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Viruses and Virus-Like Protein Assemblies--Chemically Programmable Nanoscale Building Blocks

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Nano Research 2009年第5期2卷 349-364页

作者： L.Andrew Lee zhongwei niu Qian Wang department of chemistry&biochemistry and nanocenter university of south carolina631 sumter streetcolumbiasc 29208usa

Supramolecular proteins are generated using a limited set of twenty amino acids,but have distinctive functionalities which arise from the sequential arrangement of amino acids configured to exquisite three-dimensional ***,virus-like particles,ferritins,enzyme complexes,cellular micro-compartments,and other supramolecular protein assemblies exemplify these systems,with their precise arrangements of tens to hundreds of molecules into highly organized scaffolds for nucleic acid packaging,metal storage,catalysis or sequestering reactions at the nanometer *** versatile protein systems,dubbed as bionanoparticles(BNPs),have attracted materials scientists to seek new opportunities with these pre-fabricated templates in a wide range of nanotechnology-related ***,we focus on some of the key modification strategies that have been utilized,ranging from basic protein conjugation techniques to more novel strategies,to expand the functionalities of these multimeric protein ***,in combination with molecular cloning and sophisticated chemistries,these BNPs are being incorporated into many applications ranging from functional materials to novel biomedical drug designs.

关键词： Bionanoparticles virus bioconjugation nanomaterials bioimaging drug delivery

Bacteriophage M13 as a Scaffold for Preparing Conductive Polymeric Composite Fibers

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Nano Research 2008年第3期1卷 235-241页

作者： zhongwei niu Michael ABruckman Brandon Harp Charlene MMello Qian Wang Department of Chemistry and Biochemistry and Nanocenter University of South CarolinaColumbiaSC 29208USA Bioscience and Technology Team US Army Natick Soldier ResearchDevelopment&Engineering CenterNatickMA 01760-5020USA

Using biological templates to build one-dimensional functional materials holds great promise in developing nanosized electrical devices,sensors,catalysts,and energy storage *** this communication,we report a versatile assembly process for the preparation of water-soluble conductive polyaniline(PANi)/M13 composite nanowires by employing the bacteriophage M13 as a *** surface lysine residues of M13 can be derivatized with carboxylic groups to improve its binding ability to the aniline;the resulting modifi ed M13 is denoted as *** negatively-charged poly(sulfonated styrene)was used both as a dopant acid and a stabilizing agent to enhance the stability of the composite fi bers in aqueous solution.A transparent solution of the conductive PANi/m-M13 composite fi bers can be readily obtained without any further purifi cation *** fi bers can be easily fabricated into thin conductive fi lms due to their high aspect ratio and good solubility in aqueous *** synthesis discloses a unique and versatile way of using bionanorods to produce composite fi brillar materials with narrow dispersity,high aspect ratio,and high processibility,which may have many potential applications in electronics,optics,sensing,and biomedical engineering.

关键词： Bacteriophage M13 nanofi ber conductive polymer self-assembly bioconjugation

Self-assembly of anisotropic tobacco mosaic virus nanoparticles on gold substrate

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Science China Chemistry 2011年第1期54卷 137-143页

作者： PENG Bo LIU NingNing LIN Yuan WANG LiMing ZHANG WenKe niu zhongwei WANG Qian SU ZhaoHui State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 China Department of Chemistry and Biochemistry and Nanocenter University of South Carolina Columbia SC 29208 USA

A facile approach to assembled virus film with tunable structure is ***-like tobacco mosaic virus (TMV) was selected as the prototype in this study for its anisotropic structural *** can either "lie down" or "stand up" on gold substrate by tuning the solution pH.A quartz crystal microbalance with dissipation monitoring was used to monitor the pH-dependent self-assembly behavior of TMV nanoparticles,and atomic force microscopy and single molecule force spectroscopy further confirmed the different assembly structures.

关键词： tobacco mosaic virus self-assembly quartz crystal microbalance with dissipation single molecule force spectroscopy

3D-printable supramolecular hydrogels with shear-thinning property: fabricating strength tunable bioink via dual crosslinking

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Bioactive Materials 2020年第4期5卷 808-818页

作者： Tian Hu Xiaoliang Cui Meng Zhu Man Wu Ye Tian Bin Yao Wei Song zhongwei niu Sha Huang Xiaobing Fu Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College28 Fu Xing RoadBeijing100853PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU05151 Fu Cheng RoadBeijing100048PR China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Chinese Academy of Medical Sciences(CAMS)Oxford Institute Nuffield Department of MedicineUniversity of OxfordOxford OX39DSUK School of Future Technology University of Chinese Academy of SciencesBeijing100049PR China

3-dimensional(3D)bioprinting technology provides promising strategy in the fabrication of artificial tissues and *** the fundamental element in bioprinting process,preparation of bioink with ideal mechanical properties without sacrifice of biocompatibility is a great *** this study,a supramolecular hydrogel-based bioink is prepared by polyethylene glycol(PEG)grafted chitosan,α-cyclodextrin(α-CD)and *** has a primary crosslinking structure through the aggregation of the pseudo-polyrotaxane-like side chains,which are formed from the host-guest interactions betweenα-CD and PEG side *** viscosity measurement shows the shear-shinning property of this bioink,which might be due to the reversibility of the physical ***,withβ-glycerophosphate at different concentrations as the secondary crosslinking agent,the printed constructs demonstrate different Young's modulus(p<0.001).They could also maintain the Young's modulus in cell culture condition for at least 21 days(p<0.05).By co-culturing each component with fibroblasts,CCK-8 assay demonstrate cellular viability is higher than 80%.After bioprinting and culturing,immunofluorescence staining with quantification indicate the expression of Ki-67,Paxillin,and N-cadherin is higher in day 14 than those in day 3(p<0.05).Oil red O and Nissl body specific staining reflect strength tunable bioink may have impact on the cell fate of mesenchymal stem cells(p<0.05).This work might provide new idea for advanced bioink in the application of re-establishing complicated tissues and organs.

关键词： Supramolecular hydrogel Bioink Tunable strength 3D bioprinting

microRNAs in heart failure

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Chinese Medical Journal 2014年第18期127卷 3328-3334页

作者： Xing Yujie Gao Dengfeng Liu zhongwei niu Xiaolin Department of Cardiology Second Affiliated Hospital Xi'an JiaotongUniversity School of Medicine Xi'an Shaanxi 710004 China

Heart failure is the leading cause of mortality in the world and represents the fastest growing subclass of cardiovascular diseases. An increasing body of evidence indicates an important role for microRNAs （miRNAs） in the pathogenesis and progression of heart failure. miRNAs are a class of small non-coding RNAs about 20 to 24 nucleotides （nt）（a few less than 20 nt） to regulate target gene expression at the post-transcriptional level. Mature miRNAs are formed after shearing a period of hairpin loop structure, the length of 70-80 nt and single stranded RNA precursors （pre-miRNA） with Dicer or nuclease as similar as Dicer.

关键词： microRNAs heart failure hypertrophy

Synthesis and Characterization of Bionanoparticle-Silica Composites and Mesoporous Silica with Large Pores

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Nano Research 2009年第6期2卷 474-483页

作者： zhongwei niu Saswat Kabisatpathy Jinbo He LAndrew Lee Jianhua Rong Lin Yang Godfrey Sikha Branko N.Popov Todd S.Emrick Thomas P.Russell Qian Wang Department of Chemistry and Biochemistry and Nanocenter University of South CarolinaColumbiaSC 29208USA Department of Polymer Science and Engineering University of MassachusettsAmherstMA 01003USA Brookhaven National Laboratory UptonNY 11973USA Department of Chemical Engineering University of South CarolinaColumbiaSC 29208USA

A sol-gel process has been developed to incorporate bionanoparticles,such as turnip yellow mosaic virus,cowpea mosaic virus,tobacco mosaic virus,and ferritin into silica,while maintaining the integrity and morphology of the *** structures of the resulting materials were characterized by transmission electron microscopy,small angle X-ray scattering,and N2 adsorption desorption *** results show that the shape and surface morphology of the bionanoparticles are largely preserved after being embedded into *** removal of the bionanoparticles by calcination,mesoporous silica with monodisperse pores,having the shape and surface morphology of the bionanoparticles replicated inside the silica,was produced,.This study is expected to lead to both functional composite materials and mesoporous silica with structurally well-defi ned large pores.

关键词： Mesoporous silica bionanoparticles virus ferritin sol gel

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烟草花叶病毒的特定位点改性及应用

影像科学与光化学 2017年第4期35卷 494-505页

作者：田野朱萌牛忠伟中国科学院理化技术研究所光化学转换与功能材料重点实验室北京100190 中国科学院大学北京100049

病毒是自然界中已知结构最简单却侵染能力极强的生物,作为一种典型的一维棒状植物病毒,烟草花叶病毒(TMV)具有单分散的形貌与尺寸(18nm×300nm)、明确的空间结构、丰富的表面化学基团,且对哺乳动物不具有致病性,已广泛应用于电子器件、... 详细信息

病毒是自然界中已知结构最简单却侵染能力极强的生物,作为一种典型的一维棒状植物病毒,烟草花叶病毒(TMV)具有单分散的形貌与尺寸(18nm×300nm)、明确的空间结构、丰富的表面化学基团,且对哺乳动物不具有致病性,已广泛应用于电子器件、传感、成像、生物医用材料的研究。本文简述了对TMV进行基因工程或化学改性的多种方法及应用进展,并主要介绍了烟草花叶病毒在生物医用材料领域的潜在应用。

关键词：烟草花叶病毒基因工程化学改性生物医用材料

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一维棒状烟草花叶病毒的自组装及其应用

化学进展 2015年第10期27卷 1425-1434页

作者：刘朋宁英男周全毛国梁牛忠伟东北石油大学化学化工学院大庆163318 中国科学院理化技术研究所北京100190

烟草花叶病毒(tobacco mosaic virus,TMV)是人类最早发现的一种植物病毒。由于其独特的一维棒状结构、在纳米尺度下的单分散特性、良好的生物相容性、易于基因修饰和化学修饰等特点,近年来,TMV在自组装以及制备生物纳米复合材料等领域... 详细信息

烟草花叶病毒(tobacco mosaic virus,TMV)是人类最早发现的一种植物病毒。由于其独特的一维棒状结构、在纳米尺度下的单分散特性、良好的生物相容性、易于基因修饰和化学修饰等特点,近年来,TMV在自组装以及制备生物纳米复合材料等领域受到越来越多的关注。本文主要对TMV的结构特点、在自组装领域的研究进展以及在制备生物纳米复合材料的研究现状进行详细介绍并展望了其发展前景。

关键词：纳米材料烟草花叶病毒自组装

飞控系统风洞虚拟飞行试验评估指标与评估要求

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国防科技大学学报 2017年第4期39卷 144-148页

作者：黄敏王中伟郭振云钮耀斌国防科技大学航天科学与工程学院湖南长沙410073

为明确风洞虚拟飞行试验能够评估的飞控系统性能,并为风洞虚拟飞行试验评估方法设计做出铺垫,针对风洞虚拟飞行试验特点,提出了风洞虚拟飞行试验能够评估的飞行性能指标及飞行品质指标,比较了风洞虚拟飞行试验与半实物仿真和飞行试验的... 详细信息

为明确风洞虚拟飞行试验能够评估的飞控系统性能,并为风洞虚拟飞行试验评估方法设计做出铺垫,针对风洞虚拟飞行试验特点,提出了风洞虚拟飞行试验能够评估的飞行性能指标及飞行品质指标,比较了风洞虚拟飞行试验与半实物仿真和飞行试验的评估能力差异;仿真分析了风洞虚拟飞行试验特点会造成的风洞虚拟飞行试验与自由飞行的评估结果差异;从试验、数据处理、性能评定等方面,提出了评估这些指标对风洞虚拟飞行试验评估方法的具体要求,并比较了它与半实物仿真和飞行试验的评估要求差异。

关键词：飞行控制系统评估风洞虚拟飞行试验评估指标评估方法半实物仿真飞行试验