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Rice Bran-derived Peptide KF-8 Attenuates Dexamethasone-induced Myopathy in Caenorhabditis elegans by Regulating Locomotion-related Genes

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Food Science and Human Wellness 2024年

作者： Yixin Wu Jianqiang Wang Fang Huang Yajuan chen Qinlu Lin zhongxu chen Zhigang Liu Yao Jiang Wenqing Xie Hengzhen Li Yusheng Li Ying Liang National Clinical Research Center for Geriatric Disorders， Xiangya Hospital， Central South University Molecular Nutrition Branch， National Engineering Research Center of Rice and By-product Deep Processing， College of Food Science and Engineering， Central South University of Forestry and Technology Laboratory of Functional Chemistry and Nutrition of Food， College of Food Science and Engineering， Northwest A&F University The Key Lab of Non-wood Forest Cultivation and Protection of Education Ministry， The Key Lab of Non-wood Forest Products of Forestry Ministry， Forestry Institute， Central South University of Forestry & Technology Department of Orthopedics， Xiangya Hospital， Central South University

Background and aims: Dexamethasone is a common glucocorticoid medication with adverse effects that can cause muscle atrophy， but no drug intervention has been approved or recommended for this condition. KF-8 is a rice bran-derived anti-oxidant peptide that extends the life span of Caenorhabditis elegans. Methods: We established a C. elegans model of dexamethasone-induced myopathy to evaluate the potential therapeutic effects of KF-8 in this model. C. elegans muscle function was assessed in terms of locomotory behaviors including crawling， swimming， burrowing， pharyngeal pumping， and head swing. Muscle actin filament integrity was evaluated using fluorescence imaging. The molecular mechanisms of KF-8 were investigated using transcriptome sequencing， qRT-PCR， RNA interference， and western blot analysis. Results: Dexamethasone disrupted actin filaments in the striated muscles of the body wall and inhibited C. elegans crawling， swimming， burrowing， pharyngeal pumping， and head swing. KF-8 reversed the actin filament disruption and locomotor dysfunction induced by dexamethasone. Transcriptome sequencing， pathway enrichment， and qRT-PCR analyses revealed that KF-8 regulated the locomotion-related genes W04G5.10， vha-12， and ddr-1， as well as age-1 (the catalytic subunit ortholog of PI3K)， and akt1. RNA interference， conducted using a genetically engineered E. coli HT115 strain as a food source， confirmed age-1 as a key regulator of locomotor function of C. elegans. Further mechanistic studies with C2C12 myotubes showed that KF-8 regulated the IRS-PI3K-Akt pathway， the master regulator of protein synthesis and degradation. Conclusion: Together， these findings suggest that KF-8 protects against dexamethasone-induced myopathy in C. elegans by regulating locomotion-related genes and the IRS-PI3K-Akt pathway.

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Systematic identification of wheat spike developmental regulators by integrated multiomics, transcriptional network, GWAS, and genetic analyses

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Molecular Plant 2024年第3期17卷 438-459页

作者： Xuelei Lin Yongxin Xu Dongzhi Wang Yiman Yang Xiaoyu Zhang Xiaomin Bie Lixuan Gui zhongxu chen Yiliang Ding Long Mao Xueyong Zhang Fei Lu Xiansheng Zhang Cristobal Uauyo Xiangdong Fu Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Nanjing Agricultural University NanjingJiangsu 210095China Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTaianShandong 271018China Department of Life Science Tcuni Inc.ChengduSichuan 610000China John Innes Centre Norwich Research ParkNorwich NR47UHUK Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyCASBeijing 100101China

The spike architecture of wheat plays a crucial role in determining grain number,making it a key trait for optimization in wheat breeding *** this study,we used a multi-omic approach to analyze the transcriptome and epigenome profiles of the young spike at eight developmental stages,revealing co-ordinated changes in chromatin accessibility and H3K27me3 abundance during the flowering *** constructed a core transcriptional regulatory network(TRN)that drives wheat spike formation and experimentally validated a multi-layer regulatorymodule involving TaSPL15,TaAGLG1,and *** integrating the TRN with genome-wide association studies,we identified 227 transcription factors,including 42 with known functions and 185 with unknown *** investigation of 61 novel transcription factors using multiple homozygous mutant lines revealed 36 transcription factors that regulate spike architecture or flowering time,such as TaMYC2-A1,TaMYB30-A1,and *** particular interest,TaMYB30-A1,downstream of and repressed by WFzP,was found to regulate fertile spikelet ***,the excellent haplotype of TaMYB30-A1,which contains a C allele at the WFzP binding site,was enriched during wheat breeding improvement in China,leading to improved agronomic ***,we constructed a free and open access Wheat Spike Multi-Omic Database(http://39.***.48.156:8800/#/).Our study identifies novel and high-confidence regulators and offers an effective strategy for dissecting the genetic basis of wheat spike development,with practical value forwheat breeding.

关键词： wheat spike development epigenome TRN TaMYB30-A1 breeding selection

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基于反向聚类法的公铁分离桥吊装施工安全风险因素评价

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铁道建筑技术 2024年第6期 118-121页

作者：陈忠旭中铁十九局集团第一工程有限公司辽宁辽阳111000

本文以公铁分离桥吊装施工为例,基于反向聚类法分别从五个方面选取二十六项典型风险因素,对公铁分离桥吊装施工安全风险因素进行评价。结果表明,秩效应最大风险因素为违章操作,其值为41.56,是影响桥梁吊装施工安全风险主要因素;对桥梁... 详细信息

本文以公铁分离桥吊装施工为例,基于反向聚类法分别从五个方面选取二十六项典型风险因素,对公铁分离桥吊装施工安全风险因素进行评价。结果表明,秩效应最大风险因素为违章操作,其值为41.56,是影响桥梁吊装施工安全风险主要因素;对桥梁吊装施工影响程度最低的是吊装安全警示标识不明显,其值为11.11。对桥梁吊装施工安全风险影响程度较高因素为第一类与第二类分析,人员、现场管理、技术方案等为影响梁桥吊装施工关键因素;低于平均水平的风险因素为第四类、第五类,主要包括环境、设备等因素。结合分析,提出桥梁吊装施工安全管理措施,包括吊机支腿作业安全管理、装吊工安全管理、施工现场联系安全管理、现场防护人员安全管理。

关键词：反向聚类法吊装施工安全风险评价

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A bipolar modified separator using TiO2 nanosheets anchored on N-doped carbon scaffold for high-performance Li–S batteries

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Journal of Materials Science & Technology 2020年第20期52卷 152-158页

作者： Na Li Fei chen Xiangtao chen zhongxu chen Yang Qi Xiaodong Li Xudong Sun Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China College of Environmental and Chemical Engineering Dalian UniversityDalian 116622China

Lithium-sulfur batteries hold promise for next generation batteries due to their high theoretical energy density and low ***,the rapid capacity fading caused by the shuttle of polysulfide between two electrodes severely hinders the practical application of Li-S *** address the issue,we reported a three-dimensional heterostructured TiO2 nanosheets/N-doped carbon(TO/NC),which is coated on a commercial polypro pylene(PP) separator,as an efficient barrier for Li-S *** TO/NC coating layer provides a bipolar chemical adsorption of lithium polysulfides(LiPSs) via TiO2 nanosheets with exposed(001) facets and N-doped carbon,showing high trapping capacity and remarkable electrocatalytic activity for *** slurry-bladed carbon black/sulfur cathode with 64 wt% sulfur offers outstanding performance with an initial capacity of 1314 mAh g^-1 at 0.2 *** 900 cycles,the cell still maintains the capacity of 448 mA h g^-1 at a 1 C rate with a degradation rate of only 0.055% per *** separator reported in this work holds great promise for the development of high-energy Li-S batteries.

关键词： Lithium-sulfur batteries N-doped carbon Separator TiO2 Nanosheets

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Recent progress in bio-inspired macrostructure array materials with special wettability—from surface engineering to functional applications

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International Journal of Extreme Manufacturing 2024年第1期6卷 208-256页

作者： zhongxu Lian Jianhui Zhou Wanfei Ren Faze chen Jinkai Xu Yanling Tian Huadong Yu School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130022People’s Republic of China Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing Changchun University of Science and TechnologyChangchun 130022People’s Republic of China College of Mechanical and Electrical Engineering Changchun University of Science and TechnologyChangchun 130022People’s Republic of China School of Mechanical Engineering Tianjin UniversityTianjin 300350People’s Republic of China School of Engineering University of WarwickCoventry CV47ALUnited Kingdom

Bio-inspired macrostructure array(MAA,size:submillimeter to millimeter scale)materials with special wettability(MAAMs-SW)have attracted significant research attention due to their outstanding performance in many applications,including oil repellency,liquid/droplet manipulation,anti-icing,heat transfer,water collection,and oil–water *** this review,we focus on recent developments in the theory,design,fabrication,and application of bio-inspired *** first review the history of the basic theory of special wettability and discuss representative structures and corresponding functions of some biological surfaces,thus setting the stage for the design and fabrication of bio-inspired *** then summarize the fabrication methods of special wetting MAAs in terms of three categories:additive manufacturing,subtractive manufacturing,and formative manufacturing,as well as their diverse functional applications,providing insights into the development of these ***,the challenges and directions of future research on bio-inspired MAAMs-SW are briefy *** efforts,progress,and breakthroughs from surface engineering to functional applications elaborated herein will promote the practical application of bio-inspired MAAMs-SW.

关键词： macrostructure arrays superhydrophobic 3D printing laser droplet manipulation

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Mo2P Monolayer as a Superior Electrocatalyst for Urea Synthesis from Nitrogen and Carbon Dioxide Fixation:A Computational Study

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Energy & Environmental Materials 2024年第1期7卷 211-218页

作者： Dongxu Jiao zhongxu Wang Yuejie Liu Qinghai Cai Jingxiang Zhao Carlos R.Cabrera Zhongfang chen College of Chemistry and Chemical Engineering and Key Laboratory of Photonic and Electronic Bandgap Materials Ministry of Education Harbin Normal University Modern Experiment Center Harbin Normal University Heilongjiang Province Collaborative Innovation Center of Cold Region Ecological Safety Department of Chemistry and Biochemistry The University of Texas at El Paso Department of Chemistry University of Puerto Rico

Urea synthesis through the simultaneous electrocatalytic reduction of N2and CO2molecules under ambient conditions holds great promises as a sustainable alternative to its industrial production,in which the development of stable,highly efficient,and highly selective catalysts to boost the chemisorption,activation,and coupling of inert N2and CO2molecules remains rather challenging.

关键词： C–N coupling density functional theory Mo2P monolayer urea synthesis

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WheatGmap:a comprehensive platform for wheat gene mapping and genomic studies

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Molecular Plant 2021年第2期14卷 187-190页

作者： Lichao Zhang Chunhao Dong zhongxu chen Lixuan Gui cheng chen Danping Li Zhencheng Xie Qiang Zhang Xueying Zhang Chuan Xia Xu Liu Xiuying Kong Jirui Wang Key Laboratory for Crop Gene Resources and Germplasm Enhancement Ministry of Agriculture and Rural Affairs/National Key Facility for Crop Gene Resources and Genetic Improvement/Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Department of Life Science TcuniInc.Chengdu 610041China

Bulked segregant analysis(BSA)is an efficient and low-cost strategy that is widely used to identify causal genes in segregating ***-based methods,such as BSA sequencing(Wenger et al.,2010),bulked segregant RNA sequencing(BSR-seq)(del Viso et al.,2012),and MutMap(Abe et al.,2012),are powerful tools that can be used for rapidly discovering genetic markers and gene *** BSA is increasingly being used in wheat(Triticum aestivum)gene mapping efforts,few user-friendly BSA tools have been developed for researchers lacking a strong bioinformatics ***,we developed the web-based BSA platform WheatGmap(https://***),which integrates multiple BSA mapping models and large amounts of public data to accelerate gene cloning and functional research and facilitate resource sharing.

关键词： aestivum Wheat comprehensive

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Driver Steering Behaviour Modelling Based on Neuromuscular Dynamics and Multi‑Task Time‑Series Transformer

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Automotive Innovation 2024年第1期7卷 45-58页

作者： Yang Xing zhongxu Hu Xiaoyu Mo Peng Hang Shujing Li Yahui Liu Yifan Zhao chen Lv School of Aerospace Transport and ManufacturingCranfield UniversityCranfield MK430ALUnited Kingdom School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore College of Transportation Engineering Tongji UniversityShanghai 200092China College of Computer Science and Technology Jilin UniversityChangchun 130012China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China

Driver steering intention prediction provides an augmented solution to the design of an onboard collaboration mechanism between human driver and intelligent *** this study,a multi-task sequential learning framework is developed to pre-dict future steering torques and steering postures based on upper limb neuromuscular electromyography *** joint representation learning for driving postures and steering intention provides an in-depth understanding and accurate modelling of driving steering *** different testing scenarios,two driving modes,namely,both-hand and single-right-hand modes,are *** each driving mode,three different driving postures are further ***,a multi-task time-series transformer network(MTS-Trans)is developed to predict the future steering torques and driving postures based on the multi-variate sequential input and the self-attention *** evaluate the multi-task learning performance and information-sharing characteristics within the network,four distinct two-branch network architectures are *** validation is conducted through a driving simulator-based experiment,encompassing 21 *** pro-posed model achieves accurate prediction results on future steering torque prediction as well as driving posture recognition for both two-hand and single-hand driving *** findings hold significant promise for the advancement of driver steering assistance systems,fostering mutual comprehension and synergy between human drivers and intelligent vehicles.

关键词： Driver steering behaviours Neuromuscular dynamics Multi-task learning Sequential transformer Intelligent vehicles

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植源肽对啮齿动物神经退行性疾病的影响

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中国食品学报 2021年第7期21卷 360-370页

作者：蔡洁崔校基唐柳欢陈忠旭梁盈中南林业科技大学稻谷及副产物深加工国家工程实验室长沙410004

神经退行性疾病是世界主要公共卫生问题之一,然而,目前缺乏治疗神经退行性疾病的有效药物,膳食营养干预是目前最受欢迎的干预手段之一。植源肽通过诸多途径在人类健康中发挥重要作用,如抗氧化、抗炎、保护神经系统等。本文综述植源肽对... 详细信息

神经退行性疾病是世界主要公共卫生问题之一,然而,目前缺乏治疗神经退行性疾病的有效药物,膳食营养干预是目前最受欢迎的干预手段之一。植源肽通过诸多途径在人类健康中发挥重要作用,如抗氧化、抗炎、保护神经系统等。本文综述植源肽对啮齿动物神经退行性疾病的作用机制,并展望其在神经退行性疾病应用中的机遇与挑战。

关键词：植源肽退行性疾病啮齿动物

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密云水库库滨带不同植被配置下面源污染特征分析

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生态环境学报 2019年第6期28卷 1183-1192页

作者：李凯程金花陈仲旭北京林业大学水土保持学院

密云水库是北京市重要地表水源地,在首都经济发展中发挥着重要作用。随着密云水库水位上涨以及库滨带工程建设,其生态环境发生了一系列变化。通过设立12个不同植被配置的野外标准径流小区,研究天然降雨条件下不同植被配置对于总氮(TN)... 详细信息

密云水库是北京市重要地表水源地,在首都经济发展中发挥着重要作用。随着密云水库水位上涨以及库滨带工程建设,其生态环境发生了一系列变化。通过设立12个不同植被配置的野外标准径流小区,研究天然降雨条件下不同植被配置对于总氮(TN)、总磷(TP)、氨氮(NH4^+-N)、化学需氧量(COD)、生物需氧量(BOD5)5个面源污染指标的影响,以期为库滨带建设提供参考数据。研究结果表明,(1)天然降雨条件下乔灌草混交小区柳树(Salix matsudana)+丁香(Syringa oblata)+蒿(Artemisia annua)的减流作用最好,平均减流作用为62.9%,减沙作用最好的是毛白杨(Populus tomentosa)+紫丁香(Syringa oblata)+葎草(Humulus scandens)小区,减沙作用为78.18%。(2)植被对于面源污染有着显著的控制效果,毛白杨+紫丁香+葎草的乔灌草配置控制效果最好,对TN、TP、NH4^+-N、COD、BOD5的削减率在77.76%-92.24%之间。(3)3次降雨条件下各植被配置小区随着时间的推移、降雨量的减少、降雨强度的减弱,TN的流失模数显著减少(P<0.05);TP流失变化较大,但总体上呈减小的趋势;同一种植被配置下NH4+-N流失模数显著减少(P<0.05);COD和BOD5下降趋势明显。在各小区随时间及降雨条件变化的面源污染控制削减纵向比较中,3次天然降雨条件下,5个面源污染指标呈递减趋势。对于TP的削减控制,油松(Pinus tabuliformis)+臭椿(Ailanthus altissima)小区最优;而其余4个指标,削减比最高的均为油松+金叶榆(Ulmus pumila)小区。由此可见此种植被配置模式对于面源污染控制的长期效益最好。

关键词：径流植被配置面源污染

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