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Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-zhou li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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5-羟甲基糠醛在CuPd(111)上的加氢反应机理研究

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原子与分子物理学报 2025年第4期42卷 53-57页

作者：张兴云周广丽石云山东临沂大学化学化工学院临沂276000

采用密度泛函理论,利用包含零点能校正的PBE-D3方法研究了5-羟甲基糠醛在双金属催化剂CuPd(111)上表面的加氢还原反应,考虑了两种反应路径,第一种反应路径是侧链上的醛基氧首先发生加氢反应生成F-CHOH中间体,然后F-CHOH中间体继续加氢生... 详细信息

采用密度泛函理论,利用包含零点能校正的PBE-D3方法研究了5-羟甲基糠醛在双金属催化剂CuPd(111)上表面的加氢还原反应,考虑了两种反应路径,第一种反应路径是侧链上的醛基氧首先发生加氢反应生成F-CHOH中间体,然后F-CHOH中间体继续加氢生成2,5-二羟甲基呋喃;第二种反应路径是侧链上的醛基碳先加氢原还原生成F-CH_(2)O中间体,生成的F-CH_(2)O进一步加氢还原生成2,5-二羟甲基呋喃.计算了两种竞争反应路径的活化能垒和反应热,结果表明,5-羟甲基糠醛在CuPd(111)面加氢还原生成2,5-二羟甲基呋喃的最佳反应路径为:F-CHO→F-CHOH→F-CH_(2)OH.

关键词： 5-羟甲基糠醛活化能垒反应热

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New multi-layer data correlation algorithm for multi-passive-sensor location system

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Journal of Systems Engineering and Electronics 2007年第4期18卷 667-672页

作者： zhou li li lingyun He You School of Management Ludong Univ. Yantai 264025 P. R. China Research Inst. of Information Fusion Naval Aeronautical Engineering Inst. Yantai 264001 P. R. China School of Computer Science & Technology Ludong Univ. Yantai 264025 P. R. China

Under the scenario of dense targets in clutter, a multi-layer optimal data correlation algorithm is proposed. This algorithm eliminates a large number of false location points from the assignment process by rough correlations before we calculate the correlation cost, so it avoids the operations for the target state estimate and the calculation of the correlation cost for the false correlation sets. In the meantime, with the elimination of these points in the rough correlation, the disturbance from the false correlations in the assignment process is decreased, so the data correlation accuracy is improved correspondingly. Complexity analyses of the new multi-layer optimal algorithm and the traditional optimal assignment algorithm are given. Simulation results show that the new algorithm is feasible and effective.

关键词： multi-passive-sensor data correlation multi-layer correlation algorithm location system correlation cost

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Adaptive dynamic surface control for air-breathing hypersonic vehicle

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Journal of Systems Engineering and Electronics 2013年第3期24卷 463-479页

作者： li zhou Shumin Fei School of Information and Control Nanjing University of Information Science and Technology School of Automation Southeast University

This paper describes an adaptive control approach for an air-breathing hypersonic vehicle. The control objective is to provide robust altitudes and velocity tracking in the presence of model uncertainties and varying disturbances. A fuzzy-neural disturbance observer is developed to estimate uncertainties and disturbances, and the adaptive controller is synthesized by the dynamic surface approach combing with the observer. The tracking error at the steady state can be guaranteed to converge to inside of a small residue set which the size of the set can be an arbitrary small value. Simulation results demonstrate the effectiveness of the presented approach.

关键词： flight control dynamic surface control fuzzy-neura system disturbance observer hypersonic vehicle.

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A numerical study of hydrodynamic influence on collision of brash ice with a structural plate

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Journal of Hydrodynamics 2022年第1期34卷 43-51页

作者： li zhou Zhi Zong Jia-nan li School of Naval Architecture Dalian University of TechnologyDalian116024China Tianjin Branch HuaDian Heavy Industries Co.Ltd Tianjin300010China

The ice-structure collision is a transient process, which is further complicated by the presence of the water. It remains unclear how important the hydrodynamic influences are during the collision. This problem is partially investigated in this paper using numerical methods. To simplify the problem as much as possible without loss of generality, a short ice cylinder of circular section is assumed to collide with a vertical large structure plate under a variety of collision scenarios. Among them the most important cases are: (1) the rigid ice cylinder collision with the rigid or elastic structural plate at different collision velocities, (2) the elastic ice cylinder collision with the rigid or elastic structural plate at different collision velocities and (3) the elastoplastic ice cylinder collision with the rigid or elastic structural plate at different collision velocities. The numerical results show that: (1) the hydrodynamic influences are negligible in the first case, (2) the hydrodynamic influences in the second and third cases are not negligible, and become very significant in the third case. The influences are numerically estimated to be in the range of 20%–60% in terms of the momentum change. If the ice response is approximately decomposed into the rigid-body motions and the deformation modes at the instant of the collision with the structure, the previous conclusions show that the hydrodynamic influences on the rigid-body motions of the ice are negligible, but those on the elastic and elastoplastic modes of the ice are significant. Comparison with the case of a submerged ice cylinder (although not a practical case) reveals that the hydrodynamic influences are small in the first case due to the fact that the energy loss is used to produce the water splash and the cavity behind the ice cylinder. Through this study we come into the conclusion that the hydrodynamic influences are not important for the rigid-body motions, but important for the elastic or elastop

关键词： Ice-structure collision hydrodynamic influence numerical rigid mode elastic mode

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The Fuxing: The China Standard EMU

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Engineering 2020年第3期6卷 227-233页

作者： Yanhui Qi li zhou China State Railway Group Co. Ltd.Beijing 100844China China Academy of Railway Sciences Co. Ltd.Beijing 100081China

*** overview Since the first high-speed railway(HSR)intercity line was built between Beijing and Tianjin in 2008,China’s HSRs have developed *** a short span of ten years,successive HSRs have entered operation between Zhengzhou and Xi’an,Beijing and Shanghai,Beijing and Guangzhou,Lanzhou and Urumqi,and around Hainan *** the end of 2018,the HSR route length in China exceeded 29000 km,accounting for over two thirds of the world’s total.

关键词： successive Tianjin railway

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Scene recognition combining structural and textural features

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Science China(Information Sciences) 2013年第7期56卷 225-238页

作者： zhou li HU DeWen zhou ZongTan Department of Automatic Control College of Mechatronics and Automation National University of Defense Technology

Automatic recognition of the contents of a scene is an important issue in the field of computer vision. Although considerable progress has been made, the complexity of scenes remains an important challenge to computer vision research. Most previous approaches for scene recognition are based on the so-called "bag of visual words" model, which uses clustering methods to quantize numerous local region descriptors into a codebook. The size of the codebook and the selection of initial clustering centers greatly affect the performance. Furthermore, the large size of the codebook leads to high computational costs and large memory consumption. To overcome these weaknesses, we present an unsupervised natural scene recognition approach that is not based on the "bag of visual words" model. This approach constructs multiple images of different resolutions and extracts structural and textural features from these images. The structural features are represented by weighted histograms of the gradient orientation descriptor, which is presented in this paper, and the textural features are represented by filter responses of Gabor filters and a Schmid set. We regard the structural and textural features as two independent feature channels, and combine them to realize automatic categorization of scenes using a support vector machine. We then evaluated our approach using three commonly used datasets with various scene categories. Our experiments demonstrate that the weighted histograms of the gradient orientation descriptor outperform the classical scale invariant feature transform descriptor in natural-scene recognition, and our approach achieves good performance with respect to current state-of-the-art methods.

关键词： scene recognition structural feature textural feature feature combination weighted histograms of gradient orientation descriptor

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OGSRN:Optical-guided super-resolution network for SAR image

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Chinese Journal of Aeronautics 2022年第5期35卷 204-219页

作者： Yanshan li li zhou Fan XU Shifu CHEN ATR National Key Laboratory of Defense Technology Shenzhen UniversityShenzhen 518060China Guangdong Key Laboratory of Intelligent Information Processing Shenzhen UniversityShenzhen 518060China

Although Convolutional Neural Networks(CNNs)have significantly improved the development of image Super-Resolution(SR)technology in recent years,the existing SR methods for SAR image with large scale factors have rarely been studied due to technical difficulty.A more efficient method is to obtain comprehensive information to guide the SAR image ***,the co-registered High-Resolution(HR)optical image has been successfully applied to enhance the quality of SAR image due to its discriminative *** by this,we propose a novel Optical-Guided Super-Resolution Network(OGSRN)for SAR image with large scale ***,our proposed OGSRN consists of two sub-nets:a SAR image SuperResolution U-Net(SRUN)and a SAR-to-Optical Residual Translation Network(SORTN).The whole process during training includes two *** stage-1,the SR SAR images are reconstructed by the *** an Enhanced Residual Attention Module(ERAM),which is comprised of the Channel Attention(CA)and Spatial Attention(SA)mechanisms,is constructed to boost the representation ability of the *** stage-2,the output of the stage-1 and its corresponding HR SAR images are translated to optical images by the SORTN,*** then the differences between SR images and HR images are computed in the optical space to obtain feedback information that can reduce the space of possible SR *** that,we can use the optimized SRUN to directly produce HR SAR image from Low-Resolution(LR)SAR image in the testing *** experimental results show that under the guidance of optical image,our OGSRN can achieve excellent performance in both quantitative assessment metrics and visual quality.

关键词： SAR image Super-resolution Optical image Attention mechanisms Convolutional Nerual Networks(CNNs)

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Unique Properties of Heat Generation in Nanoscale Systems

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Chinese Physics Letters 2011年第12期28卷 303-305页

作者： zhou li-ling Department of Physics Jiujiang UniversityJiujiang 332005

We study the unique properties of current-induced heat generation Q in nanostructures and its absence in macroscopic bulks.A lead−quantum dot-lead system is taken into consideration and it is found that its unique properties stem from energy quantization of the system and arise only under conditions of low temperature and weak dot-lead *** relation of Q∝I(I is the system current)fails in nanosystems,while the Q peaks align with peaks of phonon−assisted current under small *** a result,one can expect a large current accompanied by relatively small Q when the elastic current peak does not coincide with the phonon-assisted one,the ideal working condition for a nanostructure.

关键词： system macroscopic relation

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POWER REFLECTION AND TRANSMISSION IN BEAM STRUCTURES CONTAINING A SEMI-INFINITE CRACK

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Acta Mechanica Solida Sinica 2008年第2期21卷 177-188页

作者： li zhou Wanchun Yuan College of Aerospace Engineering Nanjing University of Aeronautics ＆ Astronautics Nanjing 210016 China

Wave reflection and transmission in a beam containing a semi-infinite crack are studied analytically based on Timoshenko beam theory., Two kinds of crack surface conditions： non-contact （open） and fully contact （closed） cracks, are considered respectively for an isotropic beam. The analytical solution of reflection and transmission coefficients for a semi-infinite crack is obtained. The power reflection and transmission ratios depend on both the frequency and the position of the crack. Numerical results show the conservation of power transport. The transmitted energy among various wave modes is also investigated. A finite element method is used to verify the validity of the analytical results.

关键词： reflection and transmission crack power transport structural health monitoring

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