检索结果-南通市图书馆

Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： Ying-Ying Xu Chan Jin Meng Wu Jian-ye zhou Hui-Ling Wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging

引用

Genes & Diseases 2024年第5期11卷 407-427页

作者： Wenchao Wang Junjie Qian Mingge Shang Yiting Qiao Jiacheng Huang Xinxin Gao zhou ye Xinyu Tong Kangdi Xu Xiang Li Zhengtao Liu Lin zhou Shusen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China NHC Key Laboratory of Combined Multi-organ Transplantation HangzhouZhejiang 310003China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic CancerChinese Academy of Medical Sciences(2019RU019)HangzhouZhejiang 310003China Key Laboratory of Organ Transplantation Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesHangzhouZhejiang 310003China Shulan International Medical College Zhejiang Shuren UniversityHangzhouZhejiang 310015China Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College HangzhouZhejiang 310000China

Aging is a contributor to liver ***,the concept of liver aging has become prominent and has attracted considerable interest,but its underlying mechanism remains poorly *** our study,the internal mechanism of liver aging was explored via multi-omics analysis and molecular experiments to support future targeted *** aged rat liver model was established with D-galactose,and two other senescent hepatocyte models were established by treating HepG2 cells with D-galactose and *** then performed transcriptomic and metabolomic assays of the aged liver model and transcriptome analyses of the senescent hepatocyte *** livers,genes related to peroxisomes,fatty acid elongation,and fatty acid degradation exhibited down-regulated expression with aging,and the hepatokine Fgf21 expression was positively correlated with the down-regulation of these *** senescent hepatocytes,similar to the results found in aged livers,FGF21 expression was also ***,the expressions of cell cycle-related genes were significantly down-regulated,and the down-regulated gene E2F8 was the key cell cycle-regulating transcription *** then validated that FGF21 overexpression can protect against liver aging and that FGF21 can attenuate the declines in the antioxidant and regenerative capacities in the aging *** successfully validated the results from cellular and animal experiments using human liver and blood *** study indicated that FGF21 is an important target for inhibiting liver aging and suggested that pharmacological prevention of the reduction in FGF21 expression due to aging may be used to treat liver aging-related diseases.

关键词： Antioxidant capability FGF21 Liver aging Liver regeneration Multiomics analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances in memristors based on two-dimensional ferroelectric materials

引用

Frontiers of physics 2024年第1期19卷 195-218页

作者： Wenbiao Niu Guanglong Ding Ziqi Jia Xin-Qi Ma JiYu Zhao Kui zhou Su-Ting Han Chi-Ching Kuo ye zhou Institute for Advanced Study Shenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China Institute of Organic and Polymeric Materials Research and Development Center of Smart Textile TechnologyTaipei University of TechnologyTaipei 10608TaiwanChina

In this big data era, the explosive growth of information puts ultra-high demands on the data storage/computing, such as high computing power, low energy consumption, and excellent stability. However, facing this challenge, the traditional von Neumann architecture-based computing system is out of its depth owing to the separated memory and data processing unit architecture. One of the most effective ways to solve this challenge is building brain inspired computing system with in-memory computing and parallel processing ability based on neuromorphic devices. Therefore, there is a research trend toward the memristors, that can be applied to build neuromorphic computing systems due to their large switching ratio, high storage density, low power consumption, and high stability. Two-dimensional (2D) ferroelectric materials, as novel types of functional materials, show great potential in the preparations of memristors because of the atomic scale thickness, high carrier mobility, mechanical flexibility, and thermal stability. 2D ferroelectric materials can realize resistive switching (RS) because of the presence of natural dipoles whose direction can be flipped with the change of the applied electric field thus producing different polarizations, therefore, making them powerful candidates for future data storage and computing. In this review article, we introduce the physical mechanisms, characterizations, and synthetic methods of 2D ferroelectric materials, and then summarize the applications of 2D ferroelectric materials in memristors for memory and synaptic devices. At last, we deliberate the advantages and future challenges of 2D ferroelectric materials in the application of memristors devices.

关键词： two-dimensional ferroelectric materials synthesis strategies memristors artificial synapses

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meromorphic Solutions to Higher Order Nonlinear Delay Differential Equations

引用

Acta Mathematicae Applicatae Sinica 2024年

作者： ye-zhou LI Ming-yue WU He-qing SUN School of Science Beijing University of Posts and Telecommunications Key Laboratory of Mathematics and Information Networks (Beijing University of Posts and Telecommunications) Ministry of Education Beijing University of Posts and Telecommunications

Let w（z） be non-rational meromorphic solutions with hyper-order less than 1 to a family of higher order nonlinear delay differential equations w（z+1）w（z-1）+a（z）w（k）（z）/w（z）=R(z,w（z）),k∈N+,where a（z） is rational,R(z,w（z）)=P(z,w（z）)/Q(z,w（z）) is an irreducible rational function in w with rational coefficients in *** paper mainly show the relationships of the degree of P(z,w（z）) and Q(z,w（z）) when the above equations exist such solutions w（z）.There are also some examples to show that our results are sharp.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

METTL5 promotes gastric cancer progression via sphingomyelin metabolism

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： Ya-Qiong Zhang Jian Li Zhe Qin De-Ming Li Fang-zhou ye Song-Hua Bei Xiao-Hong Zhang Li Feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKGROUND The treatment of gastric cancer(GC)has caused an enormous social burden *** studies have reported that N6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in GC has not been fully *** To excavate the role of METTL5 in the development of *** METTL5 expression and clinicopathological characteristics were analyzed via The Cancer Genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of METTL5 on HGC-27 and AGS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of METTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RNA Methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between METTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether METTL5 affects the sensitivity of GC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of METTL5,which suggested a poor prognosis of GC *** METTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of METTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of GC cells in ***5 also promotes the growth of GC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that METTL5 may impact the development of GC via sphin

关键词： Gastric cancer METTL5 Sphingomyelin metabolism Cisplatin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

晚清江南地方社会的秩序危机:以武阳保卫局成立前后为个案

引用

史林 2024年第2期 151-161,219页

作者：叶舟上海社会科学院历史研究所 200235

明清以来的江南地区,经济繁荣,文化发达,社会相对安定,但这里也多有盗匪,社会治安问题频出。晚清州县成立保甲局或保卫局,是保甲制度重要的变化。武阳保卫局最初是太平天国战争期间在常州成立的保甲团练组织。战争结束后,常州所在的江... 详细信息

明清以来的江南地区,经济繁荣,文化发达,社会相对安定,但这里也多有盗匪,社会治安问题频出。晚清州县成立保甲局或保卫局,是保甲制度重要的变化。武阳保卫局最初是太平天国战争期间在常州成立的保甲团练组织。战争结束后,常州所在的江南地区社会矛盾依然激烈,流民、士兵、盐帮“结党成群”,贩卖私盐、赌博、抢劫,组成各种形式的盗匪团伙,扰乱地方治安,常州一地发生多起大案。为了重整地方秩序,光绪末,武阳保卫局再度筹划成立。本文以南京图书馆藏《光绪武阳保卫局抄件》等文献为基础,以武阳保卫局设立前后所发生的一系列事件为切入点,来讨论清末江南地方社会秩序失控背后的原因。

关键词：晚清江南武阳保卫局帮会

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acupoint catgut-embedding therapy ameliorates DNCB-induced atopic dermatitis in BALB/c mice by regulating Th2 type immune response and reducing infiltration of CD4^(+)and CD8^(+)cells

引用

Traditional Medicine Research 2024年第9期9卷 14-20页

作者： Cheng Qin Xiang-Yi Kong Fang Wang Jin Xu Zhuo Zhang Xue-Song Yang Jian-zhou ye College of First Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 650500China Yunnan Key Laboratory of Dai and Yi Medicines Yunnan University of Chinese MedicineKunming 650500China Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine Yunnan University of Chinese MedicineKunming 650500China Department of Dermatology The First Affiliated Hospital of Yunnan University of Traditional Chinese MedicineKunming 650021China

Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c *** also conducted an initial examination of the underlying molecular ***:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding *** DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day *** in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut *** was assessed using SCORAD on treatment days 1,10,and *** day 18,nine mice per group were euthanized,and the remaining on day *** changes were observed using hematoxylin-eosin and immunohistochemistry ***-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western ***:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like *** decreases occurred in serum IL-4,IL-6,IL-13,and TNF-α*** analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein ***:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.

关键词： atopic dermatitis acupoint catgut-embedding therapy Th2 type immune response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

39码(创作谈)

引用

当代文坛 2024年第3期 111-114页

作者：叶舟甘肃省作家协会

我的脚较小,只有39码。在相继出版了长篇小说《敦煌本纪》和《凉州十八拍》之后,相识或初见的朋友总要问我,你下一部写什么?落脚点在哪里?这期间,也有替我慨然做主的,说你既然写完了敦煌与武威,那么酒泉和张掖就不能落下,毕竟它们都属... 详细信息

我的脚较小,只有39码。在相继出版了长篇小说《敦煌本纪》和《凉州十八拍》之后,相识或初见的朋友总要问我,你下一部写什么?落脚点在哪里?这期间,也有替我慨然做主的,说你既然写完了敦煌与武威,那么酒泉和张掖就不能落下,毕竟它们都属于河西四郡,乃是丝绸之路上的闪光地标,不能厚此薄彼呀。又或者,他们直接签发了邀请函,来吧,我的老家在平凉、在庆阳、在天水、在陇西、在古河州、在甘南……,总之为我打开了方便之门。每逢此刻,我只有语塞,低头盯看着自己的这一双脚,这两只39码的鞋子,一方面困惑与抉择,另一方面等待着出发的敕令。

关键词：河西四郡丝绸之路创作谈敦煌

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

习近平“教育强国”重要论述视域中的严复教育思想再析

引用

复旦教育论坛 2024年第2期22卷 5-9页

作者：周晔复旦大学机关党委上海200433

习近平总书记在党的二十大报告中,明确提出了加快建设教育强国的任务;在二十届中央政治局第五次集体学习的重要讲话中,对建设教育强国这一重大命题做了系统阐述。习近平在福建及中央工作期间,曾多次就严复启蒙思想发表重要讲话。在习近... 详细信息

习近平总书记在党的二十大报告中,明确提出了加快建设教育强国的任务;在二十届中央政治局第五次集体学习的重要讲话中,对建设教育强国这一重大命题做了系统阐述。习近平在福建及中央工作期间,曾多次就严复启蒙思想发表重要讲话。在习近平“教育强国”重要论述指引下,重温严复的“教育救国、教育强国”“三育并举”“三学段”等教育思想及其主政复旦公学等学府的实践探索,能使我们更加深入、全面地理解今天提倡“教育强国”的渊源与根基,从而为强国建设、民族复兴伟业提供强大的精神动力。

关键词：习近平“教育强国”重要论述严复教育思想复旦公学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

数字化转型与银行信贷配置——基于银行贷款投向实体经济的视角

引用

数量经济技术经济研究 2024年第3期41卷 193-216页

作者：丁鑫周晔浙江财经大学金融学院首都经济贸易大学金融学院

在建设数字中国、构建适应现代经济发展的数字金融新格局下,数字化转型能够缓解银企之间信息不对称,精准识别企业信贷需求,成为金融供给侧结构性改革的重要路径。基于成本优化和信息传递视角,本文在微观银行经济学理论框架中引入数字化... 详细信息

在建设数字中国、构建适应现代经济发展的数字金融新格局下,数字化转型能够缓解银企之间信息不对称,精准识别企业信贷需求,成为金融供给侧结构性改革的重要路径。基于成本优化和信息传递视角,本文在微观银行经济学理论框架中引入数字化转型进行理论分析,并采用2010~2021年217家商业银行的面板数据,实证检验银行数字化转型对信贷配置的影响及其内在机理。研究发现,银行数字化转型能够促进信贷供给增加,促使银行信贷由金融业配置到实体行业。作用机制为数字化转型利用信息技术与数据要素增强银行信息甄别能力,缓解银企之间信息不对称性,并通过降低银行经营成本与人力费用,推动信贷配置到实体行业。进一步地,数字化转型具有“顶层设计”的特征,不同转型路径中“创新理念型”对信贷配置的效果最优;相较于“合作式”转型,“自主式”转型方式的信贷配置效果更佳;银行实体网点数量的增加和人力成本的减少有助于数字化转型推动信贷投向实体行业,数字化转型在经济繁荣和信贷上行阶段具有更明显的顺周期性。异质性检验发现,规模较小、盈利较高与贷款质量较低的银行在数字化转型过程中对信贷投向实体行业的边际影响更强。本文的研究为进一步优化金融供求结构,推动商业银行支持实体经济发展提供理论参考。

关键词：数字化转型信贷配置实体经济信贷供给

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：