检索结果-南通市图书馆

One stone two birds:electrochemical and colorimetric dual-mode biosensor based on copper peroxide/covalent organic framework nanocomposite for ultrasensentive norovirus detection

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 920-931页

作者： Guobao Ning Quanmei Duan Huan Liang Huifang Liu Min zhou chunlan Chen Chong Zhang Hui Zhao Canpeng Li School of Chemical Science and Technology Yunnan UniversityKunming 650091China Laboratory for Conservation and Utilization of Bio-resource Yunnan UniversityKunming 650091China Kunming Customs Technology Center Kunming 650228China

Norovirus(NoV)is regarded as one of the most common causes of foodborne diarrhea in the *** is urgent to identify the pathogenic microorganism of the diarrhea in short *** this work,we developed an electrochemical and colorimetric dual-mode detection for NoV based on the excellent dual catalytic properties of copper peroxide/COF-NH_(2)nanocomposite(CuO_(2)@COF-NH_(2)).For the colorimetric detection,NoV can be directly detected by the naked eye based on CuO_(2)@COF-NH_(2)as a laccase-like nonazyme using“peptide-NoV-antibody”recognition *** colorimetric assay displayed a wide and quality linear detection range from 1 copy/mL to 5000 copies/mL of NoV with a low limit of detection(LOD)of 0.125 copy/*** the electrochemical detection of NoV,CuO_(2)@COF-NH_(2)showed an oxidation peak of copper ion from Cu^(+)to Cu^(2+)using“peptide-NoV-antibody”recognition *** electrochemical assay showed a linear detection range was 1-5000 copies/mL with a LOD of 0.152 copy/***'s worthy to note that this assay does not need other electrical signal molecule,which provide the stable and sensitive electrochemial detection for *** electrochemical and colorimetric dual-mode detection was used to detect NoV in foods and faceal samples,which has the potential for improving food safety and diagnosing of NoV-infected diarrhea.

关键词： Norovirus Specific peptides Electrochemical and colorimetric assay Dual-mode Copper peroxide/covalent organic framework

Structure and electrical properties of polysilicon films doped with ammonium tetraborate tetrahydrate

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2024年第10期45卷 60-68页

作者： Yehua Tang Yuchao Wang chunlan zhou Ke-Fan Wang Electrical and Energy Engineering Department Nantong Institute of TechnologyNantong 226000China Ningxia Research Center of Silicon Target and Silicon-Carbon Negative Materials Engineering Technology School of Materials Science and EngineeringNorth Minzu UniversityYinchuan 750021China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100049China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Henan Key Laboratory of Quantum Materials and Quantum Energy School of Future TechnologyHenan UniversityKaifeng 475004China

Here,p-type polysilicon films are fabricated by ex-situ doping method with ammonium tetraborate tetrahydrate(ATT)as the boron source,named *** effects of ATT on the properties of polysilicon films are comprehensively *** Raman spectra reveal that the ATT-pPoly film is composed of grain boundary and crystalline *** preferred orientation is the(111)*** grain size increases from 16−23 nm to 21−47 nm,by~70%on *** with other reported films,Hall measurements reveal that the ATT-pPoly film has a higher carrier concentration(>10^(20)cm^(−3))and higher carrier mobility(>30 cm2/(V·s)).The superior properties of the ATT-pPoly film are attributed to the heavy doping and improved grain *** doping property is proved by the mean sheet resistance(Rsheet,m)and distribution *** R_(sheet,m)decreases by more than 30%,and it can be further decreased by 90%if the annealing temperature or duration is *** boron concentration of ATT-pPoly film annealed at 950℃ for 45 min is~3×10^(20)cm^(−3),and the distribution is nearly the same,except near the ***,the standard deviation coefficient(σ)of Rsheet,m is less than 5.0%,which verifies the excellent uniformity of ATT-pPoly film.

关键词： polysilicon film boron doping ammonium tetraborate tetrahydrate(ATT) electrical properties crystallization

Transcranial Magneto-Acoustic Stimulation Attenuates Synaptic Plasticity Impairment through the Activation of Piezo1 in Alzheimer’s Disease Mouse Model

在线全文

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 81-95页

作者： Fangxuan Chu Ruxin Tan Xin Wang Xiaoqing zhou Ren Ma Xiaoxu Ma Ying Li Ruixu Liu chunlan Zhang Xu Liu Tao Yin Zhipeng Liu Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Tianjin Institutes of Health Science Tianjin301600China Neuroscience Center Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing100730China

The neuropathological features of Alzheimer’s disease include amyloid *** emerging evidence suggests that Piezo1,a mechanosensitive cation channel,plays a critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure,but the importance of Piezo1-mediated mechanotransduction in brain functions is less ***,apart from mechanical stimulation,Piezo1 channels are strongly modulated by *** assume that Piezo1 may play a role in converting mechanical and electrical signals,which could induce the phagocytosis and degradation of Aβ,and the combined effect of mechanical and electrical stimulation is superior to single mechanical ***,we design a transcranial magneto-acoustic stimulation(TMAS)system,based on transcranial ultrasound stimulation(TUS)within a magnetic field that combines a magnetoacoustic coupling effect electric field and the mechanical force of ultrasound,and applied it to test the above hypothesis in 5xFAD *** tests,in vivo electrophysiological recordings,Golgi–Cox staining,enzyme-linked immunosorbent assay,immunofluorescence,immunohistochemistry,real-time quantitative PCR,Western blotting,RNA sequencing,and cerebral blood flow monitoring were used to assess whether TMAS can alleviate the symptoms of AD mouse model by activating Piezo1.

关键词： stimulation Alzheimer Piezo1

X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl)phthalate-induced testis toxicity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 935-951页

作者： Yifan Hong Xiazhu zhou Qi Li Jing Chen Yuexin Wei chunlan Long Lianju Shen Xiangqin Zheng Dinggang Li Xia Wang Chenjun Yu Shengde Wu Guanghui Wei Department of Urology Children's Hospital of Chongqing Medical UniversityChongqing 400014China Pediatric Research Institute Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical UniversityChongqing 400014China Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and Technology Cooperation Base of Child Development and Critical Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China

As a widely used plasticizer,di-(2-ethylhexyl)phthalate(DEHP)is known to induce significant testicular ***,the potential mechanism and effects of pubertal exposure to DEHP on testis development remain *** vivo,postnatal day(PND)21 male rats were gavaged with 0,250,and 500 mg/kg DEHP for ten *** to the seminiferous epithelium and disturbed spermatogenesis were observed after DEHP ***,oxidative stress-induced injury and pyroptosis were *** endoplasmic reticulum(ER)stress and mitophagy were involved in this *** phthalate(MEHP)was used as the biometabolite of DEHP in *** GC-1 and GC-2 cell lines were exposed to 0,100μM,200μM,and 400μM MEHP for 24 *** oxygen species(ROS)generation,oxidative stress damage,ER stress,mitophagy,and pyroptosis were significantly increased after MEHP *** ultrastructure of the ER and mitochondria was destroyed.X-box binding protein 1(XBP1)was observed to be activated and translocated into the *** generation was inhibited by *** levels of antioxidative stress,ER stress,mitophagy,and pyroptosis were decreased as *** the administration of the ER stress inhibitor 4-phenyl-butyric acid,both mitophagy and pyroptosis were ***-induced XBP1 down-regulation decreased the levels of mitophagy and *** equilibrium between pyroptosis and mitophagy was disturbed by XBP1 *** summary,our findings confirmed that DEHP induced a ROS-mediated imbalance in pyroptosis and mitophagy in immature rat testes via ***,XBP1 might be the key target in DEHP-related testis dysfunction.

关键词： DEHP Mitophagy Pyroptosis Testicular development XBP1

The passivation role of the Si based film on the crystallinesillicon substrate

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The passivation role of the Si based film on the crystalline...

Long-term Variation of the Solar Polar Magnetic Fields at Different Latitudes

第二届晶体硅太阳电池及材料科学与技术国际研讨会

作者： Zhangyan12 Zhao lei1 Diao hongweit Zeng xiangboa zhou chunlan1 Wang wenjing1 Guo bei2 Zhang bing2 Li hongyuan2 Institute of electrician Chinese Academy of Sciences HaiDian District Beijing 100083 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China. Institute of Semiconductors Chinese Academy of Sciences HaiDian District Beijing 100083 China.

＜正＞Combination of characteristics of both crystalline and thin film Si,the amorphous /crystalline silicon heterojunction solar cells have attracted a growing amount of attention because of its low-temperature processes,high efficiency,and low cost *** solar cells were considered as interfacial *** the photo-carrier generation occurs mostly in the c-Si, it is known that the interface recombination between c-Si/a-Si:H,the surface passivation of the crystalline silicon substrate is a critical *** amorphous silicon film on texturised c-Si heterojunction solar cells with 20.1% efficiency developed by Sanyo were achieved by insert a thin hydrogenated amorphous silicon（a-Si:H） buffer *** goal of the paper is to research the the passivation role of the si based film on the crystalline silicon *** Deposite a series of thin film silicon layers on polished crystalline silicon substrate by *** influence of RF power,substrate temperature,hydrogen dilution and gas pressure have been systematically investigated on the properties of Si based *** the construction of the Si based films by laman spectrum and test the minority carrier lifetime by *** is found that the minority carrier lifetime of the silicon substrate became much better than *** shows that the Si based films play an important role on the passivation of the silicon substrate。And the passivation is related to the microstructure of the si based film,the best passivation role can be achieved by Complete amorphous si based *** also showed in this paper about the direction to make better si based films by PECVD.

关键词： PECVD passivation thin film

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第7期24卷 190-197页

作者： Shuhong Yang Jie Jiang Zifan Wang Yijun Hou chunlan Jin Qiao Song Yukun Luo Ting Li Jun Zhang Yuzong Zhang Guiping zhou Yuanyong Deng Jingxiu Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China School of Space and Environment Beihang UniversityBeijing 102206China Key Laboratory of Space Weather National Satellite Meteorological Center(National Center for Space Weather)China Meteorological AdministrationBeijing 100081China Innovation Center for FengYun Meteorological Satellite(FYSIC) Beijing 100081China School of Physics and Materials Science Anhui UniversityHefei 230601China

The polar magnetic fields of the Sun play an important role in governing solar activity and powering fast solar ***,because our view of the Sun is limited in the ecliptic plane,the polar regions remain largely *** the high spatial resolution and polarimetric precision vector magnetograms observed by Hinode from 2012 to 2021,we investigate the long-term variation of the magnetic fields in polar caps at different *** Hinode magnetic measurements show that the polarity reversal processes in the north and south polar caps are *** variation of the averaged radial magnetic flux density reveals that,in each polar cap,the polarity reversal is completed successively from the 70°latitude to the pole,reflecting a poleward magnetic flux migration *** results clarify the polar magnetic polarity reversal process at different latitudes.

关键词： dynamo-Sun magnetic fields-Sun photosphere

Tri-signal colorimetric/electrochemical detection of egg allergen based on boric acid affinity reagent modified CuO nanoparticles

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： chunlan Chen Fengqi zhou Hongmin Zhu Ding Ma Yufan Huang Jing Li Linjiang Guo Lin Xiao Guobao Ning Xiaokang Lu Bilian Li Hui Zhao Can-Peng Li School of Chemical Science and Technology， Yunnan University Laboratory for Conservation and Utilization of Bio-resource， Yunnan University

A tri-signal ultrasensitive colorimetric/electrochemical detection of ovomucoid （OM） was developed. Herein， copper oxide nanoparticles （CuO NPs） were prepared， which exhibit excellent enzyme-like activity （peroxidase-like and laccase-like） and electrochemical activity. CuO@3-APBA nanoparticles （CuO@3-APBA NPs） were prepared by the coordinating Cu with the amino group on 3-aminophenobenic boric acid （3-APBA） in CuO NPs. 3-APBA of CuO@3-APBA can react with diol structure on sugar chain of OM under alkaline conditions. Then， a tri-signal ultrasensitive biosensing platform for OM was established based on the catalytic activity of CuO@3-APBA nanozyme. For the first signal， CuO@3-APBA can catalyze oxidation of TMB to turn the solution from colorless to blue in the presence of H2O2（absorbance at 652 nm）. For the second signal， CuO@3-APBA can catalyze the oxidation of substrates （2， 4-dichlorophenol and 4-aminoantipyrine） and turn the solution from colorless to pink （absorbance at 510 nm）. For the third signal， electrochemical oxidation peak of copper ion from Cu+to Cu2+of CuO@3-APBA was recorded by differential pulse voltammetry， which was used to determine the OM. The sensing platform exhibited a wide linear range （0.0000316-100 ng/mL） with a low detection limit （0.0105 pg/mL）， as well as showed advantages， such as satisfactory reproducibility， good stability， and excellent selectivity. The assay has the potential applications for ultrasensitive detection of allergen in foods.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

含能射流侵彻混凝土径向扩孔理论模型研究

弹箭与制导学报 2024年第2期44卷 21-29页

作者：杜烨姜春兰李强周炜智中北大学机电工程学院山西太原030051 北京理工大学爆炸科学与技术国家重点实验室北京100081

针对聚能装药侵彻混凝土目标开孔孔径不足导致后级弹丸无法顺利随进的问题,在对混凝土的力学特性和损伤模式分析的基础上,基于动态球形空腔膨胀理论,分析了含能射流对混凝土目标径向扩孔的物理过程。通过引入含能射流释能参量,构建出根... 详细信息

针对聚能装药侵彻混凝土目标开孔孔径不足导致后级弹丸无法顺利随进的问题,在对混凝土的力学特性和损伤模式分析的基础上,基于动态球形空腔膨胀理论,分析了含能射流对混凝土目标径向扩孔的物理过程。通过引入含能射流释能参量,构建出根据不同侵彻速度下含能射流侵彻混凝土各阶段的径向扩孔工程计算模型,并进行了试验验证。结果表明:工程计算模型所得数值计算结果与试验数据误差在10%以内,模型可推广到射流对各种强度的素混凝土结构的扩孔计算,对串联侵彻战斗部前级聚能装药结构设计具有一定的指导意义。

关键词：爆炸力学含能射流混凝土靶径向扩孔工程计算

维普期刊数据库博看期刊

GDM孕妇血清甲状腺激素、25-羟维生素D水平与新生儿低血糖关系

在线全文

学校读者我要写书评

暂无评论

中国计划生育学杂志 2024年第2期32卷 455-459页

作者：黎国春周春兰湖北省宜昌市夷陵人民医院 443100

目的:探讨妊娠期糖尿病(GDM)孕妇血清甲状腺激素、25-羟基维生素D[25-(OH)D]水平与新生儿低血糖的相关性。方法:选择2021年9月-2022年6月在本院分娩的305例GDM产妇临床资料,根据新生儿是否发生低血糖分为低血糖组58例与血糖正常组247例... 详细信息

目的:探讨妊娠期糖尿病(GDM)孕妇血清甲状腺激素、25-羟基维生素D[25-(OH)D]水平与新生儿低血糖的相关性。方法:选择2021年9月-2022年6月在本院分娩的305例GDM产妇临床资料,根据新生儿是否发生低血糖分为低血糖组58例与血糖正常组247例,检测血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、25-(OH)D水平,采用pearson法分析血清FT3、FT4、25-(OH)D水平与血糖指标相关性,logistic回归模型分析影响新生儿发生低血糖的影响因素。结果:血糖正常组与低血糖组年龄、孕前体质指数、确诊时孕周、孕次、分娩方式、新生儿性别及空腹胰岛素、稳态模型胰岛素抵抗指数无差异(P>0.05),低血糖组分娩期血糖控制不佳、早产儿、低出生体重儿、出生1minApgar评分≤7分患儿占比、空腹血糖(FBG)、糖化血红蛋白(HbA1c)均高于血糖正常组,血清FT3(6.25±1.47pmmol/L)、FT4(13.95±1.44pmmol/L)、25-(OH)D(27.56±3.28ng/ml)水平均低于血糖正常组(6.76±1.51pmmol/L、18.43±1.56pmmol/L、36.42±5.24ng/ml)(均P0.05);相关性分析显示,血清FT3、FT4与FBG、HbA1c呈负相关(P0.05);25-(OH)D与FBG、HbA1c、FINS、HOMA-IR呈负相关(P1c升高、FT3降低、FT4降低、25-(OH)D降低是GDM孕妇分娩低血糖新生儿的影响因素(均P<0.05)。结论:新生儿低血糖与GDM孕妇血清FT3、FT4、25-(OH)D水平降低有关。

关键词：妊娠期糖尿病新生儿低血糖甲状腺激素 25-羟维生素D 相关性影响因素

维普期刊数据库博看期刊