between brain *** Compared with their NT peers,the ADHD group showed less dependence of their segmentation behaviour on social information,indicating that they did not consider social information to the same extent as their unaffected *** divergence was accompanied by differences in EEG theta band activity and a different effective connectivity network architecture at the source ***,NT adolescents primarily showed error signalling in and between the left and right fusiform gyri related to social information processing,which was not the case in the ADHD *** the ADHD group,the inferior frontal cortex associated with attentional sampling served as a hub instead,indicating problems in the deployment of attentional *** This study shows that adolescents with ADHD perceive events differently from their NT peers,in association with a different brain network architecture that reflects less adaptation to the situation and problems in attentional sampling of environmental *** results call for a novel conceptual view of ADHD,based on event segmentation theory.

关键词： instead meaningful primarily

Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7

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Chinese Journal of Integrative Medicine 2024年第6期30卷 543-550页

作者： YU Qian SHU Shi JU Xin-yao PENG Wei REN Xue-qi SI Shu-han SONG Shi-zhen XIE Xue-yun FANG Bang-jiang zhou Shuang School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China College of Basic Medicine Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China

Objective To observe the angiogenesis effect of electroacupuncture(EA)at Shuigou acupoint(GV 26)in the treatment of cerebral ischemia,and explore the value of miRNA-7(miR-7)in *** First,48 mice were randomly divided into sham operation,middle cerebral artery occlusion(MCAO)model,and EA treatment *** 9 mice were divided into carrier control group,miR-7 knockout group and miR-7 overexpression group(n=3 each group).Finally,20 mice were divided into model and carrier control group,model and miR-7 knockout group,EA treatment and carrier control group and EA treatment and miR-7 overexpression group,with 3–6 mice in each *** MCAO model was established in the MCAO and EA *** deficit score and 2,3,5-triphenyltetrazolium chloride(TTC)staining were used to evaluate the severity of cerebral ***-eosin staining was used to describe basic pathological *** was used to quantify cerebral microvessel ***-time PCR and Western blot were used to detect the expression of miR-7 and its downstream target genes krüppel-like factor 4/vascular endothelial growth factor(KLF4/VEGF)and angiopoietin-2(ANG-2)in the ischemic cerebral *** After EA,neurological deficit scores and infarction volumes decreased,and the density of cerebral microvessels *** the MCAO group,miR-7 expression was higher than that in the sham group(P<0.01).After EA at GV 26,miR-7 expression decreased(P<0.01)and the expression of downstream target genes KLF4/VEGF and ANG-2 increased as compared with the MCAO group(P<0.01).After EA combined with overexpression of miR-7,the expression of downstream target genes KLF4/VEGF and ANG-2 decreased compared to the control EA group(P<0.01).After miR-7 knockdown,the expression of KLF4/VEGF and ANG-2 increased(P<0.05 or P<0.01).Conclusions EA could promote angiogenesis in MCAO mice likely by inhibiting the expression of miR-7 and relieving inhibition of downstream target genes KLF4/VEG

关键词： electroacupuncture cerebral ischemia miRNA-7 angiogenesis Shuigou(GV 26) acupuncture points

DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis

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Genes & Diseases 2024年第1期11卷 91-94页

作者： Qiuxia Cui Jian Sun Jingping Yuan Juanjuan Li Chuanyu Yang Guangshi Du Chengang zhou Pu Qiu Jidong Gao Yuanqi Zhang Dewei Jiang Ceshi Chen Affiliated Hospital of Guangdong Medical University Science&Technology of China ZhanjiangGuangdong 524000China Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong 518116China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Department of Pathology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Breast and Thyroid Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Translational Medicine Research Center of Guizhou Medical University GuiyangGuizhou 550025China Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Yunnan Cancer Hospital and the Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer Center KunmingYunnan 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunmingYunnan 650500China

Most basal-like breast cancers(BLBCs)have a poor prognosis and high crossover with triple-negative breast cancers(TNBCs).However,approximately 50%of TNBC patients develop chemoresistance.^(1) Dexamethasone reportedly induces krüppel-like factor 5(KLF5)and can cause docetaxel and cisplatin resistance in TNBC.A super-enhancer can maintain the transcription of KLF5.

关键词： FOXO1 drugs damage

Kinetic Resolution of Racemic 4-Substituted Chroman-2-ones Through Asymmetric Lactone Hydrogenation

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CCS Chemistry 2024年第10期6卷 2560-2576页

作者： Xiong Wu Hai-Tao Yue Xiao-Dong Zuo Xiao-Hui Yang Pu-Cha Yan Jian-Hua Xie Qi-Lin zhou State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryFrontiers Science Center for New Organic MatterNankai UniversityTianjin 300071 Zhejiang Jiuzhou Pharmaceutical Co. Ltd.TaizhouZhejiang 318000

Esters are abundant in natural and synthetic products and their conversion into primary alcohols holds great importance in fine chemical ***,achieving asymmetric hydrogenation(AH)of racemic esters with remote stereocenters via kinetic resolution(kr)remains a formidable challenge due to the difficulties associated with discerning spatially distant *** address this issue,we have designed a hydroxy-assisted strategy that introduces a hydroxy group into racemicβ-aryl esters to facilitate hydrogenation and enhance chiral discrimination through a lactone *** employing chiral Ir-SpiroPAP catalysts,we achieved exceptional AH of racemic 4-substituted chroman-2-ones,lactone form of ortho-hydroxylatedβ-aryl esters,via kr,resulting in impressive selectivity factor(s)values of up to *** approach exhibited significant efficacy for racemic chroman-2-ones containingβ-aryl,alkenyl,alkynyl,and alkyl groups,enabling the synthesis of chiralγ-aryl primary alcohols and the recovery of chiralβ-aryl esters or chroman-2-ones,typically difficult to access using existing *** scalability and broad synthetic applications of this method were exemplified by successfully synthesizing chiral drugs(R)-fesoterodine and enrasentan,alongside various chiral intermediates essential for producing chiral drugs and natural *** promising results highlight the potential of this approach as a powerful tool for synthesizing valuable chiral compounds.

关键词： asymmetric hydrogenation chiralγ-aryl primary alcohols hydrogenation of esters iridium catalysts kinetic resolution

THE INVESTIGATION OF METHANE OXIDATIVE COUPLING ON BaF_2-LaOF CATALYST

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Chinese Chemical Letters 1995年第8期6卷 715-719页

作者： Chao, ZS zhou, XP Wan, HL Tsai, kr Xiamen Univ Dept Chem Xiamen 361005 Peoples R China Xiamen Univ State Key Lab Phys Chem Solid Surface Xiamen 361005 Peoples R China

The OCM reaction waa stndied on BaF2-LaOF catalyst and the results show that CH4 can be effectively activated and selectively converted to C2 Under the reaction conditions of CHSV=15000h-1and reaction temperature *** high C2 yield of 20.66% with CH4 conversion of 33.08% and C2 selectivity of 62.47% was obtained at CH4:O2=3: 1, and the high C2'selectivity of 84.55% with CH4 conversion of 16. 54% was obtained at CH4:O2=9: 1. XRD results suggest that tetragonal LaOF is the active phase in BaF2-LaOF catalyst.

关键词：

OXIDATIVE　DEHYDROGENATION　OF　ETHANE（ODE）　OVER　LaOF　CATALYST　PROMOTED　WITH　BaF_2

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Chinese Chemical Letters 1995年第4期6卷 347-348页

作者： zhou, XP Chao, ZS Wan, HL Tsai, kr Xiamen Univ Dept Chem Xiamen 361005 Peoples R China

The addition of BaF2 into LaOF catalyst significantly improves the catalytic properties of LaOF for the ODE reaction.

关键词： ODE ETHANE OVER LaOF DEHYDROGENATION BaF2 CATALYST

水牛KLF 15基因克隆、分子特征和组织差异表达分析

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中国畜牧兽医 2024年第9期51卷 3715-3725页

作者：周芳廷玉溪师范学院化学生物与环境学院玉溪653100

【目的】试验旨在获取水牛krüppel样因子15(krüppel-like factor 15,KLF15)基因,分析其分子特征和组织差异表达,初步揭示该基因的结构和功能。【方法】克隆水牛KLF 15基因编码区,对该基因的结构、氨基酸序列一致性、理化特性、基序、... 详细信息

【目的】试验旨在获取水牛krüppel样因子15(krüppel-like factor 15,KLF15)基因,分析其分子特征和组织差异表达,初步揭示该基因的结构和功能。【方法】克隆水牛KLF 15基因编码区,对该基因的结构、氨基酸序列一致性、理化特性、基序、保守结构域、生物学功能等进行比较分析,并采用实时荧光定量PCR法检测KLF 15基因在水牛各组织中的表达水平。【结果】克隆得到水牛KLF 15基因编码区长为1212 bp,编码403个氨基酸。生物信息学分析显示,水牛KLF15与其他牛科物种氨基酸序列的一致性较高,是核内的亲水性蛋白,无信号肽序列及跨膜结构,包含KLF15_N、COG5048和zf-C2H2锌指结构等保守结构域。水牛KLF15的主要功能是调控DNA转录、结合DNA、结合锌指结构等。KLF 15基因在泌乳期水牛的脂肪中表达量最高,在非泌乳期水牛的肌肉中表达量最高,但在2个时期的水牛中均为在乳腺、心脏、肝脏、脾脏等组织中中度表达,在肺脏、肾脏、瘤胃和小肠等组织中低表达或几乎不表达。【结论】水牛KLF15是细胞核内的蛋白,可结合锌指结构调控DNA的转录,在脂合成旺盛的组织中发挥功能。

关键词：水牛 KLF 15基因分子特征组织表达生物信息学

An Intelligent Coordinated Protection and Control Strategy for Distribution Network with Wind Generation Integration

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CSEE Journal of Power and Energy Systems 2016年第4期2卷 23-30页

作者： zhou Liu Hans kr.Høidalen Murari Mohan Saha Electrical Power Engineering Department Norwegian University of Science and Technology(NTNU)TrondheimNO 7491Norway Grid Automation Product ABB AB72244Vasteras Sweden

Integration of distributed generation(DG)can change the fault current level and direction in the distribution system,which affects the related protection *** order to limit the negative impact of DG integration and upgrade the protection system performance,an intelligent coordinated protection and control strategy is proposed.A cost based optimization method is adopted to minimize the operation costs of possible *** aim is to define the optimal relay settings for the present operation condition,and the most suitable control mode of converter based wind turbine *** studies on a hardware in the loop real time simulation platform demonstrate the proposed protection strategy.

关键词： Converter based wind turbine DG coordinated protection and control hardware in the loop real time simulation