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Research on the width of filling body in gob-side entry retaining with high-water materials

International Journal of Mining Science and Technology 2018年第3期28卷 519-524页

作者： Chang Qingliang Tang Weijun Xu Ying zhou huaqiang Laboratory of Deep Coal Resource Key Mining Ministry of Education School of Mines China University of Mining and Technology Postdoctoral Station Zibo Coal Mining Group Co. Ltd.

To determine the filling body's width along the gob-side remained roadway which is underneath the gob,the authors analyzed the interaction mechanism between the roof and the supporting body along the remained roadway, based on the elastic thin plate theory of the stope roof. The stress state and mechanical response of the filling body along the remained roadway were studied. Specifically, firstly, the supporting pressure of the coal pillar which is on one side of the gob-side remained roadway was ***, an equation that is used to calculate the width of the balance area in the stress limit state was acquired. Then, an equation that is used to calculate the roof cutting force on one side of the supporting body was obtained. By using FLAC3D, the authors investigated the displacement field and stress field response laws of rock masses around the roadway with different filling body's widths. The results show that with the filling body's width increasing, the supporting ability of the filling body ***, the rock mass displacement around the roadway and the filling body deformation *** better the filling body's supporting effect is, the higher the roof cutting force will be. When the filling body's width is larger than 3.0 m, its internal bearing ability becomes stable and the filling body's deformation became non-apparent. Finally, analysis shows that the filling body's width should be 2.5 ***, the authors conducted field tests in the supply roadway 1204, using high-water materials and acquired expected outcomes.

关键词： Gob-side entry retaining High-water materials Numerical simulation Support along the roadway

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Anchoring mechanism and application of hydraulic expansion bolts used in soft rock roadway floor heave control

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International Journal of Mining Science and Technology 2013年第3期23卷 323-328页

作者： Chang Qingliang zhou huaqiang Xie Zhihong Shen Shiping School of Mines China University of Mining & Technology Key Laboratory of Deep Coal Resource Mining Ministry of Education of China Xuchang Mine Shandong Energy Zibo Mining Group Co. Ltd.

Comparing with the resin bolt, the hydraulic expansion bolt has different anchoring mechanism and application advantage. According to the working mechanism of the hydraulic expansion bolt, its anchoring force is expressed in four forms including support anchoring force, tension anchoring force, expansion anchoring force and tangent anchoring force, and their values can be obtained on the basis of each calculation formula. Among them, the expansion anchoring force, which is the unique anchoring force of the hydraulic expansion bolt, can provide confining pressure to increase the strength of rock. Aiming at solving the problem of stability control in the soft rock roadway in Jinbaotun Coal Mine which has a double layer of 40 U-type sheds and cannot provide enough resistance support to control floor heave, the study reveals the mechanism of floor heave in the soft rock roadway, and designs the reasonable support parameters of the hydraulic expansion bolts. The observed results of floor convergence indicate that the hydraulic expansion bolts can prevent the development and flow of the plastic zone in the floor rock to control floor heave. Research results enrich the control technology in the soft rock roadway.

关键词： Hydraulic expansion bolt Anchoring force Soft rock roadway Floor heave Shed support

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Movement and deformation laws of the overlying strata in paste filling stope

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Mining Science and Technology 2011年第6期21卷 863-868页

作者： Xu Ying Chang Qingliang zhou huaqiang Cao Zhong Li Xiushan Chen Jianhang School of Mines China University of Mining ＆ Technology Xuzhou 22116 China State Key Laboratory of Coal Resources and Mine Safety China University of Mining ＆ Technology Xuzhou 221116 China Daizhuang Mine of Shandong Energy Zibo Mining Group Co. Ltd. Jining 272000 China

We combined the similar simulation with numerical simulation to analyze the movement and deforma- tion features of overlying strata caused by paste backfill mining, study the movement and deformation laws of the overlying strata in paste backfill mining, structural movement of the stope strata as well as the stope stress distribution laws. Furthermore, authors also explored the key factors to the movement and deformation of the overlying strata in paste backfill mining. The results indicate that a caving zone existed in the bending zone only in the overlying strata of the paste backfill mining. Compared with the roof caving mining, the degree of stress concentration and area of influence in the paste filling stope were apparently smaller. And the degree of destruction and area of the overlying strata decreased prominently. Also, there was no apparent strata behavior in the working face. Lastly, the filling ratio was the key to control the movement and deformation of the overlying strata. Combined with a specific engineering example, the author proved the reliability of the simulation results and provided a theoretical basis for the further extension of the paste backfill mining.

关键词： Paste backfill mining Movement of overlying strata Stope stress Similar simulation

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Surufatinib plus toripalimab combined with etoposide and cisplatin as first-line treatment in advanced small-cell lung cancer patients: a phase Ib/Ⅱ trial

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4700-4707页

作者： Yaxiong Zhang Yan Huang Yunpeng Yang Yuanyuan Zhao Ting zhou Gang Chen Shen Zhao huaqiang zhou Yuxiang Ma Shaodong Hong Hongyun Zhao Li Zhang Wenfeng Fang Department of Medical Oncology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina Department of Clinical Research State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina

There is still room for improvement in first-line treatment of advanced small cell lung cancer(SCLC).This trial firstly investigated efficacy and safety of antiangiogenic therapy(surufatinib)(200 mg,qd,po)plus anti-PD-1 treatment(toripalimab)(240 mg,d1,ivdrip)combined with etoposide(100 mg/m²,d1-d3,iv,drip)and cisplatin(25 mg/m²,d1-d3,ivdrip)for advanced SCLC as first-line treatment,which has been registered on *** under the identifier *** four-drug regimen was conducted q3w for 4 cycles with maintenance therapy of surufatinib and *** primary endpoint was progression-free survival(PFS).The secondary end points included objective response rate(ORR),disease control rate(DCR),overall survival(OS)and *** of the 38 patients were enrolled for safety analysis,while only 35 patients were enrolled for efficacy analysis since loss of efficacy evaluation in 3 cases after *** a median follow-up of 21.3 months,the ORR was 97.1%(34/35),and the DCR and the tumor shrinkage rate were both 100%(35/35).The median PFS was 6.9 months(95%CI:4.6 m–9.2 m)and the median OS was 21.1 months(95%CI:12.1 m–30.1 m).The 12-month,18-month,and 24-month OS rates were 66.94%,51.39%and 38.54%.The occurrence rate of grade≥3 treatment-emergent adverse events(TEAEs)was 63.2%(24/38),including neutrophil count decreased(31.6%,12/38),white blood cell count decreased(23.7%,9/38)and platelet count decreased(10.5%,4/38).No unexpected adverse events *** novel four-drug regimen(surufatinib,toripalimab,etoposide plus cisplatin)revealed impressive therapeutic efficacy and tolerable toxicities.

关键词： cisplatin patients etoposide

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Preferable background filtering for next-generation sequencing analysis in non-small cell lung cancer:pericarcinomatous tissues or peripheral blood lymphocytes?

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Cancer Communications 2019年第1期39卷 314-317页

作者： Yaxiong Zhang Lianpeng Chang Wenfeng Fang Yunpeng Yang Lanjun Zhang Shaodong Hong huaqiang zhou Yanfang Guan Xin Yi Li Zhang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Geneplus-Beijing Institute Beijing 100000P.R.China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Dear editor,Lung cancer is the leading cause of cancer-related death worldwide,with the predominant pathological type being non-small cell lung cancer(NSCLC)[1,2].Next-gener-ation sequencing(NGS)analysis is increasingly used to help clinicians select appropriate target therapies,such as epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)for EGFR-mutant patients[3].Both pericarcinomatous tissues and peripheral blood lymphocytes are widely used as normal control for NGS ***,whether pericarcinomatous tissue is suitable for background filtering in mutation analysis remains *** to the whole-genome sequencing data from The Cancer Genome Atlas(TCGA)database,there were some genomic variations in peri-carcinomatous tissue from NSCLC patients,but no driver gene mutation was detected[4,5].Therefore,deep sequencing of pericarcinomatous and tumor tissues is necessary to confirm whether pericarcinomatous tissue harbors low-frequency mutations.

关键词： lymphocytes lung filtering

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基于小波变换的心电采集分析系统设计与实现

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计算机测量与控制 2014年第3期22卷 854-856页

作者：胡广平周华强河南工程学院郑州451191 中原工学院郑州450007

针对心电信号微弱和非平稳的特点,采用Ag/AgCl表面心电电极拾取心电信号,设计了心电信号预处理电路,并在LABVIEW环境下开发了心电信号小波滤波与心电波群检测应用程序;在LabVIEW程序设计过程中采用正交小波变换去除心电的基线漂移,再用... 详细信息

针对心电信号微弱和非平稳的特点,采用Ag/AgCl表面心电电极拾取心电信号,设计了心电信号预处理电路,并在LABVIEW环境下开发了心电信号小波滤波与心电波群检测应用程序;在LabVIEW程序设计过程中采用正交小波变换去除心电的基线漂移,再用非抽样小波变换去除心电信号中的噪声,最后用多尺度小波变换检测心电信号中的心电波群点位;经过实验表明,系统不仅能够有效的采集心电信号,消除信号中的基线漂移和噪声,并且还能找到心电倌号中重要的点位。

关键词：心电信号小波变换基线漂移数字滤波虚拟仪器

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膏体充填回收条带煤柱覆岩活化规律研究

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煤矿安全 2019年第2期50卷 228-231页

作者：宋光远周华强徐州中矿大贝克福尔科技股份有限公司江苏徐州221116 中国矿业大学煤炭资源与安全开采国家重点实验室矿业工程学院江苏徐州221116 中国矿业大学矿业工程学院江苏徐州221116

为分析膏体充填回收条带煤柱覆岩活化规律,通过建立条带开采、回收遗留煤柱和单独充填开采3种模型,采用数值模拟和岱庄煤矿膏体充填回收条带煤柱地表沉陷实测,研究得出了充填开采孤岛煤柱引起的覆岩活化机理,以及覆岩活化对地表沉陷影... 详细信息

为分析膏体充填回收条带煤柱覆岩活化规律,通过建立条带开采、回收遗留煤柱和单独充填开采3种模型,采用数值模拟和岱庄煤矿膏体充填回收条带煤柱地表沉陷实测,研究得出了充填开采孤岛煤柱引起的覆岩活化机理,以及覆岩活化对地表沉陷影响的程度。研究表明:充填开采覆岩活化程度随着与煤层距离的增加,呈现先增加后减小的趋势,最大活化发生在距煤层100 m内;膏体回收条带煤柱覆岩活化率在15%～30%,反应至地表的在15%左右。

关键词：膏体充填覆岩活化活化率地表沉陷采带煤柱

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急倾斜特厚煤层水平分层大采高充填膏体与煤体协调承载特性研究

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采矿与安全工程学报 2021年第5期38卷 919-928页

作者：常庆粮冷强袁崇亮周华强张彪中国矿业大学矿业工程学院江苏徐州221116 窑街煤电集团有限公司甘肃兰州730000 中国矿业大学煤炭资源与安全开采国家重点实验室江苏徐州221116 宁夏宝丰能源集团有限公司红四煤业宁夏银川750000

为了研究窑街三矿特厚急倾斜煤层水平分层膏体充填工作面煤壁的稳定性,首先基于压杆稳定力学模型,给出最大临界力Fct计算公式,进一步导出临界应力σct与分层高度的关系曲线,并给出了挠曲方程计算公式;其次建立FLAC3D数值计算模型,通过... 详细信息

为了研究窑街三矿特厚急倾斜煤层水平分层膏体充填工作面煤壁的稳定性,首先基于压杆稳定力学模型,给出最大临界力Fct计算公式,进一步导出临界应力σct与分层高度的关系曲线,并给出了挠曲方程计算公式;其次建立FLAC3D数值计算模型,通过垮落法与充填法对比分析工作面前方煤壁的支撑压力、煤壁塑性区范围以及水平位移量与推进距离的关系;最后模拟分析了随着采充平行作业的推进,不同分层高度与工作面煤壁前方的支撑压力、煤壁塑性区范围以及水平位移量的关系。结果表明,当分层高度为4,5,6 m时,煤壁分别在距离底板3.12,3.9,4.46 m位置处挠曲最大,煤壁最大位移量分别为19,24,27 mm,且煤壁发生失稳片帮的临界应力分别为6.6,4.4,2.6 MPa,根据窑街具体情况,当分层高度为5 m,膏体充填工作面前方煤壁的最大支撑应力为3 MPa,未超过临界应力,即便煤壁向采空区最大移动24 mm也不会在工作面推进过程中发生煤壁片帮,且理论分析与数值计算结果基本一致,对窑街三矿特厚急倾斜煤层水平分层膏体充填开采具有借鉴意义。

关键词：急倾斜煤层水平分层开采膏体充填开采煤壁稳定性压杆理论

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论文人才评价作用的反思:回归、认可、补充与反对

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中国科技论坛 2020年第1期 143-155页

作者：周华强周颖冯文帅王敬东四川省农村科技发展中心四川成都610041 四川省人力资源和社会保障厅专业技术人员管理处四川成都610015

本文开展了弱化论文人才评价作用认可度影响因素、专业技术职称晋升影响因素、论文综合作用、科技人员视角的人才评价指标等探索性研究,在此基础上探讨了论文综合作用与价值。研究认为,应回归论文提高人才基本科学能力的本质作用,认可... 详细信息

本文开展了弱化论文人才评价作用认可度影响因素、专业技术职称晋升影响因素、论文综合作用、科技人员视角的人才评价指标等探索性研究,在此基础上探讨了论文综合作用与价值。研究认为,应回归论文提高人才基本科学能力的本质作用,认可论文人才评价的重要作用,补充不同工作性质的特性指标,反对人才评价中的唯论文论和论文无用论。

关键词：论文人才评价农业科技政策

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压力对热压法制备LaFe_(11.6)Si_(1.4)H_(1.02)-In复合材料组织与性能的影响（英文）

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稀有金属材料与工程 2017年第9期46卷 2384-2388页

作者：庞文凯陈云贵唐永柏周龄童郭华强四川大学四川成都610065

主动式磁蓄冷器中的制冷材料需要满足优良的机械性能、磁热性能和导热性能。然而,目前大多数磁制冷材料在成形和导热性能方面存在着一些问题。在本研究中,介绍了一种在430 K的温度下,将LaFe_(11.6)Si_(1.4)H_(1.02)和铟粉混合后在不同... 详细信息

主动式磁蓄冷器中的制冷材料需要满足优良的机械性能、磁热性能和导热性能。然而,目前大多数磁制冷材料在成形和导热性能方面存在着一些问题。在本研究中,介绍了一种在430 K的温度下,将LaFe_(11.6)Si_(1.4)H_(1.02)和铟粉混合后在不同压力下进行压制成形的方法。结果显示,当压制压力超过200 MPa时,复合磁工质的磁热性能将会大幅度降低。在压制压力为100 MPa时,厚度为0.8 mm的片状磁工质在0~2 T的磁场下,达到的最大绝热温变为5.88 K。

关键词：磁热效应热压工艺 LaFe11.6Si1.4H1.02复合材料

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