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Engineering 2024年第2期33卷 108-120页

作者： Kang Yuan Yanjun Huang Shuo Yang zewei zhou Yulei Wang Dongpu Cao Hong Chen College of Electronic and Information Engineering Tongji UniversityShanghai 201804China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201210China School of Automotive Studies Tongji UniversityShanghai 201804China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China

Decision-making and motion planning are extremely important in autonomous driving to ensure safe driving in a real-world *** study proposes an online evolutionary decision-making and motion planning framework for autonomous driving based on a hybrid data-and model-driven ***,a data-driven decision-making module based on deep reinforcement learning(DRL)is developed to pursue a rational driving performance as much as ***,model predictive control(MPC)is employed to execute both longitudinal and lateral motion planning *** constraints are defined according to the vehicle’s physical limit to meet the driving task ***,two principles of safety and rationality for the self-evolution of autonomous driving are proposed.A motion envelope is established and embedded into a rational exploration and exploitation scheme,which filters out unreasonable experiences by masking unsafe actions so as to collect high-quality training data for the DRL *** with a high-fidelity vehicle model and MATLAB/Simulink co-simulation environment are conducted,and the results show that the proposed online-evolution framework is able to generate safer,more rational,and more efficient driving action in a real-world environment.

关键词： Autonomous driving Decision-making Motion planning Deep reinforcement learning Model predictive control

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抗水树XLPE绝缘加速水老化特性研究

电线电缆 2024年第2期67卷 62-64,69页

作者：单潜瑜赵远涛李培瑶周则威潘矗直宁波东方电缆股份有限公司宁波315801

为探究湿式海缆在海水环境中长期运行时抗水树交联聚乙烯(XLPE)绝缘材料的水老化特性,对海底电缆开展了抗水树绝缘材料的加速水老化试验。通过步进应力法对绝缘样品水老化后的击穿特性进行测试,并在电缆样品经历加速水老化后评估其使用... 详细信息

为探究湿式海缆在海水环境中长期运行时抗水树交联聚乙烯(XLPE)绝缘材料的水老化特性,对海底电缆开展了抗水树绝缘材料的加速水老化试验。通过步进应力法对绝缘样品水老化后的击穿特性进行测试,并在电缆样品经历加速水老化后评估其使用寿命结束阶段的剩余介电强度。测试结果表明,试验电缆的牌号为LH4201R抗水树绝缘料在加速水老化试验后通过了标准要求的击穿场强,该抗水树绝缘料适用于海上风电阵列电缆。

关键词：抗水树绝缘加速水老化试验步进应力法击穿特性

Virtual Reality Based Process Integrated Simulation Platform in Refinery:Virtual Refinery and Its Application

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China Petroleum Processing & Petrochemical Technology 2011年第3期13卷 74-84页

作者： zhou zewei Feng Yiping Rong Gang Wu Yucheng (State Key Laboratory of Industrial Control Technology,Institute of Cyber-Systems and Control,Zhejiang University,Hangzhou 310027,China) State Key Laboratory of Industrial Control Technology Institute of Cyber-Systems and Control Zhejiang University Hangzhou 310027 China

With the combination between system simulation and virtual reality,we have established an integrated virtual refinery simulation platform,and analyzed the overall design and principal *** paper introduces a simulation algorithm about a refinery based on virtual reality,and explains how the algorithm can be applied to the virtual refinery integrated simulation platform in *** virtual refinery simulation platform,which consists of a three-dimensional scene system,an integrated database system and a dynamic-static simulation system,has many applications,such as dynamic-static simulation of key process unit used as process control and oil tank blending simulation for *** the visualization and human-computer interaction for acquiring production and process data,this platform can provide effective supports on staff training related with monitoring,control and operation in *** refinery can also be web published through the internet and it is helpful for the distance training and education.

关键词： virtual refinery petrochemical enterprise process integrated simulation information representation intelligent manufacturing systems

以免疫应答为基础的《医学免疫学》综合实验设计及实践

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中国继续医学教育 2024年第1期16卷 14-19页

作者：蔡振明周泽伟施冬艳杨晓帆张明顺王慧娟陈云卢燕来南京医科大学基础医学院免疫学系江苏南京211166

以往的《医学免疫学》实验课程内容设置相对分散、不同节次之间缺乏联系,不能有效地展现机体内免疫应答这一连续的反应过程。为解决这些问题,南京医科大学基础医学院免疫学系在前期《医学免疫学》实验课的基础上,紧密围绕机体抗感染免... 详细信息

以往的《医学免疫学》实验课程内容设置相对分散、不同节次之间缺乏联系,不能有效地展现机体内免疫应答这一连续的反应过程。为解决这些问题,南京医科大学基础医学院免疫学系在前期《医学免疫学》实验课的基础上,紧密围绕机体抗感染免疫应答这一主线,制定了综合实验课程方案:(1)小鼠外周血中性粒细胞的吞噬作用、(2)流式细胞术检测小鼠外周血中性粒细胞含量、(3)酶联免疫吸附试验检测小鼠外周血肿瘤坏死因子α(Tumor necrosis factor α,TNF-α)含量。通过建立细菌腹腔免疫小鼠模型,本研究依次串联出这3个目前免疫学常用且先进的实验方法,同时检测指标契合抗感染免疫应答的时序性和整体性。学生通过显微镜能够直接观察到具有分叶核的中性粒细胞,胞质内可见被吞噬的白色葡萄球菌;白色葡萄球菌腹腔免疫小鼠后外周血中性粒细胞(CD11b~+Ly-6G~+)占外周血单个核细胞比例显著升高,血清中TNF-α的含量也显著增高。该综合实验的实施有助于学生更系统地理解机体应对细菌感染的早期免疫应答过程:外周血中性粒细胞对细菌的直接吞噬、中性粒细胞的活化增殖及炎性细胞因子(TNF-α)的分泌在机体抗感染过程中的作用;同时通过综合实验改革能够切实提高学生的实验操作和数据分析能力,并有助于培养他们的科研思维能力和团队合作精神。

关键词：综合实验免疫应答中性粒细胞吞噬作用流式细胞术实验酶联免疫吸附试验

Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8^(+)T cell proportion in tumor-bearing mice through the USP9X signaling pathway

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Chinese Journal of Natural Medicines 2024年第4期22卷 329-340页

作者： FENG Yutao LI Yuan MA Fen WU Enjiang CHENG zewei zhou Shiling WANG Zhengtao YANG Li SUN Xun ZHANG Jiwei Shanghai Key Laboratory of Compound Chinese Medicines The MOE Key Laboratory for Standardization of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Gastrointestinal surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

The management of colorectal cancer(CRC)poses a significant challenge,necessitating the development of innovative and effective *** research has shown that notoginsenoside Ft1(Ng-Ft1),a small molecule,markedly inhibits subcutaneous tumor formation in CRC and enhances the proportion of CD8^(+)T cells in tumor-bearing mice,thus restraining tumor *** into the mechanism revealed that Ng-Ft1 selectively targets the deubiquitination enzyme USP9X,undermining its role in shieldingβ-*** leads to a reduction in the expression of downstream effectors in the Wnt signaling *** findings indicate that Ng-Ft1 could be a promising small-molecule treatment for CRC,working by blocking tumor progression via the Wnt signaling pathway and augmenting CD8^(+)T cell prevalence within the tumor environment.

关键词： Notoginsenoside Ft1 Colorectal cancer CD8^(+)T cell Ubiquitin-specific peptidase 9 X-linked β-Catenin Wnt

Steering surface reconstruction of hybrid metal oxides for efficient oxygen evolution reaction in water splitting and zinc-air batteries

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Journal of Energy Chemistry 2024年第5期92卷 383-393页

作者： Jie Zhu Junxue Chen Xida Li Kun Luo zewei Xiong Zhiyu zhou Wenyun Zhu Zhihong Luo Jingbin Huang Yibing Li Key Lab of New Processing Technology for Nonferrous Metals and Materials Ministry of EducationSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541000GuangxiChina The Key Laboratory of Rare Earth Functional Materials and Applications Zhoukou Normal UniversityZhoukou 466001HenanChina School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China School of Materials Science and Engineering Changzhou UniversityChangzhou 213164JiangsuChina Wuhan Sunmoon Battery Co. LtdWuhan 430090HubeiChina

Surface reconstruction yields real active species in electrochemical oxygen evolution reaction(OER)conditions;however,rationally regulating reconstruction in a targeted manner for constructing highly active OER electrocatalysts remains a formidable ***,an electrochemical activation strategy with selective etching was utilized to guide the reconstruction process of a hybrid cobalt-molybdenum oxide(CoMoO_(4)/Co_(3)O_(4)@CC)in a favorable direction to improve the OER *** in-situ Raman and multiple ex-situ characterization tools demonstrate that controlled surface reconstruction can be easily achieved through Mo etching,with the formation of a dynamically stable amorphous-crystalline *** calculations together with experimental results reveal that the synergistic effects between amorphous CoOOH and crystalline Co_(3)O_(4) are crucial in enhancing the catalytic ***,the reconstructed CoMoO_(4)/Co_(3)O_(4)@CC exhibits a low overpotential of 250 mV to achieve a current density of 10 mA cm^(-2) in 1 M KOH,and more importantly it can be practiced in electrolytic water splitting and rechargeable zinc-air batteries devices,achieving ultra-long stability for over 500 and 1200 h,*** work provides a promising route for the construction of high-performance electrocatalysts.

关键词： Electrocatalyst Oxygen evolution reaction Surface reconstruction Selective etching Amorphous-crystalline heterostructures

CMKLR1 senses chemerin/resolvin E1 to control adipose thermogenesis and modulate metabolic homeostasis

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Fundamental Research 2024年第3期4卷 575-588页

作者： zewei Zhao Siqi Liu Bingxiu Qian Lin zhou Jianglin Shi Junxi Liu Lin Xu Zhonghan Yang Department of Biochemistry Molecular Cancer Research CenterSchool of MedicineSun Yat-sen UniversityShenzhenGuangdong 518107China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China School of Public Health Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Induction of beige fat for thermogenesis is a potential therapy to improve homeostasis against obesity.β3-adrenoceptor(β3-AR),a type of G protein-coupled receptor(GPCR),is believed to mediate the thermogenesis of brown fat in ***,β3-AR has low expression in human adipose tissue,precluding its activation as a standalone clinical *** study aimed at identifying a potential GPCR target to induce beige *** found that chemerin chemokine-like receptor 1(CMKLR1),one of the novel GPCRs,mediated the development of beige fat via its two ligands,chemerin and resolvin E1(RvE1).The RvE1 levels were decreased in the obese mice,and RvE1 treatment led to a substantial improvement in obese features and augmented beige fat ***,despite sharing the same receptor as RvE1,the chemerin levels were increased in obesogenic conditions,and chemerin treatment led to an augmented obese phenotype and a decline of beige fat ***,RvE1 and chemerin induced or restrained the development of beige fat,respectively,via the mechanistic target of rapamycin complex 1(mTORC1)signaling *** further showed that RvE1 and chemerin regulated mTORC1 signaling differentially by forming hydrogen bonds with different binding sites of *** conclusion,our study showed that RvE1 and chemerin affected metabolic homeostasis differentially,suggesting that selectively modulating CMKLR1 may be a potential therapeutic target for restoring metabolic homeostasis.

关键词： Obesity Insulin resistance Thermogenesis CMKLR1 Resolvin E1 Chemerin

Recent advancements in the diagnosis and treatment of acral melanoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 106-122页

作者： Ahmad ALHASKAWI Sohaib Hasan Abdullah EZZI Yanzhao DONG Haiying zhou zewei WANG Jingtian LAI Chengjun YAO Vishnu Goutham KOTA Mohamed Hasan Abdulla Hasan ABDULLA Hui LU Department of Orthopedics the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Department of Orthopaedics Third Xiangya HospitalCentral South UniversityChangsha410013China Zhejiang University School of Medicine Hangzhou310058China Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare Zhejiang UniversityHangzhou310058China

Acral melanoma(AM)is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate,largely due to the inconspicuous nature of early-stage lesions,which can lead to late *** of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas,early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities,including clinical examination,dermoscopy,histopathology,molecular testing,radiological imaging,and blood *** surgery is the preferred method of treatment for AM,other therapeutic options may be employed based on the stage and underlying etiology of the *** checkpoint inhibitors,molecular targeted therapy,radiotherapy,chemotherapy,and oncolytic virotherapy represent promising advanced treatment options for *** this review,we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM,highlighting the importance of early detection and the prompt,individualized management of this challenging disease.

关键词： Acral melanoma Acral lentiginous melanoma Acral nevus Cutaneous malignant melanoma Dermoscopy Oncolytic virotherapy

等离子体裂解煤工艺过程的三维仿真与可视化监控系统

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化工学报 2011年第8期62卷 2303-2311页

作者：周泽伟冯毅萍荣冈浙江大学智能系统与控制研究所工业控制技术国家重点实验室浙江杭州310027

将等离子体裂解煤的新工艺过程,利用三维仿真可视化技术建立了全流程的监控系统,通过采集生产实时数据,可以对生产过程进行三维可视化监控。该工艺过程监控系统的三个组成部分,包括三维建模环境、过程集成仿真系统与可视化监控平台,并... 详细信息

将等离子体裂解煤的新工艺过程,利用三维仿真可视化技术建立了全流程的监控系统,通过采集生产实时数据,可以对生产过程进行三维可视化监控。该工艺过程监控系统的三个组成部分,包括三维建模环境、过程集成仿真系统与可视化监控平台,并且针对具体的工艺流程,详细说明了每个部分的原理与实现过程。该系统通过生产过程与数据的可视化呈现以及现场应用实例,可以为等离子体裂解煤工艺过程的流程模拟仿真培训与三维可视化的实时过程监控提供有效的支持。

关键词：可视化监控三维仿真流程模拟信息呈现过程监控

A Novel Approach for Evaluation of Food Functions and Safety Applied in RR GM Soybeans

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Agricultural Biotechnology 2013年第3期2卷 5-11页

作者： Wei LONG Hao WANG Weihong LI Xiu SHEN Jiali BAI Dezhi WANG Xiaoguang WANG Saijun FAN zewei zhou Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College

[Objective] This study aimed to evaluate tbe healthy risk of genetically modified （ GM ） soybeans by using a novel approach for functions and safety of food. [ Me^od] Different from traditional evaluation of substantial equivalence, three great innovations were performed in this study, involving in basic diet, evalu- ation approaches and principle, as well as the clarification of connotation differences between absolute and relative mass of organs. Hence a novel BDI-GS （Bendib Damage Index and General Score） evaluation approach was established and applied in comparative evaluation between RR GM and natural soybeans. Healthy male ICR mice during linear growth were selected; experimental mice were fed with 15% RR GM soybeans and 15% natural soybeans blending maize meal diets, and control mice were fed with single maize meal diet for 13 d; the mice were dissected after collecting blood samples and perfectly obtained nine organs or tissues to re- cord their masses and conduct statistical analyses. [Result] Plenty of matching information was obtained through simple design. The growth performance of treated mice was markedly of individual differences, some mice were thwarted due to regular intake of RR soybeans. Meanwhile, the functions and safety of RR soybeans were markedly lowered in overall nutritional and healthy effects than those of natural soybeans expressed in GS values, and presents some declines in nutrition and health of thymus, pancreas and spermary; especially, it can make thymus immune （P 〈0.05） in markedly lower level than that of natural soybeans. [ Conclusion] Therefore, major troubles and risks of RR soybeans intake are of personal risks in different degrees, in addition, it may increase sub-health and related chronic epi- demics risks, and herein it will presents certain safety issues. The creation of this novel evaluation system provides a simple and available evaluation approach for functions and potential risks revelation of food effects, and will y

关键词： Genetically modified soybeans Animal model Food quality Evaluation approach Function and safety