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Polarity-activated super-resolution imaging probe for the formation and morphology of amyloid fibrils

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Nano Research 2020年第9期13卷 2556-2563页

作者： Zheng Lv Li Li zhongwei man Zhenzhen Xu Hongtu Cui Rui Zhan Qihua He Lemin Zheng Hongbing Fu Beijing Key Laboratory for Optical Materials and Photonic Devices Capital Normal UniversityBeijing 100048China Tianjin Key L aboratory of Molecular Optoelectronic Sciences Institute of Molecular PlusTianjin UniversityTianjin 300072China 3 The Institute of Cardiovascular Sciences and Institute of Systems BiomedicineSchool of Basic Medical SciencesKey Laboratory of Molecular Cardiovascular Sciences of Ministry of Education NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesHealth Science CenterPeking UniversityBeijing 100191China China National Clinical Research Center for Neurological Diseases Tiantan HospitalAdvanced Innovation Center for Human Brain ProtectionThe Capital Medical UniversityBeijing 100050China

The formation of amyloid plaques usually occurs in the early-stage of Alzheimer’s disease(AD).Stimulated emission depletion(STED)imaging provided a powerful tool for visualizing amyloid structures on the nanometer ***,many commercial probes adopted in detecting amyloid fibrils are inapplicable to STED imaging,owing to their unmatched absorption and emission wavelengths,small Stokes'shift,easy photo-bleaching,***,we demonstrated a polarity-activated STED probe based on an intramolecular charge transfer donor(D)-7c-acceptor(A)*** electron-rich carbazole group and the electron-poor pyridinium bromide group,linked by 7i-conjugated thiophen-bridge,ensure strong near infrared(NIR)emission with a Stokes'shift larger than 200 *** tiny change in polarity before and after binding with amyloid plaques leads to a transition from weakly emission charge-transfer(CT)state(Φ<0.04)to highly emissive locally-excited(LE)state(Φ=0.57),giving rise to a fluorescence Turn-On *** with large Stokes'shift,good photostability and high depletion efficiency,the super-resolution imaging of the formation and morphology of amyloid fibrils in vitro based on this probe was realized with a lateral spatial resolution better than 33 nm at an extremely low depletion ***,the ex-vivo super-resolution imaging of(E)-1-butyl-4(2-(5-(9-ethyl-9Hcarbazol-3-yl)thiophen-2-yl)vinyl)pyridinium bromide(CTPB)probe in Aβ plaques in the brain slices of a Tg mouse was *** research provides a demonstration of the super resolution imaging probe of amyloid fibrils based on polarity-response mechanism,providing a new approach to the development of future amyloid probes.

关键词： polarity-activated amyloid fibrils super-resolution imaging charge transfer near infrared(NIR)emission

Organic nanoparticles with ultrahigh stimulated emission depletion efficiency for low-power STED nanoscopy

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Organic nanoparticles with ultrahigh stimulated emission dep...

基于神经网络的机床-工件系统热误差补偿技术研究

第十一届全国化学生物学学术会议

作者： zhongwei man Zheng Lv Zhenzhen Xu Qing Liao Hongbing Fu Beijing Key Laboratory for Optical Materials and Photonic Devices Capital Normal UniversitySchool of Chemistry

Stimulated emission depletion(STED) nanoscopy with a high lateral spatial resolution(<50 nm) has provided a powerful sub-diffraction imaging tool to probe the most relevant subcellular structure and organelles. Recently,various luminescent probes have been developed and successfully applied to STED nanoscopy such as QDots,perovskite QDs,AIE nanoparticles,upconversion nanoparticles(UCNPs),commercially organic dyes and so on. Herein,we developed highly-emissive silica-coated core-shell ONPs(CSONPs) as a new type of photostable probes with ultrahigh stimulated emission depletion efficiency(99%) for low-power super-resolution STED nanoscopy.A nonplanar twist intramolecular charge transfer(TICT) compound((E,E)-(2,5-bis(diphenylamino)-1,4-phenylene)bis(ethene-2,1-diyl))bis(3-fluorobenzonitrile)(DAPF) was designed and synthesized to prevent effective π-π interaction and excimer formation in the solid state,offering our CSONPs with i) high solid-state fluorescence quantum yields around 0.6,ii) large Stokes’ shift of 150 nm and iii) high photostability owing to silica shell protection.

关键词： STED core-shell ONPs stimulated emission depletion efficiency

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制造技术与机床 2011年第7期 99-102页

作者：满忠伟汪世益山东山推机械有限公司山东济宁272023 安徽工业大学机械工程学院安徽马鞍山243002

以机床-工件系统的热变形为研究对象,应用神经网络理论建立机床-工件系统的热误差模型,对热误差神经网络模型的关键输入参数进行了分析讨论,提出了该模型的误差补偿策略。以某型号大尺寸回转支承滚道数控车削加工为例,建立了热误差模型... 详细信息

以机床-工件系统的热变形为研究对象,应用神经网络理论建立机床-工件系统的热误差模型,对热误差神经网络模型的关键输入参数进行了分析讨论,提出了该模型的误差补偿策略。以某型号大尺寸回转支承滚道数控车削加工为例,建立了热误差模型,对回转支承滚道加工实施热误差补偿,结果表明,机床-工件系统的热误差模型有较强的预测能力,提出的补偿方法有较好的补偿效果。

关键词：数控机床干式切削神经网络热误差补偿

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金属切削刀具后刀面的切削热研究

制造技术与机床 2011年第1期 92-97页

作者：汪世益满忠伟方勇安徽工业大学机械工程学院安徽马鞍山243002

在以往的金属切削热研究中,认为刀具后刀面处产生的切削热很小而被忽略。文章应用平面热源法,建立了刀具后刀面与工件摩擦面的切削热模型,推导了该摩擦面的切削热分配和切削温度理论计算公式,对影响后刀面切削热的主要因素进行了分析。... 详细信息

在以往的金属切削热研究中,认为刀具后刀面处产生的切削热很小而被忽略。文章应用平面热源法,建立了刀具后刀面与工件摩擦面的切削热模型,推导了该摩擦面的切削热分配和切削温度理论计算公式,对影响后刀面切削热的主要因素进行了分析。研究结果表明,当刀具后刀面磨损带宽度达到一定程度时,则刀具后刀面处产生的切削热不能忽略。

关键词：切削热切削温度刀具后刀面刀具磨损平面热源法

课程思政建设哲学方法论探析——基于历史与逻辑相统一的视角

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天津电大学报 2023年第1期27卷 7-12页

作者：满忠卫天津商务职业学院马克思主义学院天津300350

历史与逻辑相统一的方法既是一种辩证逻辑思维方法,又是广泛应用于社会科学研究的普遍方法。课程思政建设是高校思想政治工作的重要组成部分,需要以党的思想政治工作百年发展历史为理论视野,梳理党在各个历史时期的文献资料,洞察党的思... 详细信息

历史与逻辑相统一的方法既是一种辩证逻辑思维方法,又是广泛应用于社会科学研究的普遍方法。课程思政建设是高校思想政治工作的重要组成部分,需要以党的思想政治工作百年发展历史为理论视野,梳理党在各个历史时期的文献资料,洞察党的思想政治教育的历史发展脉络,为课程思政建设提供方法论借鉴。一方面,用逻辑的方法总结提炼思想政治工作规律,探究课程思政建设的科学内涵,另一方面,对党的思想政治工作百年历史经验教训进行反思,传承创新思想政治工作方法,为课程思政建设未来发展指明方向。

关键词：历史与逻辑相统一课程思政思想政治工作

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黄炎培劳动教育思想方法探析

天津职业大学学报 2023年第3期32卷 60-64页

作者：满忠卫南开大学天津300074 天津商务职业学院天津300350

黄炎培劳动教育思想是一个相对完整的理论体系,是内容与方法的统一。黄炎培从思想维度、实践维度和价值维度,综合运用多种具体方法,直面当时中国劳动教育现状,探究劳动教育变革的方针、政策和措施,阐述劳动教育对于个人、国家和社会的... 详细信息

黄炎培劳动教育思想是一个相对完整的理论体系,是内容与方法的统一。黄炎培从思想维度、实践维度和价值维度,综合运用多种具体方法,直面当时中国劳动教育现状,探究劳动教育变革的方针、政策和措施,阐述劳动教育对于个人、国家和社会的重要影响,洞悉中国劳动教育规律。一方面,黄炎培劳动教育思想方法为科学总结黄炎培劳动教育思想规律提供了重要的方法借鉴,另一方面,具有相对稳定性的方法,能够跨越时空条件的限制,继续发挥其实用价值,为指导当前中国劳动教育实践提供重要思想武器。

关键词：黄炎培劳动教育思想方法思想维度方法实践维度方法价值维度方法

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工程机械液压节能技术的现状及发展趋势

工程机械 2010年第9期41卷 51-57+9页

作者：汪世益方勇满忠伟安徽工业大学机械工程学院

综述国内外工程机械应用的液压节能技术,介绍变量泵的排量控制、LS负载敏感控制和LUDV控制等几种节能控制方式,以及它们在不同工况下的控制措施。介绍混合动力控制在工程机械中的应用,对工程机械液压节能的发展趋势进行分析,提出基于全... 详细信息

综述国内外工程机械应用的液压节能技术,介绍变量泵的排量控制、LS负载敏感控制和LUDV控制等几种节能控制方式,以及它们在不同工况下的控制措施。介绍混合动力控制在工程机械中的应用,对工程机械液压节能的发展趋势进行分析,提出基于全局功率匹配控制的节能构想。

关键词：工程机械节能技术功率匹配变量泵

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-man Chen Shuo Zhang Shi-Qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade