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An Activatable Near-Infrared Molecular Chemiluminescence Probe for Visualization of NQO1 Activity In Vivo

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Chinese Journal of Chemistry 2022年第20期40卷 2400-2406页

作者： Jianyong Liu zhongxiang chen Hongqi Huo Lanlan chen Ying Wu Xuan Zhang Lichao Su Qian Li Jibin Song MOE Key Laboratory for Analytical Science of Food Safety and Biology College of ChemistryFuzhou UniversityFuzhouFujian350108 China Department of Nuclear Medicine Han Dan Central HospitalHandanHebei056001 China

Chemiluminescence(CL)is a promising tool for diagnostics and sensing due to its inherent excitation ***,most CL probes emit exclusively visible light with limited penetration depth,hindering their broad application for in vivo deep tissue *** work reports an activated unimolecular CL probe(CL-P)that emits light in the near-infrared(NIR)region allowing a superior real-time visualization and detection of NAD(P)H quinone oxidoreductase 1(NQO1)in *** NQO1-specific trimethyl-locked quinone is a lock for masking the NQO1 trigger site,and it was conjugated on the NIR Schaap's dioxetane chemiluminophore,achieving not only a subtle signal-to-noise ratio even at a depth of 15 mm in the chicken breast tissues,but also sensitively detecting the positive expression of NQO1 in A549 ***-P has been successfully used for visualizing the aberrantly expressed NQO1 in subcutaneous xenograft A549 *** our knowledge,this is the first work reporting the detection of NQO1 activity in the NIR region by unimolecular CL ***,the NQO1-activated visualization platform provides a guideline to transform a unimolecular CL sensor into a licensed imaging agent for the in vivo detection of enzyme-related diseases.

关键词： chemiluminescence imaging probe biosensor NQO1 enzyme

REGULATING THE INDUSTRIAL STRUCTURE IS AN PRINCIPAL APPROACH TO THE ENVIONMENT ADMINISTRATION IN ARID AND SEMI-ARID AREAS

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干旱区资源与环境 1993年第Z1期7卷 74-80页

作者： chen zhongxiang Geography Department, Ningxia University

1. The crux of the environment administration problem is theeconomic development As we Know that the evolution of environment is not only due to Nature itself, but al-so to human being particularly. In the course of history, the Loess Plateau in China, oncewoody and rich in plants has now become a serious soil-erosion area on which lies thou-

关键词： Industrial structure Arid and Semiarid Area Environmental control

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宁夏吊庄移民的理论分析

干旱区地理 1998年第4期21卷 22-27页

作者：陈忠祥宁夏大学银川750021

宁夏回族自治区针对南部山区的扶贫工程和北部灌区的区域开发，成功地实施了吊庄移民。本文从吊庄移民的基本指导思想、人口迁移机制、扶贫和区域开发机制入手，对其理论基础即人口迁移理论、人口与资源环境协调发展理论及区域科学理论... 详细信息

宁夏回族自治区针对南部山区的扶贫工程和北部灌区的区域开发，成功地实施了吊庄移民。本文从吊庄移民的基本指导思想、人口迁移机制、扶贫和区域开发机制入手，对其理论基础即人口迁移理论、人口与资源环境协调发展理论及区域科学理论作了比较深入的分析论述。

关键词：吊庄移民理论分析宁夏扶贫工程区域经济

硫磷化改性菜子油润滑剂的制备及其摩擦学性能

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润滑与密封 2005年第4期30卷 91-92,102页

作者：陈忠祥蒋伟锋安徽工业大学化学与化工学院安徽马鞍山243002

以菜子油为原料,甲醇为酯交换剂,并以S粉和P2O5作为改性剂,合成了一种带有极压元素硫和磷的多羟基脂肪酸(酯)极压润滑剂。在制备成2%(质量分数)左右的乳化液后,经摩擦学性能考察,结果表明:该润滑液的最大无咬卡载荷(pB)为1260N,表面磨... 详细信息

以菜子油为原料,甲醇为酯交换剂,并以S粉和P2O5作为改性剂,合成了一种带有极压元素硫和磷的多羟基脂肪酸(酯)极压润滑剂。在制备成2%(质量分数)左右的乳化液后,经摩擦学性能考察,结果表明:该润滑液的最大无咬卡载荷(pB)为1260N,表面磨斑直径(WSD)和摩擦因数(μ)的最佳值分别为0.33mm和0.039,达到并超过了资料报导的目前以油为润滑介质的国内同类产品的性能指标。

关键词：硫磷化改性菜子油乳化液润滑剂摩擦学性能

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聚乙二醇对聚醚砜微孔膜致孔作用的研究

高分子学报 2005年第4期15卷 566-570页

作者：陈忠祥张瑞丰陈珊妹宁波大学膜分离实验室宁波315211

以聚醚砜聚乙二醇溶剂为铸膜液体系、采用干湿相转化法制备微孔滤膜,研究了各种制膜条件对膜孔径结构的影响.实验发现聚乙二醇在体系中起到分散稳定的作用,只有到浓度大于70%时,才会对铸膜液的粘度产生明显影响,聚合物在铸膜液中的溶解... 详细信息

以聚醚砜聚乙二醇溶剂为铸膜液体系、采用干湿相转化法制备微孔滤膜,研究了各种制膜条件对膜孔径结构的影响.实验发现聚乙二醇在体系中起到分散稳定的作用,只有到浓度大于70%时,才会对铸膜液的粘度产生明显影响,聚合物在铸膜液中的溶解状态也随之改变,进而影响膜的结构.不同溶剂NMP、DMF、DMAc、DMSO等极性溶剂或固体溶剂己内酰胺均可制得开孔率较高的微孔膜,但对膜的结构和性能影响差别不大.在本研究体系中,膜的结构取决于聚乙二醇、溶剂的浓度比例关系.

关键词：聚乙二醇聚醚砜微孔滤膜微孔膜致孔作用极性溶剂孔径结构铸膜液相转化法实验发现

A single Amino-acid Substitution of Polygalacturonase Inhabiting Protein （OsPGIP2） Allows Rice to Acquire Higher Resistance to Sheath Blight

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A single Amino-acid Substitution of Polygalacturonase Inhabi...

中国植物病理学会2017年学术年会

作者： chen Xijun Li Lili Zhang Lina Xu Bin chen zhongxiang Zuo Shimin Xu Jingyou Horticulture and Plant Protection College Yangzhou University Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education College of AgricultureYangzhou University

A possible strategy to control plant diseases is improvement of natural plant defense mechanisms against the infection of *** one kind of leucine-rich repeat proteins,polygalacturonase inhibiting proteins（PGIPs） have been found involved in plant defense against the pathogens by inhibiting the activity of fungal endo-polygalacturonases（endo-PGs）.To dig more resistant gene,a single amino acid of the OsPGIP2,which has no effect on the endo-PGs activity of Rhizoctonia solani,was substituted and it allowed OsPGIP2 to acquire the inhibiting *** of OsPGIP2 significandy increased rice resistance to rice sheath blight and counteracted the tissue degradation caused by ***,OsPGIP2 overexpression did not affect rice agronomic traits or yield *** these indicated that OsPGIP2 was an important potential gene that could be applied to rice sheath blight resistance breeding.

关键词： Single amino acid substitution Polygalacturonase inhibiting protein Sheath blight resistance Oryzae sativa

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宁夏南部回族聚居区人口问题分析

西北人口 1995年第4期 49-55页

作者：陈忠祥宁夏大学地理系

本文实地调查分析了宁夏南部回族聚居区的人口问题,深刻剖析了问题的根源和症结所在,并立足于回民族的繁荣提出了中肯而切实的解决途径。

关键词：回族聚居区人口增长人口素质人口经济

The Status Assessment and Preliminary Risk Assessment of Total Mercury in Sediments from Middle and Lower Reaches of the Yarlung Zangbo River

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Meteorological and Environmental Research 2019年第3期10卷 84-89页

作者： Qin Dongli Li Lei Wu Song Wang Nianmin Wang Peng chen zhongxiang Ma Bo Bai Shuyan Gao Lei Heilongjiang River Fishery Research Institute Chinese Academy of Fishery SciencesHarbin 150070China Key Laboratory of Control of Quality and Safety for Aquatic Products Ministry of AgricultureBeijing 100041China

The occurrence and accumulation of total mercury (T-Hg) in sediments collected from the Yarlung Zangbo River (YLZB),the Lhasa River,the Niyang River and the Palongzangbu River were analyzed and the soil samples simultaneously collected from the bank were employed as ***,pollution status and potential ecological risk of Hg were calculated and assessed using index of geoaccumulation ( I geo ) and potential ecological risk assessment method (Er) in this *** results showed that the T-Hg concentrations in sediments at eight sections of YLZB ranged from 4.23 to 48.1 μg/kg with mean concentration of 25.1 μg/kg,which was higher than background Hg value of soils in Tibet.T-Hg concentrations in sediments at three typical segments of YLZB were all significantly higher than those in soils collected from its bank (P<0.05).The Igeo and E r indexes revealed that the T-Hg pollution levels were slight pollution in two sections and moderate ecological risk in six sections of *** pollution risks also existed in the sediments of partial sections of the Lhasa River and the Niyang River,and slightly moderate Hg contamination with high ecological risk was presented in Lhasa urban *** level of Hg in sediments of YLZB showed a notable spatial distribution characteristic with a trend of increasing firstly and then *** activities played an important role in increasing Hg content in sediments of the river.

关键词： The Yarlung Zangbo River Total mercury Sediment Index of geoaccumulation Potential ecological risk index

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考虑结合面法向刚度的拉杆转子轴向振动特性

中国机械工程 2018年第24期29卷 2954-2958页

作者：何谦王艾伦陈中祥杨俊湖南师范大学工程与设计学院长沙410081 中南大学高性能复杂制造国家重点实验室长沙410083

针对接触刚度解析模型参数确定困难、精度难以保证等问题,提出了根据弹塑性粗糙表面微体单元受力变形的有限元分析结果确定轮盘结合面法向刚度的方法;为准确获取拉杆转子的轴向振动特性,建立了考虑轮盘结合面法向刚度的集中质量动力学模... 详细信息

针对接触刚度解析模型参数确定困难、精度难以保证等问题,提出了根据弹塑性粗糙表面微体单元受力变形的有限元分析结果确定轮盘结合面法向刚度的方法;为准确获取拉杆转子的轴向振动特性,建立了考虑轮盘结合面法向刚度的集中质量动力学模型;运用上述方法和模型计算了某型实验转子轴向振动的固有频率,并将结果与实测数据进行对比,误差低于5%,证明了该方法的有效性;改变拉杆预紧力,进一步研究预紧力对拉杆转子动力学行为的影响,结果表明:拉杆预紧力对转子的作用效果存在一个饱和区域,可为拉杆预紧力数值的确定提供重要的设计依据。

关键词：拉杆转子结合面法向刚度轴向振动拉杆预紧力