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An Evaluation Method of Human Gut Microbial Homeostasis by Testing Specific Fecal Microbiota

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Engineering 2023年第10期29卷 110-119页

作者： zhongwen wu Xiaxia Pan Yin Yuan Pengcheng Lou Lorina Gordejeva Shuo Ni Xiaofei Zhu Bowen Liu Lingyun wu Lanjuan Li Bo Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Jinan Microecological Biomedicine Shandong Laboratory Jinan 250000China Research Units of Infectious Disease and Microecology Chinese Academy of Medical SciencesBeijing 100730China School of Medicine Zhejiang UniversityHangzhou 310000China Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China Department of Infectious Diseases Hangzhou Ninth People’s HospitalHangzhou 310003China Department of Radiation Oncology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Research on microecology has been carried out with broad perspectives in recent decades,which has enabled a better understanding of the gut microbiota and its roles in human health and *** is of great significance to routinely acquire the status of the human gut microbiota;however,there is no method to evaluate the gut microbiome through small amounts of fecal *** this study,we found ten predominant groups of gut bacteria that characterized the whole microbiome in the human gut from a large-sample Chinese cohort,constructed a real-time quantitative polymerase chain reaction(qPCR)method and developed a set of analytical approaches to detect these ten groups of predominant gut bacterial species with great maneuverability,efficiency,and quantitative *** ranges for the ten predominant gut bacterial groups were established,and we found that the concentration and pairwise ratios of the ten predominant gut bacterial groups varied with age,indicating gut microbial *** comparing the detection results of liver cirrhosis(LC)patients with those of healthy control subjects,differences were then analyzed,and a classification model for the two groups was built by machine *** the six established classification models,the model established by using the random forest algorithm achieved the highest area under the curve(AUC)value and sensitivity for predicting *** research enables easy,rapid,stable,and reliable testing and evaluation of the balance of the gut microbiota in the human body,which may contribute to clinical work.

关键词： Gut microbiota Machine learning Microbial dysbiosis Quantitative polymerase chain reaction Chinese cohort

Electron-impact single ionizaiton for W^(4+) and W^(5+)

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Chinese Physics B 2018年第5期27卷 172-178页

作者： Denghong Zhang Luyou Xie Jun Jiang zhongwen wu Chenzhong Dong Yinglong Shi Yizhi Qu Key Laboratory of Atomic and Molecular Physics ＆ Functional Materials of Gansu Province College of Physics and Electronic Engineering Northwest Normal University Lanzhou 730070 China Department of physics Tianshui Normal University Tianshui 741000 China College of Material Sciences and Opto-electronic Technology University of Chinese Academy of Sciences Beijing 100049 China

Electron-impact single ionization cross sections for W^q＋（q = 4–5） were calculated using the flexible atomic code（FAC） in the level-to-level distorted-wave method, considering the explicit branching ratio. The calculated cross sections are compared with the available theoretical and experiment results in detail. In the case of the contribution from the same channles as the available theoretical results, all of the calculated ionization cross sections agree with the experimental measured cross sections. But the present calculated results are larger than the experimental measurement when all channels contributions are included. Some important channels excitation autoionization（EA） contributions, such as the excitation to higher higher nl subshell from 4 f and 5[s,p], were not included into the available theoretical calculation. In general, the distorted-wave（DW） results are overestimated.

关键词： tungsten ions electron-impact ionization cross section

Micro-ecology restoration of colonic inflammation by in-Situ oral delivery of antibody-laden hydrogel microcapsules

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Bioactive Materials 2022年第9期7卷 305-315页

作者： Bo Li Xin Li Xiaodong Chu Pengcheng Lou Yin Yuan Aoxiang Zhuge Xueling Zhu Yangfan Shen Jinghua Pan Liyuan Zhang Lanjuan Li zhongwen wu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310003China Research Units of Infectious Disease and Microecology Chinese Academy of Medical SciencesBeijing100730China Department of Pharmacology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310003China Department of General Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou510632China School of Engineering and Applied Sciences Harvard University9 Oxford StCambridgeMAUSA02138 School of Petroleum Engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao266580China

In-situ oral delivery of therapeutic antibodies,like monoclonal antibody,for chronic inflammation treatment is the most convenient approach compared with other administration ***,the abundant links between the gut microbiota and colonic inflammation indicate that the synergistic or antagonistic effect of gut microbiota to colonic ***,the antibody activity would be significantly affected while transferring through the gastrointestinal tract due to hostile ***,these antibodies have short serum half-lives,thus,require to be frequently administered with high doses to be effective,leading to low patient ***,we develop a strategy utilizing thin shell hydrogel microcapsule fabricated by microfluidic technique as the oral delivering *** encapsulating antibodies in these microcapsules,antibodies survive in the hostile gastrointestinal environment and rapidly release into the small intestine through oral administration route,achieving the same therapeutic effect as the intravenous injection evaluated by a colonic inflammation disease ***,the abundance of some intestinal microorganisms as the indication of the improvement of inflammation has remarkably altered after in-situ antibody-laden microcapsules delivery,implying the restoration of micro-ecology of the *** findings prove our microcapsules are exploited as an efficient oral delivery agent for antibodies with programmable function in clinical application.

关键词： Antibody oral delivery Hydrogel thin-shell microcapsules Microfluidic Gut microbiota Colonic inflammation Micro-ecology restoration

聚醚醚酮类树脂的国际、国内发展历程及新进展

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化工新型材料 2010年第12期38卷 1-4页

作者：吴忠文吉林大学特种工程塑料教育部工程研究中心吉林130012

本文对国际上聚醚醚酮树脂的研究开发、主要特性、应用领域和本世纪以来的新进展做了比较全面的介绍。并对国内聚醚醚酮树脂的研究开发背景、曲折的产业化历程及目前的已形成千吨/年产业规模以及与国际发展相适应,走自主创新的技术路线... 详细信息

本文对国际上聚醚醚酮树脂的研究开发、主要特性、应用领域和本世纪以来的新进展做了比较全面的介绍。并对国内聚醚醚酮树脂的研究开发背景、曲折的产业化历程及目前的已形成千吨/年产业规模以及与国际发展相适应,走自主创新的技术路线研发成功的第二代、第三代产品的特点及经济优势做了介绍。

关键词：特种工程塑料聚醚醚酮聚芳醚酮聚醚醚酮酮联苯聚醚酮原料成本特性

免疫球蛋白G4相关肝胆胰疾病的微生态免疫学进展

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中华肝脏病杂志 2022年第4期30卷 452-456页

作者：潘厦厦吴仲文浙江大学医学院附属第一医院传染病诊治国家重点实验室国家感染性疾病临床医学研究中心感染性疾病诊治协同创新中心杭州310000

免疫球蛋白(Ig)G4相关疾病是一种免疫介导的累及多个器官的慢性纤维炎性疾病。IgG4相关肝胆胰疾病是IgG4相关疾病在肝胆胰系统中的表现,以血清IgG4滴度升高、病变组织中大量IgG4阳性浆细胞浸润、组织纤维化、影像学器官形态改变等为主... 详细信息

免疫球蛋白(Ig)G4相关疾病是一种免疫介导的累及多个器官的慢性纤维炎性疾病。IgG4相关肝胆胰疾病是IgG4相关疾病在肝胆胰系统中的表现,以血清IgG4滴度升高、病变组织中大量IgG4阳性浆细胞浸润、组织纤维化、影像学器官形态改变等为主要特点,因缺乏可靠的生物标志物,组织病理学仍是诊断的重要依据。IgG4相关肝胆胰疾病发病机制尚未完全明确,现重点报道IgG4相关肝胆胰疾病近年来在肠道微生态-免疫学、宿主遗传-免疫及复发监测领域的进展。

关键词：免疫球蛋白G4 肠道微生态 IgG4相关自身免疫性胰腺炎 IgG4相关硬化性胆管炎 IgG4相关自身免疫性肝炎

Chaos Control for the Boost Converter under Current-mode Control

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Chaos Control for the Boost Converter under Current-mode Con...

民事裁判结论逻辑正确的形式基础——浅论裁判文书形式的规范化

2010 Chinese Control and Decision Conference

作者： Lihong He,Meimei Jia,zhongwen Dong,Jianhua wu School of Information Science and Engineering,Northeastern University,Shenyang,110004

Chaotic phenomena of the Boost converter under current-mode control are studied *** to the reference current I which works as a bifurcation parameter,the bifurcation map,the 3-period window diagram and the strange attractors of the intermittent chaos are obtained by applying the discrete *** employing a nonlinear feedback controller which is a piecewise-quadratic function in the form of x|x| in the chaotic Boost converter,chaos control of the Boost converter is *** simulation shows that this method is suitable for the stability control of diversified periodic orbits by adjusting the feedback gain in the nonlinear feedback controller.

关键词： Boost Converter Piecewise-quadratic Function x|x| Chaos Control Controllable Range Chart

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河南司法警官职业学院学报 2023年第2期21卷 84-88页

作者：武中文河南博颂律师事务所河南郑州450000

我国民事诉讼裁判文书整体质量比较高,但还存在部分裁判文书归纳争议焦点不准确、未全面反映当事人举证、脱离诉求与抗辩逻辑、事实重建不够谨严、对妨碍民事诉讼行为置之不理等问题;应当通过准确归纳争议焦点、全面反映当事人举证、事... 详细信息

我国民事诉讼裁判文书整体质量比较高,但还存在部分裁判文书归纳争议焦点不准确、未全面反映当事人举证、脱离诉求与抗辩逻辑、事实重建不够谨严、对妨碍民事诉讼行为置之不理等问题;应当通过准确归纳争议焦点、全面反映当事人举证、事实重建逻辑谨严、判决书内容完整、对妨害民事诉讼行为予以处理等对策提高裁判文书整体质量。

关键词：民事诉讼裁判文书质量存在问题对策

对《民法典》第392条“约定情形”的辨析——人民法院对金融债权司法保护原则的一个重大转变

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河南司法警官职业学院学报 2024年第1期22卷 69-72页

作者：武中文河南博颂律师事务所河南郑州450016

《民法典》施行之后,司法判决对混合担保前提下约定各类担保权同时优先的做法不再支持,这是一个重大的变化,这意味司法机关开始更多关注债务人的合法权益。新的法律适用标准对金融机构早已经约定俗成的债权保护模式形成了明显的消极影响... 详细信息

《民法典》施行之后,司法判决对混合担保前提下约定各类担保权同时优先的做法不再支持,这是一个重大的变化,这意味司法机关开始更多关注债务人的合法权益。新的法律适用标准对金融机构早已经约定俗成的债权保护模式形成了明显的消极影响,准确理解《民法典》第392条中“约定情形”的内涵与外延就显得非常重要。债权人必须避免担保条款约定中出现“对不同担保权同时拥有优先权”的情形,“同时优先”意味着担保的先后顺序不明确。

关键词：混合担保顺序优先权约定约定不明

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公开原则在侦查中的适用

铁道警官高等专科学校学报 2013年第2期23卷 37-40页

作者：武中文河南裕达律师事务所河南郑州450003

我国在传统的侦查活动中,一直反对将公开原则作为侦查程序的价值取向之一。侦查机关抵触的原因主要是:一旦将侦查活动公之于众,将会极大地影响到侦查活动的顺利进行,并且在各方力量的监督下,侦查工作的压力将大大增强。而增加司法过程... 详细信息

我国在传统的侦查活动中,一直反对将公开原则作为侦查程序的价值取向之一。侦查机关抵触的原因主要是:一旦将侦查活动公之于众,将会极大地影响到侦查活动的顺利进行,并且在各方力量的监督下,侦查工作的压力将大大增强。而增加司法过程的透明度,又是法治国家必然的趁势,因此,侦查活动的合理公开,是未来我国侦查改革的重要内容。侦查合理公开,主要是指向当事人公开和社会公开。在侦查公开的方式上,可以考虑侦查公告、新闻发布会、错案质询和公告等。

关键词：公开原则侦查