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Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： Qian-Yun Guo Jia-Qi Yang Xun-Xun Feng Yu-jie zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

ChatGPT: potential, prospects, and limitations

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 6-11页

作者： jie zhou Pei KE Xipeng QIU Minlie HUANG Junping ZHANG School of Computer Science Fudan UniversityShanghai 200433China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Shanghai Key Laboratory of Intelligent Information Processing Shanghai 200433China

Recently,OpenAI released Chat Generative Pre-trained Transformer(ChatGPT)(Schulman et al.,2022)(https://***),which has attracted considerable attention from the industry and academia because of its impressive abilities.This is the first time that such a variety of open tasks can be well solved within one large language model.To better understand ChatGPT,we briefly introduce its history,discuss its advantages and disadvantages,and point out several potential applications.Finally,we analyze its impact on the development of trustworthy artificial intelligence,conversational search engine,and artificial general intelligence.

关键词： artificial limitations intelligence

Updates of developments in interventional therapy for elderly patients with cardiovascular diseases

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Journal of Geriatric Cardiology 2024年第1期21卷 1-3页

作者： Hua SHEN Xun-Xun FENG Qian-Yun GUO Yu-jie zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina

Cardiovascular diseases(CVD)are the leading cause of death in the world and one of the most common diseases in the elderly,with high prevalence and poor prognosis,which seriously affect the health of the elder patients.One report showed that global deaths from CVD increased from 12.4 million in 1990 to 19.8 million in 2022,reflecting the global population growth and aging,as well as the impact of metabolic,environmental,and behavioral risks.[1]With the progress of aging population,the burden of CVD in the elderly in China has increased year by year,and factors including multiple complications,organ function decline,and high complication rate have made the interventional treatment of CVD in the elderly one of the difficulties and focuses in the field of cardiology in China.

关键词： diseases patients prognosis

The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato

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Molecular Plant 2024年第4期17卷 598-613页

作者： Shaofang Wu Chaoyi Hu Changan Zhu Yanfen Fan jie zhou Xiaojia Xia Kai Shi Yanhong zhou Christine H.Foyer Jingquan Yu Department of Horticulture Zijingang CampusZhejiang UniversityHangzhou 310058China Hainan Institute Zhejiang UniversityYazhou Bay Science and Technology CitySanya 572025China College of Horticulture Northwest Agriculture&Forestry UniversityXianyang 712100China School of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK Key Laboratory of Horticultural Plants Growth and Development Agricultural Ministry of ChinaZhejiang UniversityHangzhou 310058China

Jasmonates(JAs),a class of lipid-derived stress hormones,play a crucial role across an array of plant physiological processes and stress responses.Although JA signaling is thought to rely predominantly on the degradation of specific JAZ proteins by SCF^(COI1),it remains unclear whether other pathways are involved in the regulation of JAZ protein stability.Here,we report that PUB22,a plant U-box type E3 ubiquitin ligase,plays a critical role in the regulation of plant resistance against Helicoverpa armigera and other JA responses in tomato.Whereas COI1 physically interacts with JAZ1/2/5/7,PUB22 physically interacts with JAZ1/3/4/6.PUB22 ubiquitinates JAZ4 to promote its degradation via the 26S proteasome pathway.Importantly,we observed that pub22 mutants showreduced resistance to H.armigera,whereas jaz4 single mutants and jaz1 jaz3 jaz4 jaz6 quadruple mutants have enhanced resistance.The hypersensitivity of pub22 mutants to herbivores could be partially rescued by JAZ4 mutation.Moreover,we found that expression of PUB22 can be transcriptionally activated by MYC2,thus forming a positive feedback circuit in JA signaling.We noticed that the PUB22-JAZ4 module also regulates other JA responses,including defense against B.cinerea,inhibition of root elongation,and anthocyanin accumulation.Taken together,these results indicate that PUB22 plays a crucial role in plant growth and defense responses,together with COI1-regulated JA signaling,by targeting specific JAZs.

关键词： PUB22 JAZ COI1 MYC2 JA signaling Solanum lycopersicum

Concomitant hepatocellular carcinoma recurrence and mantle cell lymphoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 434-437页

作者： Liang Xue Da-Long Wan Chen Hu Qing-Hong Ke jie zhou Yan Shen Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Mantle cell lymphoma(MCL)is a rare subgroup of B-cell nonHodgkin’s lymphoma(NHL)that occurs in approximately 6%of NHL patients.Chronic hepatitis and cirrhosis may promote hepatocellular carcinoma(HCC)de... 详细信息

关键词： lymphoma hepatocellular NHL

Bio-inspired Attachment Mechanism of Dynastes Hercules:Vertical Climbing for On-Orbit Assembly Legged Robots

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Journal of Bionic Engineering 2024年第1期21卷 137-148页

作者： Yuetian Shi Xuyan Hou Zhonglai Na jie zhou Nan Yu Song Liu Linbo Xin Guowei Gao Yuhui Liu School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

With the increasing size of space facilities,on-orbit assembly requires robots to move on different heights of trusses.This paper proposes a bio-inspired attachment mechanism for robot feet to enable climbing on different heights of trusses.Inspired by the attachment and grasping abilities of Dynastes Hercules,we utilize its foot microstructures,such as microhooks and setae,to achieve efficient contact and firm grip with the surface.The morphology and arrangement of these structures can inspire the design of robot feet to improve their grasping and stability performance.We study the biological structure of Dynastes Hercules,design and optimize the bio-inspired structure,analyze the influence of various factors from theoretical and experimental perspectives,and verify the feasibility of the scheme through simulation.We propose an ideal climbing strategy that provides useful reference for robot applications in practice.Moreover,the influence laws of various factors in this paper can be applied to robot foot design to improve their operation ability and stability performance in the space environment.This bio-inspired mechanism can improve robot working range and efficiency,which is critical for on-orbit assemblyin space.

关键词： Space assembly robot Truss climbing Bionic structure Dynastes Hercules tarsus

Electroacupuncture ameliorates cardiac dysfunction in myocardial ischemia model rats:a potential role of the hypothalamic-pituitary-adrenal axis

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中医杂志:英文版 2023年第5期43卷 944-954页

作者： WANG Kun zhou jie CUI Shuai WU Xin ZHU Guoqi WU Shengbing zhou Meiqi Key Laboratory of Xin’an Medicine Ministry of EducationAnhui University of Chinese MedicineHefei 230038China Department of Acupuncture and Moxibustion the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053China Colleges of Acupuncture and Massage Anhui University of Chinese MedicineHefei 230038China Bozhou Institute of Chinese Medicine Anhui Academy of Traditional Chinese MedicineBozhou 236800China

OBJECTIVE:To verify the hypothesis that electroacupuncture inhibits the hyperactivity of the hypothalamic-pituitary-adrenal(HPA)axis via regulating the expression of glial fibrillary acidic protein(GFAP)in the hippocampus of acute myocardial ischemia(AMI)rats.METHODS:Sixty-six healthy male Sprague-Dawley rats were randomly divided into five groups:Sham,AMI(Model),electroacupuncture at Shenmen(HT7)-Tongli(HT5)segment(EA),non-acupoint electroacupuncture(Control),and Model+corticosterone(Model+CORT).AMI was induced via occlusion of the left anterior descending coronary artery,followed by 3 d of electroacupuncture at Shenmen(HT7)-Tongli(HT5)segment.In the Control group,electroacupuncture was applied at points lying 5 and 10 mm from the base of the tail.The AMI+CORT group was injected with CORT(20 mg/kg)in saline.Hemorheology,electrocardiography(ECG),hematoxylin and eosin staining,and expression of glycogen phosphorylase BB(GPBB)and heart-type fatty acid-binding protein(H-FABP)were used to assess cardiac function.The effects of adrenocorticotropic hormone(ACTH)and CORT were evaluated by enzymelinked immunosorbent assay.Protein expression in the Sham and Model groups were screened by tandem mass tag-based quantitative proteomics analysis.Protein expression was evaluated by Western blotting(vimentin and GFAP)and immunofluorescence staining(GFAP).RESULTS:Compared with the Sham group,the hemorheology indicators,heart rate,ECG-ST segment elevation,and GPBB and H-FABP levels were higher in Model rats.The EA group showed reductions in these indicators compared with the Model group.Similarly,in Model rats,the expression of ACTH and CORT were significantly increased compared with the Sham group.The EA group also showed reduced expression of ACTH and CORT.Importantly,proteomics analysis showed that vimentin was differentially expressed in Model rats.Compared with the Sham group,vimentin and GFAP expression in the hippocampus was increased in the Model group but decreased in the AMI+EA group.Additionally,intraperitoneal injectio

关键词： acupuncture myocardial ischemia hippocampus vimentin glial fibrillary acidic protein hypothalamic-pituitary-adrenal

Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway

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Neural Regeneration Research 2024年第1期19卷 180-189页

作者： Zhihao Zhang Zhiwen Song Liang Luo Zhijie Zhu Xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang Ma Tingyu Wu zhou Yao jie zhou Beiyu Chen Tan Ding Zhe Wang Xueyu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment.The cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous repair.These proteins are thus candidate targets for spinal cord injury therapy.Our previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model animals.However,the specific mechanism and potential targets involved remain to be clarified.In this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive days.We found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal cord.Bioinformatics analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed molecules.Immunofluorescence staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord tissue.The expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve rsican.Furthermore,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB 202190.This suggests that Sma d 3/Sox9 and MAP K/Sox9 pathways may be involved in the effects of photobiomodulation.In summary,our findings show that photobiomodu

关键词： chondroitin sulfate proteoglycans Erk MAPK P38 photobiomodulation principal component analysis Smad3 Sox9 spinal cord injury versican

Flow Characteristics Analysis of TC18 Titanium Alloy during Hot Deformation Based on Phase Transformation

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Journal of Wuhan University of Technology(Materials Science) 2023年第6期38卷 1418-1425页

作者： SUN Tao TENG Haihao JIANG Xiaojuan TENG Shuman zhou jie College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Key Laboratory of Advanced Die Intelligent Manufacturing of Chongqing Chongqing 400044China School of Mechanical Engineering and Automation Chongqing Industry Polytechnic CollegeChongqing 401120China Liuzhou Steel Group Liuzhou 545002China

An accurate flow stress model was established by considering the parameters of strain rate,strain and temperature as well asβ→a+βphase transformation in order to develop the plastic forming theory of TC18 titanium alloy.Firstly,the phase transition kinetics of TC18 titanium alloy during isothermal and continuous cooling at 1073 and 1273 K was studied by thermodynamic calculation,meanwhile,the relationship of volume fraction of phase transition with temperature and time was obtained.Constitutive models were calculated by investigating flow behaviors under hot compression tests with the strain rates of 0.001-1s^(-1) and temperatures of 973-1223 K in the singleβand a+βregions in TC18 titanium alloy,respectively.By combining the phase transformation dynamic kinetics with constitutive models,an accurate flow stress model was established,providing theoretical basis and data support for the hot forging of TC18 titanium alloy.

关键词： constitutive modeling TC18 titanium alloy phase transformation flow stress