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Chinese Journal of Structural Chemistry 2010年第10期29卷 1574-1578页

作者： zhou zhong-zhen YOU Wen-Wei ZHAO Pei-Liang Department of Chemistry College of Pharmaceutical SciencesSouthern Medical University

The title compound,(Z)-methyl-3-methoxy-2-{2-[(4-(E-3-p-tolylacryloyl)phenoxy)-methyl]phenyl}acrylate,was synthesized and determined by X-ray single-crystal *** crystal belongs to the triclinic system,space group P1 with a=8.0157(8),b=12.5748(13),c=13.3768(14)Å,α=64.770(2),β=75.720(2),γ=89.784(2)°,μ=0.085 mm^(-1),Mr=442.49,V=1174.1(2)Å3,Z=2,Dc=1.252 g/cm^(3),F(000)=468,T=294(2)K,R=0.0603 and wR=0.1498 for 2644 observed reflections with I〉2σ(I).X-ray diffraction analysis reveals that the single crystal contains strong non-classical hydrogen *** preliminary bioassay showed that the title compound exhibits inhibitory activity against the Pseudoperoniospora cubensis and Rhizoctonia solani at the test concentration of 200 mg/L.

关键词： synthesis crystal structure (Z)-methyl-3-methoxy-2-{2-[(4-(E-3-p-tolylacryloyl)phenoxy)methyl]phenyl}acrylate

A SPECTRAL METHOD FOR A CLASS OF NONLINEAR QUASI-PARABOLIC EQUATIONS

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Journal of Computational Mathematics 1994年第1期12卷 88-97页

作者： zhou zhen-zhong (Hunan Computing Center, Changsha, China) HUNAN COMP CTR CHANGSHAPEOPLES R CHINA

In this paper, we consider the numerical solution of quasi-parabolic equations of higher order by a spectral method, and propose a computational formula. We give an error estimate of approximate solutions, and prove the convergence of the approximate method and numerical stability on initial values. Under certain conditions, which are much weaker than the conditions in [6], we gain the same convergence rate as in [6].

关键词： Math A SPECTRAL METHOD FOR A CLASS OF NONLINEAR QUASI-PARABOLIC EQUATIONS

Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP^+ -induced decline of mitochondrial membrane potential and oxidative stress

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中国药理学与毒理学杂志 2018年第9期32卷 699-700页

作者： zhong Jia-hong XIE Jin-feng XIAO Jiao LI Dan zhou zhong-zhen WANG Hai-tao XU Jiang-ping Department of Neuropharmacology and Drug Discovery Southern Medical University Guangzhou 510515 China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 China

Parkinson disease(PD) is a chronic neurodegenerative disorder caused by progressive dopaminergic neuronal death in the substantia nigra pars compacta within the *** still is no cure,effective treatments for PD,available therapies are only capable of offering temporary and symptomatic relief to the *** are certain patents that claim phosphodiesterase(PDE) inhibitors as possible anti-PD drugs,PDE4 is a promising target for the treatment of PD and the underlying mechanism has not yet been well ***4 is an enzyme that specifically hydrolyzes intracellular cyclic adenosine monophosphate(cAMP)throughout the body,including the *** of the available PDE4 inhibitors exert unpleasant and serious side effects,such as emesis and nausea,which hinder its clinical ***,more efforts are needed before PDE4 inhibitors with high therapeutic indices are available for treatment of ***16 is a novel PDE4 inhibitor with little emetic potential,which exhibits excellent enzyme inhibition activity(IC50=90 nmol·L^(-1)).METHODS SH-SY5 Y cell was induced with 1-methyl-4-phenylpyridinium(MPP+)to mimic PD cell injury in vitro,and CCK-8 assay was used to investigate the viability effects of different concentration of FCPR16(3.1-50 μmol·L^(-1)) on MPP+-injured SH-SY5 Y *** of apoptosis was performed by flow *** level of ntracellular reactive oxygen species was detected with the fluorescent probe DCFH-DA,and the mitochondrial membrane potential of cells in different experimental groups was detected with the JC-1 fluorescent *** staining and Lysotracker Red staining were used to detect the intracellular antophagy *** expression of apoptosis related proteins,autophagy and other related signal molecules were demonstrated by Western *** cellular signaling pathway inhibitors were used to invesitigate the specific cellular mechanisms of FCPR16 protecting MPP+-induced cell *** FCPR16(12.5-

关键词： phosphodiesterase 4 FCPR16 oxidative stress mitochondrial membrane potential Parkinson disease

FCPR16 induces AMPK-dependent autophagy and provides neuroprotection in SH-SY5Y cells and neurons exposed to MPP^+-induced oxidative damage

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中国药理学与毒理学杂志 2019年第6期33卷 460-461页

作者： zhong Jia-hong XIE Jin-feng XIAO Jiao zhou zhong-zhen WANG Hai-tao XU Jiang-ping Department of Neuropharmacology and Drug Discovery School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou510515China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou510515China

OBJECTIVE The cause of Parkinson disease (PD) is generally not clear, but it is considered to be related to excessive oxidative damage. Therefore, the identification of therapeutic targets and compounds with antioxidant damage is a reasonable strategy to slow down the progress of PD. FCPR16 is a novel phosphodiesterase4 inhibitor with little emetic potential. Our previous studies showed that FCPR16 was an effective compound for blocking 1-methyl-4-phenylpyridine(MPP+)-induced oxidative damage in SH-SY5Y cells and neurons. However, the detailed mechanisms underlying its protective effect have not been investigated. The level of oxidative stress in neurons is closely related to the balance of mitochondria mass, while autophagy strongly regulates mitochondrial activity in neurons. Our previous study indicated that inhibition of PDE4 or PDE4 knockdown enhanced the activation of autophagy in microglial cells. While whether PDE4 inhibition mediates autophagy in neurons is largely unknown. As described above, autophagy plays a pivotal role in maintaining redox and mitochondrial homeostasis. We were interested in exploring the impact of PDE4 inhibition on autophagy in neurons. METHODS SH-SY5Y cells and neurons was induced with MPP+to mimic PD cell injury in vitro, and MTT assay was used to investigate the viability effects of FCPR16 (50μmol·L-1) with or without different autophagy inhibitors on MPP+-injured SH-SY5Y cells. Detection of apoptosis was performed by PI staining fluorescence. Lysosomes are essential in autophagy, so LYT Red Stain was used to detect lysosomes in SY5Y cells and neurons. Cells were exposed to Cell ROX Deep Red Reagent to detect intracellular reactive oxygen species (ROS). Mitochondrial membrane potential (Δψm)measurement was executed by 5, 5′, 6, 6′-tetrachloro-1, 1′, 3, 3′-tetraethylbenzimidazolyl-carbocyanineiodide (JC-1).To better detect intracellular autophagy, we used the CYTO-ID Autophagy detection kit to detect the autophagic vacuoles and mon

关键词： phosphodiesterase 4 FCPR16 oxidative stress mitochondrial membrane potential Parkinson disease

Experimental Study Enhancing the Chemosensitivityof Multiple Myeloma to Melphalan by Using a Tissue-Specific APE1-Silencing RNA Expression Vector

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中国实用内科杂志 2007年第S1期27卷 72-73页

作者： CHEN Xing- Hua ZHANG Xi YANG zhen- zhou LI zhong- Jun WANG Ji-Gang WANG Qing-Yu

Introduction:Multiple myeloma (MM) is a geriatric disease with onset at an average age of approximately 61 *** the aging of the population,the incidence rate of MM is *** the United States,the annual incidence rate of MM is 2-5/100,*** myeloma accounts for approximately 1% of all tumor eases and slightly >10% of cases with hematologic *** an

关键词： APE RNA Experimental Study Enhancing the Chemosensitivityof Multiple Myeloma to Melphalan by Using a Tissue-Specific APE1-Silencing RNA Expression Vector

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功能主义多元论

中山大学学报（社会科学版） 2020年第4期60卷 134-140页

作者：周振忠中山大学逻辑与认知研究所、哲学系广州510275

迈克尔·林奇在克里斯平·怀特首倡的真理多元论的基础上,参照心灵哲学中的功能主义提出了功能主义多元论。他认为真概念是一个功能概念,真性质是一种功能性质,能够被不同领域的低阶真性质所实现或显示,因此,"真"既是一也是多。林奇的... 详细信息

迈克尔·林奇在克里斯平·怀特首倡的真理多元论的基础上,参照心灵哲学中的功能主义提出了功能主义多元论。他认为真概念是一个功能概念,真性质是一种功能性质,能够被不同领域的低阶真性质所实现或显示,因此,"真"既是一也是多。林奇的多元论思想既不同于传统的实质论,也不同于收缩论。不过林奇的理论存在内在的缺陷。而从收缩论的角度来看,也可以吸收多元论思想,并且能够以较少的概念资源达到同样的理论目的,因此是一条值得探索的路径。

关键词：真理论多元论功能主义收缩论

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塔斯基的真理论与符合论

自然辩证法研究 2005年第8期21卷 41-44,83页

作者：周振忠中山大学逻辑与认知研究所哲学系广东广州510275

塔斯基的语义真理论常被当作符合论。通过区分塔斯基式真定义的普遍特征和具体的定义形式,并对不同语言构造具有不同语义特征的定义实例,揭示出塔斯基所持的是一种语义工具论。塔斯基的真理论并不是符合论。

关键词：塔斯基的真理论符合论语义工具论

Inhibition of PDE4 by FCPR16 Induces AMPK-Dependent Autophagy and Confers Neuroprotection in SH-SY5Y Cells and Neurons Exposed to MPP~+-Induced Oxidative Insult

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神经药理学报 2019年第4期 52-54页

作者： zhong Jia-hong XIE Jin-feng XIAO-Jiao zhou zhong-zhen WANG Hai-tao XU Jiang-ping Department of Neuropharmacology and Drug Discovery School of Pharmaceutical SciencesSouthern Medical University Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical University

Objective:The cause of Parkinson disease( PD) is generally not clear,butit is considered to be related to excessive oxidative damage. Therefore,the identification of therapeutic targets and compounds with antioxidant damage is a reasonable strategy to slow down the progress of PD. FCPR16 is a novel phosphodiesterase4 inhibitor with little emetic potential. Our previous studies showed that FCPR16 was an effective compound for blocking 1-Methyl-4-phenylpyridine( MPP+)-induced oxidative damage in SH-SY5 Y cells and neurons. However,the detailed mechanisms underlying its protective effect have not been investigated. The level of oxidative stress in neurons is closely related to the balance of mitochondria mass,while autophagy strongly regulates mitochondrial activity in neurons. Our previous study indicated that inhibition of PDE4 or PDE4 knockdown enhanced the activation of autophagy in microglial cells. While whether PDE4 inhibition mediates autophagy in neurons is largely unknown. As described above,autophagy plays a pivotal role in maintaining redox and mitochondrial homeostasis. We were interested in exploring the impact of PDE4 inhibition on autophagy in neurons. Methods:SH-SY5 Y cells and neurons was induced with 1-methyl-4-phenylpyridinium( MPP+) to mimic Parkinson’s disease cell injury in vitro,and MTT assay was used to investigate the viability effects of FCPR16( 50 μmol·L-1) with or without different autophagy inhibitors on MPP+-injured SH-SY5 Y cells. Detection of apoptosis was performed by PI staining fluorescence. Lysosomes are essential in autophagy,so LYT Red Stain was used to detect lysosomes in SY5 Y cells and neurons. Cells were exposed to CellROX Deep Red Reagent to detect intracellular reactive oxygen species( ROS). Mitochondrial membrane potential( Δψm) measurement was executed by 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolyl-carbocyanineiodide( JC-1). To better detect intracellular autophagy,we used the CYTO-ID Autophagy detection kit t

关键词： phosphodiesterase 4 FCPR16 oxidative stress mitochondrial membrane potential Parkinson’s disease

C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： zhen-Yu Xu zhong-Shang Dai Guo-zhong Gong Min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(P<0.01).Notably,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

2,3a-二氢-苯并吡喃[4,3-c]吡唑-3-酮类衍生物的合成及其活性

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有机化学 2009年第11期29卷 1774-1783页

作者：周中振陈琼杨光富华中师范大学农药与化学生物学教育部重点实验室武汉430079 南方医科大学药学院广州510515

为了进一步寻找新型黄酮类农药,以苯并吡喃[4,3-c]并吡唑-3-酮为先导结构,以4-氯苯甲醚为起始原料,设计合成了33种新型的2,3a-二氢-苯并吡喃[4,3-c]吡唑-3-酮类化合物,其结构经MS,HNMR和元素分析确证.并对化合1物7k的单晶进行了结构测定... 详细信息

为了进一步寻找新型黄酮类农药,以苯并吡喃[4,3-c]并吡唑-3-酮为先导结构,以4-氯苯甲醚为起始原料,设计合成了33种新型的2,3a-二氢-苯并吡喃[4,3-c]吡唑-3-酮类化合物,其结构经MS,HNMR和元素分析确证.并对化合1物7k的单晶进行了结构测定,对目标化合物进行了杀虫和杀菌活性测试.结果表明,大部分化合物显示出一定的杀菌活性和弱的杀虫活性.

关键词：苯并吡喃[4,3-c]吡唑合成杀虫活性杀菌活性