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Genes & Diseases 2023年第3期10卷 675-678页

作者： Mingshi Xu Gang Zhang Xiaofan Gu Fangqin Zhao Zhongmin Yang Xiongwen Zhang Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

Chemoresistance is still one of the main obstacles to treat colorectal cancer(CRC).Substantial studies on biomarkers related to chemoresistance have emerged in recent years.Many microRNAs(miRNA)have been reported to involved in drug resistance and CRC.1 MiR-126-5p participates in malignant behaviors of numerous cancers.2,3 However,it is not known if miR-126-5p participates in multidrug resistance in CRC.Especially,the impact of miR-126-5p on drug resistance of CRC and its drug resistance mechanism have not been reported.

关键词： colorectal miR cancer

Genomics Approaches to Domestication Studies of Horticultural Crops

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Horticultural Plant Journal 2019年第6期5卷 240-246页

作者： Zhongmin Yang Guixiang Li Denise Tieman Guangtao Zhu Key Lab for Potato Biology in Universities of Yunnan The CAAS-YNNU Joint Academy of Potato SciencesYunnan Normal UniversityKunming 650500China Horticultural Sciences Department Plant Innovation CenterUniversity of FloridaGainesvilleFlorida 32611USA

The majority of crops we eat today are derived from the domestication of their wild progenitors. Crop domestication satisfies the human need for food and nutrition. Characterization of the history and genetic basis of crop domestication is essential for us to conduct modern breeding practices. Genomics provide unprecedented opportunities for us to study domestication. In this review, the typical domestication syndromes of horticultural crops will be introduced. Using the tomato as a typical example, we will discuss how genetic and genomic data were used to decipher the origins, progenitors, and domestication processes of this crop. In the domestication exploration of the genetic basis especially,genome-scaled diversity scanning approaches have gained great popularity. Combining these approaches with QTL(Quantitative trait locus)-mapping, GWAS(Genome wide association study), metabolomics and homology-based searches as well as pan-genomics have demonstrated tremendous advantages and significantly contribute to our understanding of domestication. Genomics studies will accelerate domestication research and further breeding of crops.

关键词： domestication syndrome crop origin genomic scanning domestication genes genetic analysis

Transparent glassy composites incorporating lead-free anti-perovskite halide nanocrystals enable tunable emission and ultrastable X-ray imaging

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Advanced Photonics 2023年第4期5卷 23-32页

作者： Yakun Le Xiongjian Huang Hao Zhang Zhihao Zhou Dandan yang Bozhao Yin Xiaofeng Liu Zhiguo Xia Jianrong Qiu Zhongmin Yang Guoping Dong South China University of Technology School of Materials Science and EngineeringState Key Laboratory of Luminescent Materials and DevicesGuangzhouChina South China University of Technology School of Physics and OptoelectronicsGuangzhouChina Zhejiang University School of Materials Science and EngineeringHangzhouChina Zhejiang University College of Optical Science and EngineeringState Key Laboratory of Modern Optical InstrumentationHangzhouChina

Lead halide perovskite materials exhibit excellent scintillation performance,which,however,suffer from serious stability and toxicity problems.In contrast,the heavy metal-free anti-perovskite materials[MX_(4)]XA_(3)(A=alkali metal;M=transition metal;X=Cl,Br,I),a class of electron-inverted perovskite derivatives,exhibit robust structural and photophysical stability.Here,we design and prepare a lead-free[MnBr_(4)]BrCs_(3) anti-perovskite nanocrystal(NC)-embedded glass for efficient X-ray-excited luminescence with high-resolution X-ray imaging with a spatial resolution of 19.1 Ip mm^(-1).Due to the unique crystal structure and the protection of the glass matrix,the Cs_(3)MnBr_(5) NC-embedded glass exhibits excellent X-ray irradiation stability,thermal stability,and water resistance.These merits enable the demonstration of real-time and durable X-ray radiography based on the developed glassy composite.This work could stimulate the research and development of novel metal halide anti-perovskite materials and open a new path for future development in the field of high-resolution and ultrastable X-ray imaging.

关键词： lead-free metal halides anti-perovskite nanocrystals glass ultrastable X-ray imaging

The Potassium Transporter AtKUP12 Enhances Tolerance to Salt Stress through the Maintenance of the K^(+)/Na^(+)Ratio in Arabidopsis

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 389-402页

作者： Hua Zhang Zhongmin Yang Xilong You Youqiang Heng Yan Wang Xinjiang Key Laboratory of Biological Resources and Genetic Engineering College of Life Science and TechnologyXinjiang UniversityUrumqi830046China

Potassium(K^(+))is a necessary nutrient for plant growth and crop production.The K^(+)transporter plays crucial roles in the absorption and transport of K^(+)in plants.Most K^(+)transporters in Arabidopsis have been reported,but AtKUP12,which is a member of the KT/KUP/HAK family,has not yet been the subject of relevant in-depth research.In the present study,we demonstrated that AtKUP12 plays a crucial role in K^(+)uptake in Arabidopsis under 100μM low-K^(+)and 125 mM salt stress conditions.AtKUP12 transcripts were induced by K^(+)deficiency and salt stress.We analyzed the K^(+)uptake of AtKUP12 using the K^(+)uptake-deficient yeast R5421 and Arabidopsis mutant atkup12.Transformation with AtKUP12 rescued the growth defect of mutant yeast and atkup12 mutant plants at the low-K^(+)concentration,which suggested that AtKUP12 might be involved in high-affinity K^(+)uptake in low-K^(+)environments.In comparison to the wild-type(WT)and atkup12-AtKUP12 complementation lines,atkup12 showed a dramatic reduction in potassium concentration,K^(+)/Na^(+)ratio,and root and shoot growth on 12-day-old seedlings under the salt conditions;however,there was no significant difference between the complementation and WT lines.Taken together,these results demonstrate that AtKUP12 might participate in salt tolerance in Arabidopsis through K^(+)uptake and K^(+)/Na^(+)homeostasis.

关键词： AtKUP12 atkup12 mutant K+uptake K^(+)/Na^(+)homeostasis salt tolerance

High-efficiency and high-power single-frequency fiber laser at 1.6μm based on cascaded energy-transfer pumping

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Photonics Research 2020年第3期8卷 414-420页

作者： XIANCHAO GUAN QILAI ZHAO WEI LIN TIANYI TAN CHANGSHENG yang PENGFEI MA Zhongmin Yang SHANHUI XU School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China State Key Laboratory of Luminescent Materials and Devices and Institute of Optical Communication Materials South China University of TechnologyGuangzhou 510640China Guangdong Engineering Technology Research and Development Center of High-performance Fiber Laser Techniques and Equipment Zhuhai 519031China Hengqin Firay Sci-Tech Company Ltd. Zhuhai 519031China Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques South China University of TechnologyGuangzhou 510640China Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and Devices Guangzhou 510640China

In this paper,a technique combining the cascaded energy-transfer pumping(CEP)method and master-oscillator power-amplifier(MOPA)configuration is proposed for power scaling of 1.6-μm-band single-frequency fiber lasers(SFFLs),where the Er^(3+)ion has a limited gain.The CEP technique is fulfilled by coupling a primary signal light at 1.6μm and a C-band auxiliary laser.The numerical model of the fiber amplifier with the CEP technique reveals that the energy transfer process involves the pump competition and the in-band particle transition between the signal and auxiliary lights.Moreover,for the signal emission,the population density in the upper level is enhanced,and the effective population inversion is achieved thanks to the CEP.A single-frequency MOPA laser at 1603 nm with an output power of 52.6 W and an improved slope efficiency of 30.4%is experimentally obtained through the CEP technique.Besides,a laser linewidth of 5.2 k Hz and a signal-to-auxiliary laser ratio of 60.7 d B are obtained at the maximum output power.The proposed technique is anticipated to be promising for increasing the slope efficiency and power scaling for fiber lasers operating at L band.

关键词： fiber pumping power

Haplotype-resolved and chromosome-level genome assembly of Colorado potato beetle

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Journal of Genetics and Genomics 2023年第7期50卷 532-535页

作者： Ziqi Ye Ruirui Lu Chao Li Doudou yang Zhuozhen Zeng Weichao Lin Jie Cheng Zhongmin Yang Li Wang Yulin Gao Sanwen Huang Xingtan Zhang Suhua Li Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsChinese Academy of Agricultural SciencesShenzhenGuangdong 518000China Key Laboratory of Prevention and Control of Invasive Alien Species in Agriculture&Forestry of the North-western Desert Oasis Ministry of Agriculture and Rural AffairsCollege of AgronomyXinjiang Agricultural UniversityUrumqiXinjiang Uygur Autonomous Region 830052China School of Life Sciences Henan UniversityKaifengHenan 475004China Shenzhen Research Institute of Henan University ShenzhenGuangdong 518000China College of Horticulture Xinjiang Agricultural UniversityUrumuqiXinjiang Uygur Autonomous Region 830052China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Chinese Academy of Tropical Agricultural Sciences HaikouHainan 571101China

As the most important non-cereal food crop,potatoes are a staple food for 1.3 billion people(Stokstad,2019).However,these cultivated potatoes are challenged with multiple biotic stresses(i.e.,pathogens and pests),some of which can evade host resistance,leading to a serious dampening of potato yield.One of these pests is the Colorado potato beetle(hereafter referred to as CPB,Leptinotarsa decemlineata Say).CPB is a member of the order Coleoptera,and originated in the southwestern United States and Mexico(Alyokhin et al.,2008).

关键词： originated hereafter

Realization of one-dimensional 2^(n)-root topological states in photonic lattices

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Science China(Technological Sciences) 2024年第1期67卷 98-104页

作者： WEI RuiShan ZHANG QingLong yang DanDan HUANG XiongJian PAN QiWen KANG Juan QIU JianRong yang zhongmin DONG GuoPing State Key Laboratory of Luminescent Materials and Devices and Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied TechniquesGuangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and DevicesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

Square-root topological insulators recently discovered are intriguing topological phases.They possess topological properties inherited from the squared Hamiltonian and exhibit double-band structures.The mechanism of the square root was generalized to 2^(n)-root topological insulators,giving rise to more band gaps.In this study,we describe the experimental realization of onedimensional 2^(n)-root topological insulators in photonic waveguide arrays using the archetypical Su-Schrieffer-Heeger(SSH)model.Topological edge states with tunable numbers are clearly observed under visible light.In particular,we visualized the dynamic evolutions of the light propagation by varying the sample lengths,which further proved the localization and multiple numbers of edge states in 2^(n)-root topological systems.The experiment,which involves constructing 2^(n)-root topological photonic lattices in various geometric arrangements,provides a stable platform for studying topological states that exhibit a remarkable degree of flexibility and control.

关键词： 2^(n)-root topological insulators multiple edge states photonic waveguide arrays light dynamics

X-ray diffraction performance of thermally distorted crystals

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High Power Laser Science and Engineering 2023年第6期11卷 29-38页

作者： Chuan yang Tao Liu Kai Hu Ye Zhu Xiaohao Dong zhongmin Xu Chao Feng Weiqing Zhang Institute of Advanced Science Facilities ShenzhenChina College of Science Southern University of Science and TechnologyShenzhenChina Shanghai Advanced Research Institute Chinese Academy of SciencesShenzhenChina State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina

The development of high-brightness X-ray free electron lasers(XFELs),such as hard X-ray self-seeding free electron lasers and XFEL oscillators(XFELOs),brings a severe challenge to the crystal monochromator due to a strong nonuniform thermal load.The distortion caused by spatial temperature gradients can severely affect the optical performance of crystals.Therefore,this paper presents a model to estimate the performance of non-uniform thermally distorted crystals.The model not only takes into account thermal strain,slope error and incident angle deviation,but also considers temperature-dependent factors such as the Debye-Waller factor and electric susceptibility.Our investigation indicates that the Debye-Waller factor reduces the height and bandwidth of rocking curves,and the impact of the electric susceptibility is tiny.The proposed model can describe the distortion of the reflectivity and transmissivity curves of nonuniform thermally loaded crystals and can be applied in the design of crystal monochromators,crystal splitters,crystal compressors and XFELOs.

关键词： crystal monochromator free electron laser thermal load X-ray diffraction

Aggregated carbon dots-loaded macrophages treat sepsis by eliminating multidrug-resistant bacteria and attenuating inflammation

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聚集体(英文)

聚集体(英文) 2023年第1期4卷 184-198页

作者： Lihua Li Lingling Chen Yao Lu Binglin Li Rong Hu Ling Huang Tao Zhang Xiaoming Wei Zhongmin Yang Chuanbin Mao State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied TechniquesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhouGuangdongP.R.China Guangdong Key Lab of Orthopedic Technology and Implant General Hospital of Southern Theater Command of PLAThe First School of Clinical MedicineSouthern Medical UniversityGuangzhouGuangdongP.R.China Orthopedic Centre Clinical Research CentreZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China School of Materials Science and Engineering Zhejiang UniversityHangzhouZhejiangP.R.China Department of Chemistry&Biochemistry Stephenson Life Science Research CenterUniversity of OklahomaNormanOklahomaUSA

Sepsis,caused by uncontrollable infection and inflammatory response,leads to more than 30 million infected patients and results in high morbidity worldwide every year.Currently,no efficient approaches have been developed for sepsis therapy due to antimicrobial resistance and inflammatory storm.Here,we report macrophages loaded with aggregated carbon dots(ACDs)in the lysosome,termed MCDs,to treat sepsis in immunosuppressive mice.The ACDs are constructed by negative CDs and amine-abundant polyethyleneimine(PEI),enabling them to bear the strong antibacterial ability and enhanced photoluminescent efficacy.The ACDs are specifically located in the macrophage lysosomes,efficiently enhancing the multidrug-resistant bacteria-killing ability of MCDs.More importantly,the MCDs possess superior anti-inflammatory effects such as reducing the number of pro-inflammatory(M1)and stimulating anti-inflammatory(M2)macrophages.These effects upregulate the inflammatory cytokines(TNF-α,IL-1β,IL-4,and IL-10),ultimately resulting in increased sepsis survival.Our work provides an intelligent approach to overcoming multidrug-resistant bacteria-induced infection from sepsis patients and paves a new avenue on employing nanoparticle-loaded cells for combating inflammation-related infection.

关键词： aggregated carbon dots in macrophages(MCDs) inflammation multidrug-resistant bacteria sepsis

Wearable ultrasensitive and rapid human physiological monitoring based on microfiber Sagnac interferometer

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Science China(Information Sciences) 2024年第3期67卷 281-290页

作者： Xin WANG Hongyou ZHOU Meihua CHEN Yongcheng HE Zhishen ZHANG Jiulin GAN Zhongmin Yang State Key Laboratory Luminescent Materials and Devices Institute of Optical Communication MaterialsSpecial Glass Fiber and Device Engineering Technology Research and Development Center of Guangdong ProvinceGuangdong Provincial Key Laboratory of Fiber Laser Materials and Applied TechniquesSouth China University of Technology Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan University

High-sensitive and fast-responding flexible strain sensors are essential for the smart wearable devices that precisely and dynamically perceive the weak deformations induced by human physiological signals. Here, a flexible strain sensor via polydimethylsiloxane(PDMS)-encapsulated microfiber Sagnac interferometer was designed and prepared for monitoring the human pulse signals and sound vibrations. The sensor achieved a record-breaking sensitivity(gauge factor, GF = 9977) and an extremely low detection limit(0.00025%) due to the strong polarization-dependent coupling effect in the microfiber coupler and the polarization-mixing effect in the Sagnac loop. The relative intensity demodulation method also enabled a fast response time of 10 μs. The wearable pulse measurements were implemented by attaching this flexible strain sensor directly to human skin at various locations and the waveform details were accurately captured. Taking advantage of the ultra-high sensitivity and fast response performance of the prepared sensor, the real-time dynamic acquisition of the underwater weak signal, such as the hydro-acoustic waves with a wide range of 20 Hz–16.86 k Hz, has been demonstrated. These initial results pave the way for a new and innovative category of underwater wearable devices with rapid detection of human physiological signals and weak environmental vibrations.

关键词： flexible strain sensor microfiber Sagnac interferometer underwater detection