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Expert Consensus on the Treat-to-Target Strategy for Psoriasis With Biological Agents in China(Simplified Edition)

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International Journal of Dermatology and Venereology 2024年第2期7卷 61-69页

作者： Ai-Jun Chen Da-Xing Cai xiang Chen yong Cui Yan Ding Heng Gu Xing-Hua Gao Chao Ji xiao-Jing Kang Ye-Hong Kuang Cheng-Zhi Lyu Min Li Wei Li xia Li Yu-Zhen Li xiao-yong Man Jian-Jun Qiao Juan Su Liang-Dan Sun Yu-Ling Shi Juan Tao Jian-Xin xia Rong xiao Bin Yang Wu Zhu Xue-Jun Zhang Committee on Psoriasis Dermatology and Venereology Branch of the Chinese Medical Association Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Dermatology Qilu HospitalShandong UniversityJinanShandong 250100China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology China-Japan Friendship HospitalBeijing 100192China Department of Dermatology Hainan Provincial Hospital of Skin DiseaseHaikouHainan 570311China Department of Dermatology Hospital for Skin DiseasesChinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110002China Department of Dermatology The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uyghur Autonomous Region 830001China Department of Dermatology Dalian Dermatosis HospitalDalianLiaoning 116021China Department of Dermatology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhouJiangsu 215127China Department of Dermatology West China Hospital of Sichuan UniversityChengduSichuan 610044China Department of Dermatology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Dermatology Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200093China Department of Dermatology The Union Hospital of Tongji Medical CollegeHuazhong University of Science and Te

Psoriasis is a chronic,recurrent,inflammatory systemic disease that is not only characterized by skin manifestations but may also be accompanied by various comorbidities,imposing a heavy burden on patients’physical and mental health and affecting their quality of *** the continuous approval of various biological agents for clinical use has provided more effective treatment options to patients with psoriasis,no consensus on the evaluation of comprehensive treatment goals has yet been *** treat-to-target(T2T)strategy requires consideration of multiple dimensions of treatment outcomes,the development of long-term management goals,and regular assessments of treatment conditions,which are often used in the management of chronic ***,based on the latest consensuses and guidelines,research data,and clinical experience as well as the combination of survey results and expert group discussions,the present consensus focuses on 4 dimensions of short-and long-term integrated management goals for biological agents:alleviating skin lesions,improving quality of life,screening and managing psoriasis comorbidities,and ensuring drug *** implementation methods,evaluation time,treatment monitoring,and program adjustments are also herein described to achieve comprehensive management of psoriasis to the maximum *** consensus provides a reference for clinical practice.

关键词： psoriasis biological agents treat-to-target comorbidity consensus

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不同衣藻光合作用响应汞胁迫的比较研究

水生生物学报 2024年第6期48卷 1040-1050页

作者：夏亦雪艾晓寒朱飞霞毕永红中国科学院水生生物研究所淡水生态与生物技术国家重点试验室武汉430072 中国科学院大学北京100049 大连海洋大学水产与生命学院大连116023

为筛选耐受汞胁迫的衣藻(Chlamydomonas reinhardtii)藻株,研究不同衣藻光合作用过程响应汞胁迫的差异,比较了不同汞浓度下11株衣藻的生长、叶绿素a含量及叶绿素荧光活性。结果表明,随着汞离子浓度升高,叶绿素a含量显著下降且生长受抑制... 详细信息

为筛选耐受汞胁迫的衣藻(Chlamydomonas reinhardtii)藻株,研究不同衣藻光合作用过程响应汞胁迫的差异,比较了不同汞浓度下11株衣藻的生长、叶绿素a含量及叶绿素荧光活性。结果表明,随着汞离子浓度升高,叶绿素a含量显著下降且生长受抑制,叶绿素荧光活性参数W_(k)、V_(j)和M_(o)快速增加,ψ_(o)和φEo快速下降,表明光合系统Ⅱ(PSⅡ)反应中心的供体侧和受体侧的电子传递受阻,光合活性被抑制。在11株衣藻中,衣藻FACHB-889(EC_(50)为0.762 mg/L)对汞耐受能力最弱,衣藻FACHB-2217对汞耐受能力最强(EC_(50)为2.848 mg/L)。与对照相比,在低浓度汞(1.0 mg/L)胁迫下,衣藻FACHB-889光合活性受抑制,单位面积活性反应中心数量(RC/CS_(o))显著下降(P<0.05),单位活性反应中心吸收的能量(ABS/RC)持续增加,单位反应中心耗散的能量(DIo/RC)和单位反应中心捕获的用于电子传递的能量(ET_(o)/RC)呈下降趋势,表明吸收的能量不能被光合作用有效利用,且无法通过热耗散释放,导致能量的非正常积累,使细胞失活甚至死亡;衣藻FACHB-2217单位活性反应中心吸收的能量(ABS/RC)、用于还原Q_(A)的能量(TR_(o)/RC)及用于电子传递的能量(ET_(o)/RC)均显著升高,细胞通过有活性的单位反应中心光合能力的增强,有效转化吸收的能量,消除部分反应中心失活的负面影响。研究表明,光合活性及其能量分配的差异是衣藻对汞敏感/耐受的重要原因。

关键词：汞光系统Ⅱ 毒性效应衣藻

海底泥浆举升钻井系统钻遇天然气水合物时的动态风险分析

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安全与环境学报 2024年第2期24卷 479-487页

作者：王川陈秋帆夏勇西南石油大学机电工程学院成都610500 中国船舶集团海装风电股份有限公司重庆401123

海底泥浆举升钻井(Subsea Mud Lift Drilling,SMD)系统属于双梯度钻井系统。在钻井过程中遇到天然气水合物层(Natural Gas Hydrate,NGH)时,NGH的分解和二次生成造成了重大的风险。为了预测风险事故,对环境因素和设备因素进行了分析。首... 详细信息

海底泥浆举升钻井(Subsea Mud Lift Drilling,SMD)系统属于双梯度钻井系统。在钻井过程中遇到天然气水合物层(Natural Gas Hydrate,NGH)时,NGH的分解和二次生成造成了重大的风险。为了预测风险事故,对环境因素和设备因素进行了分析。首先,在建立蝴蝶结模型后,利用映射算法将其转化为贝叶斯网络(Bayesian Networks,BN);其次,考虑不确定性影响,在BN中进行不确定性建模;然后,考虑设备因素的动态不确定性,通过转移概率矩阵将建立的BN转化为不确定性动态贝叶斯网络(Uncertain Dynamic Bayesian Networks,UDBN)。此外,还利用模糊理论和专家判断来量化设备故障的先验概率。结果表明,钻遇NGH层时,钻井风险概率比正常工况下有所增加。由于有天然气水合物的影响,发生风险的概率也变得具有不确定性。

关键词：安全工程不确定性动态贝叶斯网络海底泥浆举升钻井钻井风险天然气水合物

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流域生态补偿试点的经济效益

世界经济 2024年第5期47卷 64-95页

作者：夏勇钟茂初寇冬雪南京财经大学国际经贸学院南开大学经济学院中国信息通信研究院政策与经济研究所

本文基于中国流域生态补偿试点分期分批次渐进推行的典型事实,手动匹配2007-2018年全国148个交界断面水质监测点数据与县域经济数据,采用多期双重差分方法剖析了试点对受偿地区所获经济效益的影响及其作用机制。研究发现,试点通过增加... 详细信息

本文基于中国流域生态补偿试点分期分批次渐进推行的典型事实,手动匹配2007-2018年全国148个交界断面水质监测点数据与县域经济数据,采用多期双重差分方法剖析了试点对受偿地区所获经济效益的影响及其作用机制。研究发现,试点通过增加就业数量和改善就业结构助力居民增收并促进共同富裕,但试点效果因政策选择偏向而呈现出单向生态补偿“益乡不益城”、双向生态补偿“益乡更益城”、纵向生态补偿“益城不益乡”的特征。在政策变迁的过程中,纵向转单向生态补偿的政策效果由初始的“益城不益乡”恶化为“既不益乡也不益城”,但纵向转双向生态补偿和单向转双向生态补偿两项政策变迁均由既有效果转变为“益乡更益城”效果。

关键词：双向生态补偿共同富裕政策变迁多期双重差分

A Retrospective Investigation of a Case of Dual Infection by Avian-Origin Influenza A(H10N5)and Seasonal Influenza A(H3N2)Viruses-Anhui Province,China,December 2023-January 2024

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China CDC weekly 2024年第25期6卷 605-613页

作者： Jun He Lei Gong xiaolong Chen Deman Cheng Sai Hou Mengyao Kong Xun Wei Junling Yu Qian Zhu Weiwei Li Wanhang Lu Yujie Feng Hongya Gui Weixi Fang Peng Wang Yidan xia yong Sun Wanrong Luo Yun Yang Guowei Shen Hui Wang Jiabing Wu Anhui Provincial Center for Disease Control and Prevention Hefei CityAnhui ProvinceChina School of Public Health Bengbu Medical UniversityBengbu CityAnhui ProvinceChina Public Health Research Institute of Anhui Province Hefei CityAnhui ProvinceChina School of Public Health Anhui Medical UniversityHefei CityAnhui ProvinceChina Xuancheng City Center for Disease Control and Prevention Xuancheng CityAnhui ProvinceChina Guangde City Center for Disease Control and Prevention Guangde CityAnhui ProvinceChina

Summary What is known about this topic?H10 avian influenza viruses circulate in wild birds and can reassort with other subtypes.H10N8 and H10N3 have previously caused sporadic human infections in *** is added by this report?This report documents the first human case of coinfection with avian-origin H10N5 and seasonal H3N2 influenza *** investigations identified H10N5 in environmental samples linked to the patient,but no transmission to close contacts *** are the implications for public health practice?Enhanced surveillance of avian influenza in live poultry markets and poultry populations is crucial for thoroughly characterizing the epidemiology,transmission,and pathogenesis of H10N5 *** assessments of outbreak control measures is essential to guide effective management.

关键词： poultry Anhui thoroughly

基于神经网络和GIS的耕地土壤铊含量分布及其驱动因素

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中国环境科学 2024年第1期44卷 269-277页

作者：张云霞郭朝晖肖顺勇谢慧民肖细元李长周中南大学冶金与环境学院湖南长沙410083 湖南省生态环境农村工作站湖南长沙410014

采用多元统计、GIS和神经网络相结合的方法研究了耕地土壤Tl含量的空间分布格局及其主要驱动因素.结果表明,研究区耕地土壤Tl环境质量较好.研究区耕地土壤Tl含量范围为0.01~7.33mg/kg,算术平均值(0.91±0.40)mg/kg,超过湖南省土壤Tl含... 详细信息

采用多元统计、GIS和神经网络相结合的方法研究了耕地土壤Tl含量的空间分布格局及其主要驱动因素.结果表明,研究区耕地土壤Tl环境质量较好.研究区耕地土壤Tl含量范围为0.01~7.33mg/kg,算术平均值(0.91±0.40)mg/kg,超过湖南省土壤Tl含量背景值(0.61mg/kg),耕地Tl含量累积特征明显,但明显低于2017年全国农用地土壤污染状况详查工作中土壤Tl含量评价参考值(1.0mg/kg).耕地土壤中Tl含量流域分布特征明显,耕地土壤Tl含量呈现“东高西低,南高北低”趋势,高值聚类区主要分布湘江流域南部地区和武水流域.武水流域耕地土壤Tl含量算术均值达到1.10mg/kg,存在潜在污染风险.研究区耕地土壤Tl含量积累和分布格局受水力、工业活动和自然因素的综合影响.高海拔和水网密度区耕地土壤Tl累积明显.黄棕壤的土壤Tl含量显著高于其他类型土壤.

关键词： Tl 耕地土壤空间分布流域特征驱动因素

以数量为基准的橡胶粒子粒径多样性及年度变化研究

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热带作物学报 2024年第1期45卷 154-161页

作者：王越桂涌胡彦师周世俊曾霞中国热带农业科学院橡胶研究所海南海口571101 云南农业大学热带作物学院云南普洱665099 国家橡胶种质资源圃海南儋州571737

橡胶粒子是胶乳中的重要组分,对胶乳稳定性、橡胶生物合成和加工性能等方面具有重要影响,但橡胶粒子的大小和分布在不同种质间的差异及其年变化尚无系统研究。本研究以国家橡胶种质资源圃种植的486份巴西橡胶野生种和栽培种为研究对象,... 详细信息

橡胶粒子是胶乳中的重要组分,对胶乳稳定性、橡胶生物合成和加工性能等方面具有重要影响,但橡胶粒子的大小和分布在不同种质间的差异及其年变化尚无系统研究。本研究以国家橡胶种质资源圃种植的486份巴西橡胶野生种和栽培种为研究对象,于2020—2021年割胶期间每月采割胶乳,应用激光散射粒度分布分析仪,对橡胶粒子平均径(Da)、中径(Di)、中径/平均径(Di/Da)、粒径≤0.259μm的橡胶粒子频度、粒径≤0.197μm的橡胶粒子频度进行分析研究。结果表明:(1)不同种质Da范围为0.313~0.439μm,变异系数为0.008~0.206;Di范围为0.209~0.366μm,变异系数为0.009~0.235;Di/Da为58.3%~84.9%,变异系数为0.015~0.123;粒径≤0.259μm的橡胶粒子频度范围为31.1%~61.8%,变异系数为0.013~0.322;粒径≤0.197μm的橡胶粒子频度范围为17.6%~46.4%,变异系数为0.018~0.588,且5项指标在不同种质间均达到极显著差异,适宜作为胶乳特性指标。(2)对5项指标进行相关性分析表明,Di与Da的相关系数为0.781;粒径≤0.259μm的橡胶粒子频度与粒径≤0.197μm的橡胶粒子频度的相关系数为0.976;相比Da,Di与Di/Da的相关性更大,相关系数达0.814;相比Da,Di与粒径≤0.259μm的橡胶粒子频度和粒径≤0.197μm的橡胶粒子频度也更为相关,相关系数分别为-0.520和-0.632,表明Di具有更强的统计学意义。(3)对Da、Di、Di/Da指标年变化研究结果表明,各月份间存在一定差异,Da在6—8月、10月、12月差异不显著,9月和11月稍低于其他月份;Di在6—9月、11月、12月间差异不显著,10月份稍低于其他月份;Di/Da在6月、8月和9月之间差异不显著,11月和12月上升,7月和10月明显下降。(4)Da、Di、Di/Da、粒径≤0.259μm的橡胶粒子频度、粒径≤0.197μm的橡胶粒子频度各月的测定值与年平均值均呈显著相关,隔月测定3次(6月、8月、10月,7月、9月、11月,8月、10月、12月)与全年平均值相关系数均达0.850以上,可供未来橡胶粒子粒径测试采用。

关键词：橡胶粒子粒径年变化

Achievements and challenges of primate conservation in China

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Zoological Research(Diversity and Conservation) 2024年第1期1卷 66-74页

作者： Bao-Guo Li He Zhang Ming Li Xue-Long Jiang Peng-Fei Fan Jiang zhou Song-Tao Guo xiao-Guang Qi Jin-Hua Li Ji-Qi Lu Dong-Po xia Liang-Wei Cui Zuo-Fu xiang Qi-Hai zhou Zhi-Pang Huang Cheng-Ming Huang Wen xiao Hui-Jian Hu Zhi-Xin zhou Ming-yong Chen Da-yong Li Peng-Lai Fan Yin Yang Ru-Liang Pan Shaanxi Key Laboratory for Animal Conservation College of Life SciencesNorthwest UniversityXi’anShaanxi 710069China Jiangxi Provincial Key Laboratory of Conservation Biology College of ForestryJiangxi Agricultural UniversityNanchangJiangxi 330045China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China School of Karst Science Guizhou Normal UniversityGuiyangGuizhou 550025China International Collaborative Research Center for Huangshan Biodiversity and Tibetan Macaque Behavioral Ecology Anhui UniversityHefeiAnhui 230601China Institute of Biodiversity and Ecology Zhengzhou UniversityZhengzhouHenan 450001China Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunmingYunnan 650224China College of Life Sciences and Technology Central South University of Forestry and TechnologyChangshaHunan 410004China Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Ministry of Education) Guangxi Normal UniversityGuilinGuangxi 541004China International Centre of Biodiversity and Primate Conservation Centre Dali UniversityDaliYunnan 671003China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Institute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510663China School of Life Sciences Yunnan UniversityKunmingYunnan 650500China Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchongSichuan 637001China Institute of International Rivers and Eco-security Yunnan UniversityKunmingYunnan 650500China School of Human Sciences The University of Western AustraliaPerthWA 6009Australia

The dual impact of climate change and human activities has precipitated a sharp decline in primate biodiversity *** is home to the most diverse primate species in the Northern hemisphere,which face severe ecological threats due to the expansion of modern agriculture,extensive exploitation and consumption of natural resources,and excessive land development during its transition from an agricultural to a modern *** response,China has implemented various ecological conservation measures,including habitat restoration and *** efforts have made substantial strides in biodiversity conservation,with certain regions witnessing an increase in primate *** the current study,we conducted a systematic review of historical documents and field research data related to Chinese primates,evaluating the endangered status of primate species in *** improvements in the habitats of most primate species and some population growth,many species still face severe threats,including declining and small *** such as the Myanmar snub-nosed monkey(Rhinopithecus strykeri),eastern black crested gibbon(Nomascus nasutus),and Hainan gibbon(***)remain particularly vulnerable due to their limited distribution ranges and extremely small *** scientific data,fragmented information,and not enough studies in conservation biology further compound the ***,there is a notable lack of detailed population monitoring data for species such as the Bengal slow loris(Nycticebus bengalensis),pygmy slow loris(***),Indochinese gray langur(Trachypithecus crepusculus),Shortridge’s langur(***),and capped langur(***),which hinders the development of practical and targeted conservation management ***,for national biodiversity conservation,there is an urgent need for specialized primate surveys,enhancing habitat protection and restoration,and increasing focus on cross-border conse

关键词： Primates Biodiversity Habitat fragmentation Habitat restoration Conservation strategies

金沙江上游叶巴滩水电站智能建设关键技术探索与应用

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四川水力发电 2024年第1期43卷 111-115,122页

作者：夏勇华电金沙江上游水电开发有限公司叶巴滩分公司四川成都610041

面对金沙江上游水电工程建设环境复杂、施工条件恶劣、生态环境脆弱等技术与管理的挑战,遵循大型水电工程科学有序开发建设的理念,致力于水电工程数字化、信息化技术与管理体系的建设,以工程结构真实工作性态的安全为目标,对工程建设中... 详细信息

面对金沙江上游水电工程建设环境复杂、施工条件恶劣、生态环境脆弱等技术与管理的挑战,遵循大型水电工程科学有序开发建设的理念,致力于水电工程数字化、信息化技术与管理体系的建设,以工程结构真实工作性态的安全为目标,对工程建设中的资源要素、管理程序、结构性态、进度计划进行实时动态分析和耦合仿真预测。笔者以叶巴滩水电站工程智能建设为例,运用当前最新科技和管理方法进行了探索与实践,有效解决了设计、施工和管理等难题,为引领精品工程创建提供参考价值。

关键词：水电站智能建设数字化信息化