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泛免疫炎症值与结直肠癌患者术后感染性并发症及预后的关系

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现代肿瘤医学 2024年第1期32卷 87-92页

作者：倪子龙朱正秋周双冯晓慧徐州医科大学附属宿迁医院消化内科江苏宿迁223800 徐州医科大学附属医院肿瘤内科江苏徐州221000 徐州医科大学研究生学院江苏徐州221000

目的:探讨泛免疫炎症值(pan-immune-inflammation value,PIV)与结直肠癌(colorectal cancer,CRC)患者术后感染性并发症及预后的关系。方法:回顾分析437例在徐州医科大学附属医院行根治手术的CRC患者的临床资料,根据ROC曲线确定PIV的最... 详细信息

目的:探讨泛免疫炎症值(pan-immune-inflammation value,PIV)与结直肠癌(colorectal cancer,CRC)患者术后感染性并发症及预后的关系。方法:回顾分析437例在徐州医科大学附属医院行根治手术的CRC患者的临床资料,根据ROC曲线确定PIV的最佳临界值,将患者分别分为高、低水平组。通过Kaplan-Meier比较两组患者的生存曲线情况,通过Logistic回归分析影响患者术后感染性并发症的危险因素,通过Cox比例风险模型分析影响患者OS的危险因素。结果:PIV最佳临界值为463.7,Kaplan-Meier生存曲线显示,高PIV组和低PIV组的中位生存时间分别为33个月和80个月,高PIV组的OS明显比低PIV组更差(Log-rank检验,P<0.05)。Logistic回归分析,年龄≥60岁、开腹手术、糖尿病史及PIV≥463.7是患者术后感染性并发症的独立危险因素。Cox多因素分析,低分化、浸润深度(T_(3)-T_(4))、TNM分期(Ⅲ-Ⅳ)、淋巴结检出数目≤12、远处转移及PIV≥463.7是患者OS的独立预后不良因素。结论:PIV可作为结直肠癌患者术后感染性并发症及术后总生存期的有效预测指标。

关键词：泛免疫炎症值结直肠肿瘤外科手术预后

S-scheme heterojunction photocatalysts for CO_(2) conversion: Design, characterization and categories

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Energy Reviews 2023年第4期2卷 63-80页

作者： Aiyun Meng Bicheng Zhu Yucun Zhong shuang zhou Peigang Han Yaorong Su College of New Materials and New Energies Shenzhen Technology UniversityShenzhenPR China'Laboratory of Solar FuelFaculty of Materials Science and ChemistryChina University of Geosciences68 Jincheng StreetWuhan430078PR China

Photocatalytic CO_(2) conversion into valuable hydrocarbon fuels via solar light is a promising strategy to simul-taneously address energy shortage and environmental ***,the photocatalytic CO_(2) reduction performance is too poor to be practically utilized due to the rapid recombination of photogenerated charge *** step-scheme(S-scheme)heterojunction photocatalysts can facilitate the charge separation and maximize the redox ability,thus remarkably enhancing the photocatalytic CO_(2) reduction *** review summarizes the progress of S-scheme heterojunction photocatalysts applied in the photocatalytic CO_(2) reduction ***,we introduce the fundamental design principles and characterization *** direct and indirect techniques to confirm the S-scheme charge transfer mechanism are ***,we divide S-scheme composite photocatalyst into the following categories depending on their compositions:g-C_(3)N_(4)-based,metal-chalcogenide-based,TiO_(2)-based,bismuth-based,other metal oxide-based and other semiconductor-based S-scheme *** synergistic effect of the S-scheme charge transfer pathway as well as the unique intrinsic properties of semiconductor materials on the photocatalytic CO_(2) reduction performance is discussed in ***,concluding perspectives on the challenges and opportunities for the further exploration of highly efficient S-scheme photocatalysts in photocatalytic CO_(2) conversion are presented.

关键词： Step-scheme heterojunction Photocatalyst CO_(2)reduction Characterization techniques

Vanadium-modified hard carbon spheres with sufficient pseudographitic domains as high-performance anode for sodium-ion batteries

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Carbon Energy 2023年第2期5卷 12-23页

作者： Fuping Chen Yujie Di Qiong Su Dongming Xu Yangpu Zhang shuang zhou Shuquan Liang Xinxin Cao Anqiang Pan School of Material Science and Engineering Central South UniversityChangshaHunanChina School of Physics and Chemistry Hunan First Normal UniversityChangshaHunanChina Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South UniversityChangshaHunanChina

Hard carbons are promising anode materials for sodium-ion *** meet practical requirements,searching for durable and conductive carbon with a stable interface is of great ***,we prepare a series of vanadiummodified hard carbon submicrospheres by using hydrothermal carbonization followed by high-temperature ***,the introduction of vanadium can facilitate the nucleation and uniform growth of carbon spheres and generate abundant V-O-C interface bonds,thus optimizing the reaction ***,the optimized hard carbon spheres modified by vanadium carbide,with sufficient pseudographitic domains,provide more active sites for Na ion migration and *** a result,the HC/VC-1300 electrode exhibits excellent Na storage performance,including a high capacity of 420 mAh g^(-1) at 50mA g^(-1) and good rate capability at 1 A g^(-1).This study proposes a new strategy for the synthesis of hard carbon spheres with high tap density and emphasizes the key role of pseudographitic structure for Na storage and interface stabilization.

关键词： anode materials hard carbon sodium-ion batteries stable interface vanadium carbide

Surfactant Mediated Microphase Separation in Miscible Block Copolymer of Poly(4-vinyl pyridine-b-hydroxybutylacrylate)

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Chinese Journal of Polymer Science 2023年第6期41卷 897-904,I0007页

作者： Xiang-Yun Xu Yu-Tong Gao Ying-Ying Wang You-shuang zhou Bi-Jin Xiong Jin-Tao Zhu Key Laboratory of Materials Chemistry for Energy Conversion and Storage(HUST)of Ministry of Education School of Chemistry and Chemical Engineering.Huazhong University of Science and Technology(HUST)Wuhan 430074China Key Laboratory of Optoelectronic Chemical Materials and Devices(Ministry of Education) Jianghan UniversityWuhan 430056China Key Laboratory of Green Preparation and Application of Functional Materials(Ministry of Education) Hubei Key Laboratory of Polymer MaterialsFaculty of Materials Science and EngineeringHubei UniversityWuhan 430062China

Miscible disordered block copolymers(BCPs)are rarely studied due to the limits in self-assembly into ordered ***,we proposed a facile method for the transformation of disordered miscible BCPs to comb-like BCPs with well-ordered microphase separation structures via blending with amphiphilic *** this work,poly(4-vinyl pyridine-b-hydroxybutylacrylate)(P4VP-b-P4HBA)was applied as a model of miscible disordered BCPs and the microphase separation was induced via blending with surfactants of dodecylbenzene sulfonic acid(DBSA)and 3-pentadecylphenol(PDP).The ordered microstructures including spherical and cylindrical morphologies were confirmed by transmission electron microscopy(TEM)and small angle X-ray scattering(SAXS)*** ordered microstructures thermal sensitive,in which ordered and disordered transformation(ODT)was observed in the blend of P4VP-b-P4HBA and PDP whereas it disappeared in the blend of P4VP-b-P4HBA and *** results show that the thermal stability of the ordered microstructures are strongly depends on the interactions between the miscible BCPs and surfactants,which investigated by in situ SAXS and Fourier transform infrared spectrometer(FTIR).The combination of miscible BCPs and surfactant creates a feasible strategy to fabricate ordered nanostructures,which could be employed to develop complicated nanomaterials.

关键词： ordered disordered vinyl

Quantifying key model parameters for wheat leaf gas exchange under different environmental conditions

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Journal of Integrative Agriculture 2020年第9期19卷 2188-2205页

作者： ZHAO Fu-nian zhou shuang-xi WANG Run-yuan ZHANG Kai WANG He-ling YU Qiang Key Laboratory of Water Cycle&Related Land Surface Processes/Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101P.R.China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049P.R.China Key Laboratory of Arid Climatic Change and Disaster Reduction of Gansu Province/Key Laboratory of Arid Climate Change and Disaster Reduction of China Meteorological Administration(CMA)/Lanzhou Institute of Arid Meteorology CMALanzhou 730020P.R.China The New Zealand Institute for Plant and Food Research Limited Hawke's Bay 4130New Zealand State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau/Institute of Soil and Water Conservation Northwest A&F UniversityYangling 712100P.R.China School of Life Sciences University of Technology SydneySydney 2000Australia

The maximum carboxylation rate of Rubisco(Vcmax)and maximum rate of electron transport(Jmax)for the biochemical photosynthetic model,and the slope(m)of the Ball-Berry stomatal conductance model influence gas exchange estimates between plants and the ***,there is limited data on the variation of these three parameters for annual crops under different environmental *** exchange measurements of light and CO2 response curves on leaves of winter wheat and spring wheat were conducted during the wheat growing season under different environmental *** were no significant differences for Vcmax,Jmax or m between the two wheat *** seasonal variation of Vcmax,Jmax and m for spring wheat was not pronounced,except a rapid decrease for Vcmax and Jmax at the end of growing *** and Jmax show no significant changes during soil drying until light saturated stomatal conductance(gssat)was smaller than 0.15 mol m^–2 s^–***,there was a significant difference in m during two different water supply conditions separated by gssat at 0.15 mol m^–2 s^–***,the misestimation of Vcmax and Jmax had great impacts on the net photosynthesis rate simulation,whereas,the underestimation of m resulted in underestimated stomatal conductance and transpiration rate and an overestimation of water use *** work demonstrates that the impact of severe environmental conditions and specific growing stages on the variation of key model parameters should be taken into account for simulating gas exchange between plants and the ***,modification of m and Vcmax(and Jmax)successively based on water stress severity might be adopted to simulate gas exchange between plants and the atmosphere under drought.

关键词： biochemical photosynthetic model stomatal conductance model maximum carboxylation rate of Rubisco maximum rate of electron transport drought

A novel mitochondria-targeting tetrapeptide for subcellular delivery of nanoparticles

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Chinese Chemical Letters 2019年第7期30卷 1435-1439页

作者： Yanhui Sun Aiyan Zhan shuang zhou Xiao Kuang Hongyan Shen Hongzhuo Liu Youjun Xu School of Pharmaceutial Engineering Key Laboratory of Structure-Based Drug Design & Discovery(Ministry of Education) Shenyang Pharmaceutical University Shenyang 110016 China Wuya College of Innovation Shenyang Pharmaceutical University Shenyang 110016 China

Mitochondrial dysfunction is associated with the emergence of several neurological and cardiovascular diseases. Hence, mitochondria-targeting delivery strategies are highly significant and critically needed. In this study, we developed a small library of peptides simulating the mitochondria-targeting peptide SS-31, a promising tetra-peptide with antioxidant character, and subsequently evaluated the toxicity, antioxidant ability and mitochondrial delivery of nanoparticles. Among the designed peptides, RF-2 (DArg-Dmt-Arg-Phe-NH2) showed controlled toxicity and excellent protection against gentamicin-induced hair cell damage, as compared with SS-31. More importantly, RF-2-modified PLGA nanoparticles demonstrated high colocalization with mitochondria and comparable specific subcellular accumulation, when compared with SS-31. Taken together, the obtained results supported RF-2 as a mitochondriatargeting peptide with high potential as a targeted carrier.

关键词： Mitochondrial targeting Peptide SS-31 Toxicity Nanoparticles Zebrafish

Tongue and pulse features of 668 asymptomatic patients infected with the severe acute respiratory syndrome coronavirus 2 omicron variant in Shanghai

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Journal of Traditional Chinese Medicine 2022年第6期42卷 1006-1011页

作者： ZHANG Wen CAO Min SUN Ding SHI Li LU Wei XU Xiangru zhou shuang FANG Bangjiang Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Rheumatology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Pediatrics Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nursing Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China College of Acumox and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Emergency and Critical Care Medicine Shanghai University of Traditional Chinese MedicineShanghai 200032China

OBJECTIVE: To characterize the tongue and pulse manifestations in asymptomatic coronavirus disease 2019(COVID-19) cases in Shanghai. METHODS: We conducted a clinical study of 668 patients with asymptomatic infections in which we analyzed the tongue and pulse features in the Shanghai New International Expo Center mobile cabin hospital. The medical records of the patients, including tongue color, tongue coating, and pulse manifestations, were reviewed by healthcare workers. RESULTS: In total, 668 COVID-19 cases were included in the study. Patient age ranged from 5 to 96 years, with a median of 44.0(IQR 33.0-53.0) years. Among the patients, 6.14% had comorbidities. The most common comorbid condition was diabetes(1.65%), followed by hypertension(0.89%), coronary heart disease(0.89%), thrombotic diseases(0.89%), congestive heart failure(0.60%), and stroke(0.45%). Pink-red(75.4%) was the most common tongue color, followed by red(23.4%) and pale red(1.2%). Tongue coating color and thickness were classified as white fur(9.28%), thin and yellow fur(48.65%), white greasy fur(8.98%), yellow greasy fur(24.70%), and less coating(8.39%). In addition, a large number of patients(n = 300, 44.91%) presented superficial and rapid pulses, and 250 patients(37.4%) exhibited a slippery pulse. CONCLUSION: Our preliminary results showed that wind, heat, and dampness were the main etiologies of the severe acute respiratory syndrome coronavirus 2 Omicron(B.1.1.529) variant infection in traditional Chinese medicine. Furthermore, the main symptoms of the disease may be wind-heat invading the lung syndrome or damp-heat with the exuberance of virulence syndrome, which is of most significance in COVID-19 treatment.

关键词： SARS-Co V-2 Omicron asymptomatic infections tongue feature pulse feature

Bone marrow inhibition induced by azathioprine in a patient without mutation in the thiopurine S-methyltransferase pathogenic site:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4230-4237页

作者： Xiao-shuang zhou Yuan-Yue Lu Yan-Fang Gao Wen Shao Jia Yao College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030012Shanxi ProvinceChina Department of Nephrology The Affiliated People's Hospital of Shanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina Department of Gastroenterology Shanxi Bethune HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Azathioprine(AZA)and its close analog 6-mercaptopurine are thiopurines widely used in the treatment of patients with cancer,organ transplantation,and autoimmune or inflammatory diseases,including systemic lupus *** marrow inhibition is a common side effect of AZA,and severe bone marrow inhibition is related to decreased thiopurine S-methyltransferase(TPMT)*** SUMMARY We herein report a patient with proliferative lupus nephritis who was using AZA for maintenance therapy,had no common TPMT pathogenic site mutations,and exhibited severe bone marrow inhibition on the 15th day after oral *** This report alerts physicians to the fact that even though the TPMT gene has no common pathogenic site mutation,severe myelosuppression may also occur.

关键词： Azathioprine Thiopurine S-methyltransferase Bone marrow inhibition Lupus nephritis Case report

进食障碍患者主要照顾者准备度现状及影响因素分析

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护理实践与研究 2024年第10期21卷 1517-1522页

作者：赵云淞郑明华郭伟冬高士凯周爽天津市安定医院天津市300222

目的探讨进食障碍患者的主要照顾者准备度现状及影响因素,以期为低水平照顾者准备度的进食障碍患者主要照顾者制订针对性干预措施。方法选取2019年10月—2022年1月在天津市安定医院就诊的153例进食障碍患者的主要照顾者作为调查对象,采... 详细信息

目的探讨进食障碍患者的主要照顾者准备度现状及影响因素,以期为低水平照顾者准备度的进食障碍患者主要照顾者制订针对性干预措施。方法选取2019年10月—2022年1月在天津市安定医院就诊的153例进食障碍患者的主要照顾者作为调查对象,采用一般资料调查表、照顾者准备度量表、照顾者负担问卷、抑郁-焦虑-压力量表和Herth希望量表对进食障碍患者主要照顾者进行调查。采用单因素分析及多元线性回归分析进食障碍患者的主要照顾者准备度的影响因素。结果进食障碍患者的主要照顾者准备度得分为13.69±3.26分,多元线性回归分析结果显示,主要照顾者年龄(b=-0.080)、文化程度(b=0.612)、家庭月收入(b=0.581)、照顾者负担(b=-0.143)、焦虑(b=-0.144)和希望水平(b=0.238)是进食障碍患者主要照顾者准备度的影响因素(P<0.05),共解释总变异的78.3%。结论年龄、文化程度、家庭月收入、照顾者负担、焦虑和希望水平是进食障碍患者主要照顾者准备度的影响因素。临床护理人员应充分评估并重点关注低准备度的照顾者,并给予健康教育和指导,提高主要照顾者准备度,从而促进进食障碍患者康复。

关键词：进食障碍主要照顾者准备度照顾者负担焦虑希望水平