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Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina

World Journal of Diabetes 2024年第3期15卷 519-529页

作者： Jian Tan Ang Xiao Lin Yang Yu-Lin Tao Yi Shao qiong zhou Department of Ophthalmology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is a major ocular complication of diabetes mellitus,leading to visual *** pigment epithelium(RPE)injury is a key component of the outer blood retinal barrier,and its damage is an important indicator of *** for activated C kinase 1(RACK1)activates protein kinase C-ε(PKC-ε)to promote the generation of reactive oxygen species(ROS)in RPE cells,leading to ***,we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS,thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of *** To investigate the role and associated underlying mechanisms of RACK1 in the development of early *** In this study,Sprague-Dawley rats and adult RPE cell line-19(ARPE-19)cells were used as in vivo and in vitro models,respectively,to explore the role of RACK1 in mediating PKC-εin early ***,the impact of RACK1 on apoptosis and barrier function of RPE cells was also investigated in the former *** Streptozotocin-induced diabetic rats showed increased apoptosis and upregulated expression of RACK1 and PKC-εproteins in RPE cells following a prolonged ***,ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RACK1 and PKC-ε,accompanied by an increases in ROS production,apoptosis rate,and monolayer ***,silencing RACK1 significantly downregulated the expression of PKC-εand ROS,reduced cell apoptosis and permeability,and protected barrier *** RACK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.

关键词： Diabetic retinopathy Receptor for activated C kinase 1 Protein kinase C-ε Adult retinal pigment epithelium cell line-19

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Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients

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Journal of Geriatric Cardiology 2024年第5期21卷 542-549页

作者： Qian LI Yue YU Ya-qiong zhou Yi ZHAO Jin WU Yuan-Jing WU Bin DU Pei-Jian WANG Tao ZHENG Department of Cardiovascular Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Cardiology First Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Neurology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

BACKGROUND The neutrophil to lymphocyte ratio(NLR)has been reported as a novel predictor for atherosclerosis and car-diovascular *** study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion(CTO)*** A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up *** were divided into tertiles according to their baseline NLR levels at admission:low(n=223),intermediate(n=223),and high(n=224).The incidence of major adverse cardiac events(MACEs)during the follow-up period,including all-cause death,nonfatal myocardial infarction(MI),or ischemia-driven revascularization,were compared among the three *** Major adverse cardiac events were observed in 27 patients(12.1%)in the low tertile,40(17.9%)in the intermediate tertile,and 61(27.2%)in the high NLR tertile(P<0.001).Kaplan-Meier analysis demonstrated a significantly higher incidence of MACE,ischemia-driven coronary revascularization,non-fatal MI,and mortality in patients within the high tertile than those in the low and intermediate groups(all P<0.001).Multivariable COX regression analysis showed that the high tertile of baseline NLR level showed a strong association with the risk of MACE(hazard ratio[HR]=2.21;95%confidence interval[CI]:1.21-4.03;P=0.009),ischemia-driven coronary revascularization(HR=3.19;95%CI:1.56-6.52;P=0.001),MI(HR=2.61;95%CI:1.35-5.03;P=0.043)and mortality(HR=3.78;95%CI:1.65-8.77;P=0.001).CONCLUSION Our findings suggest that NLR is an inexpensive and readily available biomarker that can independently pre-dict cardiovascular risk in patients with CTO.

关键词： patients coronary occlusion

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Synergistic anionic/zwitterionic mixed surfactant system with high emulsification efficiency for enhanced oil recovery in low permeability reservoirs

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Petroleum Science 2024年第2期21卷 936-950页

作者： Hai-Rong Wu Rong Tan Shi-Ping Hong qiong zhou Bang-Yu Liu Jia-Wei Chang Tian-Fang Luan Ning Kang Ji-Rui Hou National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing102249China Unconventional Petroleum Research Institute China University of Petroleum-BeijingBeijing102249China Gas Production Plant 5 of PetroChina Changqing Oilfield Company PetroChinaXi'an710000ShaanxiChina College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China College of Science China University of Petroleum-BeijingBeijing102249China Kazakh-British Technical University Almaty050000Kazakhstan

Emulsification is one of the important mechanisms of surfactant flooding. To improve oil recovery for low permeability reservoirs, a highly efficient emulsification oil flooding system consisting of anionic surfactant sodium alkyl glucosyl hydroxypropyl sulfonate(APGSHS) and zwitterionic surfactant octadecyl betaine(BS-18) is proposed. The performance of APGSHS/BS-18 mixed surfactant system was evaluated in terms of interfacial tension, emulsification capability, emulsion size and distribution, wettability alteration, temperature-resistance and salt-resistance. The emulsification speed was used to evaluate the emulsification ability of surfactant systems, and the results show that mixed surfactant systems can completely emulsify the crude oil into emulsions droplets even under low energy conditions. Meanwhile,the system exhibits good temperature and salt resistance. Finally, the best oil recovery of 25.45% is achieved for low permeability core by the mixed surfactant system with a total concentration of 0.3 wt%while the molar ratio of APGSHS:BS-18 is 4:6. The current study indicates that the anionic/zwitterionic mixed surfactant system can improve the oil flooding efficiency and is potential candidate for application in low permeability reservoirs.

关键词： Anionic/zwitterionic mixed surfactant system Emulsification Synergistic effect Low permeability reservoir Enhanced oil recovery

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西南地区疟疾联防机制与边疆健康共同体塑造研究——以1950年后云南疟疾防治为例

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云南社会科学 2024年第3期 82-96页

作者：周琼中央民族大学历史文化学院

中国疟疾防治的政策和制度建设,以及所取得的良好成效,与云南的联防机制及严密的边疆疟疾监管体系有密切关系。1950—1979年间建立起了初步的疟疾防治政策,1980—2000年间疟防制度化建设取得了重大进展,21世纪后国内专项疟疾防治研究项... 详细信息

中国疟疾防治的政策和制度建设,以及所取得的良好成效,与云南的联防机制及严密的边疆疟疾监管体系有密切关系。1950—1979年间建立起了初步的疟疾防治政策,1980—2000年间疟防制度化建设取得了重大进展,21世纪后国内专项疟疾防治研究项目及其制度推广取得明显成效。在疾病防治体系塑造中,云南疟疾防控的内外能力得到增强,疟疾防治研究机构的建立是疾病防治体系塑造的基础,在疾病防治体系的塑造中彰显其内控能力增强的内显性效应,疟疾控制的国际化实践暨境内向境外防治的格局彰显了其严防疟疾源头的外显性效应。但在新的国际局势及环境危机背景下,疾控能力的提升也遇到了新危机,因势优化的新型防治策略,成为新疾控防治体系建设及人类卫生健康共同体目标实现的当务之急。

关键词：西南疟疾联防机制边疆健康共同体塑造

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作为网络社会本质特征的互联网群聚传播及其研究体系建构——《互联网群聚传播》评介

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出版发行研究 2024年第1期 75-81页

作者：周琼浙江工业大学人文学院复旦大学新闻学院

群聚传播模式成为现代性的加速逻辑在互联网时代的具体呈现,信息传播技术超越工业制造技术,成为推动社会发展的新引擎。立足于网络社会传播变革的本质特征,《互联网群聚传播》聚焦互联网传播中多类型的极端多元主体,从传统的身体聚集转... 详细信息

群聚传播模式成为现代性的加速逻辑在互联网时代的具体呈现,信息传播技术超越工业制造技术,成为推动社会发展的新引擎。立足于网络社会传播变革的本质特征,《互联网群聚传播》聚焦互联网传播中多类型的极端多元主体,从传统的身体聚集转向互联网的注意力聚合,围绕常态化的社会集合行为,对信息现代性张力带来的传播逻辑及社会变革进行深度剖析。该书作者首创“群聚传播”概念,通过分析主体关系偏向、网络行为与心理、传播特性和信息生产四个维度,揭示当下互联网传播的底层逻辑与风险社会治理的核心,旨在减少社会秩序、社会管理乃至社会发展进程的不确定因素,拓展中国互联网治理的新视野,重塑信息社会的现代性价值。

关键词：群聚传播自组织关系模式形塑机制网络社会

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物种引进与意识塑造:近代中国橡胶认知与生态潜在危机的孕育

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民国档案 2024年第1期 88-100页

作者：周琼中央民族大学历史文化学院 100081

橡胶作为全新的物种在近代中国成功引种,其经济战略潜力备受关注,报纸杂志及知识分子从不同视角对橡胶进行了介绍及研究。但精英及公众对新物种引进的生态影响处于无意识状态,致使橡胶的生态负面影响和潜在危机长期无人关注,塑造了20世... 详细信息

橡胶作为全新的物种在近代中国成功引种,其经济战略潜力备受关注,报纸杂志及知识分子从不同视角对橡胶进行了介绍及研究。但精英及公众对新物种引进的生态影响处于无意识状态,致使橡胶的生态负面影响和潜在危机长期无人关注,塑造了20世纪上半期橡胶经济战略价值的益树形象及生态意识缺失的时代特征,决定了近百年时间中国人对新物种生态认知的缺失状态,并潜移默化到事关国计民生的治国理政方略中,导致橡胶的负面生态影响成为全社会选择性忽视的盲区,成为近现代生态危机孕育、发端的诱因。这说明生态认知及意识塑造在生态文化生成及传承中具有重要的价值与作用,在当前生态文明理念及意识的国民化普及中具有极大的资鉴意义。

关键词：橡胶稀缺资源生态意识缺失生态危机

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Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU Man-qi YAN Ge zhou Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

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Programmed cell death 1 inhibitor sintilimab plus concurrent chemoradiotherapy for locally advanced pancreatic adenocarcinoma

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World Journal of Clinical Oncology 2024年第7期15卷 859-866页

作者： Shi-qiong zhou Peng Wan Sen Zhang Yuan Ren Hong-Tao Li Qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic adenocarcinoma,a malignancy that arises in the cells of the pancreas,is a devastating disease with unclear etiology and often poor *** advanced pancreatic cancer,a stage where the tumor has grown significantly but has not yet spread to distant organs,presents unique challenges in *** article aims to discuss the current strategies,challenges,and future directions in the management of locally advanced pancreatic adenocarcinoma(LAPC).AIM To investigate the feasibility and efficacy of programmed cell death 1(PD-1)inhibitor sintilimab plus concurrent chemoradiotherapy for *** Eligible patients had LAPC,an Eastern cooperative oncology group performance status of 0 or 1,adequate organ and marrow functions,and no prior anticancer *** the observation group,participants received intravenous sintilimab 200 mg once every 3 wk,and received concurrent chemoradiotherapy(concurrent conventional fractionated radiotherapy with doses planning target volume 50.4 Gy and gross tumor volume 60 Gy in 28 fractions and oral S-140 mg/m2 twice daily on days 1-14 of a 21-d cycle and intravenous gemcitabine 1000 mg/m2 on days 1 and 8 of a 21-d cycle for eight cycles until disease progression,death,or unacceptable toxicity).In the control group,participants only received concurrent *** April 2020 to November 2021,64 participants were finally enrolled with 34 in the observation group and 30 in the control *** Thirty-four patients completed the scheduled course of chemoradiotherapy,while 32(94.1%)received sintilimab plus concurrent chemoradiotherapy with 2 patients discontinuing sintilimab in the observation *** patients completed the scheduled course of chemoradiotherapy in the control *** on the Response Evaluation Criteria in Solid Tumors guidelines,the analysis of the observation group revealed that a partial response was observed in 11 patients(32.4%),stable disease was evident in 19 pa

关键词： Immunotherapy Concurrent chemoradiotherapy Locally advanced pancreatic adenocarcinoma Programmed cell death 1 Sintilimab

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ACE2/Ang 1-7/MasR轴在糖尿病视网膜病变中的作用研究进展

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中华眼视光学与视觉科学杂志 2024年第9期26卷 710-715页

作者：胡卫文周琼南昌大学第一附属医院眼科南昌大学江西医学院南昌

糖尿病视网膜病变(DR)是糖尿病引起的眼底神经-微血管并发症, 是常见且严重的可致盲性眼病。DR的具体致病机制仍在不断探索, 多种因素共同参与其发生发展。研究表明, 激活血管紧张素转换酶2(ACE2)/血管紧张素1-7(Ang 1-7)/Mas受体(MasR... 详细信息

糖尿病视网膜病变(DR)是糖尿病引起的眼底神经-微血管并发症, 是常见且严重的可致盲性眼病。DR的具体致病机制仍在不断探索, 多种因素共同参与其发生发展。研究表明, 激活血管紧张素转换酶2(ACE2)/血管紧张素1-7(Ang 1-7)/Mas受体(MasR)轴具有改善胰岛素抵抗、炎症反应、氧化应激、血管内皮功能、O-GlcNAc修饰、骨髓造血干/祖细胞功能和肠道屏障等作用, 在DR发生发展中起到一定的保护作用。随着对ACE2/Ang 1-7/MasR轴与DR研究的深入以及各种针对ACE2/Ang 1-7/MasR轴药物的研发, 未来有望为防治DR提供新的观点和策略。

关键词：血管紧张素转换酶2 血管紧张素1-7 糖尿病视网膜病变炎症反应肠道屏障

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Retinal nerve fiber layer defects and chronic kidney disease:the Kailuan Eye Study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1696-1706页

作者： Qian-Qian Wan Jin-qiong zhou Li-Jian Fang Ya-Xing Wang Ye-Nan Wang Qian Wang Yan-Ni Yan Xuan Yang Shou-Ling Wu Shuo-Hua Chen Jost B Jonas Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102400China Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 69117Germany

AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese ***:The Kailuan Eye Study was a populationbased study that included 14440 *** participants underwent detailed assessments,RNFLDs were diagnosed using color fundus ***:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus *** were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,*** RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 ***,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of ***:The strongest risk factors for RNFLDs are CKD and ***,RNFLDs can be an ocular feature in patients with *** can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.

关键词： chronic kidney disease retinal nerve fiber layer defects Kailuan Eye Study fundus examination

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