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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1225-1242页

作者： zhou hu Zhibo WEI Yan CHEN Rui Zhu School of Aerospace Engineering Beijing Institute of TechnologyBeijing100081China School of Mechanical Engineering Tianjin UniversityTianjin300350China Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin300350China

Elastic metamaterials with unusual elastic properties offer unprecedented ways to modulate the polarization and propagation of elastic ***,most of them rely on the resonant structural components,and thus are frequency-dependent and ***,we present a reconfigurable 2D mechanism-based metamaterial which possesses transformable and frequency-independent elastic *** on the proposed mechanism-based metamaterial,interesting functionalities,such as ternarycoded elastic wave polarizer and programmable refraction,are ***,unique ternary-coded polarizers,with 1-trit polarization filtering and 2-trit polarization separating of longitudinal and transverse waves,are first ***,the strong anisotropy of the proposed metamaterial is harnessed to realize positive-negative bi-refraction,only-positive refraction,and only-negative ***,the wave functions with detailed microstructures are numerically verified.

关键词： elastic metamaterial elastic wave reconfigurable design zero mode ternary code programmable refraction

Deep genome skimming reveals the hybrid origin of Pseudosasa gracilis (Poaceae: Bambusoideae)

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Plant Diversity 2024年第3期46卷 344-352页

作者： Xiang-zhou hu Cen Guo Sheng-Yuan Qin De-Zhu Li Zhen-hua Guo Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Pseudosasa gracilis(Poaceae:Bambusoideae)is a temperate woody bamboo species endemic to Southcentral China with a narrow *** phylogenetic studies revealed an unexpected,isolated phylogenetic position of *** we conducted phylogenomic analysis by sampling populations of *** and its sympatric species *** and Sinosasa polytricha reflecting different genomic signals,by deep genome *** molecular evidence from chloroplast genes and genome-wide SNPs,we deciphered the phylogenetic relationships of *** plastid and nuclear data indicate that *** is more closely related to Sinosasa,which is discordant with the taxonomic *** further explore this molecular-morphological conflict,we screened 411“perfect-copy”syntenic genes to reconstruct phylogenies using both the concatenation and coalescent *** observed extensive discordance between gene trees and the putative species tree.A significant hybridization event was detected based on 411 genes from the D subgenome,showing *** was a hybrid descendant between Sinosasa longiligulata and ***,with 63.56%and 36.44%inheritance probabilities of each ***,introgression events were detected in the C subgenome between *** and *** in the same distribution *** findings suggest that sympatric hybridization and introgression play a crucial role in the origin of *** providing an empirical example of bamboo of hybrid origin using comprehensive analyses based on genomic data from different inheritance systems and morphological characters,our study represents a step forward in understanding of reticulate evolution of bamboos.

关键词： Phylogenomics Hybridization Introgression Pseudosasa gracilis Pseudosasa Sinosasa

CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu Tianyi Tian Lu Wang Yinmei Tian Tian Tian Yuanyuan Guo hu zhou Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-MDSCs)are highly infiltrated in SMAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-MDSCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-MDSC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of SMAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in SMAD4-deficient CRC.

关键词： SMAD4-deficient CRC Metastasis G-MDSCs TGF-β CCR1 TGFBR2

堆石混凝土坝概述及下一代混凝土坝施工技术展望

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Engineering 2024年第1期32卷 99-105页

作者： Feng Jin Duruo huang Michel Lino hu zhou Department of Hydraulic Engineering Tsinghua UniversityBeijing 100084China ISL Ingénierie International Commission on Large DamsParis 75016France

Over the past few decades,one of the most significant advances in dam construction has been the inven-tion of the rock-filled concrete(RFC)dam,which is constructed by pouring high-performance self-compacting concrete(HSCC)to fill the voids in preplaced large *** innovative use of large rocks in dam construction provides engineers with a material that requires less cement consumption and hydration heat while enhancing construction efficiency and environmental ***,two fundamental scientific issues related to RFC need to be addressed:namely,the pouring compactness and the effect of large rocks on the mechanical and physical properties of *** article provides a timely review of fundamental research and innovations in the design,construction,and quality control of *** for next-generation concrete dams are discussed from the perspectives of envi-ronmental friendliness,intrinsic safety,and labor savings.

关键词： Rock-filled concrete dam Pouring compactness Effect of large rocks Intelligent quality control Unmanned dam construction

基于数据关联感知的无监督深度融合指针网络模型

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控制与决策 2024年第2期39卷 499-508页

作者：张长勇周虎中国民航大学电子信息与自动化学院天津300300

为了提高组合优化问题可行解集合的收敛性和泛化性,根据不同无监督学习策略的特点,提出一种基于数据关联感知的深度融合指针网络模型(DMAG-PN),模型通过指针网络框架将Mogrifier LSTM、多头注意力机制与图卷积神经网络三者融合.首先,编... 详细信息

为了提高组合优化问题可行解集合的收敛性和泛化性,根据不同无监督学习策略的特点,提出一种基于数据关联感知的深度融合指针网络模型(DMAG-PN),模型通过指针网络框架将Mogrifier LSTM、多头注意力机制与图卷积神经网络三者融合.首先,编码器模块中的嵌入层对输入序列进行编码,引入多头注意力机制获取编码矩阵中的特征信息;然后构建数据关联模型探索序列节点间的关联性,采用图卷积神经网络获取其多维度关联特征信息并融合互补,旨在生成多个嵌入有效捕捉序列深层的节点特征和边缘特征;最后,基于多头注意力机制的解码器模块以节点嵌入数据和融合图嵌入数据作为输入,生成选择下一个未访问节点的全局概率分布.采用对称旅行商问题作为测试问题,与当前先进算法进行对比,实验结果表明,所提出DMAG-PN模型在泛化性和求解精确性方面获得较大的改进与提高,预训练好的DMAG-PN模型能够直接对大规模实例进行端到端的求解,避免传统算法迭代搜索的过程,具有较高的求解效率.

关键词：指针网络 Mogrifier LSTM 多头注意力机制图卷积神经网络旅行商问题数据关联

N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 228-238页

作者： Yu-Ze Zhao Xue-Ning Zhang Yi Yin Pei-Lun Xiao Meng Gao Lu-Ming Zhang Shuan-hu zhou Shu-Na Yu Xiao-Li Wang Yan-Song Zhao Department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina School of Medical Imaging Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Anatomy Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Departments of Orthopedic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

AIM:To observe the effects of N-acetylserotonin(NAS)administration on retinal ischemia-reperfusion(RIR)injury in rats and explore the underlying mechanisms involving the high mobility group box 1(HMGB1)/receptor for advanced glycation end-products(RAGE)/nuclear factor-kappa B(NF-κB)signaling ***:A rat model of RIR was developed by increasing the pressure of the anterior chamber of the *** male Sprague Dawley were randomly divided into five groups:sham group(n=8),RIR group(n=28),RIR+NAS group(n=28),RIR+FPS-ZM1 group(n=8)and RIR+NAS+FPS-ZM1 group(n=8).The therapeutic effects of NAS were examined by hematoxylin-eosin(H&E)staining,and retinal ganglion cells(RGCs)*** expression of interleukin 1 beta(IL-1β),HMGB1,RAGE,and nod-like receptor 3(NLRP3)proteins and the phosphorylation of nuclear factorkappa B(p-NF-κB)were analyzed by immunohistochemistry staining and Western blot *** expression of HMGB1 protein was also detected by enzyme-linked immunosorbent assay(ELISA).RESULTS:H&E staining results showed that NAS significantly reduced retinal edema and increased the number of RGCs in RIR *** NAS therapy,the HMGB1 and RAGE expression decreased significantly,and the activation of the NF-κB/NLRP3 pathway was antagonized along with the inhibition of p-NF-κB and NLRP3 protein ***,NAS exhibited an anti-inflammatory effect by reducing IL-1β*** inhibitory of RAGE binding to HMGB1 by RAGE inhibitor FPS-ZM1 led to a significant decrease of p-NF-κB and NLRP3 expression,so as to the IL-1βexpression and retinal edema,accompanied by an increase of RGCs in RIR ***:NAS may exhibit a neuroprotective effect against RIR via the HMGB1/RAGE/NF-κB signaling pathway,which may be a useful therapeutic target for retinal disease.

关键词： retinal diseases retinal ischemia—reperfusion injury N-acetylserotonin high mobility group box 1 receptor for advanced glycation end-products nuclear factor-κB rats

学术参与的影响因素及理论逻辑——基于扎根理论的探索性分析

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科学管理研究 2024年第1期42卷 45-52页

作者：鞠伟周小虎南京理工大学经济管理学院江苏南京210094 南京理工大学泰州科技学院江苏泰州225300

学术参与对产学深度融合,提升经济发展质量具有重要意义。然而,如何有效推动学术参与却是长久以来的难题,且学界又缺少对学术参与动因的关注和针对性研究。基于多源访谈数据,运用扎根理论构建学术参与影响因素理论模型,揭示学术参与发... 详细信息

学术参与对产学深度融合,提升经济发展质量具有重要意义。然而,如何有效推动学术参与却是长久以来的难题,且学界又缺少对学术参与动因的关注和针对性研究。基于多源访谈数据,运用扎根理论构建学术参与影响因素理论模型,揭示学术参与发生的内在逻辑。研究发现:①宏观情境因素、组织情境因素和个体特征因素是影响学术参与的关键因素;宏观情境因素是外部前提因素,组织情境因素是过程支持因素,而个体特征禀赋则是内部动力因素;②因素间具有差异化作用,彼此既相互独立,能单独对学术参与产生影响,又能相互叠加对其产生联合影响;③在情境因素作用下,个体特征因素和学术参与之间形成动态循环作用关系。研究深化了学术参与研究的理论体系及内容框架,也能为个体层面产学合作的持续发展提供实践启示。

关键词：学术参与影响因素理论框架扎根理论

Sc和Si相互作用对铸造Al-Si-Sc合金组织和性能的影响

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铸造 2024年第5期73卷 612-620页

作者：周荣虎周鹏飞盐城工业职业技术学院汽车与交通学院江苏盐城224005

通常在铸造Al-Si合金加入Sc来改善合金的性能,但是Si和Sc的相互作用对合金组织和性能影响仍需要进一步深入研究。本文研究了不同含量的Si和Sc对合金组织和性能的影响,结果表明,Sc通过原位形成初生Al_(3)Sc作为α-Al异质形核质点从而细化... 详细信息

通常在铸造Al-Si合金加入Sc来改善合金的性能,但是Si和Sc的相互作用对合金组织和性能影响仍需要进一步深入研究。本文研究了不同含量的Si和Sc对合金组织和性能的影响,结果表明,Sc通过原位形成初生Al_(3)Sc作为α-Al异质形核质点从而细化α-Al晶粒;在凝固过程中,共晶反应生成了网格状AlSi_(2)Sc_(2)相,包晶反应形成了块状AlSi_(2)Sc_(2)相;两种AlSi_(2)Sc_(2)相都会消耗合金中Sc原子,从而降低了Al_(3)Sc的细化效果;Sc还变质共晶Si为更有序的纤维/片状结构,适当的Si与Sc的比可以避免AlSi_(2)Sc_(2)的形成;Al-6Si中Sc含量从0.3%增加至1%时,抗拉强度和屈服强度均上升,但由于AlSi_(2)Sc_(2)相的存在,其伸长率下降;当Sc含量为1%、Si含量从6%降至3%时,抗拉强度、屈服强度和伸长率分别上升2%、12%和21%,主要是凝固过程中析出了Al_(3)Sc而非AlSi_(2)Sc_(2)相。最后,还讨论了Si-Sc交互作用对组织演变的机制。

关键词： Al-Si-Sc合金组织异质形核变质

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全球治理中国方案研究:进展综述与进路展望

理论建设 2024年第1期40卷 36-52页

作者：周虎南京中医药大学马克思主义学院江苏南京210023

“全球治理与中国方案”是一个具有紧密关联的重大时代课题。国内学界对全球治理中国方案的研究阐释见仁见智,现有成果主要围绕四大板块共计十二个方面的议题展开。第一大板块是关于全球治理中国方案形成逻辑、提出依据和产生背景的研究... 详细信息

“全球治理与中国方案”是一个具有紧密关联的重大时代课题。国内学界对全球治理中国方案的研究阐释见仁见智,现有成果主要围绕四大板块共计十二个方面的议题展开。第一大板块是关于全球治理中国方案形成逻辑、提出依据和产生背景的研究,第二大板块是关于全球治理中国方案核心要义、层次划分和内容架构的研究,第三大板块是关于全球治理中国方案典型做法、适用领域和改革诉求的研究,第四大板块是关于全球治理中国方案理论贡献、实践要旨和当代价值的研究。既有文献对以上四大板块的论述呈现抓主线、分专题、多层次、宽领域、跨学科的基本特点,但一定程度上还存在“就中国方案谈中国方案”的循环论证现象,学理性阐释尚显不足,整体性研究有待加强。今后,还需要把全球治理中国方案与全人类共同价值和“三大全球倡议”更加紧密地联系起来,站在人类命运共同体的高度深入研究,阐释好全球治理变革和建设的中国方案。

关键词：全球治理中国方案 “三大全球倡议” 人类命运共同体研究综述

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大党独有难题研究:进展综述与进路展望

云南行政学院学报 2024年第3期26卷 32-45,79页

作者：周虎南京中医药大学马克思主义学院

从我国政党制度的话语创新角度看,进一步理解和把握“大党”的概念,既要看到大党“大的样子”“大的优势”,也要知晓大党“大的难处”“大的特殊性”。当前,国内学界关于大党独有难题的学理阐述主要聚焦“何谓大党”“难在何处”“有何... 详细信息

从我国政党制度的话语创新角度看,进一步理解和把握“大党”的概念,既要看到大党“大的样子”“大的优势”,也要知晓大党“大的难处”“大的特殊性”。当前,国内学界关于大党独有难题的学理阐述主要聚焦“何谓大党”“难在何处”“有何破解之道”“破解意义何在”四个议题。大党独有难题研究的难点在于讲清楚大党独有难题“何为独有”,即特殊性所在;重点在于找出破解之道,而非仅仅局限于发现问题这一初级环节;不足之处在于研究视角、研究思路、研究方法较为单一,学理性阐释和整体性研究尚待加强。当前,进一步深化大党独有难题研究,仍需立足系统观念,坚持问题导向,不断增强辩证思维能力,精准聚焦党的自我革命这一根本解决之道,始终着眼于中国共产党领导推进中国式现代化的能力提升和本领增长。今后,要重点研究阐释大党独有难题的应对之策,不断深化对党的自我革命的规律性认识;要注重沿循“领题—破题—解题—答题—阅题”的整体性解释框架,不断丰富和拓展学界对大党独有难题这一重大命题的学理性阐释。

关键词：大党独有难题党的自我革命全面从严治党