检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

高血压患病的影响因素分析

中国社区医师 2024年第16期40卷 19-22页

作者：强锐杜中平北京市昌平区沙河医院北京102206

目的:分析高血压患病的影响因素。方法:选取2022年11月—2023年11月于北京市昌平区沙河医院进行体检的168例体检人员作为研究对象。统计研究对象高血压发病情况,分析高血压患病的影响因素。结果:168例体检者中,高血压57例(33.93%),纳入... 详细信息

目的:分析高血压患病的影响因素。方法:选取2022年11月—2023年11月于北京市昌平区沙河医院进行体检的168例体检人员作为研究对象。统计研究对象高血压发病情况,分析高血压患病的影响因素。结果:168例体检者中,高血压57例(33.93%),纳入高血压组;非高血压111例(66.07%),纳入非高血压组。性别、年龄、吸烟史、饮酒史、高血压家族史、合并糖尿病、运动量、超重、血脂异常是高血压患病的影响因素,差异有统计学意义(P<0.05)。男性、高龄、饮酒史、吸烟史、高血压家族史、超重、血脂异常、合并糖尿病是高血压患病的独立危险因素(P<0.05)。结论:高血压患病与年龄、性别、吸烟史、饮酒史、高血压家族史等因素相关,临床应给予高度重视,积极采取应对措施,预防危险因素。

关键词：高血压影响因素血糖血脂

Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2015年第6期5卷 569-576页

作者： Gui Chen Baohua Hao Dahong Ju Meijie Liu Hongyan Zhao zhongping du Jizi Xia School of Life and Science Northwest University Qiannan Institute for Food and Drug Control Institute of Theory China Academy of Traditional Chinese Medicine

Triptolide (TP), a major active component of Triptelygium wilfordii Hook.F. (TWHF), is used to treat rheumatoid arthritis (RA). However, it has a narrow therapeutic window due to its serious toxicities. To increase the therapeutic index, a new triptolide-loaded transdermal delivery system, named triptolide-loaded liposome hydrogel patch (TP-LHP), has been developed. In this paper, we used a micro-needle array to deliver TP-LHP to promote transdermal absorption and evaluated this treatment on the pharmacokinetics and pharmacodynamics of TP-LHP in a rat model of collagen-induced arthritis (CIA). The pharmacokinetic results showed that transdermal delivery of microneedle TP-LHP yielded plasma drug levels which fit a one compartment open model. The relationship equation between plasma concentration and time was C=303.59 x (e(-0.064t)-e(-0.287t)). The results of pharmacodynamic study demonstrated that TP-LHP treatment mitigated the degree of joint swelling and suppressed the expressions of fetal liver kinase-1, fetal liver tyrosine kinase-4 and hypoxia-inducible factor-1a in synovium. Other indicators were also reduced by TP-LHP, including hyperfunction of immune, interleukin-1/3 and interleukin-6 levels in serum. The therapeutic mechanism of TP-LHP might be regulation of the balance between Thl and Th2, as well as inhibition of the expression and biological effects of vascular endothelial growth factor. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

关键词： Pharmacokinetics Pharmaeodynamics Triptolide Micro-electro-mehanical system Microneedles Collagen-induced arthritis

Intelligent Sensing and Control of Road Construction Robot Scenes Based on Road Construction

在线全文

学校读者我要写书评

暂无评论

Structural durability & Health Monitoring 2024年第2期18卷 111-124页

作者： zhongping Chen Weigong Zhang School of Instrument Science and Engineering Southeast UniversityNanjing210096China

Automatic control technology is the basis of road robot improvement,according to the characteristics of construction equipment and functions,the research will be input type perception from positioning acquisition,real-world monitoring,the process will use RTK-GNSS positional perception technology,by projecting the left side of the earth from Gauss-Krueger projection method,and then carry out the Cartesian conversion based on the characteristics of drawing;steering control system is the core of the electric drive unmanned module,on the basis of the analysis of the composition of the steering system of unmanned engineering vehicles,the steering system key components such as direction,torque sensor,drive motor and other models are established,the joint simulation model of unmanned engineering vehicles is established,the steering controller is designed using the PID method,the simulation results show that the control method can meet the construction path demand for automatic *** path planning will first formulate the construction area with preset values and realize the steering angle correction during driving by PID algorithm,and never realize the construction-based path planning,and the results show that the method can control the straight path within the error of 10 cm and the curve error within 20 *** the collaboration of various modules,the automatic construction simulation results of this robot show that the design path and control method is effective.

关键词： Scene perception remote control technology cartesian coordinate system construction robot highway construction

Rainfall-triggered waste dump instability analysis based on surface 3D deformation in physical model test

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2024年第5期21卷 1549-1563页

作者： LI Hanlin JIN Xiaoguang HE Jie XUE Yunchuan YANG zhongping School of Civil Engineering Chongqing UniversityChongqing 400038China

Landslide is the second largest natural disaster after earthquake. It is of significance to study the evolution laws and failure mechanism of landslides based on its surface 3D deformation information. Based on the rainfall-triggered waste dump instability model test, we studied the failure mechanisms of the waste dump by integrating surface deformation and internal slope stress and proposed novel parameters for identifying landslide stability. We developed a noncontact measurement device, which can obtain millimeter-level 3D deformation data for surface scene in physical model test;Then we developed the similar materials and established a test model for a waste dump. Based on the failure characteristics of slope surface, internal stress of slope body and displacement contours during the whole process, we divided the slope instability process in model test into four stages: rainfall infiltration and surface erosion, shallow sliding, deep sliding, and overall instability. Based on the obtained surface deformation data, we calculated the volume change during slope instability process and compared it with the point displacement on slope surface. The results showed that the volume change can not only reflect the slow-ultra acceleration process of slope failure, but also fully reflect the above four stages and reduce the fluctuations caused by random factors. Finally, this paper proposed two stability identification parameters: the volume change rate above the slip surface and the relative velocity of volume change rate. According to the calculation of these two parameters in model test, they can be used for study the deformation and failure mechanism of slope stability.

关键词： Waste dump stability Physical model test Surface 3D deformation Stability identification

Investigating Load Regulation Characteristics of a Wind-PV-Coal Storage Multi-Power Generation System

在线全文

学校读者我要写书评

暂无评论

Energy Engineering 2024年第4期121卷 913-932页

作者： zhongping Liu Enhui Sun Jiahao Shi Lei Zhang Qi Wang Jiali Dong Sinopec Star Co. Ltd.Zhengzhou450000China Hebei Key Laboratory of Low Carbon and High Efficiency Power Generation Technology North China Electric Power UniversityBaoding071003China

There is a growing need to explore the potential of coal-fired power plants(CFPPs)to enhance the utilization rate of wind power(wind)and photovoltaic power(PV)in the green energy *** study developed a load regulation model for a multi-power generation system comprising wind,PV,and coal energy storage using realworld *** power supply process was divided into eight fundamental load regulation scenarios,elucidating the influence of each scenario on load *** the framework of the multi-power generation system with the wind(50 MW)and PV(50 MW)alongside a CFPP(330 MW),a lithium-iron phosphate energy storage system(LIPBESS)was integrated to improve the system’s load regulation *** energy storage operation strategy was formulated based on the charging and discharging priority of the LIPBESS for each basic scenario and the charging and discharging load calculation method of LIPBESS auxiliary *** optimization using the particle swarm algorithm,the optimal capacity of LIPBESS was determined to be within the 5.24-4.88 MWh *** an economic perspective,the LIPBESS operating with CFPP as the regulating power source was 49.1% lower in capacity compared to the renewable energy-based storage mode.

关键词： Wind power coal-fired power PV multi-power generation system lithium-iron phosphate energy storage system

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不同羊粪使用量对番茄品质及产量的影响

北方园艺 2016年第2期 36-38页

作者：杜中平聂书明青海省农林科学院园艺研究所青海省蔬菜遗传与生理重点实验室青海西宁810016

以充分腐熟的羊粪及尿素和二铵为试材,以最佳尿素和二铵使用量与不同羊粪使用量作为基肥进行温室番茄栽培比较,以期得出最优羊粪使用量。结果表明:处理A(尿素0.15t/hm2+二铵0.45t/hm2)的番茄株高最高(113cm),茎粗也最粗(1.220 4cm);产... 详细信息

以充分腐熟的羊粪及尿素和二铵为试材,以最佳尿素和二铵使用量与不同羊粪使用量作为基肥进行温室番茄栽培比较,以期得出最优羊粪使用量。结果表明:处理A(尿素0.15t/hm2+二铵0.45t/hm2)的番茄株高最高(113cm),茎粗也最粗(1.220 4cm);产量也较高,达到103.96t/hm2;但其可溶性蛋白质含量(1.74mg/g)和可溶性总糖(1.48%)含量最低,且亚硝酸盐含量(1.86mg/kg)最高,分别显著性低于和高于其它各处理番茄的品质。处理D(羊粪75t/hm2)的番茄株高较高(106cm),茎粗也较粗(1.206 8cm),叶长最长(15.9cm),单株果数最多,达到17.71个,果实品质较好,产量也较高,达到(100.18t/hm2)。综合考虑番茄产量、品质、种植成本和经济效益等方面,在夏季温室栽培番茄时,推荐使用羊粪做为基肥,最佳使用量为75t/hm2。

关键词：羊粪番茄品质产量

基于核心价值的服务创新型图书馆组织管理模式

在线全文

学校读者我要写书评

暂无评论

现代情报 2009年第3期29卷 104-106页

作者：杜忠平北华大学图书馆吉林吉林132013

本文首先重点探讨了图书馆核心价值问题。通过对图书馆核心价值的认识,提出了知识管理、知识教育和知识服务是图书馆核心价值的新观点。并阐释了知识管理与知识教育、知识服务的概念、内涵和关系以及如何构建基于核心价值提升核心能力... 详细信息

本文首先重点探讨了图书馆核心价值问题。通过对图书馆核心价值的认识,提出了知识管理、知识教育和知识服务是图书馆核心价值的新观点。并阐释了知识管理与知识教育、知识服务的概念、内涵和关系以及如何构建基于核心价值提升核心能力的服务创新型图书馆组织管理模式。

关键词：图书馆核心价值服务创新图书馆组织管理模式

A Solvent-Free Covalent Organic Framework Single-Ion Conductor Based on Ion-Dipole Interaction for All-Solid-State Lithium Organic Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第12期16卷 189-200页

作者： zhongping Li Kyeong-Seok Oh Jeong-Min Seo Wenliang Qin Soohyoung Lee Lipeng Zhai Changqing Li Jong-Beom Baek Sang-Young Lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)50 UNIST-GilEonyang-EupUlju-GunUlsan 44919Republic of Korea Henan Key Laboratory of Functional Salt Materials Center for Advanced Materials ResearchZhongyuan University of TechnologyZhengzhou 450007People’s Republic of China Department of Battery Conflation Engineering Yonsei University50Yonsei-RoSeodaemun-GuSeoul 03772Republic of Korea Department of Battery Engineering Yonsei University50Yonsei-RoSeodaemun-GuSeoul 03772Republic of Korea

Single-ion conductors based on covalent organic frameworks(COFs)have garnered attention as a potential alternative to currently prevalent inorganic ion conductors owing to their structural uniqueness and chemical ***,the sluggish Li+conduction has hindered their practical ***,we present a class of solvent-free COF single-ion conductors(Li-COF@P)based on weak ion-dipole interaction as opposed to traditional strong ion-ion *** ion(Li+from the COF)-dipole(oxygen from poly(ethylene glycol)diacrylate embedded in the COF pores)interaction in the Li-COF@P promotes ion dissociation and Li+migration via directional ionic *** by this single-ion transport behavior,the Li-COF@P enables reversible Li plating/stripping on Li-metal electrodes and stable cycling performance(88.3%after 2000 cycles)in organic batteries(Li metal anode||5,5’-dimethyl-2,2’-bis-p-benzoquinone(Me2BBQ)cathode)under ambient operating conditions,highlighting the electrochemical viability of the Li-COF@P for all-solid-state organic batteries.

关键词： Solid organic single-ion conductors Solvent-free covalent organic frameworks All-solid-state Li organic batteries Ion-dipole interaction Pore functionalization

An unexpected stereochemical effect of thio-substituted Asp in native chemical ligation

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第8期35卷 278-281页

作者： Min Fu Pan He Sen Zhou Wenqiang Liu Bo Ma Shiying Shang Yaohao Li Ruihan Wang zhongping Tan State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Center of Pharmaceutical Technology School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chemical Engineering College Hebei Normal University of Science and TechnologyQinhuangdao 066600China

This study presents an unexpected finding that the cis isomer of β-thio-Asp exhibits higher ligation ac-tivity than the trans *** discovery sheds light on the intricate nature of native chemical ligation and highligh... 详细信息

关键词： Native chemical ligation Stereochemistry Ligation activity β-Thio-Asp Intramolecular hydrogen bond