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Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage

Stroke & Vascular Neurology 2024年第4期9卷 446-456,I0147页

作者： Yunke li Sung-Min Cho Radhika Avadhani Hassan Ali Yi Hao Santosh B Murthy Joshua N Goldstein Fan Xia Xin Hu Natalie l.ullman Issam Awad Daniel Hanley Wendy C Ziai The George Institute for Global Health BeijingChina Department of Neurology Division of Neurocritical CareJohns Hopkins Medical InstitutionsBaltimoreMarylandUSA Department of Neurology Division of Brain Injury OutcomesJohns Hopkins Medical Institutions CampusBaltimoreMarylandUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNew YorkUSA Department of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA Department of Neurosurgery West China Hospital of MedicineChengduSichuanChina Department of Neurosurgery University of Chicago Pritzker School of MedicineChicagoIllinoisUSA

Background Minimally invasive surgery(MIS)for spontaneous supratentorial intracerebral haemorrhage(ICH)is controversial but may be beneficial if end-of-treatment(EOT)haematoma volume is reduced to≤15 *** explored whether MRI findings of cerebral small vessel disease(CSVD)modify the effect of MIS on long-term *** Prespecified blinded subgroup analysis of 288 subjects with qualified imaging sequences from the phase 3 Minimally Invasive Surgery Plus Alteplase for Intracerebral Haemorrhage Evacuation(MISTIE)*** tested for heterogeneity in the effects of MIS and MIS+EOT volume≤15 ml on the trial’s primary outcome of good versus poor function at 1 year by the presence of single CSVD features and CSVD scores using multivariable *** Of 499 patients enrolled in MISTIE III,288 patients had MRI,149(51.7%)randomised to MIS and 139(48.3%)to standard medical care(SMC).Median(IQR)ICH volume was 42(30–53)*** the full MRI cohort,there was no statistically significant heterogeneity in the effects of MIS versus SMC on 1-year outcomes by any specific CSVD feature or by CSVD scores(all P_(interaction)>0.05).In 94 MIS patients with EOT ICH volume≤15 ml,significant reduction in odds of poor outcome was found with cerebral amyloid angiopathy scorelacunes(OR,0.37(0.18–0.80);P_(interaction)=0.02)and absence of severe white matter hyperintensities(WMHs)(OR,0.22(0.08–0.58);P_(interaction)=0.03).Conclusions Following successful haematoma reduction by MIS,we found significantly lower odds of poor functional outcome with lower total burden of CSVD in addition to absence of lacunes and severe *** features may have utility for prognostication and patient selection in clinical trials of MIS.

关键词： Surgery surgery absence

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Pressure Distinguishes the Dual Emissions in Pseudohalide 2D Ruddlesden-Popper Perovskite Cs_(2)Pb(SCN)_(2)Br_(2)

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CCS Chemistry 2024年第7期6卷 1748-1756页

作者： Songhao Guo Yuhong Mao Congcong Chen Yao Zhang Guoxiang Zhao Kejun Bu Qingyang Hu Haiming Zhu Guifu Zou Wenge Yang lingling Mao Xujie lü Center for High Pressure Science and Technology Advanced Research(HPSTAR) Shanghai Department of Chemistry Southern University of Science and TechnologyShenzhen Department of Chemistry Zhejiang UniversityHangzhou College of Energy Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou

Two-dimensional(2D)Ruddlesden-Popper(RP)halide perovskites with diverse structures and properties have drawn increasing attention due to their promising optoelectronic ***,a new all-inorganic Cs_(2)Pb(SCN)_(2)Br_(2) has been reported that opens up new potential for the development of 2D RP ***,recent reports of unusual dual emissions and two-edge absorption in Cs_(2)Pb(SCN)_(2)Br_(2) have generated intense debate about its origin and remains ***,by combining continuous pressure tuning with in situ diagnostics,we have unambiguously revealed the underlying mechanisms that the 2D Cs_(2)Pb(SCN)_(2)Br_(2) exhibits an intrinsic blue emission at 2.66 eV and an absorption edge close to the emission *** the gradually formed CsPbBr_(3) is responsible for the green emission at 2.33 eV with the absorption shoulder at 2.41 ***,by fitting the temperature-dependent intensity of the intrinsic blue emission,we have determined the corrected value of exciton binding energy for 2D Cs_(2)Pb(SCN)_(2)Br_(2) to be 90 ***,an emission enhancement of 2.5 times is achieved in Cs_(2)Pb(SCN)_(2)Br_(2) under a mild pressure within 0.8 GPa,caused by the pressuresuppressed exciton-phonon *** work not only elucidates the origin of the dual emissions and two-edge absorption in Cs_(2)Pb(SCN)_(2)Br_(2),but it also provides a potential means to regulate and optimize the optoelectronic properties of 2D perovskites.

关键词： two-dimensional perovskite dual emissions two-edge absorption high pressure in situ characterization enhanced photoluminescence

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A comparison of animal color measurements using a commercially available digital color sensor and photograph analysis

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Current Zoology 2020年第6期66卷 601-606页

作者： Alex D.Potash Daniel.u.Greene Gabrielle A.Foursa Verity l.Mathis l.Mike Conner Robert A.McCleery Department of Wildlife Ecology and Conservation University of Florida Institute of Food and Agricultural ScienceGainesvilleFL 32611USA Weyerhaeuser Company Environmental Research SouthColumbusMS 39701USA Department of Biology University of FloridaGainesvilleFL 32611USA Florida Museum of Natural History University of FloridaGainesvilleFL 32611USA The Jones Center at Ichauway NewtonGA 39870USA

An animal's pelage,feather,or skin color can serve a variety of functions,so it is important to have multiple standardized methods for measuring *** of the most common and reliable methods for measuring animal coloration is the use of standardized digital photographs of *** tech no logy in the form of a commercially available handheld digital color sensor could provide an alter native to photography-based animal color *** determine whether a digital color sensor could be used to measure animal coloration,we tested the ability of a digital color sensor to measure coloration of mammalian,avian,and lepidopteran museums *** compared results from the sensor to measurements taken using traditional photography *** study yielded significant differences between photography-based and digital color sensor measurements of brightness(light to dark)and colors along the green to red *** was no difference between photographs and the digital color sensor measurements for colors along the blue to yellow *** average difference in recorded color(AE)by the 2 methods was above the threshold at which humans can perceive a *** were sign讦icant correlations between the sensor and photographs for all measurements indicating that the sensor is an effective animal coloration measuring ***,the sensor's small aperture and narrow light spectrum range designed for human-vision limit its value for ecological *** discuss the conditions in which a digital color sensor can be an effective tool for measuring animal coloration in both laboratory settings and in the field.

关键词： animal coloration color measurement comparative method digital photography museum specimens Nix color sensor

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Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-lópez Iva Tic David Valle-García Marta Ribalta-Vilella luis labrador Deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer lyon Universitéde LyonLyonFrance Inserm u1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS uMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-uTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cul.ures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

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The AlMaQuEST Survey ⅩⅤ:The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 174-196页

作者： Niankun Yu Zheng Zheng Chao-Wei Tsai Pei Zuo Sara l.Ellison David V.Stark Di li Jingwen Wu Karen l.Masters Ting Xiao Yinghui Zheng Zongnan li Kai Zhang Hongying Chen Shu l.u Sihan Jiao Fanyi Meng National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Department of Physics&Astronomy University of VictoriaVictoriaV8P 1A1Canada Departments of Physics and Astronomy Haverford CollegeHaverford19041USA Space Telescope Science Institute San Martin Dr.Baltimore 21218USA Zhejiang laboratory Hangzhou 311121China New Cornerstone Science laboratory Shenzhen 518054China School of Physics Zhejiang UniversityHangzhou 310058China

The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies,which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar *** compiled a sample of 94 nearby galaxies with observations of multi-phase gas contents by utilizing public H_(Ⅰ),CO,and optical IFu data from the Ma ngA survey together with new FAST H_(Ⅰ)*** agreement with previous results,our sample shows that the global molecular-to-atomic gas ratio(R_(mol)≡log M_(H2)/M_(H_(Ⅰ)))is correlated with the global stellar mass surface densityμ_*with a Kendall'sτcoefficient of 0.25 and pless tightly but still correlated with stellar mass and NuV-r color,and not related to the specific star formation rate(sSFR).The cold gas distribution and kinematics inferred from the H_(Ⅰ)and CO global profile asymmetry and shape do not significantly rely on R_(mol).Thanks to the availability of kpc-scale observations of MangA,we decompose galaxies into H_(Ⅱ),composite,and AGN-dominated regions by using the BPT *** increasing R_(mol),the fraction of H_(Ⅱ)regions within 1.5 effective radius decreases slightly;the density distribution in the spatially resolved BPT diagram also changes significantly,suggesting changes in metallicity and ionization *** with high R_(mol)tend to have high oxygen abundance,both at one effective radius with a Kendall'sτcoefficient of 0.37(pl *** all parameters investigated here,the oxygen abundance at one effective radius has the strongest relation with global R_(mol).The dependence of gas conversion on gas distribution and galaxy ionization states is *** contrast,the observed positive relation between oxygen abundance(μ_(*))and R_(mol)indicates that the gas conversion is efficient in regions of high metallicity(density).

关键词： Galaxies baryon cycle radio lines H_(Ⅰ)21 cm atomic-to-molecular gas conversion

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Physics-based,data-driven approach for predicting natural ventilation of residential high-rise buildings

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Building Simulation 2022年第1期15卷 129-148页

作者： Vincent J.l.Gan Boyu Wang C.M.Chan A.u.Weerasuriya Jack C.P.Cheng Department of Building School of Design and EnvironmentNational University of SingaporeSingapore117566 Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Natural ventilation is particularly important for residential high-rise buildings as it maintains indoor human comfort without incurring the energy demands that air-conditioning *** improve a building’s natural ventilation,it is essential to develop models to understand the relationship between wind flow characteristics and the building's *** more effort is still needed for developing such reliable,accurate,and computationally economical models instead of currently the most popular physics-based models such as computational fluid dynamics(CFD)*** paper,therefore,presents a novel model developed based on physics-based modelling and a data-driven approach to evaluate natural ventilation in residential high-rise *** model first uses CFD to simulate wind pressures on the exterior surfaces of a high-rise *** the surface pressures have been obtained,multizone modelling is used to predict the air change per hour(ACH)for different flats in various ***-driven prediction models are then developed using data from the simulation and deep neural networks that are based on mean absolute error,mean absolute percentage error,and a fusion algorithm *** data-driven models are used to predict the ACH of 25 *** results from multizone modelling and data-driven modelling are *** results imply a high accuracy of the data-driven prediction in comparison with physics-based *** fusion algorithm-based neural network performs best,achieving 96%accuracy,which is the highest of all models *** study contributes a more efficient and robust method for predicting wind-induced natural *** findings describe the relationship between building design(e.g.,plan layout),distribution of surface pressure,and the resulting ACH,which serve to improve the practical design of sustainable buildings.

关键词： computational fluid dynamics data-driven prediction machine learning multizone model natural ventilation residential building

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基于直接约束法的预应力构件张拉全过程分析方法

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世界桥梁 2015年第4期43卷 69-73页

作者：梁天福武汉地铁集团有限公司湖北武汉430030

为准确模拟预应力构件张拉过程中预应力筋与混凝土之间的相互作用,引入一种基于直接约束法的张拉全过程分析方法。该方法运用***软件建立预应力构件模型,混凝土和预应力筋采用三维实体单元模拟,定义库仑双线性模型为混凝土和预应力筋之... 详细信息

为准确模拟预应力构件张拉过程中预应力筋与混凝土之间的相互作用,引入一种基于直接约束法的张拉全过程分析方法。该方法运用***软件建立预应力构件模型,混凝土和预应力筋采用三维实体单元模拟,定义库仑双线性模型为混凝土和预应力筋之间的摩擦本构关系,利用直接约束法描述接触关系,进行预应力张拉全过程分析。采用该方法对2个预应力构件模型进行预应力构件张拉全过程分析,将模拟计算值、试验实测值和按设计规范计算的理论值进行对比,结果表明该方法模拟的有效预应力值与实测值、理论值吻合较好,验证了该方法的准确性。

关键词：预应力混凝土结构有效预应力库仑双线性摩擦模型直接约束法接触分析摩擦损失数值模拟

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A Statistical Mechanical Analysis on the Bound State Solution of an Energy-Dependent Deformed Hulthén Potential Energy

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Communications in Theoretical Physics 2019年第9期71卷 1127-1138页

作者： B.C.lütfüoglu A.N.Ikot u.S.Okorie A.T.ngiangia Department of Physics Faculty of ScienceAkdeniz University07058AntalyaTurkey Department of Physics Faculty of ScienceUniversity of Hradec KraloveRokitanskeho6250003Hradec KraloveCzechia Department of Physics Theoretical Physics GroupUniversity of Port HarcourtChobaPort HarcourtNigeria Department of Physics Akwa Ibom State UniversityIkot AkpadenP.M.B.1167UyoNigeria

In this article, we investigate the bound state solution of the Klein Gordon equation under mixed vector and scalar coupling of an energy-dependent deformed Hulthén potential in D dimensions. We obtain a transcendental equation after we impose the boundary conditions. We cal.ulate energy spectra in four different limits and in arbitrary dimension via the Newton-Raphson method. Then, we use a statistical method, namely canonical partition function, and discuss the thermodynamic properties of the system in a comprehensive way. We find out that some of the thermodynamic properties overlap with each other, some of them do not.

关键词： Klein-Gordon equation energy-dependent deformed Hulthén potential energy bound state solution thermodynamic properties

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基于背景噪声反演华南块体岩石圈三维S波速度结构

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北京大学学报（自然科学版） 2024年第3期60卷 442-452页

作者：吕杰陈永顺郭震北京大学地球与空间科学学院北京100871 南方科技大学海洋科学与工程系深圳518055

利用背景噪声方法,对布设在华南块体及其周边区域数个流动地震台阵中共704个地震台站的连续数据进行分析,反演得到华南岩石圈的三维S波速度结构。结果表明,地表附近S波速度结构与华南块体的地表构造高度相关,低速异常区集中在四川盆地... 详细信息

利用背景噪声方法,对布设在华南块体及其周边区域数个流动地震台阵中共704个地震台站的连续数据进行分析,反演得到华南岩石圈的三维S波速度结构。结果表明,地表附近S波速度结构与华南块体的地表构造高度相关,低速异常区集中在四川盆地和江汉盆地等沉积层较厚的区域。江南造山带的中上地壳呈现明显的高速异常,该高速异常即为华夏块体与扬子块体的分界区域。华夏块体中地壳低速异常区与该区域广泛分布的中生代花岗岩对应较好。华南上地幔岩石圈的东部与西部存在显著的速度差异,西部呈现显著的高速异常,反映西部四川盆地底部稳固的克拉通结构;上地幔的低速异常揭示华南东部岩石圈因太平洋板块俯冲的影响而明显减薄(<70km)。推测华夏块体以琼州海峡为中心的上地幔显著低速区可能对应海南地幔柱的热物质上涌。

关键词：华南块体 S波速度结构江南造山带板块俯冲

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Cal.ulation of stratosphere–troposphere exchange in East Asia cut-off lows:cases from the lagrangian perspective

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Atmospheric and Oceanic Science letters 2016年第1期9卷 31-37页

作者： Wu Xue lü Da-Ren Key laboratory for Atmosphere and Global environment Observation Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

In this study,the authors focus on the cut-off low pressure systems（COls）lingering over East Asia in late spring and early summer and quantify the two-way stratosphere–troposphere exchange（STE）by 3D trajectory integrations,achieved using a revised version of the uK universities Global Atmospheric Modelling Programme Offline Trajectory Code（Version 3）.By selecting 10 typical COls and cal.ulating the cross-tropopause air mass fluxes,it is found that stratosphere-to-troposphere transport（STT）fluxes exist in the center of COls;and in the periphery of the COl center,troposphereto-stratosphere transport（TST）fluxes and STT fluxes are distributed *** transport fluxes in COls are from stratosphere to troposphere,and the magnitude is about 10-4 kg m-2 *** ratio between the area-averaged STT and TST fluxes increases with increasing strength of the *** adopting appropriate residence time,the spurious transports are effectively ***,the authors compare the results with previous studies,and find that the cross-tropopause fluxes（CTFs）induced by COls are about one to two orders of magnitude larger than global *** play a significant role in local,rapid air mass exchanges,although they may only be responsible for a fraction of the total STE.

关键词： stratosphere–troposphere exchange cut-off low trajectory model

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