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Utility of TPP-manufactured biophysical restrictions to probe multiscale cellular dynamics

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Bio-Design and Manufacturing 2021年第4期4卷 776-789页

作者： Panyu Fei Haibo Ding Yu Duan Xinyi wang Wei Hu Peng Wu Mengxiao Wei Zhengchun Peng zhongze Gu Wei Chen Department of Cardiology of the Second Affiliated Hospital and Department of Cell Biology Zhejiang University School of MedicineHangzhou 310058China School of Mechanical Engineering Zhejiang UniversityHangzhou 310027China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Center for Stretchable Electronics and Nano Sensors College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Department of Cardiology of the Second Affiliated Hospital and Department of Biochemistry Zhejiang University School of MedicineHangzhou 310058China

Biophysical restrictions regulate protein diffusion,nucleus deformation,and cell migration,which are all universal and important processes for cells to perform their biological ***,current technologies addressing these multiscale questions are extremely ***,through two-photon polymerization(TPP),we present the precise,low-cost,and multiscale microstructures(micro-fences)as a versatile investigating *** nanometer-scale printing resolution and multiscale scanning capacity,TPP is capable of generating micro-fences with sizes of 0.5-1000μ*** micro-fences are utilized as biophysical restrictions to determine the fluidity of supported lipid bilayers(SLB),to investigate the restricted diffusion of Src family kinase protein Lck on SLB,and also to reveal the mechanical bending of cell nucleus and T cell climbing *** together,the proposed versatile and low-cost micro-fences have great potential in probing the restricted dynamics of molecules,organelles,and cells to understand the basics of physical biology.

关键词： Micro-fence Multiscale Protein diffusion Nucleus mechanical bending Cell-climbing ability

Cost-Effective Fiber Multiplexing System Based on Low Coherence Interferometers and Application to Temperature Measurement

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Photonic Sensors 2016年第4期6卷 318-323页

作者： Meng JIANG zhongze ZHAO Kun LI Zeming wang Yage ZHAN Hongying ZHOU Fu YANG College of Science Donghua University of China Shanghai 201620 China

Based on the low-coherence interferometric principles, a cost-effective all-fiber Mach-Zehnder multiplexing system is proposed and demonstrated. The system consists of two interferometers： sensing interferometer and demodulation interferometer. By scanning an optical tunable delay line back and forth constantly with a stable speed, sensing fibers with different optical paths can be temporal interrogated. The system is experimentally proved to have a high performance with a good stability and low system noises. The multiplexing capacity of the system is also investigated. An experiment of measuring the surrounding temperature is carried out. A sensitivity of 12 gm/℃ is achieved within the range of 20 ℃ to 80 ℃. This low cost fiber multiplexing system has a potential application in the remote monitoring of temperature and strain in building structures, such as bridges and towers.

关键词： Mach-Zehnder interferometer low-coherence multiplexing fiber system

A Hf0.5Zr0.5O2 ferroelectric capacitor-based half-destructive read scheme for computing-in-memory

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Science China(Information Sciences) 2023年第5期66卷 303-304页

作者： Yulin ZHAO Yuan wang Donglin ZHANG zhongze HAN Qiao HU Xuanzhi LIU Qingting DING Jinhui CHENG Wenjun ZHANG Yue CAO Ruixi ZHOU Qing LUO Jianguo YANG Hangbing LV Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Microelectronics University of Science and Technology of China Zhejiang Lab

The emerging non-volatile memories (NVMs), including resistive random access memory (RRAM)[1], phase-change memory (PCM)[2], and ferroelectric random access memory (Fe RAM)[3], have broad application prospects owing to their non-volatility and near-zero static energy consumption. Compared to other NVMs, ferroelectric capacitors(Fe CAPs) ofer advantages in energy consumption and endurance. However, the destructive read operation of capacitors (e.g., DRAMs and Fe CAPs) destroys the stored data.

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Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury

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Bioactive Materials 2023年第7期25卷 766-782页

作者： Ning Ran Wenxiang Li Renjie Zhang Caorui Lin Jianping Zhang Zhijian Wei Zonghao Li zhongze Yuan Min wang Baoyou Fan Wenyuan Shen Xueying Li Hengxing Zhou Xue Yao Xiaohong Kong Shiqing Feng Orthopedic Research Center of Shandong University&Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinanShandongChina Department of Orthopedics Qilu Hospital of Shandong UniversityJinanShandongChina Tianjin Key Laboratory of Spine and Spinal Cord National Spinal Cord Injury International Cooperation BaseDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina Fujian Key Laboratory of Laboratory Medicine The First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Laboratory of Medical Molecular Virology School of MedicineNankai UniversityTianjinChina Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Tianjin Lung Cancer InstituteTianjin Medical University General HospitalTianjinChina

Spinal cord injury(SCI)causes motor,sensory and automatic impairment due to rarely axon *** effective treatment for SCI in the clinic is extremely challenging because of the restrictive axonal regenerative ability and disconnection of neural elements after injury,as well as the limited systemic drug delivery efficiency caused by blood spinal cord *** develop an effective non-invasive treatment strategy for SCI in clinic,we generated an autologous plasma exosome(AP-EXO)based biological scaffold where AP-EXO was loaded with neuron targeting peptide(RVG)and growth-facilitating peptides(ILP and ISP).This scaffold can be targeted delivered to neurons in the injured area and elicit robust axon regrowth across the lesion core to the levels over 30-fold greater than naïve treatment,thus reestablish the intraspinal circuits and promote motor functional recovery after spinal cord injury in *** importantly,in ex vivo,human plasma exosomes(HP-EXO)loaded with combinatory peptides of RVG,ILP and ISP showed safety and no liver and kidney toxicity in the application to nude SCI *** the efficacy and safety,the AP-EXO-based personalized treatment confers functional recovery after SCI and showed immense promising in biomedical applications in treating *** is helpful to expand the application of combinatory peptides and human plasma derived autologous exosomes in promoting regeneration and recovery upon SCI treatment.

关键词： Spinal cord injury Targeted repair Autologous plasma exosome Drug loading Axon regeneration

Integral 2-Order Sliding Mode Control for Servo Turntable Based on Extended State Observer

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Integral 2-Order Sliding Mode Control for Servo Turntable Ba...

第37届中国控制会议

作者： zhongze Cai Qingshuang Zeng Guhao Sun Zhenhuan wang Space Control and Inertial Technology Research Center Harbin Institute of Technology

This paper investigates a globally robust and globally finite-time convergent controller for a servo turntable *** control method is formulated by using a 2-order sliding mode control（SMC） with integral sliding surface applying to an auxiliary system. To eliminate the need of advanced information, extended state observer（ESO） is applied. The proposed controller in this paper is based on geometric homogeneity approach which can ensure finite-time convergence. The finitetime stability and convergence of ESO and controller are analysed based on both the Lyapunov stability theory and negative homogeneity approach. To illustrate the effectiveness of the proposed results in this work, simulations and comparisons are shown for the angle position tracking of servo turntable system.

关键词： Servo Turntable 2-order SMC ESO Geometric Homogeneity Control Integral Sliding Surface

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中国宏观健康生产函数:理论与实证

南开经济研究 2007年第2期 20-42页

作者：王俊昌忠泽中央财经大学财政学院中央财经大学财经研究所

本文从宏观上构造了中国健康生产函数并对其进行检验。健康生产函数的单因素分析表明,人均GDP对健康的贡献有限,表现出很强的时滞性和对其他变量的依赖性。全因素分析表明,改革开放后,健康的影响因素发生了深刻的变化:(1)经济因素对健... 详细信息

本文从宏观上构造了中国健康生产函数并对其进行检验。健康生产函数的单因素分析表明,人均GDP对健康的贡献有限,表现出很强的时滞性和对其他变量的依赖性。全因素分析表明,改革开放后,健康的影响因素发生了深刻的变化:(1)经济因素对健康具有促进作用;(2)社会因素中,城市化率提高促进了健康的改善,女性比例的提高反而降低了健康水平;(3)卫生因素中,医生和门诊的增加引起健康水平总体下降,而病床数起到了改善健康的作用,疾病预防对健康正贡献的时滞性减弱;(4)教育因素对健康的促进作用明显;(5)生活因素对健康表现出一定的负贡献。

关键词：健康 Grossman模型健康生产函数因素分析

去工业化、经济增长与区域协调发展——基于土地资源错配的视角

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经济理论与经济管理 2023年第1期43卷 30-43页

作者：冯扬昌忠泽王洋中国社会科学院社会发展战略研究院 100732 中央财经大学财经研究院中央财经大学经济学院

针对我国近年来的“去工业化”现象,本文通过280座城市的面板数据,以及城市地形和省级审批建设用地占比构造的工具变量,从土地资源错配视角考察了去工业化对经济增长和区域协调发展的影响。实证结果发现,在当前经济发展阶段工业化对经... 详细信息

针对我国近年来的“去工业化”现象,本文通过280座城市的面板数据,以及城市地形和省级审批建设用地占比构造的工具变量,从土地资源错配视角考察了去工业化对经济增长和区域协调发展的影响。实证结果发现,在当前经济发展阶段工业化对经济增长仍然具有显著的积极影响,过快、过早地去工业化不利于保持经济持续增长和实现区域协调发展,而土地资源在地区间和部门间的双重错配是导致我国出现过早去工业化的重要原因。进一步的分析表明,较高的城镇化水平以及发达的生产性服务业有助于增强工业化对经济增长的推动效应。本文为新时期保持制造业比重基本稳定,推动我国经济持续稳定增长,推进区域协调发展以及促进土地资源优化配置提供了经验证据。

关键词：去工业化经济增长区域协调发展土地资源错配

All-optical generation,detection,and manipulation of picosecond acoustic pulses in 2D semiconductor/dielectric heterostructures

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Photonics Research 2023年第12期11卷 2000-2010页

作者： WENXIONG XU YUANYUAN LI QIANNAN CUI HE ZHANG CHUANSHENG XIA HAO GUO GUANGQUAN ZHOU JIANHUA CHANG HUI ZHAO JUN wang zhongze GU CHUNXIANG XU State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Electronic and Information Engineering Nanjing University of Information Science and TechnologyNanjing 210044China Department of Physics and Astronomy The University of KansasLawrenceKansas 66045USA Laboratory of Micro-Nano Optoelectronic Materials and Devices Key Laboratory of Materials for High-Power LaserShanghai Institute of Opticsand Fine MechanicsChinese Academy of SciencesShanghai 201800China

Launching,tracking,and controlling picosecond acoustic(PA)pulses are fundamentally important for the construction of ultrafast hypersonic wave sources,ultrafast manipulation of matter,and spatiotemporal imaging of ***,we show that GHz PA pulses can be all-optically generated,detected,and manipulated in a 2D layered MoS_(2)∕glass heterostructure using femtosecond laser *** on an interferometric model,PA pulse signals in glass are successfully decoupled from the coexisting temperature and photocarrier relaxation and coherent acoustic phonon(CAP)oscillation signals of MoS_(2)lattice in both time and frequency *** selective interface excitations,temperature-mediated interfacial phonon scatterings can compress PA pulse widths by about 50%.By increasing the pump fluences,anharmonic CAP oscillations of MoS_(2)lattice are *** a result,the increased interatomic distance at the MoS_(2)∕glass interface that reduces interfacial energy couplings can markedly broaden the PA pulse widths by about 150%.Our results open new avenues to obtain controllable PA pulses in 2D semiconductor/dielectric heterostructures with femtosecond laser pump-probe,which will enable many investigations and applications.

关键词： pump heterostructure scattering

Cu-Cr-Zr合金高温疲劳性能及组织演变特征

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稀有金属 2022年第11期46卷 1407-1413页

作者：王庆娟王磊杜忠泽王伟张筱雯西安建筑科技大学冶金工程学院陕西西安710055

研究了不同温度下铜铬锆(Cu-Cr-Zr)合金的高周疲劳行为,利用扫描电镜(SEM)和透射电镜(TEM)分析了析出相与位错之间的交互作用和断口附近的组织特征。结果表明Cu-Cr-Zr合金的抗拉强度随温度的升高而降低,在室温(RT)、300和400℃下分别为3... 详细信息

研究了不同温度下铜铬锆(Cu-Cr-Zr)合金的高周疲劳行为,利用扫描电镜(SEM)和透射电镜(TEM)分析了析出相与位错之间的交互作用和断口附近的组织特征。结果表明Cu-Cr-Zr合金的抗拉强度随温度的升高而降低,在室温(RT)、300和400℃下分别为363.3,309.7和263.4 MPa。在1×106循环周次下,固溶时效Cu-Cr-Zr合金的疲劳强度极限随温度的升高而降低,室温疲劳极限为318 MPa;300℃时为240MPa,相较于室温降低了24.5%;400℃下的疲劳强度极限降低到220 MPa,相比于室温降低了27.5%。疲劳断口组织特征表明,裂纹主要在材料的表面萌生并向内扩展。随试验温度的升高,疲劳断裂的典型3个区域中,裂纹扩展区减小,瞬断区所占比例增加。随温度升高,Cu-CrZr合金开始发生动态再结晶,造成位错的重新分布和湮灭,位错迁移率增快,纳米析出相长大,对位错的“钉扎”阻碍作用减弱,位错密度下降,致疲劳强度降低,位错嵌入析出相之间的界面,易于形成微孔洞和裂纹,孔洞连接裂纹扩展,并最终断裂。

关键词：铜铬锆(Cu-Cr-Zr)合金高周疲劳循环软化析出相位错塞积