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Theoretical & Applied Mechanics Letters 2024年第2期14卷 90-97页

作者： hanyu zhou Haochen Li Yaomin Zhao HEDPS Center for Applied Physics and Technologyand College of EngineeringPeking UniversityBeijing 100871China State Key Laboratory for Turbulence and Complex Systems College of EngineeringPeking UniversityBeijing 100871China

Identification of underlying partial differential equations(PDEs)for complex systems remains a formidable *** the present study,a robust PDE identification method is proposed,demonstrating the ability to extract accurate governing equations under noisy conditions without prior ***,the proposed method combines gene expression programming,one type of evolutionary algorithm capable of generating unseen terms based solely on basic operators and functional terms,with symbolic regression neural *** networks are designed to represent explicit functional expressions and optimize them with data *** particular,the specifically designed neural networks can be easily transformed to physical constraints for the training data,embedding the discovered PDEs to further optimize the metadata used for iterative PDE *** proposed method has been tested in four canonical PDE cases,validating its effectiveness without preliminary information and confirming its suitability for practical applications across various noise levels.

关键词： PDE discovery Gene Expression Programming Deep Learning Knowledge embedding

Thermo-Flow Performances for the Main-Auxiliary Integrated Natural Draft Dry Cooling System

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Journal of Thermal Science 2024年第3期33卷 1010-1025页

作者： ZHANG Zongyang HOU Yichen zhou hanyu JIA He CHEN Lei KONG Yanqiang WANG Weijia YANG Lijun DU Xiaoze Key Laboratory of Power Station Energy Transfer Conversion and System of Ministry of Education School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

Recently,natural draft dry cooling system with the main-auxiliary integrated air-cooled heat exchangers in the up and lower layers,has drawn attention to the electric power *** research firstly develops two physical models for the integrated cooling system,namely Case A and Case *** Case A,the main air-cooled heat exchanger is arranged in the upper layer and the auxiliary air-cooled heat exchanger arranged in the lower layer,while in Case B,the two heat exchanger systems are arranged in the opposite *** then,directing at the engineering TMCR and TRL 1 working conditions,the unit-local-overall thermo-flow characteristics of Case A and Case B are obtained and compared by numerical *** findings show that,for the auxiliary air-cooled exchanger,Case A has obviously higher cooling performances than Case B,with the difference varying from 5.46%to 7.55%.Whereas,for the main air-cooled exchanger,Case B shows the recovered cooling performances,with the difference changing from 1.15%to 2.99%.Case A is preferably recommended to the engineering application in consideration of more strict cooling demand of the auxiliary cooling ***,this research will provide some theoretical guidelines for the design and construction of the main-auxiliary integrated natural draft dry cooling system.

关键词： integrated dry cooling system main air-cooled heat exchanger auxiliary air-cooled heat exchanger upper layer and lower layer thermo-flow performances

建筑表皮综合环境数字孪生模型构建及模拟平台

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南方建筑 2024年第6期 107-115页

作者：周涵宇王立雄刘刚山东建筑大学建筑城规学院天津大学建筑学院

建筑表皮是多物理环境交互的接口,当前的建筑性能模拟软件多为针对单一环境的模拟,多环境联合模拟的工具平台较少。基于建筑运动几何学,遴选动态表皮的可控运动形式,提取24类动态表皮设计原型,建立面向控制的建筑表皮综合环境数字孪生模... 详细信息

建筑表皮是多物理环境交互的接口,当前的建筑性能模拟软件多为针对单一环境的模拟,多环境联合模拟的工具平台较少。基于建筑运动几何学,遴选动态表皮的可控运动形式,提取24类动态表皮设计原型,建立面向控制的建筑表皮综合环境数字孪生模型,并结合案例对数字孪生模型及模拟平台进行应用验证。使用Python语言将模型封装成动态表皮综合环境模拟平台,针对不同表皮设计形式和环境场景模拟,可以快速直观地分析动态表皮的环境响应关系和性能。模拟平台融合了热环境、光环境、声环境和空气品质这四个综合环境,解决了建筑性能模拟软件无法多环境联合模拟的问题,从而满足对建筑表皮的仿真、预测、优化和控制等实际应用需求。

关键词：动态建筑表皮数字孪生模型模拟平台运动几何学

Insights into the adsorption performance and mechanism of hydrated Ca ion on talc(001) basal surface from DFT calculation

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International Journal of Mining Science and Technology 2022年第4期32卷 887-896页

作者： Yuanjia Luo Leming Ou Jianhua Chen Guofan Zhang Yuqin Xia Bohan Zhu hanyu zhou School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China

The utilization of Ca ion as assistant depressant of CMC on talc has been widely ***,the study on the adsorption mechanism of Ca ion on talc surface is very crucial for understanding the performance of CMC on talc *** this paper,mechanism insights into hydrated Ca ion adsorption on talc(001) basal surface were creatively provided using DFT calculation.[Ca(H_(2)O)_6]^(2+) and [Ca(OH)(H_(2)O)_(3)]^(+) were determined as the effective hydrate components for Ca ion adsorption,and the top O site was the most favorable position for their adsorptions on talc ***,the adsorption mechanisms of [Ca(H_(2)O)_6]^(2+) and [Ca(OH)(H_(2)O)_(3)]^(+) on talc surface were found to be not the Ca-O chemical bond,but the hydrogen bonding formed by the H atom of the H_(2)O ligand and the surface O atom.H_(2)O acted like a bridge to connect them to the talc ***,the hydrogen bonding was formed due to the hybridization of H 1s orbital with the O 2s,O 2p ***,electrons transferred between the H atom and the surface O *** work provides theoretical insights into the Ca ion adsorption on talc surface,which can help deeply understand the talc flotation using CMC as depression.

关键词： Ca ion Talc surface Adsorption DFT H_(2)O Bridge

Hydration mechanisms of smithsonite from DFT-D calculations and MD simulations

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International Journal of Mining Science and Technology 2022年第3期32卷 605-613页

作者： Yuanjia Luo Leming Ou Jianhua Chen Guofan Zhang Yuqin Xia Bohan Zhu hanyu zhou School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China College of Resources and Metallurgy Guangxi UniversityNanning 530004China

Investigation on the mineralwater interactions is crucial for understanding the subsequent interfacial ***,the hydration mechanisms of smithsonite are still *** this paper,the adsorption of H_(2)O at different coverage rates on smithsonite(101)surface was innovatively investigated using density-functional theory(DFT)calculations and molecular dynamics(MD)simulations by analyzing adsorption model,interaction energy,atomic distance,density of state,electron density difference,concentration profile,radial distribution function and self-diffusion *** found that single H_(2)O preferred to be dissociated on smithsonite(101)surface via the interaction of surface Zn with the Ow of H_(2)O and H-bond between Hw of H_(2)O and surface ***,dissociation adsorption and molecular adsorption coexisted on the smithsonite surface at a high coverage rate of H_(2)O,and dissociation adsorption remained the main adsorption ***,we found the interaction between smithsonite surface and H_(2)O was weakened as a function of H_(2)O coverage,which was because the presence of interlayer H_(2)O and different layers of H_(2)O decreased the reactivity of the smithsonite *** H_(2)O is mainly adsorbed on the smithsonite surface by forming three layers of H_(2)O(about 10–15Å),with the ordering degree gradually decreasing.

关键词： H_(2)O Smithsonite surface DFT MD Coverage rate

miRNA-153-5p通过靶向TFRC调控巨噬细胞极化在病毒性心肌炎中的作用

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皖南医学院学报 2024年第3期43卷 205-209页

作者：张苑李雪琴朱良宇周汉宇钟民吕坤皖南医学院第一附属医院弋矶山医院中心实验室安徽芜湖241001

目的:探讨miRNA-153-5p调控巨噬细胞极化在病毒性心肌炎(VM)中的作用。方法:建立VM小鼠模型,提取心脏,RT-qPCR检测心肌组织miRNA-153-5p的表达,HE染色观察心脏炎症程度,ELISA检测小鼠血清肌钙蛋白cTnI的水平,流式细胞术检测心脏浸润巨... 详细信息

目的:探讨miRNA-153-5p调控巨噬细胞极化在病毒性心肌炎(VM)中的作用。方法:建立VM小鼠模型,提取心脏,RT-qPCR检测心肌组织miRNA-153-5p的表达,HE染色观察心脏炎症程度,ELISA检测小鼠血清肌钙蛋白cTnI的水平,流式细胞术检测心脏浸润巨噬细胞表型。体外分离BMDMs诱导为M1/M2型巨噬细胞,过表达和抑制miR-153-5p,RT-qPCR检测M1/M2标志物iNOS、IL-12、TNF-α、Arg1、YM-1、FIZZ1的表达。生物信息学软件预测结合双荧光素酶实验验证miR-153-5p与转铁蛋白受体(TFRC)的靶向关系。结果:miR-153-5p在CVB3感染7 d的VM小鼠心脏组织中表达明显增加(P<0.05)。体内实验中抑制miR-153-5p表达能减轻VM小鼠心脏的病变程度,改善心脏功能(P<0.01)。抑制miR-153-5p表达能够促进小鼠心脏浸润的巨噬细胞向M2极化(P<0.01)。体外实验中,较之M2,miR-153-5p在M1巨噬细胞中表达升高(P<0.01)。过表达miR-153-5p促进巨噬细胞向M1极化,抑制miR-153-5p表达则促进巨噬细胞向M2极化(P<0.01)。TFRC是miR-153-5p的靶基因,抑制miR-153-5p表达可上调TFRC的mRNA和蛋白水平(P<0.01)。结论:miRNA-153-5p通过靶向TFRC调控VM小鼠心脏浸润巨噬细胞的极化。

关键词： miR-153-5p 巨噬细胞转铁蛋白受体病毒性心肌炎

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电阻抗技术在银杏树干健康评估中的应用研究

植物医学 2024年第1期3卷 86-92页

作者：胡月吴道军吕志远周涵宇胡冲田立超重庆市风景园林科学研究院重庆401329 川渝共建乡土植物种质创新与利用重庆市重点实验室重庆401329

为评估银杏行道树树干健康程度,降低树干断折倒伏风险,本研究采用PiCUS Tree Tronic树木电阻抗断层成像仪分别对健康、干旱、腐烂银杏树干进行检测,并与树干的目测结果进行比较.树干的断层扫描结果显示,健康树干的电阻率为中间高四周低... 详细信息

为评估银杏行道树树干健康程度,降低树干断折倒伏风险,本研究采用PiCUS Tree Tronic树木电阻抗断层成像仪分别对健康、干旱、腐烂银杏树干进行检测,并与树干的目测结果进行比较.树干的断层扫描结果显示,健康树干的电阻率为中间高四周低,中部电阻率达1000Ω·m,四周电阻率约300Ω·m;干旱的银杏树干整体呈现高电阻率,平均电阻率达1000Ω·m以上;腐烂树干的电阻率差异与腐烂区域相关,腐烂面积占比普遍高于目测结果,说明电阻抗技术能够更准确地探测树干内部的健康状况,该结果可为银杏树干健康评估提供指导.

关键词：电阻抗断层扫描银杏树干腐烂

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铅芯隔震橡胶支座力学性能试验研究

轨道交通材料 2024年第1期3卷 66-70页

作者：彭立群林达文王进吴兴磊刘立峰周函宇株洲时代新材料科技股份有限公司湖南株洲412007 国家轨道交通高分子材料及制品质量监督检验中心(湖南) 湖南株洲412007

针对铅芯隔震橡胶支座力学性能试验,重点分析橡胶支座结构及粘接试验标准,设计一种新型抗剪粘接模块化试验装置,与现有试验装置进行分析比对,对新型试验装置的结构进行分析计算,对LRB750、LRB900两种支座进行压缩性能、水平性能、水平... 详细信息

针对铅芯隔震橡胶支座力学性能试验,重点分析橡胶支座结构及粘接试验标准,设计一种新型抗剪粘接模块化试验装置,与现有试验装置进行分析比对,对新型试验装置的结构进行分析计算,对LRB750、LRB900两种支座进行压缩性能、水平性能、水平非破坏粘接性能和破坏粘接性能试验,结果表明:试验设计满足要求,相比垂向压缩、水平剪切对隔震橡胶支座粘接性能影响更明显,且支座压缩刚度、屈服力、屈服刚度、水平等效刚度均满足要求,LRB900初始粘接破坏载荷761 kN、位移735 mm。该研究成果为橡胶支座及同类产品研发和试验提供一定指导作用。

关键词：铅芯隔震橡胶支座粘接性能试验研究

Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia

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Genes & Diseases 2024年第5期11卷 105-108页

作者： Liang zhou Youyou Li Jiaren Li hanyu Yao Jin Huang Cheng Li Long Wang Department of Urology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China

In aging males,benign prostatic hyperplasia(BPH)is a chronic pathological process that primarily causes lower urinary tract *** to histopathology,BPH is caused by an imbalance between cell death and proliferation.1 However,the exact pathophysiology remains *** is a newly discovered form of programmed cell *** cell morphology is characterized primarily by the reduction or disappearance of mitochondrial cristae and mitochondrial shrinkage.2,3 Competing endogenous RNAs(ceRNAs)are important regulators of many biological processes and have been involved in various diseases.

关键词： prostatic endogenous BPH

A Transformer-Based Ensemble Framework for the Prediction of Protein-Protein Interaction Sites

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Research 2024年第2期2023卷 703-718页

作者： Minjie Mou Ziqi Pan Zhimeng zhou Lingyan Zheng hanyu Zhang Shuiyang Shi Fengcheng Li Xiuna Sun Feng Zhu College of Pharmaceutical Sciences The Second Affliated HospitalZhejiang University School of MedicineNational Key Laboratory of Advanced Drug Delivery and Release SystemsZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University Alibaba-Zhejiang University Joint Research Center of Future Digital HealthcareHangzhou 330110China

The identification of protein-protein interaction (PPI) sites is essential in the research of protein function and the discovery of new drugs. So far, a variety of computational tools based on machine learning have been developed to accelerate the identification of PPI sites. However, existing methods suffer from the low predictive accuracy or the limited scope of application. Specifically, some methods learned only global or local sequential features, leading to low predictive accuracy, while others achieved improved performance by extracting residue interactions from structures but were limited in their application scope for the serious dependence on precise structure information. There is an urgent need to develop a method that integrates comprehensive information to realize proteome-wide accurate profiling of PPI sites. Herein, a novel ensemble framework for PPI sites prediction, EnsemPPIS, was therefore proposed based on transformer and gated convolutional networks. EnsemPPIS can effectively capture not only global and local patterns but also residue interactions. Specifically, EnsemPPIS was unique in (a) extracting residue interactions from protein sequences with transformer and (b) further integrating global and local sequential features with the ensemble learning strategy. Compared with various existing methods, EnsemPPIS exhibited either superior performance or broader applicability on multiple PPI sites prediction tasks. Moreover, pattern analysis based on the interpretability of EnsemPPIS demonstrated that EnsemPPIS was fully capable of learning residue interactions within the local structure of PPI sites using only sequence information. The web server of EnsemPPIS is freely available at http://***/ensemppis.

关键词： residue extracting ensemble