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Energy & Environmental Materials 2024年第1期7卷 104-110页

作者： Yuepeng Pang zhengfang Nie Fen Xu Lixian Sun Junhe Yang Dalin Sun Fang Fang Shiyou Zheng School of Materials and Chemistry University of Shanghai for Science and Technology Guangxi Key Laboratory of Information Materials & Guangxi Collaborative Innovation Centre of Structure and Property for New Energy and Materials Guilin University of Electronic Technology Department of Materials Science Fudan University

Searching for novel solid electrolytes is of great importance and challenge for all-solid-state Mg *** this work, we develop an amorphous Mg borohydride ammoniate,Mg（BH4）2·2NH3,as a solid Mg electrolyte that prepar... 详细信息

关键词： all-solid-state Mg batteries amorphization Mg borohydride ammoniate Mg vacancy migration solid electrolyte

Ultraviolet photodissociation dynamics of bromo-fluorobenzenes

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Calcium-chelating peptides from rabbit bone collagen:characterization,identification and mechanism elucidation

第十五届全国化学动力学会议

作者：梁昊 Chao He Min Chen zhengfang zhou Yang Chen Dongfeng Zhao Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemical PhysicsUniversity of Science and Technology of China

In the past few decades, because of the importance in atmospheric chemistry, experimental and theoretical studies on the photodissociation dynamics of organic halides have attracted great interest to physical chemists. Here, we present a detailed experimental study on the photodissociation dynamics of seven different fluorinated bromobenzenes at UV wavelengths corresponding to their first UV absorption band, aiming to validate our understanding in the dissociation mechanisms of lager aromatic molecules upon fluorine substitution effect. Recoiling velocity distributions of photofragmented Br(P) and Br(P) atoms have been measured using velocity map imaging technique combined with(2 + 1) resonance-enhanced multiphoton ionization(REMPI). It is found that the fragmented Br(P) from 266 nm photodissociation of 1-Br-2,6-FPh and 1-Br-2,4,6-FPh shows a different behavior from other bromo-fluorobenzenes, which cannot be explained by the commonly known S S(~ππ*)πσ* predissociation mechanism. Accurate three-dimensional potential energy surfaces(PESs) of the low-lying electronic states of 1-Br-2,6-FPh, have been calculated. Based on the newly calculations, subtleties in addition to S S(~ππ*)πσ* mechanism, a charge-transfer state resulting from electron transfer from nonbonding electrons to the π* orbitals of the phenyl ring, have been proposed to provide a renewed understanding of the present experimental results.

关键词： velocity map imaging fluorinated bromobenzenes photodissociation dynamics

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Food Science and Human Wellness 2024年第3期13卷 1485-1493页

作者： Fuhuan Yuan Yu Fu Liang Ma Hankun Zhu Yong Yu Xin Feng Yi Sun Hongjie Dai Xin Liu zhengfang Liu Yuhao Zhang College of Food Science Southwest UniversityChongqing 400715China Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing Chongqing 400715China Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationChongqing 400715China Angel Yeast Co. Ltd.Yichang 443003China

This study aimed to characterize and identify calcium-chelating peptides from rabbit bone collagen and explore the underlying chelating *** peptides and calcium were extracted from rabbit bone by instant ejection steam explosion(ICSE)combined with enzymatic hydrolysis,followed by chelation reaction to prepare rabbit bone peptide-calcium chelate(RBCP-Ca).The chelating sites were further analyzed by liquid chromatography-tandem mass(LC-MS/MS)spectrometry while the chelating mechanism and binding modes were *** structural characterization revealed that RBCP successfully chelated with calcium ***,LC-MS/MS analysis indicated that the binding sites included both acidic amino acids(Asp and Glu)and basic amino acids(Lys and Arg),Interestingly,three binding modes,namely Inter-Linking,Loop-Linking and Mono-Linking were for the first time found,while Inter-Linking mode accounted for the highest proportion(75.1%),suggesting that chelation of calcium ions frequently occurred between two ***,this study provides a theoretical basis for the elucidation of chelation mechanism of calcium-chelating peptides.

关键词： Rabbit bone Collagen peptide Peptide-calcium chelate Chelation mechanism Liquid chromatography-tandem mass(LC-MS/MS)

Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease

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Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4

第十二届全国免疫学学术大会

作者： Zhu Ping zhou zhengfang Wang Jingying Guo Chaoshe Chang Weiting Zhuang Jian Chen Jimei Guo Huiming Lu Cong Li Xue Department of Cardiac Surgery Guangdong Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical Sciences Departments of Urology and Surgery Boston Children's Hospital and Harvard Medical School Divisions of Genetics and Cardiovascular Medicine Brigham and Women's Hospital and Harvard Medical School

Objective:The embryonic process of forming a complex structure such as the heart remains poorly *** process whereby diverse cardiac progenitors assemble multiple anatomic components of the heart remains to be ***:Mouse embryos without Isletl fail to form the SHF derivatives including the right ventricle(RV),much of the atria,and the outflow tract(OFT).The subpopulation of SHF progenitors that contribute to the definitive OFT,which comprises the sub-arterial myocardium,the non-myocardial arterial roots with the semilunar valves,and the intrapericardial arterial trunks,is located at the ventral pharyngeal arch apparatus behind embryonic ***:Six2-positive(Six2+) progenitors are rapidly recruited and assigned,and their descendants are allocated successively to regions of the heart from the right ventricle(RV) to the pulmonary *** ablation of Six2+ progenitors resulted in RV hypoplasia and pulmonary *** early stage-specific ablation of a small subset of Six2+ progenitors did not cause any apparent structural defect at birth but rather resulted in adult-onset cardiac hypertrophy and ***,Six2 expression depends in part on Shh signaling,and Shh deletion resulted in severe deficiency of Six2+ ***:Collectively,these findings unveil the chronological features of cardiogenesis,in which the mammalian heart is built sequentially by temporally distinct populations of cardiac progenitors,and provide insights into late-onset congenital heart disease.

关键词： DTA HREM PTA Shh Six1

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Genes & Diseases 2024年第4期11卷 411-425页

作者： Mengmeng Guo Pan Hu Jiayi Xie Kefu Tang Shixiu Hu Jialiang Sun Yundong He Jing Li Weiqiang Lu Huirong Liu Mingyao Liu zhengfang Yi Shihong Peng Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Prenatal Diagnosis Center Department of Clinical LaboratoryChangning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200051China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 201203China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201400China Shanghai Yuyao Biotech Co. Ltd.Shanghai 200241China

Gastric cancer is highly prevalent among digestive tract *** to the intri-cate nature of the gastric cancer immune microenvironment,there is currently no effective treatment available for advanced gastric ***,there is promising potential for immunotherapy targeting the prostaglandin E2 receptor subtype 4(EP4)in gastric *** our previous study,we identified a novel small molecule EP4 receptor antagonist called *** with YY001 alone demonstrated a significant reduction in gastric cancer growth and inhibited tumor metastasis to the lungs in a mouse ***,adminis-tration of YYo01 stimulated a robust immune response within the tumor microenvironment,characterized by increased infiltration of antigen-presenting cells,T cells,and M1 ***,our research revealed that YYo01 exhibited remarkable synergistic ef-fects when combined with the PD-1 antibody and the clinically targeted drug apatinib,rather than *** findings suggest that YYo01 holds great promise as a potential therapeutic strategy for gastric cancer,whether used as a standalone treatment or in combination with other drugs.

关键词： EP4 Immunomodulation Synergy Tumor microenvironment YY001

左炔诺孕酮宫内缓释系统联合促性腺激素释放激素激动剂治疗子宫腺肌症的临床研究

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中国医学创新 2022年第9期19卷 169-173页

作者：周正芳福建省莆田市中医医院福建莆田351100

目的:探讨左炔诺孕酮宫内缓释系统(LNG-IUS)联合促性腺激素释放激素激动剂(GnRH-a)治疗子宫腺肌症的临床效果及对血清癌抗原125(CA125)、血红蛋白水平的影响。方法:选择2018年1月-2020年1月莆田市中医医院妇产科收治的66例符合入组标准... 详细信息

目的:探讨左炔诺孕酮宫内缓释系统(LNG-IUS)联合促性腺激素释放激素激动剂(GnRH-a)治疗子宫腺肌症的临床效果及对血清癌抗原125(CA125)、血红蛋白水平的影响。方法:选择2018年1月-2020年1月莆田市中医医院妇产科收治的66例符合入组标准的子宫腺肌症患者作为研究对象,按随机数字表法将其分为观察组(n=33)和对照组(n=33)。对照组仅放置LNG-IUS治疗,观察组先皮下注射GnRH-a,1次/月,治疗3次,再放置LNG-IUS治疗。比较两组放置LNG-IUS前及放置LNG-IUS 3、6个月后痛经[视觉模拟评分法(VAS评分)]及月经量[月经失血图(PBAC评分)],采用B超测定子宫体积,采用化学发光法测定CA125,采用干化学法检测血红蛋白水平,观察两组不良反应发生情况。结果:放置LNG-IUS 3、6个月,两组痛经VAS评分、月经量PBAC评分及子宫体积较放置LNG-IUS前均下降,且观察组均低于对照组(P<0.05)。两组不同时间点痛经VAS评分、月经量PBAC评分及子宫体积组内比较,差异均有统计学意义(P<0.05)。放置LNG-IUS 3个月,两组血清CA125较放置LNG-IUS前均下降,血红蛋白较放置LNG-IUS前均升高,且观察组血清CA125低于对照组,血红蛋白高于对照组,差异均有统计学意义(P<0.05)。观察组治疗过程中不良反应发生率为6.06%,明显低于对照组的27.27%(χ^(2)=5.345,P<0.05)。结论:LNG-IUS联合GnRH-a治疗子宫腺肌症效果确切,能有效减轻痛经程度及减少月经量,抑制子宫体积增大,且能降低CA125水平,抑制疾病进展。

关键词：子宫腺肌症左炔诺孕酮宫内缓释系统促性腺激素释放激素激动剂

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遥感影像并行服务系统设计与实现

测绘科学技术学报 2015年第1期32卷 42-46,51页

作者：周郑芳易磊王惠卢志渊陈征 61175部队信息工程大学 95956部队百年金海科技有限公司

实现海量遥感影像快速处理的重要基础是高速影像数据服务。基于影像瓦片模型、分布式并行存储体系结构,设计和实现遥感影像并行服务系统——瓦片服务系统,用于快速存储和访问以瓦片方式组织的遥感影像,为高速影像处理、实景城市等提供... 详细信息

实现海量遥感影像快速处理的重要基础是高速影像数据服务。基于影像瓦片模型、分布式并行存储体系结构,设计和实现遥感影像并行服务系统——瓦片服务系统,用于快速存储和访问以瓦片方式组织的遥感影像,为高速影像处理、实景城市等提供高吞吐数据服务。实验结果表明:瓦片服务系统具有快速存储和访问海量遥感影像的能力,在高速影像处理与影像服务等领域具有广阔应用前景。

关键词：遥感影像像素矩阵瓦片矩阵影像瓦片模型分布式并行存储瓦片服务系统

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癌结节在胃癌患者分期和预后评估中的价值

中华胃肠外科杂志 2017年第3期20卷 277-282页

作者：梁文全周正方崔建新郗洪庆陈凛解放军总医院普通外科北京100853 南开大学医学院普通外科专业天津300071

目的分析癌结节与胃癌临床病理特征的关系，评价其在胃癌分期和预后中的价值。方法收集2011年11月到2012年12月解放军总医院收治的388例胃腺癌患者临床病理资料进行回顾性队列研究。采用χ2检验和Fisher精确概率法分析癌结节状态与其他... 详细信息

目的分析癌结节与胃癌临床病理特征的关系，评价其在胃癌分期和预后中的价值。方法收集2011年11月到2012年12月解放军总医院收治的388例胃腺癌患者临床病理资料进行回顾性队列研究。采用χ2检验和Fisher精确概率法分析癌结节状态与其他临床病理资料的关系，采用Kaplan-Meier法绘制生存曲线，分别采用Log-rank检验和Cox回归模型进行单因素和多因素分析癌结节与患者预后的关系。结果388例胃腺癌患者中，癌结节阳性者67例（17.3%），其中男48例（48/289，16.6%），女19例（19/99，19.2%）；年龄≥62岁者40例（40/198，20.2%）。癌结节阳性患者的病理分期：TNM分期Ⅱb期5例（5/64，7.8%），Ⅲa期6例（6/58，10.3%），Ⅲb期14例（14/75，18.7%），Ⅲc期30例（30/135，22.2%），Ⅳ期12例（12/39，30.8%），无Ⅰb期和Ⅱa患者；肿瘤浸润深度为T2期2例（2/18，11.1%），T3期2例（2/27，7.4%），T4a期36例（36/259，13.9%），T4b期27例（27/84，32.1%）；淋巴结转移N0期5例（5/72，6.9%），N1期6例（6/72，8.3%），N2期19例（19/82，23.2%），N3a期27例（27/100，27.0%），N3b期10例（10/62，16.1%）；远处转移12例（12/40，30.0%）；脉管浸润29例（29/129，22.5%）。在癌结节阳性患者中，56.7%（38/67）的患者结节数量〉3个。癌结节状态与胃癌TNM分期（χ2= 16.898，P= 0.010）、pT分期（χ2= 17.382，P= 0.001）、pN分期（χ2=18.080，P= 0.001）、pM分期（χ2=5.060，P= 0.036）和脉管浸润（χ2=3.675，P= 0.039）有关。癌结节阳性患者的中位生存时间少于癌结节阴性患者（22月比32月，χ2=23.391，P= 0.012）。在癌结节阳性患者中，癌结节个数〉3者中位生存时间少于癌结节个数为0~3的患者（17月比25月，χ2=5.157，P= 0.023）。多因素生存分析发现，癌结节个数〉3是胃癌患者不良预后的独立危险因素（RR=2.350，95%CI：1.345~4.106，P= 0.003）。结论癌结节状态与胃癌的分期密切相关，癌结节数量超过3个的胃癌患者预后不良。

关键词：胃肿瘤癌结节分期预后

新时代全民健身高质量发展的科学内涵、问题指向与实践旨归

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成都体育学院学报 2024年第1期50卷 17-26页

作者：雷正方成都体育学院四川成都610041

文章在新发展理念指引下,全面解读了新时代全民健身高质量发展的科学内涵,即创新是全民健身高质量发展的第一动力、协调是全民健身高质量发展的内在要求、绿色是全民健身高质量发展的普遍形态、开放是全民健身高质量发展的必由之路、共... 详细信息

文章在新发展理念指引下,全面解读了新时代全民健身高质量发展的科学内涵,即创新是全民健身高质量发展的第一动力、协调是全民健身高质量发展的内在要求、绿色是全民健身高质量发展的普遍形态、开放是全民健身高质量发展的必由之路、共享是全民健身高质量发展的根本目的;系统阐述了新时代全民健身高质量发展旨在解决服务供给不充足、发展结构不平衡、生态保护不彻底、内外联动不通畅、成果共享不充分等的问题指向;针对性提出了新时代全民健身高质量发展应遵循制度完善与产品创新并创的效率优先观、补齐短板与优化结构并行的系统平衡观、提升认识与控制规模并重的持续发展观、开放发展与多元共治并举的协同实践观、强化共识与融合推进并为的民生指向观等的实践旨归。

关键词：全民健身高质量发展科学内涵问题指向实践旨归