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Concurrent chemoradiotherapyof different radiation doses and different irradiation fields for locally advanced thoracic esophageal squamous cell carcinoma:A randomized,multicenter,phase Ⅲ clinical trial

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Cancer Communications 2024年第10期44卷 1173-1188页

作者： Jian Zhang Minghao Li Kaixian Zhang Anping Zheng Guang Li Wei Huang Shaoshui Chen Xiangming Chen Xiaomin Li Yanxing Sheng Xinchen Sun Liping Liu Xiaowei Liu Jie Li Jun wang Hong Ge Shucheng Ye Qingsong Pang Xianwen Zhang Shengbin Dai Richard Yu Wendong Gu Mingming Dai Gaowa Siqin Yunwei Han Xiaolin Ge Xin Yuan Yongjing Yang Haiwen Zhu Juan Pu Lihua Dong Xiangdong Sun Jundong Zhou Weidong Mao Fei Gao Haiqun Lin Heyi Gong Tao Zhou Zhenjiang Li Hongsheng Li zhongtang wang Baosheng Li Department of Oncology Central Hospital Affiliated to Shandong First Medical UniversityJinanShandongP.R.China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandongP.R.China Department of Oncology Tengzhou Central People’s HospitalTengzhouShandongP.R.China Department of Radiation Oncology Anyang Tumor HospitalAnyangHenanP.R.China Department of Radiation Oncology the First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Department of Oncology Taian CentralHospitalTaianShandongP.R.China Department of Radiation Oncology Shanxi Province Cancer HospitalTaiyuanShanxiP.R.China Department of Oncology Liaocheng People’s HospitalLiaochengShandongP.R.China Department of Radiation Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Department of Oncology Jining First People′s HospitalJiningShandongP.R.China Department of Oncology the Affiliated Hospital of Jining Medical UniversityJiningShandongP.R.China Department of Radiation Oncology the Fourth Hospital of Hebei Medical UniversityHebei Clinical Research Center for Radiation OncologyShijiazhuangHebeiP.R.China Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Radiation Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory ofCancer Prevention and TherapyTianjin’s ClinicalResearch Center for CancerTianjinP.R.China Department of Oncology Subei People’s Hospital of Jiangsu ProvinceYangzhouJiangsuP.R.China Department of Oncology Taizhou People’s Hospital of Jiangsu ProvinceTaizhouZhejiangP.R.China Department of Radiation Oncology the Affiliated Hospital of Inner Mongolia Medical UniversityHohhotInner MongoliaP.R.China Department of Radiation O

Background:Concurrent chemoradiotherapy(CCRT)is the standard treatment for locally advanced esophageal squamous cell carcinoma(ESCC).However,the optimal radiotherapy regimen,particularly in terms of total dose and planned range of irradiation field,remains *** phase III clinical trial aimed to compare the survival benefits between different radiation doses and different target ***:This trial compared two aspects of radiation treatment,total dose and field,using a two-by-two factorial *** high-dose(HD)group received 59.4 Gy radiation,and the standard-dose(SD)group received 50.4 *** involved field irradiation(IFI)group and elective nodal irradiation(ENI)group adopted different irradiation *** participants were assigned to one of the four groups(HD+ENI,HD+IFI,SD+ENI and SD+IFI).The primary endpoint was overall survival(OS),and the secondary endpoints included progressionfree survival(PFS).The synergy indexwas used to measure the interaction effect between dose and ***:The interaction analysis did not reveal significant synergistic effects between the dose and irradiation *** comparison to the target field,patients in IFI or ENI showed similar OS(hazard ratio[HR]=0.99,95%CI:0.80-1.23,p=0.930)and PFS(HR=1.02,95%CI:0.82–1.25).TheHDtreatment did not show significantly prolonged OS compared with SD(HR=0.90,95%CI:0.72–1.11,p=0.318),but it suggested improved PFS(25.2 months to 18.0 months).Among the four groups,the HD+IFI group presented the best survival,while the SD+IFI group had the worst *** significant difference in the occurrence of severe adverse events was found in dose or field ***:IFI demonstrated similar treatment efficacy to ENI in CCRT of *** HD demonstrated improved PFS,but did not significantly improve *** dose escalation based on IFI(HD+IFI)showed better therapeutic efficacy than the current recommendation(SD+ENI)and is worth further validation.

关键词： clinical trial concurrent chemoradiotherapy elective nodal radiation esophageal squamous cell carcinoma high dose radiation involved field radiation overall survival standard dose radiation

Study on the Deformation Characteristics of the Sheet Hydroforming with a Movable Die

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Journal of Materials Science & Technology 2003年第z1期19卷 239-240页

作者： Linxin ZHOU Yi XU zhongtang wang Shihong ZHANG Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Shenyang Institute of Technology Shenyang 110016 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

An improved sheet hydroforming process with a movable die is proposed and investigated by elastoplastic FEM. The effects of varied process parameters on the deformation of the sheet blanks were investigated. The effects of the movable die on the FLD were also analyzed. Using a movable die may increase the forming limit of the blank and improve the forming performance. Moreover, the drawing ratio of the blank may be increased by changing the process conditions such as blank holder force and the counterforce of the movable die on the blank.

关键词： Hydroforming, Sheet metal forming, Movable die

Influence of loading path on formability of 304 stainless steel tubes

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Science China(Technological Sciences) 2009年第8期52卷 2263-2268页

作者： ZHANG ShiHong YUAN AnYing wang Bin ZHANG HaiQu wang zhongtang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Shenyang University Shenyang 110044China Shenyang Ligong University Shenyang 10168China

The loading path affects the metal formability remarkably in tube hydroforming, and it is also one of the research focuses. Recently, some scholars abroad proposed a new fluctuant hydraulic loading method, which can improve the formability of tubes in hydroforming. Related studies have shown that this new loading method can improve the tube formability, the distribution of deformation is more uniform and this is useful for avoiding excessive local thinning. In this paper, tube hydroforming experiments without axial feeding were carried out; the influences of the loading methods on formability of stainless steel tubes were studied. Through the comparison of the experimental results under the condition of monotonous increase loading and fluctuation hydraulic loading, the outside diameter distribution, the thickness distribution and the crack expansion forms of deformation zone all fully prove that the uniformity of the distribution of tube deformation and formability have been increased significantly under the condition of fluctuation loading without axial feeding, the reasons should be distinguished from the fluctuation hydroforming with axial feeding. In order to study the forming mechanism, uniaxial tensile test of tubes similar to fluctuation loading deformation is designed in this paper, namely intermittent tensile test. It is found that intermittent uniaxial stretch can improve the tube elongation at fracture by about 40% and the deformation distribution is more uniform than that through uniaxial tensile test of the stainless steel tube. In the process of intermittent tensile tests, changes of metal microstructures brought by the loading and unloading processes are the main reasons that improve the formability of the tubes.

关键词： loading path formability tube stainless steel

早熟鲜食枣新品种“滨枣1号”的选育及关键栽培技术

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中国南方果树 2024年第4期53卷 195-197页

作者：刘国利曹同亮王中堂李盼王守乐邢才华张琼无棣县小泊头镇农业综合服务中心山东无棣251911 无棣润阳枣业有限公司山东无棣251911 山东省果树研究所山东泰安271000

通过普查,选育出早熟、丰产、质优、适应性强的鲜食枣新品种“滨枣1号”。该品种果形如子弹头,平均单果质量19.0 g,皮薄肉厚,味甜汁多,脆熟期果实可溶性固形物含量26.9%,全红期可达30.9%,总酸含量1.92 g/kg,维生素C含量130.54 mg/100 g... 详细信息

通过普查,选育出早熟、丰产、质优、适应性强的鲜食枣新品种“滨枣1号”。该品种果形如子弹头,平均单果质量19.0 g,皮薄肉厚,味甜汁多,脆熟期果实可溶性固形物含量26.9%,全红期可达30.9%,总酸含量1.92 g/kg,维生素C含量130.54 mg/100 g,可食率96.8%,品质优良,口感极佳。“滨枣1号”在山东无棣8月中下旬成熟。该品种对丰富鲜食枣品种资源、促进枣产业结构调整具有重要意义。

关键词：鲜食品种早熟滨枣1号丰产质优

Lubrication in Hot Tube Extrusion of Superalloys and Ti Alloys

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Journal of Materials Science & Technology 2001年第1期17卷 113-114页

作者： Shihong ZHANG Yi XU Yangling SHANG Ke YANG zhongtang wang Institute of Metal Research Chinese Academy of SciencesShenyang 110015China

Tubular products made of superalloys and titanium alloys usually work in high temperature environment and applied heavy loading. Hot extrusion is the best technology to form tubular billets with fine microstructures and good mechanical properties. Lubrication is one of the key techniques in hot extrusion, glass lubricants are most suitable for hot extrusion. Lubrication technique in hot extrusion is dealt with in this paper, the lubrication principle of hot tube extrusion is presented. Experiments of glass lubricated backward tube extrusion of titanium alloys and forward tube extrusion of superalloys are also discussed.

关键词： hot extrusion titanium alloys mechanical properties high temperature environment and key techniques hot tube

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费县枣产业发展现状、存在问题及对策

落叶果树 2024年第3期56卷 50-53页

作者：谭婧腾凤舟王明金王中堂李勇费县农业农村局山东费县273400 费县国有大青山林场山东费县273400 费县柱子新村果蔬种植专业合作社山东费县273400 山东省果树研究所山东泰安271000

枣是费县传统栽培果树之一,分析了费县枣产业发展情况,指出了影响产业发展的问题,提出了协调项目资金、重点建设基础设施、调整现有品种结构、加强科技培训、提高枣园管理水平、创新栽培模式和推广多样化设施栽培技术等相应对策。

关键词：枣费县产业现状发展对策

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山东省枣产业发展状况

落叶果树 2024年第3期56卷 33-38页

作者：裴广营朱毅王中堂李盼董飞张琼费县果茶服务中心山东临沂273400 山东省果树研究所山东泰安271000 泰安市泰山风景名胜区管理委员会山东泰安271099

枣在推进山东省林业生态建设和乡村振兴中发挥着重要作用。总结了近年来山东省枣产业在品种选育、产量变化和加工技术等方面的发展情况,分析了山东省枣产业发展过程中取得的成绩和存在的问题,提出了相关对策,为振兴山东省枣产业提供参考。

关键词：枣产业产量状况品种选育

Influence of temperature rate on transitory internal friction during reverse martensitic transformation for Ti_(50)Ni_(27)Cu_(23) alloy

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Rare Metals 2010年第3期29卷 308-311页

作者： LI Yonghua,QI Guangxia,wang zhongtang,LI Yuhai,and DENG Ziyu School of Materials Science and Engineering,Shenyang Ligong University,Shenyang 110159,China School of Materials Science and Engineering Shenyang Ligong University Shenyang China

Internal friction （IF） spectra during reverse martensitic transformation from 35 to 135°C at different temperature rates of 0.5,0.75,and 1°C/min for Ti50Ni27Cu23 shape memory alloy （SMA） samples were measured with a dynamic mechanical analyzer,*** IF spectra were characterized by IF peak increasing progressively and peak shifting toward high temperature with an increase in temperature *** iterative approach was used to calculate the precise intrinsic and approximate transitory IF contributions to the normal IF *** quantitatively analyzed results indicate that the transitory IF of this alloy is nonlinearly dependent on the temperature rate and obeys a power law with a power coefficient of *** predicted and experimental IF spectra at different temperature rates of 0.75 and 1°C/min agree well with each other,respectively.

关键词： internal friction shape memory alloy TiNiCu alloy temperature rate reverse martensitic transformation

Research on Thermal Deep-drawing Technology of Magnesium Alloy (AZ31B) Sheets

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Journal of Materials Science & Technology 2004年第2期20卷 153-156页

作者： Shihong ZHANG, Kun ZHANG, zhongtang wang, Chuanfu YU, Yi XU and Qiang wangInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Forming technology of Mg alloy (AZ31B) sheets can be investigated by thermal deep drawing experiments. In the experiments, the blank holder and die contacting with the blank were heated to the same temperature as the blank by using the heating facility. The circular blank heated in an oven is formed at a temperature range of 100~400 ℃ to obtain the optimum forming temperature range and the effects of major technical parameters on the workpiece quality. It is found that the blank is brittle at temperatures lower than 200℃. Temperatures higher than 400℃ are not suitable for forming of the sheets because of severe oxidation and wrinkling. AZ31B shows an excellent formability at temperatures from 300 to 350℃ and can be formed into a workpiece with good quality. When the blank holder force is 9 kN, extruded sheets with a thickness of 1 mm can be formed into cups without wrinkling. Workpieces show strong anisotropic deformation behavior on the flanges.

关键词： Magnesium alloy (AZ31B) Thermal deep drawing Blank holder force Wrinkling