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季节性流感的多元激发理论及其包含气象和社会行为因素的数学模型

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热带气象学报 2009年第6期25卷 706-716页

作者： zhou Steven zhixiang 伦敦大学伦敦卫生及热带医学院英国伦敦英属哥伦比亚技术学院加拿大BC省本拿比

为了解流感的季节性和爆发的生物力学机制,在收集、分析、计算全球各地流感监测资料的基础上,建立了流感传播的多元激发理论及相应的数值模式,并运用该模式对全球各大洲不同气候带的季节性流感和周际流感进行了数值模拟和预报尝试。模... 详细信息

为了解流感的季节性和爆发的生物力学机制,在收集、分析、计算全球各地流感监测资料的基础上,建立了流感传播的多元激发理论及相应的数值模式,并运用该模式对全球各大洲不同气候带的季节性流感和周际流感进行了数值模拟和预报尝试。模式近似解的数学表达式以及模式输出与实况高度吻合的模拟结果证明:流感的发病率呈高度自相关,同时受生物、气象环境和社会-行为因素支配;流感的爆发是各种因素协同作用的结果。动力共振、太阳辐射、降水、露点温度变化、行为和干预效应以及人群对优势流行毒株的免疫力是支配流感季节性和每周活动变化的关键因素。具体表现为,对于所有气候区,流感发病率都是降水日数的指数函数,日照时数的1/4次方的负指数函数。在温带和寒带地区,季节性流感的发病率是露点温度的负指数函数。在热带地区,则是露点与其年平均值绝对偏差的指数函数。研究提示:早期干预(例如适时和广泛接种疫苗、迅速隔离病例、停学、遏制早期病例总数等)是控制和预防季节性流感的关键;适量的日光照射或在雨季和日照短的季节补充维生素D、增加户外活动、发布高危天气预警、设定适中的室内露点温度是值得高度重视的预防策略。模式的模拟结果在很大程度上揭示了流感季节性的机理和证明了著名医学家和诺贝尔奖获得者RobeRtEdga RHope-Simpson在上世纪提出的流感季节性成因的猜想。模拟结果还表明,模式对每周流感发病率具有一定的预报能力。该理论和模型很可能适用于当前的甲型流感大流行和其它传染性疾病,可被进一步开发应用。

关键词：流感季节性流感模拟流感大流行维生素D

XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3304-3317页

作者： Yahui Zhao Weina Zhang Miaomiao Huo Peng Wang Xianghe Liu Yu Wang Yinuo Li zhixiang zhou Ningzhi Xu Hongxia Zhu State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021BeijingChina Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021BeijingChina

Macrophages are among the most abundant immune cells in colorectal cancer (CRC). Re-educating tumor-associated macrophages (TAMs) to switch from protumoral to anti-tumoral activity is an attractive treatment strategy that warrants further investigation. However, little is known about the key pathway that is activated in TAMs. In this study, infitrating CD206^(+) TAMs in CRC were sorted and subjected to RNA-seq analysis. Differentially expressed genes were found to be enriched in unfolded protein response/endoplasmic reticulum stress response processes, and XBP1 splicing/activation was specifically observed in TAMs. XBP1 activation in TAMs promoted the growth and metastasis of CRC. Ablation of XBP1 inhibited the expression of the pro-tumor cytokine signature of TAMs, including IL-6, VEGFA, and IL-4. Simultaneously, XBP1 depletion could directly inhibit the expression of SIRPα and THBS1, thereby blocking “don’t eat me” recognition signals and enhancing phagocytosis. Therapeutic XBP1 gene editing using AAV2-sgXBP1 enhanced the anti-tumor activity. Together, XBP1 activation in TAMs drives CRC progression by elevating pro-tumor cytokine expression and secretion, as well as inhibiting macrophage phagocytosis. Targeting XBP1 signaling in TAMs may be a potential strategy for CRC therapy.

关键词： colorectal inhibited thereby

焦亡相关炎症因子与痛风性关节炎疾病活动度的相关性研究

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中国医学前沿杂志（电子版） 2024年第4期16卷 61-67页

作者：王国镇刘紫佳盛超郑雨晨舒晓明杨怡姝张铁周志祥北京工业大学化学与生命科学学院北京100124 中日友好医院检验科北京100029 中日友好医院风湿免疫科北京100029

目的分析焦亡相关炎症因子在痛风性关节炎(gouty arthritis,GA)患者不同病程中的表达水平,探讨细胞焦亡是否参与GA的病理生理过程。方法收集2022年6月至2023年6月就诊于中日友好医院风湿免疫科50例急性痛风性关节炎(acute gouty arthrit... 详细信息

目的分析焦亡相关炎症因子在痛风性关节炎(gouty arthritis,GA)患者不同病程中的表达水平,探讨细胞焦亡是否参与GA的病理生理过程。方法收集2022年6月至2023年6月就诊于中日友好医院风湿免疫科50例急性痛风性关节炎(acute gouty arthritis,AGA)患者(AGA组)和50例健康体检者(健康对照组)的外周静脉血样本,分别检测两组患者血清生化指标、血常规指标及焦亡相关炎症因子如C反应蛋白(C-reactive protein,CRP)、白介素(interleukin,IL)-1β、IL-18的表达水平;蛋白免疫印迹法检测尿酸钠结晶刺激的THP-1细胞中焦亡相关蛋白水平变化。采用SPSS统计学软件对受试者的尿酸水平、疾病活动度等指标进行统计分析。结果与健康对照组相比,AGA组患者外周血血清尿酸(uric acid,UA)、白细胞、CRP、IL-1β、IL-18、IL-6、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、Ca^(2+)水平显著升高,Mg^(2+)水平显著降低,差异具有统计学意义(P<0.05);AGA组急性发作期UA、白细胞、CRP、IL-1β、IL-18、IL-6、TNF-α、Ca^(2+)和数字分级评分法(numerical rating scale,NRS)评分显著高于缓解期,Mg^(2+)水平显著降低(P<0.05);NRS评分与血清IL-1β、IL-8、IL-18水平呈正相关(P<0.05)。尿酸钠结晶刺激的THP-1细胞中焦亡相关功能蛋白表达水平显著高于无特殊处理的THP-1细胞。结论GA患者焦亡相关炎症因子水平高于健康对照者,且GA急性期焦亡相关炎症因子水平高于GA缓解期,提示细胞焦亡可能参与了GA的免疫炎性反应。

关键词：急性痛风性关节炎白介素-1β 白介素-18β 细胞焦亡炎性体NLRP3

Efficient continuous synthesis of 2-hydroxycarbazole and 4-hydroxycarbazole in a millimeter scale photoreactor

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Chinese Chemical Letters 2024年第4期35卷 399-403页

作者： zhixiang Li Zhirong Yang Chang Yao Bin Wu Gang Qian Xuezhi Duan Xinggui zhou Jing Zhang State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237China School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China

2-Hydroxycarbazole and 4-hydroxycarbazole are important chemicals with extensive applications in optoelectronic materials and pharmaceutical *** of the art yield of 2-hydroxycarbazole is~30%and the reaction time is typically in hours or ***,we developed a green route for the continuous and high-throughput synthesis of 2-hydroxycarbazole and 4-hydroxycarbazole via photochemical intramolecular cyclization of 3–hydroxy-2–chloro-diphenylamine using a self-designed millimeter scale photoreactor,which was designed based on sizing-up and numbering-up strategies for a decent liquid holdup(6.8 m L)and fabricated via femtosecond laser engraving *** photochemical synthesis was carried out continuously under the illumination of 365 nm UV-LED with dimethyl sulfoxide as solvent and potassium t-butoxide as *** was found that under optimized conditions a 2-hydroxycarbazole yield of 31.6%and a 4-hydroxycarbazole yield of 11.1%were obtained with a residence time of 1 *** to semibatch operations,the reaction time was shortened by 1–2 orders of *** a result,a throughput of 11.3 g/day 2-hydroxycarbazole and 4.0 g/day 4-hydroxycarbazole can be achieved from the *** was proposed that the short reaction time and high product yield are resulted from higher photon transfer rates and more uniform photon distribution provided by the millimeter scale photoreactor,which enhances the reaction rates and mitigates overreaction.

关键词： Millimeter scale reactor 2-Hydroxycarbazole Photochemistry UV-LED Process intensification

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一种基桩静载试验位移测量仪研制与应用

岩石力学与工程学报 2018年第A01期37卷 3729-3737页

作者：朱世峰周志祥重庆交通大学土木工程学院重庆400074 重庆交通大学山区桥粱与隧道工程国家重点实验室培育基地重庆400074

为解决基桩静载试验中位移测量设备对基准梁的依赖、量程小、对安装垂直度要求苛刻等问题,采用理论分析、对比试验和现场试验相结合的方法,研制由连通管和差压传感器组成的液–气联动差压连通管式位移测量仪。在进行位移测量仪构造设计... 详细信息

为解决基桩静载试验中位移测量设备对基准梁的依赖、量程小、对安装垂直度要求苛刻等问题,采用理论分析、对比试验和现场试验相结合的方法,研制由连通管和差压传感器组成的液–气联动差压连通管式位移测量仪。在进行位移测量仪构造设计时,基于液体具有在重力作用下自动寻找等势且保持为水平面的特性,提出一种等液位控制方法与结构,使得差压连通管式位移测量仪两端初始液位相同,减小测量误差。100 mm位移内的对比试验得出该位移测量仪与百分表、步进电机控制式移动平台测量结果一致,最大绝对误差0.04 mm。在某长江大桥试桩工程中的现场试验,测得最大向下位移值36.46 mm,最大向上位移值127.34 mm,与采用相关设备测量的结果基本一致,最大偏差+0.28 mm。开发的位移测量仪配套应用程序采用Labview编写,支持人工干预短期测量和自动化连续长期测量。该位移测量仪测试期间无需基准梁,对安装垂直度无要求,具有低成本、易操作、环境适应性强等优势,在基桩静载试验中有良好的推广价值。

关键词：桩基础基桩静载试验位移测量仪液–气联动差压连通管基准梁液位控制

Synthesis,characterization and photodynamic activity of ethanolamino-substituted hypocrellin B(EAHB2)

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生物物理学报 2009年第S1期25卷 441-442页

作者： zhixiang zhou, Lina Zhang,Ping Ai,Hongtao Ma College of Life Science and Bio-engineering, Beijing University of Technology, Beijing, 100124, China

The limitations of currently used clinical phototherapeutic agent, Photofrin, have prompted a search for more ideal photodynamic sensitizer. The hypocrellins, have been paid the

关键词： Photodynamic therapy(PDT) ethanolamino-substituted hypocrellin B(EAHB2) MGC-803 cell MCF-7 cells cell cycle arrest apoptosis

A pilot phase Ⅱ study of neoadjuvant triplet chemotherapy regimen in patients with locally advanced resectable colon cancer

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Chinese Journal of Cancer Research 2016年第6期28卷 598-605页

作者： Haitao zhou Yan Song Jun Jiang Haitao Niu Hong Zhao Jianwei Liang Hao Su Zheng Wang zhixiang zhou Jing Huang Department of Colorectal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Imageology National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Abdominal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China

Objective： This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon ***： Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen（oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals） for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant ***： All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients（91.3%） had reductions in tumor volume after neoadjuvant treatment, and 13 patients（56.5%） had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete ***： Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer.

关键词： 5-Fluorouracil colon cancer irinotecan oxaliplatin neoadjuvant chemotherapy

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基于挠度曲率面积差的桥梁结构损伤识别方法

工程科学与技术 2021年第6期53卷 165-174页

作者：吴桐唐亮周志祥重庆交通大学省部共建山区桥梁及隧道工程国家重点实验室重庆400074 深圳大学土木与交通工程学院广东深圳518060

挠度信息是桥梁健康监测的基础数据,能够为桥梁安全状态评价提供可量化的数据。本文通过分析挠度与其1、2阶导数(转角和曲率)之间的关系,提出一种利用损伤前后荷载挠度曲线的曲率面积差参数△A_(κ)识别结构局部刚度损伤的方法。该方法... 详细信息

挠度信息是桥梁健康监测的基础数据,能够为桥梁安全状态评价提供可量化的数据。本文通过分析挠度与其1、2阶导数(转角和曲率)之间的关系,提出一种利用损伤前后荷载挠度曲线的曲率面积差参数△A_(κ)识别结构局部刚度损伤的方法。该方法采用测点数量将损伤前后的曲率曲线所围成的面积划分为若干单元,将各单元面积的平方与所有单元面积平方和的比值作为损伤定位参数,利用该参数的峰值定位结构损伤位置。作为理论实例,在一座简支T梁桥的有限元模型中设置不同程度(5%-50%)和不同数量的局部刚度损伤,以各单元的曲率面积差为参数,准确定位桥梁结构损伤位置。同时,对一座有机玻璃模型桥进行损伤识别试验。结果表明:损伤位置处的曲率面积差远远大于未损伤位置,能够准确定位结构中微小程度的局部刚度损伤;且不同损伤程度下的曲率面积差与损伤程度无关,即使有测量噪声的情况下也能清晰定位出损伤位置。该方法有助于提高桥梁日常安全巡检的效率,量化检测数据,客观化识别结果,推动在实际桥梁工程中的应用。

关键词：桥梁健康监测损伤识别曲率面积差局部刚度

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多分量多点平稳随机地震响应的快速算法

西南交通大学学报 2007年第1期42卷 55-60页

作者：赵灿晖周志祥西南交通大学土木工程学院四川成都610031 重庆交通学院土建学院重庆400074

为了解决多分量多点激励作用下大跨度桥梁平稳随机响应的计算问题,在单分量虚拟激励法的基础上,提出了多分量多点地震激励下计算大跨度桥梁平稳随机响应的虚拟激励法.理论证明,该法具有与经典随机振动理论精确解相同的精度,而计算速度... 详细信息

为了解决多分量多点激励作用下大跨度桥梁平稳随机响应的计算问题,在单分量虚拟激励法的基础上,提出了多分量多点地震激励下计算大跨度桥梁平稳随机响应的虚拟激励法.理论证明,该法具有与经典随机振动理论精确解相同的精度,而计算速度比经典随机振动理论快10倍,且可方便地计入行波效应或部分相干效应.

关键词：地震响应随机振动多分量激励多点激励