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HIV-1 Protein Tat_(1–72) Impairs Neuronal Dendrites via Activation of PP1 and Regulation of the CREB/BDNF Pathway

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Virologica Sinica 2018年第3期33卷 261-269页

作者： Yu liu Deyu zhou Jiabin Feng zhou liu Yue Hu Chang liu Xiaohong Kong Laboratory of Medical Molecular Virology School of Medicine Nankai University

Despite the success of combined antiretroviral therapy in recent years, the prevalence of human immunodeficiency virus(HIV)-associated neurocognitive disorders in people living with HIV-1 is increasing, significantly reducing the healthrelated quality of their lives. Although neurons cannot be infected by HIV-1, shed viral proteins such as transactivator of transcription(Tat) can cause dendritic damage. However, the detailed molecular mechanism of Tat-induced neuronal impairment remains unknown. In this study, we first showed that recombinant Tat(1–72 aa) induced neurotoxicity in primary cultured mouse neurons. Second, exposure to Tat_(1–72) was shown to reduce the length and number of dendrites in cultured neurons. Third, Tat_(1–72)(0–6 h) modulates protein phosphatase 1(PP1) expression and enhances its activity by decreasing the phosphorylation level of PP1 at Thr320. Finally, Tat_(1–72)(24 h) downregulates CREB activity and CREBmediated gene(BDNF, c-fos, Egr-1) expression. Together, these findings suggest that Tat_(1–72) might impair cognitive function by regulating the activity of PP1 and the CREB/BDNF pathway.

关键词： Recombinant tat HIV-associated neurocognitive disorders (HAND) - Dendrite impairment - Proteinphosphatase 1 (PP1) CREB/BDNF

Novel foaming agent used in preparation process of aluminum foams

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Journal of University of Science and Technology Beijing 2008年第6期15卷 735-739页

作者： Xiangyang zhou Xiquan liu Jie Li Hongzhuan liu School of Metallurgical Science and Engineering Central South University Changsha 410083 China

The performances of a novel foaming agent used in the preparation process of aluminum foams were investigated, and the effects of some factors, such as addition of the foaming agent, foaming temperature on the porosity, and appearance of aluminum foams were also discussed. Experimental results show that the novel foaming agent has a wide decomposition temperature range and a mild decomposed rate; the foaming agent has the ability to enhance the viscosity of aluminum melt, as a result, an extra viscosifier such as Ca or SiCp is unnecessary while using this foaming agent; the bubble-free zone in material decreases and the foaming effi- ciency increases with the increase of foaming agent; the bubble-free zone disappears and the foaming efficiency is near 100% when the addition of foaming agent is more than 1.4wt%; the porosity of the aluminum foam increases with the increase of foaming agent when the addition of foaming agent is less than 2.2wt%.

关键词： aluminum foam foaming agent porosity viscosity foaming efficiency

NiMo/Al_2O_3 catalyst containing nano-sized zeolite Y for deep hydrodesulfurization and hydrodenitrogenation of diesel

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Journal of Natural Gas Chemistry 2011年第4期20卷 441-448页

作者： Hailiang Yin Tongna zhou Yunqi liu Yongming Chai Chenguang liu State Key Laboratory of Heavy Oil Processing Key Laboratory of Catalysis CNPC China University of Petroleum Qingdao 266555 Shandong China

Two mixed-matrix NiMo/Al2O3 catalysts containing nano-and micro-sized zeolite Y have been prepared to explore the size effect of zeolite Y particle on the hydrodesulfurization（HDS）and hydrodenitrogenation（HDN）activities of fluid catalytic cracking（FCC）*** were characterized by SEM,BET,XRD,H2-TPR,NH3-TPD and *** results show that the catalyst containing nano-sized zeolite Y possesses larger average pore diameter,higher pore volume,weaker and lesser acid sites,more easily reducible metal phases,shorter MoS2 slabs and more slab layers than the catalyst containing micro-sized zeolite *** catalysts were also evaluated with a high-pressure fixed-bed reactor using real FCC diesel as *** results display that the catalyst containing nano-sized zeolite Y bears higher HDS and HDN activities and exhibits higher relative rate constant for the removal of total sulfur or nitrogen than the one containing micro-sized zeolite.

关键词： zeolite Y nano-sized zeolite micro-sized zeolite hydrodesulfurization hydrodenitrogenation diesel

Quantum gravity effects on spectroscopy of Kerr-Newman black hole in gravity's rainbow

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Communications in Theoretical Physics 2022年第2期74卷 90-98页

作者： Cheng-zhou liu Jin-Jun Tao Department of Physics Shaoxing UniversityShaoxing 312000China

The effects of quantum gravity on spectroscopy for the charged rotating gravity’s rainbow are investigated in this *** utilizing an action invariant obtained from particles tunneling through the event horizon,the entropy and area spectrum for the modified Kerr-Newman black hole are *** equally spaced entropy spectrum characteristic of Bekenstein’s original derivation is ***,the entropy spectrum is independent of the energy of the test particles,although the gravity’s rainbow itself is the energy *** that,the quantum gravity effects of gravity’s rainbow has no influence on the entropy *** the other hand,due to the spacetime quantum effects,the obtained area spectrum is different from the original Bekenstein *** is not equidistant and is dependent on the horizon *** that,by analyzing the area spectrum from a specific rainbow function,a minimum area with a Planck scale is derived for the event *** this point,the area quantum is zero and the black hole radiation ***,the black hole remnant for the gravity’s rainbow is obtained from the area *** addition,the entropy for the modified Kerr-Newman black hole is calculated and the quantum correction to the area law is obtained and discussed.

关键词： black hole spectroscopy gravity’s rainbow quantum effects

Comparison of predicting drag methods using computational fluid dynamics in 2d/3d viscous flow

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Science China(Technological Sciences) 2007年第5期50卷 534-549页

作者： ZHU ZiQiang WANG XiaoLu liu Jie liu zhou Key Laboratory of Fluid Mechanics MOE Beijing University of Aeronautics and Astronautics Beijing 100083 China Key Laboratory of Fluid Mechanics MOE Beijing University of Aeronautics and Astronautics Beijing 100083 China Key Laboratory of Fluid Mechanics MOE Beijing University of Aeronautics and Astronautics Beijing 100083 China Key Laboratory of Fluid Mechanics MOE Beijing University of Aeronautics and Astronautics Beijing 100083 China

As a result of the necessity of aircraft engineering design and the progress of computational fluid dynamics (CFD), techniques of accurately predicting aero- dynamic drag are being increasingly explored. According to the momentum bal- ance, the drag can be represented by an integral over a cross-flow plane (called wake integration method) at an arbitrary distance behind the configuration. A for- mulation to reduce the size of the wake cross plane region required for calculating the drag is developed by using cutoff parameters of vorticity and entropy. This in- creases the calculation accuracy and decreases the computation time required. Numerical experiments are made to obtain the threshold values of these cutoff pa- rameters. The wake integration method is applied to predict drags of some exam- ples including airfoil, a variety of wings and wing-body combination. Numerical results are compared with those of traditional surface integration method, showing that the predicting drag values with the wake integration method are closer to the experimental data. The results also show that drag prediction within engineering accuracy is possible by using CFD and the numerical drag optimization of complex aircraft configurations is possible, too.

关键词： drag prediction, wake integration, surface integration, computational fluid dynamics

Colour Metallography of Cast Iron

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China Foundry 2009年第1期6卷 255-267页

作者： zhou Jiyang liu Jincheng Dalian University of Technology China Fellow of Institute of Cast Metal EngineersUK

This book consists of five sections:Chapter 1 Introduction,Chapter 2 Grey Iron,Chapter 3 Ductile Iron,Chapter 4 Vermicular Cast Iron,and Chapter 5 White Cast Iron. CHINA FOUNDRY publishs this book in several parts ser... 详细信息

关键词： Colour Metallography of Cast Iron Cast

Micro-nano-fabrication of green functional materials by multiphase microfluidics for environmental and energy applications

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Green Energy & Environment 2024年第8期9卷 1199-1219页

作者： Cheng Qi Tao zhou Xingjiang Wu Kailang liu Lei Li zhou liu Zhuo Chen Jianhong Xu Tiantian Kong Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhenGuangdong518000China The State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing100084China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenGuangdong518000China Department of Biomedical Engineering School of MedicineShenzhen UniversityShenzhenGuangdong518000China

Multiphase microfluidic has emerged as a powerful platform to produce novel materials with tailor-designed functionalities,as microfluidic fabrication provides precise controls over the size,component,and structure of resultant ***,functional materials with well-defined micro-/nanostructures fabricated by microfluidics find important applications as environmental and energy *** review first illustrated in detail how different structures or shapes of droplet and jet templates are formed by typical configurations of microfluidic channel networks and multiphase flow ***,recent progresses on several representative energy and environmental applications,such as water purification,water collecting and energy storage,were ***,it is envisioned that integrating microfluidics and other novel materials will play increasing important role in contributing environmental remediation and energy storage in near future.

关键词： Microfluidics Multi-phase flow Droplet and microfiber Environmental remediation Energy Storage

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硅掺杂对不同衬底的氮化铝薄膜的影响研究

原子与分子物理学报 2025年第5期42卷 50-56页

作者：王绪杨发顺熊倩周柳含马奎贵州大学电子科学系贵阳550025 中国教育部半导体器件可靠性工程研究中心贵阳550025 贵州省微纳电子与软件技术重点实验室贵阳550025

选择硅作为N型杂质源,采用高温热扩散的方式进行实验研究.采用磁控溅射法在硅/蓝宝石衬底上外延的AlN薄膜上沉积纯硅.硅的溅射时间决定了硅层的厚度,从而决定了硅的掺杂剂量.在氮气气氛下高温(1150℃)热扩散4小时后,AlN薄膜表面的硅原... 详细信息

选择硅作为N型杂质源,采用高温热扩散的方式进行实验研究.采用磁控溅射法在硅/蓝宝石衬底上外延的AlN薄膜上沉积纯硅.硅的溅射时间决定了硅层的厚度,从而决定了硅的掺杂剂量.在氮气气氛下高温(1150℃)热扩散4小时后,AlN薄膜表面的硅原子扩散进入AlN晶格,取代铝原子的位置,形成掺杂硅的AlN薄膜.有效的硅掺杂导致AlN(002)衍射峰向一个较大的角度偏移,且偏移的角度随掺杂的浓度升高而增大.且硅衬底上的样品,使用能量色散光谱仪测试结果表明,衬底硅将作为固定的扩散源扩散到薄膜中,增加非故意掺杂浓度,因此可以在整个薄膜截面内测量到硅元素.蓝宝石的衬底的样品在热扩散后出现裂纹.

关键词： N型氮化铝硅掺杂磁控溅射热扩散衬底反扩散

Manufacturing task data chain-driven production logistics trajectory analysis and optimization decision making method

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Advances in Manufacturing 2024年第1期12卷 185-206页

作者： Lin Ling Zhe-Ming Song Xi Zhang Peng-zhou Cao Xiao-Qiao Wang Cong-Hu liu Ming-zhou liu School of Mechanical Engineering Hefei University of TechnologyHefei230009People’s Republic of China Guobo Electronics Co.Ltd. Nanjing211111People’s Republic of China School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou234000AnhuiPeople’s Republic of China Sino-US Global Logistics Institute Shanghai Jiao Tong UniversityShanghai200030People’s Republic of China

Production logistics(PL)is considered as a critical factor that affects the efficiency and cost of production operations in discrete manufacturing *** effectively utilize manufacturing big data to improve PL efficiency and promote job shop floor economic benefits,this study proposes a PL trajectory analysis and optimization decision making method driven by a manufacturing task data chain(MTDC).First,the manufacturing task chain(MTC)is defined to characterize the discrete production process of a *** handle manufacturing big data,the MTC data paradigm is designed,and the MTDC is ***,the logistics trajectory model is presented,where the various types of logistics trajectories are extracted using the MTC as the search engine for the *** on this,a logistics efficiency evaluation indicator system is proposed to support the optimization decision making for the ***,a case study is applied to verify the proposed method,and the method determines the PL optimization decisions for PL efficiency without changing the layout and workshop equipment,which can assist managers in implementing the optimization decisions.

关键词： Production logistics(PL) Logistics trajectory analysis Logistics optimization Data driven Manufacturing task data chain(MTDC)