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盐酸布比卡因注射液中基因毒性杂质含量测定与来源分析

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中国药业 2024年第9期33卷 11-14页

作者：周冰捷王非梦李超罗立骏徐登冯琴梁静重庆市食品药品检验检测研究院·国家药品监督管理局麻醉精神药品质量监测重点实验室重庆401121 西南大学药学院重庆400716

目的建立测定盐酸布比卡因注射液中基因毒性杂质2,6-二甲基苯胺(杂质F)含量的高效液相色谱法,探讨杂质F的产生原因。方法色谱柱为XbridgeShieldRP18柱(250 mm×4.6 mm,5μm),流动相为[0.05 mol/L磷酸盐缓冲液(pH 8.0)-乙腈(65∶35,V/V)]... 详细信息

目的建立测定盐酸布比卡因注射液中基因毒性杂质2,6-二甲基苯胺(杂质F)含量的高效液相色谱法,探讨杂质F的产生原因。方法色谱柱为XbridgeShieldRP18柱(250 mm×4.6 mm,5μm),流动相为[0.05 mol/L磷酸盐缓冲液(pH 8.0)-乙腈(65∶35,V/V)]-乙腈(梯度洗脱),流速为1.0 mL/min,检测波长为240 nm,柱温为30℃,进样量为10μL。从原料药合成工艺、辅料、制剂生产工艺、制剂所用原料药4个方面,抽取5家生产企业94批样品进行杂质F的检测和对比,分析基因毒性杂质F的产生原因。结果杂质F的质量浓度在0.15~3μg/mL范围内与峰面积线性关系良好(r=1.0000,n=5);精密度、重复性试验结果的RSD分别为0.42%(n=6)和9.27%(n=6);加样回收率为99.41%,RSD为2.06%(n=9)。生产企业B,D,F,G的85批样品中均未检出杂质F;企业E的9批样品中均检出杂质F,检出量分别为0.0004%,0.0004%,0.0004%,0.0006%,0.0005%,0.0005%,0.0004%,0.0004%,0.0003%。结论该方法专属性强、重复性好、精密度高,可为杂质F的定量检测和制剂的质量控制提供参考。建议各制剂生产企业重视基因毒性杂质F的质量控制,尽快建立企业的内控标准,同时对原料药进行严格的入库质控,从源头控制杂质F的引入风险。

关键词：盐酸布比卡因注射液高效液相色谱法 2,6-二甲基苯胺生产工艺

Acidity Modification of ZSM-5 for Methane Conversion in Co-feeding Method with MTA Reaction

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Chemical Research in Chinese Universities 2022年第4期38卷 1012-1017页

作者： YU Yue XI Zhixiang zhou bingjie JIANG Binbo LIAO Zuwei YANG Yao WANG Jingdai HUANG Zhengliang SUN Jingyuan YANG Yongrong Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027P.R.China

Acidity plays a vital role in methane conversion by co-feeding method,which is one of the best strategies to improve the utilization and gentle the reaction conditions of *** this work,Zn,Ni,Mo,La,Ga,Fe and Co-impregnated ZSM-5 zeolites have been prepared with the same substitutions to variate the acidities and tested in co-aromatization of methanol with *** is demonstrated that the new medium-strong acid sites formed by metal and strong acid sites are the key role to activate methane in ***-modified ZSM-5 catalyst is preferred to exhibit the best methane conversion of 12%,whose aromatic selectivity increases from 27.2%to 52.2%compared with that of ***,the addition of methane further improves the production of high-valued aromatics compared with methanol to aromatics(MTA)reaction.

关键词： Methane Methanol to aromatics(MTA) Co-reaction Acid site

南京地区饮用水“控垢”需求分析及适用技术探讨

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净水技术 2024年第S01期43卷 21-28页

作者：刘振东徐文蕙周冰洁李海兵刘成陈卫南京水务集团江苏南京210091 河海大学环境学院江苏南京210098

自来水煮沸后饮用是我国居民重要的饮水习惯,而煮沸后的“水垢”问题给供水企业和用户造成困扰。研究结合南京地区水源水质特征、现有处理工艺及“水垢”控制需求,结合“水垢”的生成反应及影响因素,探究适用于低硬度饮用水的有效“水... 详细信息

自来水煮沸后饮用是我国居民重要的饮水习惯,而煮沸后的“水垢”问题给供水企业和用户造成困扰。研究结合南京地区水源水质特征、现有处理工艺及“水垢”控制需求,结合“水垢”的生成反应及影响因素,探究适用于低硬度饮用水的有效“水垢”控制方法。结果表明,南京地区水源水质整体较好,且水厂均设置了深度处理工艺,可以较好地保证供水水质安全,目前比较典型的是基于“水垢”的感官水质问题。改良型诱导结晶软化工艺对煮沸后“水垢”具有较好的控制作用,软化药剂投加量宜控制在10~20 mg,投加二氧化碳回调pH,处理出水煮沸后则完全没有“水垢”,沸后水的总硬度也没有降低,且多次煮沸也没有“水垢”生成,工艺总运行费用可控制在0.06元/m^(3)左右。

关键词：饮用水总硬度水垢控垢适用技术南京

Glucose-responsive erythrocyte-bound nanoparticles for continuously modulated insulin release

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Nano Research 2022年第6期15卷 5205-5215页

作者： Xiaomin Xu Yani Xu Yuai Li Min Li Leilei Wang Qiang Zhang bingjie zhou Qing Lin Tao Gong Xun Sun Zhirong Zhang Ling Zhang Key laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Glucose-responsive closed-loop insulin delivery systems represent a promising treatment strategy for diabetes,but current systems generally cannot achieve long-term *** this study,we designed an erythrocyte-biomimetic glucose-responsive system(EGRS)by coupling glucose-responsive nanoparticles(GRNs)to red blood cells;these nanoparticles exhibited the dual functions of glucose-responsiveness and persistent presence in *** are generated by encapsulating with insulin through ion crosslinking,followed by coloading with glucose oxidase(GOx)and catalase(CAT),a process that endows the nanoparticles with ***,the GRNs are coupled with red blood cells to camouflage them from the immune system,therefore,these erythrocyte-coupled GRNs can circulate in the blood for a long *** conditions of hyperglycemia,GOx acts on blood glucose to produce gluconic acid,which causes the rupture of GRNs and efficient release of ***,insulin is only released at the basic rate during ***,EGRS can efficiently and continuously respond to hyperglycemia to maintain blood glucose levels within the normal range.

关键词： glucose-responsive erythrocyte-biomimetic insulin release blood glucose control diabetes

南京地区水厂上、下向流生物活性炭工艺应用效能对比

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净水技术 2024年第S01期43卷 15-20,81页

作者：周冰洁兰童王萌杨遇春毛步云刘成陈卫南京水务集团有限公司江苏南京210043 河海大学环境学院江苏南京210098

通过对南京地区两水厂中上向流和下向流生物活性炭(biological activated carbon,BAC)池的长期检测,系统对比了两种类型BAC的净化效能和自身性能变化规律。结果表明,在水厂长期运行过程中,上向流BAC池对氨、高锰酸盐指数等水质指标的总... 详细信息

通过对南京地区两水厂中上向流和下向流生物活性炭(biological activated carbon,BAC)池的长期检测,系统对比了两种类型BAC的净化效能和自身性能变化规律。结果表明,在水厂长期运行过程中,上向流BAC池对氨、高锰酸盐指数等水质指标的总体去除效能优于下向流BAC池;上向流、下向流BAC池中BAC的碘值和亚甲蓝值衰减程度相近,但上向流BAC池中BAC颗粒的吸附性能优于下向流水厂;运行8年后,两类BAC池中生物量和生物活性都趋于稳定,但上向流BAC池中的微生物群落丰富度较高,生物降解性能较好。

关键词：生物活性炭池上向流下向流氨碘值种群结构

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亲疏水调控策略在氧还原反应催化剂中的应用

当代化工研究 2024年第15期 136-138页

作者：周冰洁尹硕尧祝伟康张灵睿邵元凯李振国中汽研汽车检验中心(天津)有限公司天津300300 中国汽车技术研究中心有限责任公司移动源污染排放控制技术国家工程实验室天津300300 中国地质大学(北京)材料科学与技术学院地质储碳与资源低碳利用教育部工程研究中心北京100083

催化剂的亲疏水性是影响氧还原反应(Oxyen Reduction Reation,ORR)性能的关键因素之一。本文综述了亲疏水调控策略在提高催化剂性能方面的应用,包括杂原子掺杂、结构设计、表面改性等方法。特别强调了超亲水和超疏水表面在促进氧气传输... 详细信息

催化剂的亲疏水性是影响氧还原反应(Oxyen Reduction Reation,ORR)性能的关键因素之一。本文综述了亲疏水调控策略在提高催化剂性能方面的应用,包括杂原子掺杂、结构设计、表面改性等方法。特别强调了超亲水和超疏水表面在促进氧气传输、增加活性位点和改善三相接触界面方面的作用。为设计高效、稳定的催化剂提供了理论基础和实践指导。

关键词：催化剂氧还原亲水疏水

青少年抑郁障碍患者抑郁症状和认知缺陷的关系:焦虑和睡眠障碍的链式中介作用

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神经疾病与精神卫生 2024年第7期24卷 477-482页

作者：石竹气盟周冰洁张晨娇朱嘉琪高焕琴陈景旭北京回龙观医院北京大学回龙观临床医学院 100096 承德医学院心理学系 067000 蚌埠医科大学精神卫生学院 233030

目的研究青少年抑郁障碍患者的焦虑情绪和睡眠障碍在抑郁症状与认知缺陷之间的链式中介作用。方法采用儿童版简明国际神经精神访谈(MINI-KID)于2023年1—10月从北京回龙观医院招募141例青少年抑郁障碍患者为研究对象。应用病人健康问... 详细信息

目的研究青少年抑郁障碍患者的焦虑情绪和睡眠障碍在抑郁症状与认知缺陷之间的链式中介作用。方法采用儿童版简明国际神经精神访谈(MINI-KID)于2023年1—10月从北京回龙观医院招募141例青少年抑郁障碍患者为研究对象。应用病人健康问卷(PHQ-9)、认知缺陷问卷-抑郁(PDQ-D)、广泛性焦虑量表(GAD-7)、匹兹堡睡眠质量指数(PSQI)调查青少年抑郁障碍患者的抑郁、认知情况及焦虑情绪、睡眠情况。采用Pearson相关分析青少年抑郁障碍患者抑郁症状、认知缺陷、焦虑情绪及睡眠障碍的相关性。采用SPSS PROCESS宏程序的Model 6进行中介效应分析。结果青少年抑郁障碍患者的PHQ-9评分为(20.61±4.99)分,GAD-7评分为(17.06±4.95)分,PSQI评分为(11.27±3.66)分,PDQ-D评分为(67.32±14.77)分。认知缺陷与抑郁症状、焦虑情绪、睡眠障碍两两之间呈正相关(r=0.525~0.625;均P<0.001)。焦虑情绪和睡眠障碍在抑郁症状与认知缺陷关系中发挥链式中介作用,中介效应值为0.109,占总效应量的19.68%。结论青少年抑郁障碍患者抑郁症状可以直接导致认知缺陷,也可以通过焦虑和睡眠障碍的链式中介作用介导。

关键词：青少年抑郁症焦虑睡眠障碍认知缺陷链式中介效应

Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres

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Nano Research 2019年第10期12卷 2451-2459页

作者： Luyao Wang bingjie zhou Shiqi Huang Mengke Qu Qing Lin Tao Gong Yuan Huang Xun Sun Qin He Zhirong Zhang Ling Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengdu 610041China

Currently,prostate cancer is the most frequently diagnosed cancer in males and chemotherapy is often essential for treating advaneed prostate ***,common chemotherapies for prostate cancer suffer from serious adverse effects due to poor drug targeting ability and tissue penetration,even with the help of conventional drug delivery ***,encouraged by recent studies showing possible drug retention and tissue pen etration advan tages of unconventional non-spherical nan oparticles over conventional spherical nan oparticles,we design and construct a novel non-spherical nano disk drug delivery system for treating prostate *** to enhance tumor-targeting capability,these nanodisks are further modified with targeting peptide,Cys-Arg-Glu丄ys?Ala peptide with N-methylated Glu(CR(NMe)EKA),which recognizes extracellular matrix fibronectin and its complexes specifically expressed on the walls of tumor vessels and in tumor *** with conventional nano spheres,the nano disks achieve much higher drug accumulati on at prostate tumor *** loaded with paclitaxel,the CR(NMe)EKA-modified nan odisks display superior an titumor efficacy to free paclitaxel,unmodified nan odisks and nano *** summary,our study provides an attractive therapeutic strategy for targeted therapy against prostate cancer with simple preparation,high efficiency and low toxicity,and supplements a theoretical support for treatments realized by different shaped nano *** study also offers valuable data for understa nding biological effects of non-spherical nano disks and highlights the great pote ntial of unconventional nan oparticles in biomedical applicati ons.

关键词： Cys-Arg-Glu-Lys-Ala peptide with N-methylated Glu(CR(NMe)EKA) fibronectin nanodisks prostate cancer tumor-targeting

Effect of Hydrothermal Treatment on Suppressing Coking of ZSM-5 Zeolite during Methanol-to-Propylene Reaction

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China Petroleum Processing & Petrochemical Technology 2016年第2期18卷 7-13页

作者： Jiang Binbo zhou bingjie Yan Lixia Wei Lingze Xu Caixia Liao Zuwei Huang Zhengliang Wang Jingdai Yang Yongrong State Key Laboratory of Chemical Engineering Department of Chemical and Biochemical EngineeringZhejiang University

Fresh ZSM-5 zeolite catalysts were pretreated at 460 ℃and 500 ℃with various cumulative amount of water feed(CAWF) in a fixed bed reactor. The catalytic process was carried out under the following conditions: a temperature of 480 ℃; a methanol WHSV of 3 h-1; a methanol partial pressure of 30 k Pa; and a time on stream of 12 h, 24 h and 48 h, respectively. The BET parameters of catalysts and diffusion coefficients of toluene showed that there were two types of mesopores generated under different hydrothermal conditions. Mild temperature and moderate CAWF conditions led to external open mesopores which could be entered from the external surface of the zeolite, while a high temperature or a high CAWF condition resulted in the generation of macropores or internal isolated mesopores, which were occluded in the microporous matrix. The TGA results showed that catalyst with external open mesopores had good ability to resist coke accumulation and good performance on propylene selectivity, while the internal isolated mesopores did no contribute to the increased diffusivity of reactants and products.

关键词： methanol to propylene (MTP) hydrothermal treatment ZSM-5 coking mesopores diffusion