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Acta Pharmaceutica Sinica B 2024年第6期14卷 2657-2668页

作者： Chenxu Zhao Jingrong Li Yue Hu Lingyu Li Meng Yu Yunfeng Huang Tao Zhang Hai Shang zhongmei Zou State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Institute of Chinese Medicine Resources Guangxi Institute of Chinese Medicine&Pharmaceutical ScienceNanning 530000China

A pair of coumarin-based polycyclic meroterpenoid enantiomers(+)/(-)-gerbeloid A[(+)-1a and(-)-1b]were isolated from the medicinal plant Gerbera piloselloides,which have a unique caged oxatricyclo[4.***.2.0^(3,8)]decene *** planar and three-dimensional structures were exhaustively characterized by comprehensive spectroscopic data and X-ray diffraction *** by the hypothetical biosynthetic pathway,the biomimetic synthesis of racemic 1 was achieved using 4-hydroxy-5-methylcoumarin and citral as the starting material via oxa-6πelectrocyclization and intramolecular[2+2]***,the results of the biological activity assay demonstrated that both(+)-1a and(-)-1b exhibited potent lipid-lowering effects in 3T3-L1 adipocytes and the high-fat diet zebrafish ***,the lipid-lowering activity of(+)-1a is better than that of(-)-1b at the same concentration,and molecular mechanism study has shown that(+)-1a and(-)-1b impairs adipocyte differentiation and stimulate lipolysis by regulating C/EBPα/PPARγsignaling and Perilipin signaling in vitro and in *** findings provide a promising drug model molecule for the treatment of obesity.

关键词： Gerbera piloselloides Natural products Coumarin meroterpenoid Structural elucidation Biomimetic synthesis Lipid-lowering activity 3T3-L1 adipocytes High-fat diet zebrafish model

Roadmap for the Construction of an Ecological Rule of Law in China

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Social Sciences in China 2013年第4期34卷 162-170页

作者： Lü zhongmei Hubei University of Economics

The Report of the 18th CPC National Congress in 2012 emphasizes building a socialist country based on the rule of law as China＇s overall governance strategy. At the same time, it has expanded the ＂four in one＂ to ＂five in one＂; i.e. the construction of an ecological civilization has been added to the other major tasks in socialist construction with Chinese characteristics---economic construction, political construction, cultural construction, and social construction, thus setting out the roadmap for China＇s construction of an environmental system based on the rule of law. The aim of this construction is to establish an environmental legal system that corresponds to China＇s ecological civilization, and its main task is to integrate environmental rationality into the operation of the rule of law by improving environmental legal mechanisms and institutions.

关键词： ecological civilization environmental rule of law environmental rationality sustainable development

毛细管电泳-质谱技术在手性化合物分离分析中的研究进展

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色谱 2022年第6期40卷 509-519页

作者：迟忠美杨丽渤海大学化学与材料工程学院辽宁锦州121013 东北师范大学化学学院吉林长春130024

目前使用的绝大多数药物为手性化合物,它们具有相似的物理和化学性质,但药理活性不同,且常以外消旋混合物的形式存在,因此对手性化合物的分离在生物、环境、食品和医药等领域一直备受关注。与广泛使用的液相色谱-质谱(LC-MS)相比,毛细... 详细信息

目前使用的绝大多数药物为手性化合物,它们具有相似的物理和化学性质,但药理活性不同,且常以外消旋混合物的形式存在,因此对手性化合物的分离在生物、环境、食品和医药等领域一直备受关注。与广泛使用的液相色谱-质谱(LC-MS)相比,毛细管电泳-质谱(CE-MS)作为一种新型分离分析技术,具有分离效率高、样品和试剂消耗量低、选择性高和分离模式多样化等诸多优势,已经发展成为手性分析领域中有广阔应用前景的分析方法之一。CE-MS结合了CE的高分离效率和低样品消耗以及MS的高灵敏度和强结构解析能力,在蛋白质组学和代谢组学等领域发挥了重要作用。CE杰出的手性拆分能力与MS优势的结合,亦使CE-MS成为实现手性化合物高效分离分析的完美组合。在过去的十几年里,基于不同CE-MS分离模式的高性能手性分析体系层出不穷,如电动色谱-质谱(EKC-MS)、胶束电动色谱-质谱(MEKC-MS)和毛细管电色谱-质谱(CEC-MS)等,并成功应用于医药、生物、食品和环境科学等领域的手性化合物分析。该文主要综述了2011~2021年,CE-MS在手性化合物分析领域的技术、手性选择剂(如改性环糊精和聚合物表面活性剂等)的使用以及在医药等领域应用方面的研究进展,并讨论了不同手性分析模式的局限性,为未来的CE-MS手性分离分析技术发展及应用提供借鉴。

关键词：毛细管电泳质谱手性化合物综述

Data-driven adaptive predictive control of hydrocracking process via covariance matrix adaption evolution strategy

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Data-driven adaptive predictive control of hydrocracking pro...

Geological Characteristics and Metallogenic Setting of Representative Magmatic Cu-Ni Deposits in the Tianshan-Xingmeng Orogenic Belt, Central Asia

第32届中国过程控制会议(CPCC2021)

作者： zhongmei Li Xinjie Wang Wenli Du Minglei yang IEEE Key Laboratory of Smart Manufacturing in Energy Chemical Process East China University of Science and TechnologyMinistry of Education

Hydrocracking is an important petrochemical process,in which the reactor temperature is one of the key parameters to control product distribution and *** this paper,a novel data-driven adaptive predictive control architecture to the reactor temperature control problem in hydrocracking process is proposed with completely unknown system ***,the nonlinear relationship between the reactor temperature and conversion is established by using the echo state networks(ESNs) with intrinsic plasticity rule,and a covariance matrix adaption evolution strategy(CMA-ES) is adopted to optimize the control policy iteratively using the input and state ***,the theory of the prescribed performance function is integrated to guarantee the tracking performance in the absence of the initial *** addition,the input constraints and external disturbance are simultaneously *** simulation results are presented to validate the efficacy of the proposed methodology.

关键词： Hydrocracking process temperature control echo state networks covariance matrix adaption evolution strategy prescribed performance function

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Acta Geologica Sinica(English Edition) 2019年第5期93卷 1205-1218页

作者： HAN Chunming XIAO Wenjiao SU Benxun ZHANG Xiaohui WAN Bo SONG Dongfang ZHANG Zhiyong ZHANG Jien WANG zhongmei XIE Mingcai Key Laboratory of Mineral Resources Chinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Sciences Chinese Academy of SciencesBeijing 100029China State Key Laboratory of Lithospheric evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

A great number of magmatic Cu-Ni deposits(including Kalatongke in Xinjiang and Hongqiling in Jilin) are distributed over a distance of almost 3000 km across the Tianshan-Xingmeng Orogenic Belt, from Tianshan Mountains in Xinjiang in the west, to Jilin in eastern China in the east. These deposits were formed during a range of magmatic episodes from the Devonian to the Triassic. Significant magmatic Cu-Ni-Co-PGE deposits were formed from the Devonian period in the Nalati arc(e.g. Jingbulake Cu-Ni in Xinjiang), Carboniferous period in the Puerjin-Ertai arc(e.g. Kalatongke Cu-Ni-Co-PGE in Xinjiang), Carboniferous period in the Dananhu-Touquan arc(e.g. Huangshandong, Xiangshan and Tulaergen in estern Tianshan, Xinjiang) to Triassic period in the Hulan arc(e.g. Hongqiling Cu-Ni in Jilin). In addition to the overall tectonic, geologic and distribution of magmatic Cu-Ni deposits in the Tianshan-Xingmeng Orogenic Belt, the metallogenic setting, deposit geology and mineralization characteristics of each deposit mentioned above are summarized in this paper. Geochronologic data of Cu-Ni deposits indicate that, from west to east, the metallogenic ages in the Tianshan-Xingmeng Orogenic Belt changed with time, namely, from the Late Caledonian(~440 Ma), through the Late Hercynian(300-265 Ma) to the Late Indosinian(225-200 Ma). Such variation could reflect a gradual scissor type closure of the paleo Asian ocean between the Siberia Craton and the North China Craton from west to east.

关键词： Geochronology magmatic Cu-Ni-Co-PGE deposits Tianshan-Xingmeng Orogenic Belt Central Asia

Screening the effective components in treating dampness stagnancy due to spleen deficiency syndrome and elucidating the potential mechanism of Poria water extract

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Chinese Journal of Natural Medicines 2023年第2期21卷 83-98页

作者： LI Huijun ZHANG Dandan WANG Tianhe LUO Xinyao XIA Heyuan PAN Xiang HAN Sijie YOU Pengtao WEI Qiong LIU Dan ZOU zhongmei YE Xiaochuan Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine School of PharmacyHubei University of Chinese MedicineWuhan 430065China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China

Poria is an important medicine for inducing diuresis to drain dampness from the middle ***,the specific effective components and the potential mechanism of Poria remain largely *** identify the effective components and the mechanism of Poria water extract(PWE)to treat dampness stagnancy due to spleen deficiency syndrome(DSSD),a rat model of DSSD was established through weight-loaded forced swimming,intragastric ice-water stimulation,humid living environment,and alternate-day fasting for 21 *** 14 days of treatment with PWE,the results indicated that PWE increased fecal moisture percentage,urine output,D-xylose level and weight;amylase,albumin,and total protein levels;and the swimming time of rats with DSSD to different *** highly related components were screened out using the spectrum-effect relationship and *** studies revealed that PWE significantly increased the expression of serum motilin(MTL),gastrin(GAS),ADCY5/6,p-PKAα/β/γcat,and phosphorylated cAMP-response element binding protein in the stomach,and AQP3 expression in the ***,it decreased the levels of serum ADH,the expression of AQP3 and AQP4 in the stomach,AQP1 and AQP3 in the duodenum,and AQP4 in the *** induced diuresis to drain dampness in rats with *** main effective components were identified in *** exerted therapeutic effect by regulating the AC-cAMP-AQP signaling pathway in the stomach,MTL and GAS levels in the serum,AQP1 and AQP3 expression in the duodenum,and AQP3 and AQP4 expression in the colon.

关键词： Poria water extract Dampness stagnancy due to spleen deficiency syndrome Spectrum-effect relationship Effective components Mechanisms

Analysis on the Phase Frequency Characteristic of Soil Impedance

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Energy and Power Engineering 2018年第4期10卷 17-24页

作者： Xiaobin Cao zhongmei Li Shiwei Yao School of Electrical Engineering Southwest Jiao Tong University Chengdu China

Soil is a typical porous media and its impedance characteristic directly determines the performance of grounding system. Soil phase frequency characteristic measurements were carried out on various soil types and water content. This paper finds that the impedance angle of soil specimen presents a capacitive performance when power frequency (f) is low. As the frequency increases, soil impedance angle goes up rapidly. Furthermore the frequency characteristic while f > 1000 Hz is distinct in terms of different water content. In particular, at low moisture content, soil impedance angle would be higher than 0?, that is, the inductive component is obvious. The study result indicates that porous media possesses the unique conductivity property dif-ferent from conductor and solution. Its mechanism needs further study.

关键词： Soil Impedance Angle Frequency Characteristic Porous Media Water Content Particle Size

Atramacronoids A-C,three eudesmanolide sesquiterpene-phenol hybrids with an unprecedented C-C linkage from the rhizomes of Atractylodes macrocephala

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Chinese Chemical Letters 2023年第1期34卷 284-288页

作者： Haixin Zhang Jingrong Li Jinguang Si Chengya Dong Qi Li Meng Yu Lingling Qin Lingyu Li Chenxu Zhao Tao Zhang zhongmei Zou Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Medical Sciences Guizhou Medical UniversityGuiyang 550000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing 100193China School of Pharmacy Henan University of Chinese MedicineZhengzhou 450000China

Three eudesmanolide sesquiterpene-phenol hybrids,atramacronoids A-C(1-3),featuring an unusual6/6/5/5/6 skeleton furnished by forming an unexpected C-8-C-16 linkage,were obtained from the rhizomes of Atractylodes *** structures and absolute configurations were elucidated by spectroscopic data analysis,chemical calculations,combined with X-ray *** plausible biosynthetic pathways for compounds 1-3 are ***,compound 1 exhibited cytotoxicity against SGC-7901 cells by inducing cells apoptosis,which might relate to the promotion of synthesis of neutrophil elastase.

关键词： Atractylodes macrocephala Compositae Sesquiterpene-phenol hybrids Anti-cancer Neutrophil elastase

Description of the derived categories of tubular algebras in terms of dimension vectors

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Open Journal of Applied Sciences 2012年第4期2卷 179-182页

作者： Hongbo Lv zhongmei Wang School of Control Science and Engineering Shandong University Jinan 250061 P.R.China School of Mathematical Science University of Jinan Jinan 250022 P.R.China

In this paper, we give a description of the derived category of a tubular algebra by calculating the dimension vectors of the objects in it.

关键词： derived categories tubular algebra dimension vectors

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张量组稀疏表示的高光谱图像去噪算法

测绘学报 2017年第5期46卷 614-622页

作者：王忠美杨晓梅顾行发电子科技大学四川成都610054 中国科学院地理科学与资源研究所北京100101 中国科学院遥感与数字地球研究所北京100101

提出了一种基于张量组稀疏表示的高光谱遥感影像降噪。高光谱影像数据可视为三阶张量。首先,高光谱图像被划分为小的张量分块,然后,对相似的张量分块进行聚类,并对聚类分组进行稀疏表示。基于高光谱图像的空间非局部自相似性和光谱相关... 详细信息

提出了一种基于张量组稀疏表示的高光谱遥感影像降噪。高光谱影像数据可视为三阶张量。首先,高光谱图像被划分为小的张量分块,然后,对相似的张量分块进行聚类,并对聚类分组进行稀疏表示。基于高光谱图像的空间非局部自相似性和光谱相关性,将张量组稀疏表示模型分解为一系列无约束低秩张量的近似问题,进而通过张量分解进行求解。对模拟和真实高光谱数据进行试验,验证了该算法的有效性。

关键词：高光谱图像张量稀疏表示非局部相似性