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Human Cyber Physical Systems(HCPSs)in the Context of New-Generation Intelligent Manufacturing

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Engineering 2019年第4期5卷 624-636页

作者： zhou Ji zhou yanhong Wang Baicun Zang Jiyuan Chinese Academy of Engineering Beijing 100088China Huazhong University of Science and Technology Wuhan 430074China Tsinghua University Beijing 100084China University of Michigan Ann ArborMI 48109USA

An intelligent manufacturing system is a composite intelligent system comprising humans,cyber systems,and physical systems with the aim of achieving specific manufacturing goals at an optimized *** kind of intelligent system is called a human-cyber-physical system(HCPS).In terms of technology,HCPSs can both reveal technological principles and form the technological architecture for intelligent *** can be concluded that the essence of intelligent manufacturing is to design,construct,and apply HCPSs in various cases and at different *** advances in information technology,intelligent manufacturing has passed through the stages of digital manufacturing and digital-networked manufacturing,and is evolving toward new-generation intelligent manufacturing(NGIM).NGIM is characterized by the in-depth integration of new-generation artificial intelligence(AI)technology(i.e.,enabling technology)with advanced manufacturing technology(i.e.,root technology);it is the core driving force of the new industrial *** this study,the evolutionary footprint of intelligent manufacturing is reviewed from the perspective of HCPSs,and the implications,characteristics,technical frame,and key technologies of HCPSs for NGIM are then discussed in ***,an outlook of the major challenges of HCPSs for NGIM is proposed.

关键词： New-generation intelligent manufacturing Human-cyber-physical system Human-physical system Cyber-physical system Knowledge engineering Enabling technology Manufacturing domain technology New-generation artificial intelligence

ModuleNet:An R package on regulatory network building

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Chinese Science Bulletin 2010年第30期55卷 3430-3435页

作者： zhou Dao HE Dong LUO QingMing zhou yanhong Hubei Key Laboratory of Bioinformatics and Molecular Imaging Huazhong University of Science and Technology Wuhan 430074 China

Many researchers have used microarray gene expression data to investigate gene regulatory networks in specific life stages. In these analyses,Bayesian network was widely applied to regulatory network building from expression profiles because of its solid mathematical foundation and its robust analysis ability in noisy data. However,the building of Bayesian network is time consuming and the searching space is really large. Considering the biological feature of transcription factors (TFs) and targets (TGs),the regulatory network is possible to be separated into core TFs networks and the interactions from TFs to TGs. We developed an R package named ModuleNet which used Bayesian network model to the inner TFs network building and genetic algorithm on TF-TG interactions prediction. With determined number of transcription factors,the searching space and time requirements of ModuleNet is linear increasing according to the number of targets. After application to yeast cell-cycle expression profile,the results demonstrated the prediction accuracy of ModuleNet. Furthermore,significantly enriched Gene Ontology (GO) terms with similar expression behaviors were detected automatically by ModuleNet from expression profile,and the relationships from TFs to GO terms were figured out. The source code is available by asking for the author.

关键词：网络建设监管贝叶斯网络模型基因表达数据基因表达谱转录因子封装基因调控网络

Exploring how hydrogen at gold-sulfur interface affects spin transport in single-molecule junction

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Chinese Physics B 2020年第8期29卷 525-530页

作者： Jing Zeng Ke-Qiu Chen yanhong zhou College of Physics and Electronic Engineering Hengyang Normal UniversityHengyang 421002China Department of Applied Physics School of Physics and ElectronicsHunan UniversityChangsha 410082China Hunan Provincial Key Laboratory of Intelligent Information Processing and Application Hengyang 421002China College of Science East China Jiao Tong UniversityNanchang 330013China

Very recently,experimental evidence showed that the hydrogen is retained in dithiol-terminated single-molecule junction under the widely adopted preparation conditions,which is in contrast to the accepted view[***.11351(2019)].However,the hydrogen is generally assumed to be lost in the previous physical models of single-molecule *** the retention of the hydrogen at the gold-sulfur interface exerts a significant effect on the theoretical prediction of spin transport properties is an open ***,here in this paper we carry out a comparative study of spin transport in M-tetraphenylporphyrin-based(M=V,Cr,Mn,Fe,and Co;M-TPP)single-molecule junction through Au-SR and Au-S(H)R *** results show that the hydrogen at the gold-sulfur interface may dramatically affect the spin-filtering efficiency of M-TPP-based single-molecule junction,depending on the type of transition metal ions embedded into porphyrin ***,we find that for the Co-TPP-based molecular junction,the hydrogen at the gold-sulfur interface has no obvious effect on transmission at the Fermi level,but it has a significant effect on the spin-dependent transmission dip induced by the quantum interference on the occupied *** the fate of hydrogen should be concerned in the physical model according to the actual preparation condition,which is important for our fundamental understanding of spin transport in the single-molecule *** work also provides guidance in how to experimentally identify the nature of gold-sulfur interface in the single-molecule junction with spin-polarized transport.

关键词： transport properties molecular electronic devices gold-sulfur interface density-functional theory nonequilibrium Green’s functions

Predicting disease genes for familial dilated cardiomyopathy based on the codon usage bias

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Chinese Science Bulletin 2005年第18期50卷 2028-2032页

作者： zhou yanhong zhou Quanxiong LIU Huailan WAN Honghui Center for Bioinformatics Huazhong University of Science and Technology Wuhan 430074 China Hubei Bioinformatics and Molecular Imaging Key Laboratory Wuhan 430074 China Laboratory of Bioinformatics Maryland Institute of Dynamic Genomics Silver Spring MD 20906. USA

Familial dilated cardiomyopathy (FDC) is a common monogenic disease mostly with autosomal dominant inheritance. Fifteen different loci for autosomal dominant FDC have been mapped; however, only eight FDC genes have been found, and it is still a big challenge to identify ad-ditional seven FDC genes in their chromosomal regions. We found that the codon usage frequencies in most of known FDC gene sequences are consistently biased, and significantly different from the average codon usage frequencies of human genes. This unique feature of codon usage was used to de-velop a novel approach to predicting FDC genes. Leave-one- out cross-validation results demonstrate that this approach can effectively detect FDC genes from numbers of genes in their chromosomal regions. Another advantage of this ap-proach is that it is solely based on DNA sequences and there-fore has the ability to identify potential FDC genes whose functions are completely unknown. Further, this approach has been used to analyze the seven FDC loci in which the FDC genes are still unknown. Both the detailed prediction results and the prediction program are available at http:// ***, which might provide help for relevant experimental researches to find new FDC genes.

关键词：疾病因子心肌病家族疾病密码 FDC

Light regulation of horticultural crop nutrient uptake and utilization

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Horticultural Plant Journal 2021年第5期7卷 367-379页

作者： Jin Xu Zhixin Guo Xiaochun Jiang Golam Jalal Ahammed yanhong zhou Department of Horticulture Zijingang CampusZhejiang UniversityHangzhou310058China Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Hangzhou 310058China Key Laboratory of Plant Growth Development and Quality ImprovementAgricultural Ministry of ChinaHangzhou310058China College of Horticulture and Plant Protection Henan University of Science and TechnologyLuoyangHenan 471023China

Plants demonstrate dynamic changes in molecular structures under fluctuating light *** evidence suggests that light plays a vital role in plant growth and *** particular,light has a role in the absorption and utilization of nutrients in *** significant progress in understanding the mechanism of nutrient acquisition and assimilation,how light affects and regulates ion uptake remains a *** in model plants,Arabidopsis thaliana,suggest that light affects the nutrient utilization in roots through a complex regulatory network;nonetheless,the molecular mechanisms underlying the various effects of light on these processes in crop plants remain *** this review,we discuss the light effects(light quality,light intensity,and photoperiod)on nutrient uptake and utilization in horticultural crops for optimizing crop productivity and increasing fertilizer use efficiency.

关键词： Light signaling Nutrient utilization Horticultural crops Phytochrome

OPTIMAL FEED RATE CONTROL FOR MULTI-AXIS CNC MACHINING OF FREE FORM SURFACES

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Chinese Journal of Mechanical Engineering 2000年第3期13卷 171-177页

作者： Zhan Yong, zhou Ji, zhou yanhong, zhou Yunfei (School of Mechanical Science and Engineering, Huazhong University of Science and Technology) 华中科技大学湖北武汉

Considering machining efficiency, surface quality and wear of cutter and machine, it is necessary to maintain high, stable and constant surface feed rate as far as *** feed late control strategy for multi-axis CNC machining of free-form surfaces is presented. It comprises: ①the determination of effective feed rate; ②the adoption of suitable approaches to smooth feed rate. This strategy considers path geometry, actuator limitation and machine dynamics. The result shows that machining efficiency is improved effectively.

关键词： CNC Surface machining Feed rate Multi-axisp

Toward New-Generation Intelligent Manufacturing

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Engineering 2018年第1期4卷 11-20页

作者： zhou Ji Li Peigen zhou yanhong Wang Baicun Zang Jiyuan Meng Liu Chinese Academy of Engineering Beijing 100088 China Huazhong University of Science and Technology Wuhan 430074 China Tsinghua University Beijing 100084 China

Intelligent manufacturing is a general concept that is under continuous development. It can be categorized into three basic paradigms： digital manufacturing, digital-networked manufacturing, and newgeneration intelligent manufacturing. New-generation intelligent manufacturing represents an indepth integration of new-generation artificial intelligence （AI） technology and advanced manufacturing technology. It runs through every link in the full life-cycle of design, production, product, and service. The concept also relates to the optimization and integration of corresponding systems; the continuous improvement of enterprises＇ product quality, performance, and service levels; and reduction in resources consumption. New-generation intelligent manufacturing acts as the core driving force of the new indus- trial revolution and will continue to he the main pathway for the transformation and upgrading of the manufacturing industry in the decades to come. Human-cyher-physical systems （HCPSs） reveal the tech- nological mechanisms of new-generation intelligent manufacturing and can effectively guide related the- oretical research and engineering practice. Given the sequential development, cross interaction, and iterative upgrading characteristics of the three basic paradigms of intelligent manufacturing, a technol- ogy roadmap for ＂parallel promotion and integrated development＂ should he developed in order to drive forward the intelligent transformation of the manufacturing industry in China.

关键词： Advanced manufacturing New-generation intelligent manufacturing Human-cyber-physical systemNew-generation AIBasic paradigms Parallel promotionIntegrated development

SIMULATION SYSTEM FOR FIVE-AXIS NC MACHINING USING GENERAL CUTTING TOOL

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Chinese Journal of Mechanical Engineering 2001年第2期14卷 144-150页

作者： Wang Chenpei zhou Yunfei zhou yanhong zhou Ji National NC System Engineering Research Center, Huazhong University of Science and Technology 华中科技大学数控技术所湖北

A simulation system for five axis NC machining using general cutting tools is presented This system differs from other simulation system in that it not only focuses on the geometric simulation but also focuses on the collision detection which is usually not included in NC machining simulation Besides all of these, estimating cutting forces is also discussed In order to obtain high efficiency, all algorithms use swept volume modeling technique, so the simulation system is compact and can be performed efficiently

关键词： Simulation Envelope Z buffer structure Octree

Molecular patterns of avian influenza A viruses

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Chinese Science Bulletin 2008年第13期53卷 2002-2007页

作者： KOU Zheng LEI FuMin WANG ShengYue zhou yanhong LI TianXian Hubei Bioinformatics and Molecular Imaging Key Laboratory Department of Systems Biology Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China Institute of Zoology Chinese Academy of Sciences Beijing 100080 China Chinese National Human Genome Center Chinese Academy of Sciences Shanghai 201203 China

Avian influenza A viruses could get across the species barrier and be fatal to humans. Highly patho-genic avian influenza H5N1 virus was an example. The mechanism of interspecies transmission is not clear as yet. In this research,the protein sequences of 237 influenza A viruses with different subtypes were transformed into pseudo-signals. The energy features were extracted by the method of wavelet packet decomposition and used for virus classification by the method of hierarchical clustering. The clustering results showed that five patterns existed in avian influenza A viruses,which associated with the phenotype of interspecies transmission,and that avian viruses with patterns C and E could across species barrier and those with patterns A,B and D might not have the abilities. The results could be used to construct an early warning system to predict the transmissibility of avian influenza A viruses to humans.

关键词：禽流感病毒 H5N1 子波分解聚类种间传输