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Clinical therapeutic effect of self-prescribed Sanhanchushi Tongbi on lumbar disc herniation

World Journal of Clinical Cases 2024年第18期12卷 3444-3452页

作者： Cheng Yao Bin He jie zhou Lin Xie Department of Orthopedics The Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Traditional Chinese MedicineNanjing 210028Jiangsu ProvinceChina Department of Orthopedics The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND Lumbar disc herniation(LDH)commonly occurs during spinal surgery;LDH is on the increase in younger patients and is classified as"paralysis"and"back pain."Sanhanchushi Tongbi(SPST)is a customized *** disperses cold,relieves pain,removes cold from the meridians and viscera,and treats neuropathic ***,few studies have investigated its mechanism of pain *** To observe the clinical therapeutic effects on LDH treated with self-prescribed *** A total of 211 patients with LDH syndrome were divided into two groups:107 patients in the control group were treated with conventional massage combined with traction,and 104 patients in the observation group were treated with a combination of the control regimen and self-prescribed oral *** patients were treated for 4 *** of traditional Chinese medicine(TCM)syndrome score and serum inflammatory factor levels were *** After therapy,the TCM syndrome score in the observation group was significantly lower than that in the control group(P<0.05).The main symptoms,clinical signs,daily activities,and Japanese Orthopedic Association scores in the observation group were significantly higher than those in the control group after therapy(P<0.05).The levels of tumor necrosis factor-α,interleukin-6,and C-reactive protein were lower in the observation group than in the control group(P<0.05).In the observation group,superoxide dismutase levels were significantly higher,whereas malondialdehyde levels were significantly lower,compared with the control group(P<0.05).The overall efficacy rate in the observation group was 96.15%,which was substantially higher than that in the control group(88.79%;P<0.05).CONCLUSION Self-prescribed SPST can reduce the levels of inflammatory and pain-causing factors as well as lumbar pain in patients with LDH.

关键词： Self-prescribed Sanhanchushi Tongbi Lumbar disc herniation Pain factors Visual analog scale Japanese Orthopedic Association scores Inflammatory factor

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手术质量控制与外科医师的培养

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肿瘤 2024年第2期44卷 132-135页

作者：周杰南方医科大学南方医院肝胆外科广东广州510515

各级医院手术质量达到同质化,是医疗行政管理部门及医务工作者努力的目标。手术质量控制首先要遵循规则,严格按照手术学教科书上描述的步骤来实施手术。在培养年轻的外科医师时,需要让他们多管理危重患者,并且经历大手术的锻炼,多在病... 详细信息

各级医院手术质量达到同质化,是医疗行政管理部门及医务工作者努力的目标。手术质量控制首先要遵循规则,严格按照手术学教科书上描述的步骤来实施手术。在培养年轻的外科医师时,需要让他们多管理危重患者,并且经历大手术的锻炼,多在病房摸打滚爬,才可以逐渐积累起较为丰富的疾病诊治经验。年轻医师的成长速度与个人的刻苦程度以及在病房的工作时间呈正比。

关键词：手术质量控制外科医师成长培养

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高技术产业专业化集聚与绿色创新绩效——基于要素市场扭曲的中介效应研究

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技术经济与管理研究 2024年第2期 25-31页

作者：周杰喀什大学旅游学院新疆喀什830046 乐山师范学院经济管理学院四川乐山614000

选取2009—2021年中国224个地级及以上城市面板数据,运用双向固定效应模型,实证检验高技术产业专业化集聚、要素市场扭曲与绿色创新绩效间的内在机理与影响效果。结果显示,高技术产业专业化集聚能够显著促进绿色创新绩效攀升;缓解要素... 详细信息

选取2009—2021年中国224个地级及以上城市面板数据,运用双向固定效应模型,实证检验高技术产业专业化集聚、要素市场扭曲与绿色创新绩效间的内在机理与影响效果。结果显示,高技术产业专业化集聚能够显著促进绿色创新绩效攀升;缓解要素市场扭曲是高技术产业专业化集聚赋能绿色创新绩效的重要机制。进一步分析结果表明,在高集聚水平、经济发达以及东部和中部地区,高技术产业专业化集聚对绿色创新绩效的赋能效应更为显著。

关键词：高技术产业专业化集聚要素市场扭曲绿色创新绩效

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双边反射随机偏微分方程的近似逼近

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南开大学学报（自然科学版） 2024年第3期57卷 88-95,100页

作者：周杰南开大学数学科学学院天津300071

研究了时空白噪声驱动的双边反射随机偏微分方程的数值逼近.利用离散化方法构造渐近方程组,并处理确定性障碍问题来得到收敛性.进一步地采用时空分离的两阶段近似估计验证了强收敛性.最后完成了双边反射随机偏微分方程的数值模拟.

关键词：反射随机偏微分方程确定性障碍问题独立时间区域Skorohod型问题依分布收敛

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基于区域掩码对比蒸馏的遥感图像目标检测

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东南大学学报（自然科学版） 2024年第3期54卷 761-771页

作者：周杰周子龙罗岩刘瑞赵满艳南京信息工程大学电子与信息工程学院南京210044

为解决遥感图像中存在背景干扰以及目标密集分布的问题,采用了一种以区域掩码对比蒸馏为基础的目标检测方法,旨在提高遥感图像目标检测性能.首先,通过对目标特征区域进行掩码操作,以区分前景和背景并捕捉目标的细节纹理,生成细致的特征... 详细信息

为解决遥感图像中存在背景干扰以及目标密集分布的问题,采用了一种以区域掩码对比蒸馏为基础的目标检测方法,旨在提高遥感图像目标检测性能.首先,通过对目标特征区域进行掩码操作,以区分前景和背景并捕捉目标的细节纹理,生成细致的特征掩码.其次,结合对比蒸馏算法,通过对教师网络和学生网络的区域掩码进行对比学习,使学生网络更加充分地吸收教师网络在目标特征纹理检测方面的知识.同时,在检测阶段引入了一种旋转定位损失算法,该算法通过量化真实边界框和预测边界框之间的格点向量差来进行损失估计,从而减小了预测边界框与真实边界框之间的旋转损失.结果表明,改进算法的均值平均精度在DOTA和HRSC2016数据集上分别较传统算法提高了3.57%和5.22%.

关键词：遥感图像目标检测区域掩码对比蒸馏旋转定位损失函数

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Efficacy of Huoxue Qianyang Qutan Recipe on essential hypertension:A randomized,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第4期22卷 484-492页

作者： Jun Xie Yu-long Ma Ming-tai Gui Lei Yao Jian-hua Li Ming-zhu Wang Xun-jie zhou Yi-fan Wang Ming-yi Zhao Hui Cao Bo Lu De-yu Fu Department of Cardiology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai University of Traditional Chinese Medicine Shanghai 200120China

Background:Hypertension,a prevalent disease,is a significant risk factor for coronary heart *** Qianyang Qutan Recipe (HQQR),a traditional Chinese herbal remedy,has been used for treating hypertension over several ***:This study assesses HQQR’s efficacy for controlling blood pressure among patients with hypertension related to blood stasis,yang hyperactivity and ***,setting,participants and interventions:A randomized controlled trial was conducted at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,from July 2020 to June *** components of HQQR were identified using thin-layer chromatography and high-performance liquid *** aged18–80 years,exhibiting traditional Chinese medicine syndromes of blood stasis,yang hyperactivity or phlegm,along with grades 1 or 2 hypertension,were randomly categorized into two *** intervention group was given HQQR granules alongside conventional hypertension treatment,while the control group was given placebo granules in addition to conventional treatment for 12 *** outcome measures:The primary outcome was clinic blood pressure,whereas secondary outcomes included metabolic indices (e.g.,homeostasis model assessment of insulin resistance[HOMA-IR],total cholesterol[TC],low-density lipoprotein cholesterol and triglyceride),target organ damage indices (left ventricular mass index and urinary albumin creatinine ratio[UACR]) and inflammation indices(interleukin-6[IL-6]and high-sensitivity C-reactive protein[hs-CRP]).Results:HQQR’s primary components were identified as salvianolic acid B,emodin and ferulic *** the 216 participants (108 in each group),compared to the control,the intervention group exhibited significant improvements (P<0.001) in clinic systolic blood pressure ([136.24±7.63]vs[130.06±8.50]mmHg),clinic diastolic blood pressure ([84.34±8.72]vs[80.46±6.05]mmHg),home systol

关键词： Huoxue Qianyang Qutan Recipe Hypertension Target organ damage Glycolipid metabolism Inflammatory Chinese herbal compound

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贸易救济对我国服务业国际竞争力的作用机理

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商业经济研究 2024年第7期 175-179页

作者：周杰四川省社会科学院产业经济研究所四川成都610071

近年来,我国成为被采取贸易救济措施的首要目标国,导致我国服务业在高速发展过程中受到一定阻碍。因此,在遭遇大量贸易救济案件后,我国也逐步通过利用贸易救济措施来促进本土服务业发展。目前我国服务业对外开放程度不断提升,如何科学... 详细信息

近年来,我国成为被采取贸易救济措施的首要目标国,导致我国服务业在高速发展过程中受到一定阻碍。因此,在遭遇大量贸易救济案件后,我国也逐步通过利用贸易救济措施来促进本土服务业发展。目前我国服务业对外开放程度不断提升,如何科学利用贸易救济措施保障我国服务业健康发展、增强我国服务业国际竞争力成为各方关注焦点。基于此,本文将实证分析贸易救济对我国服务业国际竞争力的作用机理,旨在引导我国政府科学制定贸易救济措施、促进我国服务业国际竞争力提升。研究结果表明:贸易救济对我国服务业的国际竞争力起到显著的抑制作用;我国服务业国际竞争力的提升依赖于研发强度的提高、高新技术设备的引入、外资的引进以及之前自身经营状况的稳定性。

关键词：贸易救济服务业竞争力国际竞争力研发强度反倾销反补贴

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试论中国共产党科学对待马克思主义的三重逻辑

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江西师范大学学报（哲学社会科学版） 2024年第2期57卷 34-41页

作者：周利生周婕江西师范大学马克思主义学院江西南昌330022

马克思主义揭示了人类社会不断发展的内在规律,这一理论的科学性成为中国共产党人的思维认知;中国共产党人坚定信仰马克思主义,还在于这一理论能够解决中国社会的现实问题;科学对待马克思主义,要求破除机械僵化的教条式理解、不断赋予... 详细信息

马克思主义揭示了人类社会不断发展的内在规律,这一理论的科学性成为中国共产党人的思维认知;中国共产党人坚定信仰马克思主义,还在于这一理论能够解决中国社会的现实问题;科学对待马克思主义,要求破除机械僵化的教条式理解、不断赋予其新的时代内涵。中国共产党人将马克思主义基本原理运用于中国的革命、建设、改革,形成中国特色的新民主主义革命道路、中国特色的社会主义改造道路、中国特色的社会主义建设道路,构成了科学对待马克思主义的实践逻辑。科学对待马克思主义的理论逻辑和实践逻辑,最终落脚在一切为了人民、一切依靠人民的价值逻辑上,成为中国共产党坚持唯物史观的生动体现。

关键词：中国共产党马克思主义科学对待

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Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies

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Cancer Communications 2024年第3期44卷 408-432页

作者： Lu Tang Huan Zhang Fen zhou Qiuzhe Wei Mengyi Du Jianghua Wu Chenggong Li Wenjing Luo jie zhou Xindi Wang Zhaozhao Chen Yinqiang Zhang Zhongpei Huang Zhuolin Wu Yuxi Wen Huiwen Jiang Danying Liao Haiming Kou Wei Xiong Heng Mei Yu Hu Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Hubei Clinical Medical Center of Cell Therapy For Neoplastic Disease WuhanHubeiP.R.China Key Laboratory of Biological Targeted Therapy the Ministry of EducationWuhanHubeiP.R.China Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Background:Chimeric antigen receptor T(CAR-T)therapy has substantially revolutionized the clinical outcomes of patients with hematologic malignan-cies,but the cancer-intrinsic mechanisms underlying resistance to CAR-T cells remain yet to be fully *** study aims to explore the molecular deter-minants of cancer cell sensitivity to CAR-T cell-mediated killing and to provide a better understanding of the underlying mechanisms and potential modulation to improve clinical ***:The human whole-genome CRISPR/Cas9-based knockout screening was conducted to identify key genes that enable cancer cells to evade CD19 CAR-T-cell-mediated *** in vitro cytotoxicity assays and evaluation of tumor tissue and bone marrow specimens were further conducted to confirm the role of the key genes in cancer cell susceptibility to CAR-T *** addition,the specific mechanisms influencing CAR-T cell-mediated cancer clearance were elucidated in mouse and cellular ***:The CRISPR/Cas9-based knockout screening showed that the enrich-ment of autophagy-related genes(ATG3,BECN1,and RB1CC1)provided protec-tion of cancer cells from CD19 CAR-T cell-mediated *** findings were further validated by in vitro cytotoxicity assays in cells with genetic and pharmacological inhibition of ***,higher expression of the three autophagy-related proteins in tumor samples was correlated with poorer respon-siveness and worse survival in patients with relapsed/refractory B-cell lymphoma after CD19 CAR-T *** RNA sequencing analysis of bone marrow samples from B-cell leukemia patients also suggested the clinical relevance of autophagy to the therapeutic response and relapse after CD19 CAR-T cell *** inhibition of autophagy and knockout of RB1CC1 could dramatically sensitize tumor cells to CD19 CAR-T cell-mediated killing in mouse models of both B-cell leukemia and ***,our study revealed that cancer-intrinsic

关键词： CAR-T resistance Autophagy Immune evasion Apoptosis Chemotaxis

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The impact of female sex hormones on cardiovascular disease:from mechanisms to hormone therapy

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Journal of Geriatric Cardiology 2024年第6期21卷 669-681页

作者： Yi KAN Yu-Lu PENG Ze-Hao ZHAO Shu-Tong DONG Yin-Xiao XU Xiao-Teng MA Xiao-Li LIU Yu-Yang LIU Yu-jie zhou Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina

Cardiovascular disease remains the leading cause of mortality in women,yet it has not raised the awareness from the *** pathogenesis of cardiovascular disease differs significantly between females and males concerning the effect of sex *** and progestogen impact cardiovascular system through genomic and non-genomic *** menopause,cardiovascular protective effects of estrogens have been well *** were often used in combination with estrogens in hormone *** in sex hormone levels,particularly estrogen deficiency,were considered the specific risk factor in women’s cardiovascular ***,considerable heterogeneity in the impact of hormone therapy was observed in clinical *** heterogeneity is likely closely associated with factors such as the initial time,administration route,dosage,and formulation of hormone *** review will delve into the pathogenesis and hormone therapy,summarizing the effect of female sex hormones on hypertension,pre-eclampsia,coronary heart disease,heart failure with preserved ejection fraction,and cardiovascular risk factors specific to women.

关键词： impact dosage protective

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