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Crosstalk between IL-15Rα^(+)tumor-associated macrophages and breast cancer cells reduces CD8+T cell recruitment

Cancer Communications 2022年第6期42卷 536-557页

作者： Wenlong Zhang Qing Zhang Nanfei Yang Qian Shi Huifang Su Tingsheng Lin zhonglei he Wenxin Wang Hongqian Guo Pingping Shen State Key Laboratory of Pharmaceutical Biotechnology and Department of Urology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolSchool of Life SciencesNanjing UniversityNanjingJiangsu 210023P.R.China Department of Urology Drum Tower HospitalMedical School of Nanjing UniversityInstitute of UrologyNanjing UniversityNanjingJiangsu 210008P.R.China Shenzhen Research Institute of Nanjing University Shenzhen 518000China Department of Cellular and Integrative Physiology The University of Texas Health Science Center at San AntonioSan AntonioTexas 78229-3904USA Charles Institute of Dermatology School of MedicineUniversity College DublinDublin Eircode D04 V1W8Ireland

Background:Interleukin-15(IL-15)is a promising immunotherapeutic agent owing to its powerful immune-activating effects.However,the clinical benefits of these treatments are limited.Crosstalk between tumor cells and immune cells plays an important role in immune escape and immunotherapy drug resistance.herein,this study aimed to obtain in-depth understanding of crosstalk in the tumor microenvironment for providing potential therapeutic strategies to prevent tumor progression.Methods:T-cell killing assays and co-culture models were developed to determine the role of crosstalk between macrophages and tumor cells in breast cancer resistant to IL-15.Western blotting,histological analysis,CRISPR-Cas9 knockout,multi-parameter flow cytometry,and tumor cell-macrophage co-injection mouse models were developed to examine the mechanism by which IL-15Rα^(+)tumor-associated macrophages(TAMs)regulate breast cancer cell resistance to IL-15.Results:We found thatmacrophages contributed to the resistance of tumor cells to IL-15,and tumor cells induced macrophages to express high levels of theαsubunit of the IL-15 receptor(IL-15Rα).Further investigation showed that IL-15Rα^(+)TAMs reduced the protein levels of chemokine CX3C chemokine ligand 1(CX3CL1)in tumor cells to inhibit the recruitment of CD8^(+)T cells by releasing the IL-15/IL-15Rαcomplex(IL-15Rc).Administration of an IL-15Rc blocking peptide markedly suppressed breast tumor growth and overcame the resistance of cancer cells to anti-programmed cell death protein 1(PD-1)antibody immunotherapy.Interestingly,Granulocyte-macrophage colony-stimulating factor(GMCSF)inducedγchain(γc)expression to promote tumor cell-macrophage crosstalk,which facilitated tumor resistance to IL-15.Additionally,we observed that the non-transcriptional regulatory function of hypoxia inducible factor-1alpha(HIF-1α)was essential for IL-15Rc to regulateCX3CL1 expression in tumor cells.Conclusions:The IL-15Rc-HIF-1α-CX3CL1 signaling pathway serves as a crosstalk between macrophages and tumor cells in the t

关键词： breast cancer CD8^(+)T-cell crosstalk IL-15Rα immunotherapy tumor microenvironment tumor-associated macrophages

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基于正交实验法拖拉机底盘的优化设计

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农机化研究 2024年第3期46卷 228-232页

作者：黑中垒黄河交通学院河南武陟454950

拖拉机底盘作为承载拖拉机的重要部件之一,是保证拖拉机完成各项田间工作重要基础条件之一。为此,在保证拖拉机最大负载的前提下,减轻拖拉机底盘的质量和强度是拖拉机底盘优化的重要条件。针对以上问题,以拖拉机底盘优化为基础条件,在... 详细信息

拖拉机底盘作为承载拖拉机的重要部件之一,是保证拖拉机完成各项田间工作重要基础条件之一。为此,在保证拖拉机最大负载的前提下,减轻拖拉机底盘的质量和强度是拖拉机底盘优化的重要条件。针对以上问题,以拖拉机底盘优化为基础条件,在考虑拖拉机底盘具有足够的弯曲刚度的前提下,可以获得更好的田间工作性能。选取拖拉机底盘最大应力、最大等边应力和挠度作为拖拉机底盘设计的评价指标,通过拖拉机底盘两个不同的截面,即C和I进行拖拉机底盘的建模,通过正交阵列方法得到各个截面的最佳参数。采用数值模型分析腹板厚度、上翼缘厚度和下翼缘厚度等参数的影响,并对不同截面进行应力分析来确定最大挠度和应力。研究结果可为实现拖拉机底盘的优化设计提供技术参考。

关键词：拖拉机正交阵列底盘有限元分析参数优化

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Observations and parametric study on the role of plasma density on extremely low-frequency chorus wave generation

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Science China(Technological Sciences) 2022年第11期65卷 2649-2657页

作者： he Qian LIU Si XIAO FuLiang GAO zhonglei LI Tong SHANG XiongJun ZHOU QingHua YANG Chang he YiHua School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China

Extremely low-frequency(ELF)chorus waves with frequencies below 0.1 fcecan cause the scattering losses of relativistic electrons.Previous studies have suggested that ELF chorus waves are excited by anisotropic electrons with energies up to a few hundred ke V.here,we report an interesting event observed using the Van Allen Probes on November 1,2012,where distinct ELF chorus waves occurred exactly corresponding to the enhancement of the plasma density.Using the correlated data of particles and plasma environments,the continuous calculation of growth rates along the satellite trajectory was conducted.The linear analysis results display a similar pattern to the observation results.To further identify the impact of the plasma density on the frequency control of ELF chorus waves,the growth rates were then calculated by only changing the value of the plasma density.The calculation results show that the growth rates move to lower frequencies with plasma density enhancement during the event.These findings indicate that the increased plasma density has a considerable impact on the wave frequency.The current study can enrich our understanding of the possible role of plasma density on the generation of ELF chorus waves.

关键词： radiation belts plasma density extremely low-frequency chorus waves numerical simulation

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基于云平台的物联网压力变送器监测系统设计与实现

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流体测量与控制 2024年第3期5卷 60-63页

作者：张忠磊山东昱铭环保工程有限公司山东东营257100

研究了基于云平台的物联网压力变送器监测系统的设计与实现。通过引入云计算技术,构建了一个高效、可扩展、拥有实时数据共享能力的系统,能够满足工业过程控制的精确要求。从硬件的选型、网络架构到云平台的搭建,详细介绍了整个系统设... 详细信息

研究了基于云平台的物联网压力变送器监测系统的设计与实现。通过引入云计算技术,构建了一个高效、可扩展、拥有实时数据共享能力的系统,能够满足工业过程控制的精确要求。从硬件的选型、网络架构到云平台的搭建,详细介绍了整个系统设计流程,并通过实验仿真验证了系统性能。测试结果显示,系统实现了设计目标的敏捷扩展、高稳定、低时延,并能有效支持高达500个监测节点的并发连接,验证了系统的可行性和工业应用潜力。

关键词：物联网云平台压力变送器监测系统

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中国山区县域人口收缩的空间格局及其形成机制

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地理研究 2024年第5期43卷 1205-1224页

作者：侯晓静喻忠磊李雨婷袁留阳孙畅河南大学黄河文明与可持续发展研究中心暨黄河文明省部共建协同创新中心郑州450046

本文基于人口普查数据分析2000—2020年中国山区县人口收缩的时空格局,借鉴“3D(密度、距离、分割)”框架设计解释变量,运用heckman两阶段模型识别人口收缩的影响因素,并采用地理探测器识别主控因素的交互作用,进而在“四层一体”框架... 详细信息

本文基于人口普查数据分析2000—2020年中国山区县人口收缩的时空格局,借鉴“3D(密度、距离、分割)”框架设计解释变量,运用heckman两阶段模型识别人口收缩的影响因素,并采用地理探测器识别主控因素的交互作用,进而在“四层一体”框架下解析山区人口收缩空间格局的形成机制。研究发现:(1) 2000—2020年山区县人口占全国总人口比例持续降低,收缩型山区县数量不断增多,山区人口收缩程度加重并存在自我强化特征。(2)人口密度等级降低的山区县不断增加,人口密度为(100~200)人/km2的过渡区是人口变化最活跃区域,过渡区向稀疏区、集聚区向过渡区转型是山区县人口变化的主要方向,仅少数山区县由过渡区转为集聚区;位于省际和市际边缘区的山区县人口变化剧烈且以收缩为主要特征。(3)山区人口收缩区范围持续扩大且集中分布,形成内蒙古中东部-东北、武陵山、秦巴山区、大别山、太行山、云南中部、山东丘陵及福建丘陵共八大片区,其中内蒙古中东部-东北片区、武陵山片区主要表现为重度和中度收缩,其余片区以轻度收缩为主。(4)人口收缩存在等时圈指向,倾向于发生在地级市2h、省会城市4h等时圈范围内,随时间距离增加该指向先增强后减弱。(5)高就业密度抑制山区县发生人口收缩;距地级市、省会城市较远的山区县更易发生人口收缩;文化分割、制度分割分别对人口收缩具有抑制和促进作用;前述因素在自然、生计、制度和意识形态层发挥作用并交互影响共同塑造中国山区人口收缩的空间格局。

关键词：中国山区人口收缩 “3D”分析框架 “四层一体” 空间格局

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Electrospun Fluorinated Polyimide/Polyvinylidene Fluoride Composite Membranes with High Thermal Stability for Lithium Ion Battery Separator

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Advanced Fiber Materials 2022年第1期4卷 108-118页

作者： Jianwei Li Xuanning Zhang Yuyan Lu Keliang Linghu Chen Wang zhonglei Ma Xinhai he School of Materials Science and Engineering Xi’an Polytechnic UniversityXi’an 710048China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemical and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China National Advanced Functional Fiber Innovation Center Suzhou 215000China

The separator with excellent mechanical and thermal properties are highly required for lithium ion batteries(LIBs).Therefore,it is crucial to develop novel nanofbrous membranes with enhanced mechanical strength and thermal stability.In this work,the fuorinated polyimide(FPI)was synthesized and blended with polyvinylidene fuoride(PVDF)to fabricate composite nanofbrous membranes(CNMs)via electrospinning method.Benefting from the introduction of aromatic FPI,the prepared PVDF/FPI nanofbrous membranes were endowed with enhanced mechanical strength and thermal stability.When the FPI content increased from 0 to 30 wt%,the tensile strength of composite nanofbrous membranes enhanced from 1.57 to 2.30 MPa.Moreover,there are almost no dimensional shrinkage for the CNM-30 containing 30 wt%FPI after heat treatment at 160℃ for 1 h.Furthermore,the prepared CNMs show improved electrochemical performances in comparison with neat PVDF and commercial Celgard membranes.The electrolyte uptake and ionic conductivity of the CNMs could reach to 522.4% and 1.14 ms·cm^(−1),respectively.The prepared CNMs could provide an innovative and promising approach for the development and design of high-performance separators.

关键词： Nanofbrous membrane PVDF Polyimide Lithium ion battery Separator

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成人高等医学教育教学方法思考

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卫生职业教育 2007年第17期25卷 22-23页

作者：林茵何钟磊上海职工医学院上海200237 上海市卫生学校上海200237

成人高等医学教育有别于普通高等教育，在选择教学方法时应切合成人学生的实际，明确培养目标，突出教学重点，改革教学方法，采用现代教育技术，以期更好地达到教育目的，提高教学质量。

关键词：成人高等医学教育教学方法

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Hierarchical design of FeCo-based microchains for enhanced microwave absorption in C band

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Nano Research 2023年第1期16卷 1773-1778页

作者： Yixuan Han Mukun he Jinwen Hu Panbo Liu Zhongwu Liu zhonglei Ma Wenbo Ju Junwei Gu Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China School of Physics and Optoelectronics and School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Microwave absorbing materials(MAMs)has been intensively investigated in order to meet the requirement of electromagnetic radiation control,especially in S and C band.In this work,FeCo-based magnetic MAMs are hydrothermally synthesized via a magnetic-field-induced process.The composition and morphology of the MAMs are capable of being adjusted simultaneously by the atomic ratio of Fe2+to Co2+in the precursor.The hierarchical magnetic microchain,which has a core–shell structure of twodimensional FexCo1−xOOH nanosheets anchored vertically on the surface of a one-dimensional(1D)Co microchain,shows significantly enhanced microwave absorption in C band,resulting in a reflection loss(RL)of lower than−20 dB at frequencies ranging from 4.4 to 8.0 GHz under a suitable matching thickness.The magnetic coupling of Co microcrystals and the double-loss mechanisms out of the core-shell structure are considered to promote the microwave attenuation capability.The hierarchical design of 1D magnetic MAMs provides a feasible strategy to solve the electromagnetic pollution in C band.

关键词： one-dimensional micromagnets hierarchical structure microwave absorbing material magnetic coupling double-loss mechanisms

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A machine-learning-based electron density (MLED) model in the inner magnetosphere

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Earth and Planetary Physics 2022年第4期6卷 350-358页

作者： QingHua Zhou YunXiang Chen FuLiang Xiao Sai Zhang Si Liu Chang Yang YiHua he zhonglei Gao School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Hunan Provincial Key Laboratory of Flexible Electronic Materials Genome Engineering Changsha University of Science and TechnologyChangsha 410114China

Plasma density is an important factor in determining wave-particle interactions in the magnetosphere.We develop a machine-learning-based electron density(MLED)model in the inner magnetosphere using electron density data from Van Allen Probes between September 25,2012 and August 30,2019.This MLED model is a physics-based nonlinear network that employs fundamental physical principles to describe variations of electron density.It predicts the plasmapause location under different geomagnetic conditions,and models separately the electron densities of the plasmasphere and of the trough.We train the model using gradient descent and backpropagation algorithms,which are widely used to deal effectively with nonlinear relationships among physical quantities in space plasma environments.The model gives explicit expressions with few parameters and describes the associations of electron density with geomagnetic activity,solar cycle,and seasonal effects.Under various geomagnetic conditions,the electron densities calculated by this model agree well with empirical observations and provide a good description of plasmapause movement.This MLED model,which can be easily incorporated into previously developed radiation belt models,promises to be very helpful in modeling and improving forecasting of radiation belt electron dynamics.

关键词： background electron density inner magnetosphere machine learning Van Allen Probes observation

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High-Efficiency Electromagnetic Interference Shielding of rGO@FeNi/Epoxy Composites with Regular Honeycomb Structures

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Nano-Micro Letters 2022年第3期14卷 244-256页

作者： Ping Song zhonglei Ma Hua Qiu Yifan Ru Junwei Gu Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China Queen Mary University of London Engineering School Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

With the rapid development of fifth-generation mobile com-munication technology and wearable electronic devices,electromagnetic interference and radiation pollution caused by electromagnetic waves have attracted worldwide attention.Therefore,the design and development of highly efficient EMI shielding materials are of great importance.In this work,the three-dimensional graphene oxide(GO)with regular honeycomb structure(GH)is firstly constructed by sacrificial template and freeze-dry-ing methods.Then,the amino functionalized FeNi alloy particles(f-FeNi)are loaded on the GH skeleton followed by in-situ reduction to prepare rGH@FeNi aerogel.Finally,the rGH@FeNi/epoxy EMI shielding com-posites with regular honeycomb structure is obtained by vacuum-assisted impregnation of epoxy resin.Benefitting from the construction of regular honeycomb structure and electromagnetic synergistic effect,the rGH@FeNi/epoxy composites with a low rGH@FeNi mass fraction of 2.1 wt%(rGH and f-FeNi are 1.2 and 0.9 wt%,respectively)exhibit a high EMI shielding effectiveness(EMI SE)of 46 dB,which is 5.8 times of that(8 dB)for rGO/FeNi/epoxy composites with the same rGO/FeNi mass fraction.At the same time,the rGH@FeNi/epoxy composites also possess excellent thermal stability(heat-resistance index and temperature at the maximum decomposition rate are 179.1 and 389.0°C respectively)and mechanical properties(storage modulus is 8296.2 MPa).

关键词： Electromagnetic interference shielding rGO@FeNi Epoxy resins Honeycomb structures

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