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Direct, real-time PCR （MethyLight） assay for methylation of O6-methylguanine-DNA methyltransferase promoter in glioma

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Chinese Medical Journal 2009年第11期122卷 1342-1345页

作者： CHEN Gong WU Xing YAO Yu zhou liang-fu MAO Ying Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China

O6-Methylguanine-DNA methyltransferase （MGMT） is a cellular DNA repair protein that rapidly reverses alkylation （e.g. methylation） at the O6 position of guanine, thereby neutralizing the cytotoxic effects of alkylating agent therapy such as temozolomide （TMZ） and carmustine. It has been shown that epigenetic silencing of the MGMT gene by promoter methylation shuts down gene transcription and reflects a common alteration in primary human tumors leading to MGMT deficiency. Epigenetic silencing of the MGMT gene has been shown to correlate with improved survival in several studies of glioma patients treated with the alkylating agent therapy and has been substantiated in two clinical trials.

关键词： O6-methylguanine-DNA-methyltransferase real-time PCR methylation-specific PCR glioma drug resistance

Neuronavigation surgery in China： reality and prospects

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Chinese Medical Journal 2012年第24期125卷 4497-4503页

作者： WU Jin-song LU Jun-feng GONG Xiu MAO Ying zhou liang-fu Glioma Surgery Division Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China Shanghai Medical College Fudan University Shanghai 200040 China

Objective To review the history, development, and reality of neuronavigation surgery in China and to discuss the future of neuronavigation surgery. Data sources PubMed, the China Knowledge Resource Integrated Database, and the VIP Database for Chinese Technical Periodicals were searched for papers published from 1995 to the present with the key words ＂neuronavigation,＂＂functional navigation,＂＂image-guided,＂ and ＂stereotaxy.＂ Articles were reviewed for additional citations, and some information was gathered from Web searches. Study selection Articles related to neuronavigation surgery in China were selected, with special attention to application to brain tumors. Results Since the introduction of neurosurgical navigation to China in 1997, this core technique in minimally invasive neurosurgery has seen rapid development. This development has ranged from brain structural localization to functional brain mapping, from static digital models of the brain to dynamic brain-shift compensation models, and from preoperative image-guided surgery to intraoperative real-time image-guided surgery, and from application of imported equipment and technology to use of equipment and technology that possess Chinese independent intellectual property rights. Conclusions The development and application of neuronavigation techniques have made neurological surgeries in China more safe, precise and effective, and less invasive, and promoted the quality of Chinese neurosurgical practice to the rank of the most advance and excellence in the world.

关键词： neurosurgery neuronavigation medical image

Waste acid recovery utilizing monovalent cation permselective membranes through selective electrodialysis

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Chinese Journal of Chemical Engineering 2024年第7期71卷 45-57页

作者： Yanran Zhu Yue zhou Qian Chen Rongqiang fu Zhaoming Liu liang Ge Tongwen Xu Anhui Provincial Engineering Laboratory of functional Membrane Materials and Technology Department of Applied ChemistrySchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China Key Laboratory of Charged Polymeric Membrane Materials of Shandong Province Shandong Tianwei Membrane Technology Co.Ltd.Weifang 261000China

Selective electrodialysis(SED)has surfaced as a highly promising membrane separation technique in the realm of acid recovery owing to its ability to effectively separate monovalent ions through the utilization of a potential ***,the current SED process is limited by conventional commercial monovalent cation permselective membranes(MCPMs).This study systematically investigates the use of an independently developed MCPM in the SED process for acid *** factors such as current density,volume ratio,initial ion concentration,and waste acid systems are *** independently developed MCPM offers several advantages over the commercial monovalent selective cation-exchange membrane(CIMS),including higher recovered acid concentration,better ion flux ratio,improved acid recovery efficiency,increased recovered acid purity,and higher current *** SED process with the MCPM achieves a recovered acid of 95.9%and a concentration of 2.3 mol·L^(–1) in the HCl/FeCl_(2) system,when a current density of 20 mA·cm^(-2) and a volume ratio of 1:2 are ***,in the H_(2)SO_(4)/FeSO_(4) system,a purity of over 99%and a concentration of 2.1 mol·L^(–1) can be achieved in the recovered *** study thoroughly examines the impact of operation conditions on acid recovery performance in the SED *** independently developed MCPM demonstrates outstanding acid recovery performance,highlighting its potential for future commercial utilization.

关键词： Selective electrodialysis Wastewater Monovalent cation permselective membranes Separation Recovery

Superficial temporal artery-middle cerebral artery bypass combined with encephalo-duro-myo-synangiosis in treating moyamoya disease： surgical techniques, indications and midterm follow-up results

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Chinese Medical Journal 2012年第24期125卷 4398-4405页

作者： XU Bin SONG Dong-lei MAO Ying GU Yu-xiang XU Hong LIAO Yu-jun LIU Chuang-hong zhou liang-fu Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China Department of Neurosurgery Changshu First People's Hospital Changshu Jiangsu 215500 China

Background Surgical interventions for moyamoya disease include direct and indirect revascularizations. This study aimed to evaluate the therapeutic effect of superficial temporal artery-middle cerebral artery bypass combined with an indirect revascularization procedure, encephalo-duro-myo-synangiosis, in the treatment of moyamoya disease. Methods From October 2005 to November 2009, we performed this combined revascularization procedure in 111 patients with different types and stages of moyamoya disease. The superficial temporal artery, middle meningeal artery and the deep temporal artery were evaluated for individualized surgical planning in these cases. The integrity of the deep temporal artery and the middle meningeal artery network, and the pre-existing spontaneous anastomoses of the distal branches of the external carotid artery with the cortical arteries were well preserved. The mean follow-up time was 72.5 months, all clinical and radiological data were retrospectively reviewed. Results A total of 198 stomas were performed in 122 hemispheres, all remaining patent until the last follow-up. The encephalo-duro-myo-synangiosis resulted in extensive anastomoses of the deep temporal artery （100%）, the middle meningeal artery （90.9%）, and the sphenopalatine artery （39.8%） with the cortical arteries, respectitvely. The superficial temporal artery, deep temporal artery, and the middle meningeal artery were significantly thickened in 88 patients as determined by digital subtraction angiography at follow-up. The relative cerebral blood flow increased significantly within one week after the operation. At 6 months post the operation, the relative cerebral blood flow was further increased by 15.5% from the gradual formation of anastomoses as a result of indirect revascularization. Transient ischemic attacks were effectively reduced or totally arrested. The neurological deficits significantly improved in 37 patients, with the National Institutes of Health Stroke Scale scores

关键词： moyamoya disease cerebral revascularization superficial temporal artery-middle cerebral artery bypass

A new interacting capillary bundle model on the multiphase flow in micropores of tight rocks

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Petroleum Science 2024年第2期21卷 1099-1112页

作者： Wen-Quan Deng Tian-Bo liang Wen-Zhong Wang Hao Liu Jun-Lin Wu fu-Jian zhou National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

Surfactants are widely used in the fracturing fluid to enhance the imbibition and thus the oil recovery rate. However, current numerical models cannot capture the physics behind capillary imbibition during the wettability alteration by surfactants. Although the interacting capillary bundle(ICB) model shows potential in characterizing imbibition rates in different pores during wettability alteration, the existing ICB models neglect the influence of wettability and viscosity ratio on the imbibition behavior, making it difficult to accurately describe the oil-water imbibition behavior within the porous media. In this work,a new ICB mathematical model is established by introducing pressure balance without assuming the position of the leading front to comprehensively describe the imbibition behavior in a porous medium under different conditions, including gas-liquid spontaneous imbibition and oil-water *** the pore size distribution of a tight rock is known, this new model can predict the changes of water saturation during the displacement process in the tight rock, and also determine the imbibition rate in pores of different sizes. The water saturation profiles obtained from the new model are validated against the waterflooding simulation results from the CMG, while the imbibition rates calculated by the model are validated against the experimental observations of gas-liquid spontaneous imbibition. The good match above indicates the newly proposed model can show the water saturation profile at a macroscopic scale while capture the underlying physics of the multiphase flow in a porous medium at a microscopic scale. Simulation results obtained from this model indicate that both wettability and viscosity ratio can affect the sequence of fluid imbibition into pores of different sizes during the multiphase flow, where less-viscous wetting fluid is preferentially imbibed into larger pores while more-viscous wetting fluid tends to be imbibed into smaller pores. fur

关键词： Imbibition Multiphase flow Tight rock Interacting capillary bundle model Wettability

Small Cycles Property of Some Cremer Rational Maps and Polynomials

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 123-136页

作者： Rong fu Ji zhou Faculty of Science Yibin UniversityYibin 644000SichuanChina Department of Mathematical Sciences Sichuan Normal UniversityChengdu 610066China

This paper concerns the linearization problem on rational maps of degree d≥2 and polynomials of degree d>2 from the perspective of *** authors introduce a set l_(∞) of irrational numbers and show that if α∈l_(∞),then any rational map is not linearizable and has infinitely many cycles in every neighborhood of the fixed point with multiplier λ=e^(2πiα),Adding more constraints to cubic polynomials,they discuss the above problems by polynomial-like *** the family of polynomials,with the help of Yoccoz's method,they obtain its maximum dimension of the set in which the polynomials are non-linearizable.

关键词： Irrationally indifferent fixed point Linearization problem Small cycles property

Current status of cerebral glioma surgery in China

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Chinese Medical Journal 2011年第17期124卷 2569-2577页

作者： WU Jin-song ZHANG Jie ZHUANG Dong-xiao YAO Cheng-jun QIU Tian-ming LU Jun-feng ZHU Feng-ping MAO Ying zhou liang-fu Glioma Surgery Division Department of Neurosurgery Huashan Hospital Shanghai Medical School Fudan University Shanghai 200040 China

The treatment of gliomas is highly individualized. Surgery for gliomas is essentially for histological diagnosis, to alleviate mass effect, and most importantly, to favor longer survival expectancy. During the past two decades, many surgical techniques and adjuvants have been applied to glioma surgery in China, which lead to a rapid development in the field of cerebral glioma surgery. This article broadly and critically reviewed the existing studies on cerebral glioma surgery and to portrait the current status of glioma surgery in China. A literature search was conducted covering major innovative surgical techniques and adjuvants for glioma surgery in China. The following databases were searched： the Pubmed （January 1995 to date）; China Knowledge Resource Integrated Database （January 1995 to date） and VIP Database for Chinese Technical Periodicals （January 1995 to date）. A selection criterion was established to exclude duplicates and irrelevant studies. The outcome measures were extracted from included studies. A total of 3307 articles were initially searched. After excluded by abstracts and full texts, 69 studies conducted in the mainland of China were included and went through further analysis. The philosophy of surgical strategies for cerebral gliomas in China is undergoing tremendous change. Nowadays Chinese neurosurgeons pay more attention to the postoperative neurofunctional status of the patients. The aim of the glioma surgery is not only the more extensive tumor resection but also the maximal safety of intervention. The well balance of longer overall survival and higher quality of life should be judged with respect to each individual patient.

关键词： glioma neurosurgery China

Doping-driven dual heterogeneous interfacial structures boosting the durability of industry-compatible water splitting at high current density

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Science China Chemistry 2024年第10期67卷 3468-3481页

作者： Chunming Yang Lihai zhou Zhijie Kong Xiang Li Wangchuan Zhu Guangqing Wang Yanzhong Zhen Feng fu Yucang liang Research Institute of Comprehensive Energy Industry Technology College of Chemistry & Chemical EngineeringYan'an University Henan Key Laboratory of Crystalline Molecular functional Materials Green Catalysis CenterCollege of ChemistryZhengzhou University Institut für Anorganische Chemie Eberhard Karls Universit?t

Developing highly stable electrocatalysts under industry-compatible current densities(>500 mA cm-2) in an anion-exchange membrane water electrolyzer（AEMWE） is an enormous challenge for water ***,based on the results of density function theory calculations,a dual heterogeneous interfacial structured NiSe/Fe-Ni（OH）2catalyst was subtly designed and successfully prepared by electrodepositing Fe-doped Ni（OH）2on NiSe-loaded nickel foam（NF）.Fe doping-driven heterogeneous structures in NiSe/Fe-Ni（OH）2markedly boost catalytic activity and durability at industrially compatible current densities in single hydrogen and oxygen evolution reactions under alkaline *** particular,NiSe/Fe-Ni（OH）2shows a negligible performance loss at 600 mA cm-2at least 1,000 h for overall water splitting,a distinguished long-term durability acting as AEMWE electrodes at 600 mA cm-2and 1 A cm-2at 85℃ for at least 95 *** to Fe doping-induced strong synergetic effect between Ni and Fe,dual heterostructure-promoted charge transfer and redistribution,abundant catalytic active sites,and improvement of stability and durability,a mechanism of Fe doping-driven heterogeneous interfacial structurepromoted catalytic performance was *** study provides a successful example of theory-directed catalyst preparation and pioneers a creative strategy for industry-compatible water splitting at high current density.

关键词： doping-induced heterojunction structure NiSe/Fe-Ni(OH)2 large current density anion-exchange membrane industry-compatible water electrolysis

Recent progress of cobalt-based electrocatalysts for water splitting: Electron modulation, surface reconstitution, and applications

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Nano Research 2024年第4期17卷 2234-2269页

作者： Zhijian liang Di Shen Lei Wang Honggang fu Key Laboratory of functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Electrocatalytic water splitting is an essential and effective means to produce green hydrogen energy structures,so it is necessary to develop non-precious metal catalysts to replace precious ***-based catalysts present effective alternatives due to the diverse valence states,adjustable electronic structures,and plentiful *** this review,the catalytic mechanisms of hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)for electrocatalytic water splitting are ***,the synthesis strategies of various cobalt-based catalysts are systematically summarized,followed by the relationships between the structure and performance ***,the effects of d-band center and spin regulation for cobalt-based catalysts are also ***,the dynamic electronic and structural devolution of cobalt-based catalysts are elucidated by combining a series of in-situ ***,we highlight the challenges and future developed directions of cobalt-based catalysts for electrocatalytic water splitting.

关键词： cobalt-based electrocatalysts water splitting electron modulation surface reconfiguration