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Two-dimensional metallic tantalum ditelluride with an intrinsic basal-plane activity for oxygen reduction:A microkinetic modeling study

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Green Energy & Environment 2022年第3期7卷 525-532页

作者： Yu Wang kun zhou Environmental Process Modelling Centre Nanyang Environment and Water Research InstituteNanyang Technological University1 CleanTech Loop637141Singapore School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore

Two-dimensional(2D) materials have exhibited great potential for replacing costly Pt for oxygen reduction reaction(ORR) because of their distinctive structural features and high pre-site ***,their performance is generally hindered by the limited density of active sites(e.g.,at the layer edges).Although they feature a high exposure of surface sites,these sites are typically inert for ***,through density functional theory calculations,we propose a promising ORR catalyst candidate,a 2D TaTe_(2) nanosheet,which has an intrinsic high basal-plane *** of the thermodynamic and kinetic processes are explored,which demonstrates that the basal-plane Te sites of the TaTe_(2) nanosheet have great potential for facilitating ***,we construct a microkinetic model of ORR proceeding on TaTe_(2),which unveils its dynamic intermediate coverage under different electrode potentials and identifies the dominating associative *** theoretical half-wave potential of TaTe_(2) is predicted to be 0.87 V,which exceeds those of the well-established Pt(111) and Fe–N–C single-atom catalysts computed at the same *** study not only presents the first 2D,non-Pt ORR catalyst candidate with an intrinsic basal-plane activity but also offers a rational methodology for unveiling the mechanism/activity of ORR and other electrochemical reactions.

关键词： plane intrinsic kinetic

Science Letters:Research on 3D fiber orientation distribution in arbitrary planar flows

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1021-1025页

作者： zhou kun LIN Jian-zhong State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China China Jiliang University Hangzhou 310018 China

A non-stretchable fiber rotation in planar flows has been solved. The fiber will rotate periodically or run to the asymptotical direction decided by a discriminant defined in the paper involving the fiber aspect ratio and the flow characteristics. Subsequently the fiber orientation distribution is derived directly without the bother of solving the Fokker-Planck equation. The research clearly indicates the overall configuration of a fiber rotation movement in planar flows.

关键词： Fiber suspension flow Jeffery orbit Fiber orientation distribution

DNA damage repair:historical perspectives,mechanistic pathways and clinical translation for targeted cancer therapy

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2391-2425页

作者： Ruixue Huang Ping-kun zhou Department of Occupational and Environmental Health Xiangya School of Public HealthCentral South UniversityChangshaHunanChina Department of Radiation Biology Beijing Key Laboratory for RadiobiologyBeijing Institute of Radiation MedicineAMMSBeijingChina

Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA *** application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of ***,the adverse effects including normal tissues injury are also accompanied by the radiotherapy and *** cancer therapy has the potential to suppress cancer cells'DNA damage response through tailoring therapy to cancer patients lacking specific DNA damage response ***,understanding the broader role of DNA damage repair in cancers has became a basic and attractive strategy for targeted cancer therapy,in particular,raising novel hypothesis or theory in this field on the basis of previous scientists'findings would be important for future promising druggable emerging *** this review,we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed,then we summarize the mechanisms regarding DNA damage repair associated with targeted cancer therapy,highlighting the specific proteins behind targeting DNA damage repair that initiate functioning abnormally duo to extrinsic harm by environmental DNA damage factors,also,the DNA damage baseline drift leads to the harmful intrinsic targeted cancer *** addition,clinical therapeutic drugs for DNA damage and repair including therapeutic effects,as well as the strategy and scheme of relative clinical trials were intensive *** on this background,we suggest two hypotheses,namely"environmental gear selection”to describe DNA damage repair pathway evolution,and"DNA damage baseline drift”,which may play a magnified role in mediating repair during cancer *** two new hypothesis would shed new light on targeted cancer therapy,provide a much better or more comprehensive holistic view and also promote the development of new research direction and new overcoming strategies for

关键词： damage clinical targeted

A New Method of Simulating Fiber Suspensions and Applications to Channel Flows

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Chinese Physics Letters 2012年第6期29卷 189-192页

作者： YANG Wei zhou kun Department of Mechanics Zhejiang UniversityHangzhou 310027 Clean Combustion Research Center King Abudullah University of Science and TechnologyThuwalSaudi Arabia

A successive iteration method is proposed to numerically simulate fiber *** computational field is discretized with the collocated finite volume method,and an ergodic hypothesis is adopted to gready accelerate the solution to the Fokker-Planck *** method is employed in channel flows with different fiber volume fractions and aspect ratios,and its effectiveness is *** numerical results show that the existence of fibers significantly changes the pressure distribution,and the fiber aspect ratio has a greater effect on the velocity profile than on the volume *** the center of the channel,the velocity increases along the streamwise direction,while the velocity near the wall decreases *** uncoupling and coupling solutions of the additional stress of the fiber suspensions are quite different.

关键词： equation suspensions iteration

“The Poem Is More Philosophical Than History” ——Discussion on Authenticity of Pushkin's Historical Literature

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学术界 2012年第8期 257-263页

作者： zhou kun Shanghai University of Electric Power Department of Foreign Language Shanghai 201100

Pushkin is a great Russian *** addition,he is a famous *** achieved the peak by virtue of history-themed poems including Poltava and The Bronze *** was good at applying realism and romanticism for *** two ways complement each *** the mid-to-late period of Pushkin's writing career,his creation style transformed to realism ***,he was better at mixing historical events and imaginary plots so as to perfectly blend historical reality and artistic truth.

关键词：历史事件普希金文学家哲学现实主义创作风格浪漫主义俄罗斯

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1925-1951页

作者： Rui-Xue Huang Ping-kun zhou Department of Occupational and Environmental Health Xiangya School of Public HealthCentral South University410078 ChangshaPeople’s Republic of China Department of Radiation Biology Beijing Key Laboratory for RadiobiologyBeijing Institute of Radiation MedicineAMMS100850 BeijingPeople’s Republic of China Institute for Chemical Carcinogenesis State Key Laboratory of RespiratoryGuangzhou Medical University511436 GuangzhouPeople’s Republic of China

Radiotherapy is one of the most common countermeasures for treating a wide range of ***,the radioresistance of cancer cells is still a major limitation for radiotherapy *** are continuously ongoing to explore sensitizing targets and develop radiosensitizers for improving the outcomes of *** double-strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular DNA damage responses(DDRs),including those helping cells recover from radiation injuries,such as the activation of DNA damage sensing and early transduction pathways,cell cycle arrest,and DNA ***,these protective DDRs confer tumor *** DDR signaling pathways has become an attractive strategy for overcoming tumor radioresistance,and some important advances and breakthroughs have already been achieved in recent *** the basis of comprehensively reviewing the DDR signal pathways,we provide an update on the novel and promising druggable targets emerging from DDR pathways that can be exploited for *** further discuss recent advances identified from preclinical studies,current clinical trials,and clinical application of chemical inhibitors targeting key DDR proteins,including DNA-PKcs(DNA-dependent protein kinase,catalytic subunit),ATM/ATR(ataxia–telangiectasia mutated and Rad3-related),the MRN(MRE11-RAD50-NBS1)complex,the PARP(poly[ADP-ribose]polymerase)family,MDC1,Wee1,LIG4(ligase IV),CDK1,BRCA1(BRCA1 C terminal),CHK1,and HIF-1(hypoxia-inducible factor-1).Challenges for ionizing radiation-induced signal transduction and targeted therapy are also discussed based on recent achievements in the biological field of radiotherapy.

关键词： damage radiotherapy injuries

Generalized Inverses and Units in a Unitary Ring

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1000-1014页

作者： Yu kun zhou Jian Long CHEN School of Mathematics Southeast UniversityNanjing 210096P.R.China

Let R be a unitary ring and a,b∈R with ab=*** find the 2/3 property of Drazin invertibility:if any two of a,b and a+b are Drazin invertible,then so is the third ***,we combine the 2/3 property of Drazin invertibility to characterize the existence of generalized inverses by means of *** applications,the need for two invertible morphisms used by You and Chen to characterize the group invertibility of a sum of morphisms is reduced to that for one invertible morphism,and the existence and expression of the inverse along a product of two regular elements are obtained,which generalizes the main result of Mary and Patricio(2016)about the group inverse of a product.

关键词： Leftπ-regular element stronglyπ-regular element group inverse Drazin inverse inverse along an element

Single-view facial reflectance inference with a differentiable renderer

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Science China(Information Sciences) 2021年第11期64卷 5-21页

作者： Jiahao GENG Yanlin WENG Lvdi WANG kun zhou State Key Lab of CAD&CG Zhejiang University ZJU-Face Unity Joint Lab of Intelligent Graphics

We introduce a deep-learning based algorithm to infer high-fidelity facial reflectance from a single image. The algorithm uses convolutional neural networks to encode the input image into a latent representation, from which a decoder and a detail enhancing network reconstruct decoupled facial reflectance(albedo, specular, and normal) as well as the environmental lighting. These decoupled components, together with a 3 D facial mesh estimated from the image, are then fed into a differentiable renderer to produce a rendered facial image. This allows us to iteratively optimize the latent representation of the facial image by minimizing the image-space reconstruction loss. Experimental results show that optimizing the latent representation through the differentiable renderer can effectively reduce the discrepancy between the original image and the rendered one, leading to a more accurate reconstruction of characteristic facial features such as skin tone, lip color, and facial hair.

关键词： facial modeling reflectance inference differentiable renderer

Modelling of Non-Newtonian Starved Thermal-elastohydrodynamic Lubrication of Heterogeneous Materials in Impact Motion

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Acta Mechanica Solida Sinica 2021年第6期34卷 954-976页

作者： Xueyu Bai Qingbing Dong Han Zheng kun zhou School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore639798Singapore State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing400030China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400030China Environmental Process Modelling Centre Nanyang Environment and Water Research InstituteNanyang Technological University1 Cleantech LoopSingapore637141Singapore

This study presents a numerical model for the thermal-elastohydrodynamic lubrication of heterogeneous materials in impact motion,in which a rigid ball bounces on a starved non-Newtonian oil-covered plane surface of an elastic semi-infinite heterogeneous solid with inhomogeneous *** impact–rebound process and the microscopic response of the subsurface inhomogeneous inclusions are *** inclusions are homogenized according to Eshelby’s equivalent inclusion *** Elrod algorithm is adopted to determine the lubrication starvation based on the solutions of pressure and film thickness,while the lubricant velocity and shear rate of the non-Newtonian lubricant are derived by using the separation flow *** dynamic response of the cases subjected to constant impact mass,momentum,and energy is discussed to reveal the influence of the initial drop height on the impact–rebound *** results imply that the inclusion disturbs the subsurface stress field and affects the dynamic response of the contact system when the surface pressure is *** impact energy is the decisive factor for the stress peak,maximum hydrodynamic force,and restitution coefficient,while the dynamic response during the early approaching process is controlled by the drop height.

关键词： Thermal-elastohydrodynamic lubrication Impact motion Lubrication starvation Non-Newtonian behaviour Inhomogeneous inclusion