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C-CORE:Clustering by Code Representation to Prioritize Test Cases in Compiler Testing

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2069-2093页

作者： wei zhou Xincong Jiang Chuan Qin School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai200240China Hikvision Research Institute Hangzhou Hikvision Digital Technology Co.Ltd.Hangzhou310051China

Edge devices,due to their limited computational and storage resources,often require the use of compilers for program ***,ensuring the security and reliability of these compilers is of paramount importance in the emerging field of edge *** widely used testing method for this purpose is fuzz testing,which detects bugs by inputting random test cases into the target ***,this process consumes significant time and *** improve the efficiency of compiler fuzz testing,it is common practice to utilize test case prioritization *** researchers use machine learning to predict the code coverage of test cases,aiming to maximize the test capability for the target compiler by increasing the overall predicted coverage of the test ***,these methods can only forecast the code coverage of the compiler at a specific optimization level,potentially missing many optimization-related *** this paper,we introduce C-CORE(short for Clustering by Code Representation),the first framework to prioritize test cases according to their code representations,which are derived directly from the source *** approach avoids being limited to specific compiler states and extends to a broader range of compiler ***,we first train a scaled pre-trained programming language model to capture as many common features as possible from the test cases generated by a *** this pre-trained model,we then train two downstream models:one for predicting the likelihood of triggering a bug and another for identifying code representations associated with ***,we cluster the test cases according to their code representations and select the highest-scoring test case from each cluster as the high-quality test *** reduction in redundant testing cases leads to time *** evaluation results reveal that code representations are better at distinguishing test capabilities,and C-CORE significantly enhanc

关键词： Compiler testing test case prioritization code representation

Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

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World Journal of Emergency Medicine 2024年第1期15卷 35-40页

作者： wei zhou Maiying Fan Xiang Li Fang Yu En zhou Xiaotong Han Department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China Department of Otolaryngology-head and Neck Surgery the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China

BACKGROUND:Xuebijing(XBJ)can alleviate the inflammatory response,improve organ function,and shorten the intensive care unit(ICU)stay in patients with pyogenic liver abscess(PLA)complicated with sepsis,but the molecular mechanisms have not been *** study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology ***:The active ingredients and targets of XBJ were retrieved from the ETCM *** targets related to PLA and sepsis were retrieved from the GeneCards,PharmGKB,DisGeNet,Online Mendelian Inheritance in Man(OMIM),Therapeutic Targets Database(TTD),and DrugBank *** targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment ***-protein interaction networks were analyzed using the STRING *** treatment targets were imported into the Metascape platform for Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** docking was performed to validate the interactions between active ingredients and core ***:XBJ was found to have 54 potential treatment targets for PLA complicated with ***-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor(TNF)were identifi ed as core *** enrichment analysis revealed important pathways,including the interleukin-17(IL-17)signaling pathway,the TNF signaling pathway,the nuclear factor-kappa B(NF-κB)signaling pathway,and the Toll-like receptor(TLR)signaling *** docking experiments indicated stable binding between XBJ active ingredients and core ***:XBJ may exert therapeutic eff ects on PLA complicated with sepsis by modulating signaling pathways,such as the IL-17,TNF,NF-κB,and TLR pathways,and targeting IL-1β,IL-6,and TNF.

关键词： Xuebijing injection Pyogenic liver abscess Sepsis

Multiple damage zones around hydraulic fractures generated by high-frequency pulsating hydraulic fracturing

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Petroleum Science 2024年第4期21卷 2688-2702页

作者： Yan Peng Sheng-Jie wei Guang-Qing Zhang Da-wei zhou Chuang-Chao Xu School of Petroleum Engineering China University of Petroleum PetroChina Changqing Oilfield Company

Pulsating hydraulic fracturing(PHF) is a promising fracturing method and can generate a dynamic periodic pressure. The periodic pressure can induce fatigue failure of rocks and decrease initiation pressure of fracture. If the frequency of periodic pressure exceeds 10 Hz, the distribution of pressure along the main fracture will be heterogeneous, which is much different from the one induced by the common fracturing method. In this study, the impact of this special spatial feature of pressure on hydraulic fracture is mainly investigated. A coupled numerical simulation model is first proposed and verified through experimental and theoretical solutions. The mechanism of secondary fracture initiation around the main fracture is then discovered. In addition, sensitivity studies are conducted to find out the application potential of this new method. The results show that(1) this coupled numerical simulation model is accurate. Through comparison with experimental and theoretical data, the average error of this coupled model is less than 1.01%.(2) Even if a reservoir has no natural fracture, this heterogeneous distribution pressure can also cause many secondary fractures around the main fracture.(3) The mechanism of secondary fracture initiation is that this heterogeneous distribution pressure causes tensile stress at many locations along the main fracture.(4) Through adjusting the stimulation parameters, the stimulation efficiency can be improved. The average and amplitude of pressure can increase possibility of secondary fracture initiation. The frequency of this periodic pressure can increase number of secondary fractures. Even 6 secondary fractures along a 100 m-length main fracture can be generated.(5) The influence magnitudes of stimulation parameters are larger than ones of geomechanical properties, therefore, this new fracturing method has a wide application potential.

关键词： Tight reservoir Reservoir stimulation Numerical simulation Secondary fracture Fracture initiation

Metallosalen covalent organic frameworks for heterogeneous catalysis

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Interdisciplinary Materials 2024年第1期3卷 87-112页

作者： wei zhou wei‐Qiao Deng Xing Lu School of Chemistry and Chemical Engineering Hainan UniversityHaikouHainanChina Institute of Molecular Sciences and Engineering Shandong UniversityQingdaoShandongChina

Metallosalen covalent organic frameworks(M(salen)-COFs)have garnered significant attention as promising candidates for advanced heterogeneous catalysis,including organocatalysis,electrocatalysis,and photocatalysis,due to their unique structural advantages(combining molecules catalysts and crystalline porous materials)and tunable topological *** is essential to provide a comprehensive overview of emerging designs of M(salen)-COFs and corresponding advances in this ***,this review first summarizes the reported metallolinkers and the synthesis methods of M(salen)-*** addition,the review enumerates the excellent M(salen)-COF based heterogeneous catalysts and discusses the fundamental mechanisms behind the outstanding heterogeneous catalytic performance of M(salen)-*** mechanisms include the pore enrichment effect(enhancing local concentration within porous materials to promote catalytic reactions),the three-in-one strategy(integrating enrichment,reduction,and oxidation sites in one system),and the incorporation of a built-in electric field(implanting a built-in electric field in heterometallic phthalocyanine covalent organic frameworks).Furthermore,this review discusses the challenges and prospects related to M(salen)-COFs in heterogeneous catalysis.

关键词： covalent organic frameworks heterogeneous catalysis metallosalen

Cellular strategies to induce immune tolerance after liver transplantation:Clinical perspectives

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World Journal of Gastroenterology 2024年第13期30卷 1791-1800页

作者： Ai-wei zhou Jing Jin Yuan Liu Department of Liver Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Nursing Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Liver Transplantation Shanghai Immune Therapy InstituteShanghai 200127China

Liver transplantation(LT)has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative ***,long-term side-effects of immunosuppressants,like infection,metabolic disorders and malignant tumor are gaining more *** tolerance is the status in which LT recipients no longer need to take any immunosuppressants,but the liver function and intrahepatic histology maintain *** approaches to achieve immune tolerance after transplantation include spontaneous,operational and induced *** first two means require no specific intervention but withdrawing immunosuppressant gradually during *** clinical factors or biomarkers so far could accurately predict who are suitable for immunosuppressant withdraw after *** the understanding to the underlying mechanisms of immune tolerance,many strategies have been developed to induce tolerance in LT *** strategy is one of the most promising methods for immune tolerance induction,including chimerism induced by hematopoietic stem cells and adoptive transfer of regulatory immune *** safety and efficacy of various cell products have been evaluated by prospective preclinical and clinical trials,while obstacles still exist before translating into clinical ***,we will summarize the latest perspectives and concerns on the clinical application of cellular strategies in LT recipients.

关键词： Cellular therapy Induced tolerance Liver transplantation Regulatory T cells Regulatory dendritic cells

A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers

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Biomedical and Environmental Sciences 2024年第5期37卷 445-456页

作者： HU wei Qiong zhou wei Guang zhou Guang wei LIAO Jia Xi SHI Jia Xing XIE FengYang LI Shou Heng WANG Yong FENG Xian Hong GU Xiu Li CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Institute of WUT-AMU Wuhan University of TechnologyWuhan 430070HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People’s HospitalWuhan 430499HubeiChina Department of Reproductive Genetics Wuhan Huake Reproductive HospitalWuhan 430013HubeiChina

Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than ***,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer *** A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were *** of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger ***-four eligible studies were included in the *** After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the Hubei Chinese *** meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese *** The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关键词： LEPR gene rs1137101 Digestive system cancers Genetic susceptibility Meta-analysis

High sensitivity of semimetal photodetection via Bose–Einstein condensation

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InfoMat 2024年第2期6卷 142-151页

作者： Tuntan Wu Qinxi Qiu Yongzhen Li Qiangguo zhou Wanli Ma Jingbo Li Lin Jiang wei zhou Zhiming Huang State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghaithe People's Republic of China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhouthe People's Republic of China University of Chinese Academy of Sciences Beijingthe People's Republic of China Institute of Optoelectronics Fudan UniversityShanghaithe People's Republic of China Key Laboratory of Space Active Optical-Electro Technology Chinese Academy of SciencesShanghaithe People's Republic of China

The discovery of semiconductor has witnessed remarkable strides toward high performance of photodetectors attributed to its excellent carrier ***,semimetal,owning to the high carrier concentration and low carrier mobility compared to those of semiconductor,is generally considered unsuitable for ***,we demonstrate an outstanding photodetection in a layered semimetal titanium diselenide(TiSe_(2))in Bose-Einstein condensation(BEC)*** sensitivity of semimetal photodetector is realized in the range of visible,infrared and terahertz *** noise equivalent power(NEP)has threefold improvement at the visible and infrared wavebands,and significant decrease by one order of magnitude in the terahertz frequencies via BEC phenomenon,attributed to the electrical parameter variation after *** best NEP value in the terahertz frequency is comparable to that of commercial Si *** results show another recipe to fabricate high performance of photodetection via semimetal except for semiconductor and pave the way to exploit macroscopic quantum phenomena for optoelectronics.

关键词： Bose-Einstein condensation electromagnetic induced well effect photodetector semimetal

New Strategy for Boosting Cathodic Performance of Protonic Ceramic Fuel Cells Through Incorporating a Superior Hydronation Second Phase

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Energy & Environmental Materials 2024年第4期7卷 83-92页

作者： Chuan zhou Xixi Wang Dongliang Liu Meijuan Fei Jie Dai Daqin Guan Zhiwei Hu Linjuan Zhang Yu Wang wei Wang Ryan O'Hayre San Ping Jiang wei zhou Meilin Liu Zongping Shao State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Max Planck Institute for Chemical Physics of Solids Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences Department of Metallurgical and Materials Engineering Colorado School of Mines WA School of Mines: Minerals Energy and Chemical Engineering (WASM-MECE) Curtin University Suzhou Laboratory School of Materials Science and Engineering Georgia Institute of Technology

For protonic ceramic fuel cells,it is key to develop material with high intrinsic activity for oxygen activation and bulk proton conductivity enabling water formation at entire electrode ***,a higher water content which benefitting for the increasing proton conductivity will not only dilute the oxygen in the gas,but also suppress the O2adsorption on the electrode surface.

关键词： cathode high-hydrating capability proton conductivity protonic ceramic fuel cells

Producing circularly polarized luminescence by radiative energy transfer from achiral metal-organic cage to chiral organic molecules

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Chinese Chemical Letters 2024年第8期35卷 498-502页

作者： Zhao-Xia Lian Xue-Zhi Wang Chuang-wei zhou Jiayu Li Ming-De Li Xiao-Ping zhou Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China College of Chemistry and Chemical Engineering Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China

The development of circularly polarized luminescence(CPL)materials with high performance is signifi-cantly ***,we develop a facial strategy for fabricating a CPL-active system by employing an achiral luminescent metal-organic cage(MOC)and chiral boron dipyrromethene(BODIPY)*** is achieved by taking advantage of the radiative energy transfer process,in which BODIPY molecules act as energy acceptors and MOCs act as *** CPL performance(maximum luminescence dissymme-try factor up to±1.5×10^(−3))can be tuned by adjusting the ratio between MOCs and ***-light emission with the CPL feature is obtained by using a ternary system including MOC,chiral BODIPY,and Rhodamine *** present work provides a facile and universal strategy to construct a CPL-active system by integrating achiral luminophores and chiral molecules.

关键词： Circularly polarized luminescence Metal-organic cage Radiative energy transfer Chiral small molecules Bodipy Chirality