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High-throughput and simultaneous inertial separation of tumor cells and clusters from malignant effusions using spiral-contraction-expansion channels

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Microsystems & Nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian zhu Hui Ren Dan Wu zhonghua Ni Nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a microfluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231 tumor cells were recovered at a high flow rate of 3500µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

鄱阳湖水利调控对湖区典型丰枯水年水动力水质影响研究

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水利学报 2018年第2期49卷 156-167页

作者：杨中华朱政涛槐文信白凤朋武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072 浙江省水利水电勘测设计院浙江杭州310002

鄱阳湖水利枢纽工程的修建会在一定程度上阻拦长江与鄱阳湖的江湖连通性,湖区水流情势将发生改变。本研究采用有限体积法求解非结构网格下的二维浅水水动力水质模型,根据初定的枢纽工程水位调度方案,研究典型丰枯水年湖区水动力与水质... 详细信息

鄱阳湖水利枢纽工程的修建会在一定程度上阻拦长江与鄱阳湖的江湖连通性,湖区水流情势将发生改变。本研究采用有限体积法求解非结构网格下的二维浅水水动力水质模型,根据初定的枢纽工程水位调度方案,研究典型丰枯水年湖区水动力与水质条件变化。结果表明,枢纽工程建成后,丰水年星子站年平均水位抬升1.49 m,枯水年星子站年平均水位抬升1.88 m,枯水年水利枢纽工程对湖泊水位抬升变幅值、流速变幅值和工程影响的持续时间均高于丰水年。工程后丰水年枯水期水面面积增加15.3%,水量增加29.2%,枯水年枯水期水面面积增加22.8%,水量增加54.1%。选用示踪剂模型研究工程后湖区物质输运条件的改变,发现湖区物质输运过程明显减慢。典型丰水年水力滞留时间增幅为1~2 d,典型枯水年水力滞留时间增幅2~9 d;典型丰水年示踪剂传输时间增加值1~9 d,典型枯水年示踪剂传输时间增加值1~20 d。

关键词：鄱阳湖水利枢纽工程水文水动力水力滞留时间示踪剂传输时间

Self-healing Ga-based liquid metal/alloy anodes for rechargeable batteries

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Nano Research 2024年第3期17卷 1366-1383页

作者： Meijia Song zhonghua Zhang School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212000China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJingshi Road 17923Jinan 250061China

With the rapid development of electronics,electric vehicles,and grid energy storage stations,higher requirements have been put forward for advanced secondary *** metal/alloy electrodes have been considered as a promising development direction to achieve excellent electrochemical performance in metal-ion batteries,due to their specific advantages including the excellent electrode kinetics and self-healing ability against microstructural electrode *** conventional liquid batteries,high temperatures are needed to keep electrode liquid and ensure the high conductivity of molten salt electrolytes,which also brings the corrosion and safety ***-based metal/alloys,which can be operated at or near room temperature,are potential candidates to circumvent the above *** this review,the properties and advantages of Ga-based metal/alloys are ***,Ga-based liquid metal/alloys as anodes in various metal-ion batteries are reviewed in terms of their self-healing ability,battery configurations,working mechanisms,and so ***,some views on the future development of Ga-based electrodes in batteries are provided.

关键词： metal-ion batteries Ga-based liquid metal/alloy anodes self-healing capability room temperature

Optimizing urban block morphologies for net-zero energy cities:Exploring photovoltaic potential and urban design prototype

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Building Simulation 2024年第4期17卷 607-624页

作者： Xiaotian Geng Dong Xie zhonghua Gou School of Urban Design Wuhan UniversityWuhanChina

The morphology of urban areas plays a crucial role in determining solar potential,which directly affects photovoltaic capacity and the achievement of net-zero *** study focuses on the City of Melbourne to investigate the utilization of solar energy across different urban densities and proposes optimized *** analysis encompasses blocks with diverse population densities,examining medium and high-density *** utilizing a multi-objective genetic optimization approach,the urban morphology of these blocks is *** findings indicate that low-density blocks exhibit photovoltaic potential ranging from 1 to 6.6 times their total energy *** and high-density blocks achieve photovoltaic potential levels approximately equivalent to 40%-85%of their overall energy ***,significant variations in photovoltaic potential are observed among different urban forms within medium and high-density ***“elevated corners with central valley”prototype is proposed as an effective approach,enhancing the overall photovoltaic potential by approximately 14%.This study introduces novel analytical concepts,shedding light on the intricate relationship between urban morphologies and photovoltaic potential.

关键词： net-zero energy solar energy urban density urban morphology multi-objective optimization photovoltaic potential

Impact of COVID-19 on the energy consumption of commercial buildings:A case study in Singapore

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Energy and Built Environment 2024年第3期5卷 364-373页

作者： Senhong Cai zhonghua Gou School of Urban Design Wuhan UniversityWuhanChina

Numerous studies have demonstrated that commercial activities have significantly reduced during COVID-19,while there are few studies disclosing the consequent impacts on the energy consumption of commercial *** study explores the changes in energy consumption of different types of commercial buildings in Sin-gapore under the impact of the pandemic,using commercial building energy performance data from 2017 to 2020(n=540).The sampled buildings include 93 hotel buildings,303 office buildings,106 retail buildings,and 38 mixed *** analysis mainly used linear regression and paired sample *** results showed that relative to 2019,the mean energy use intensity(EUI)of sampled commercial buildings decreased by 56.77 kWh/m^(2)in the pandemic year(2020),a plunge of 19.9%.The extent to which the EUI of each type of commercial building is affected by the pandemic is found as:mixed development>retail>office>*** study also identi-fied the factors that significantly influenced the EUI of commercial buildings before and during the *** results of the study complement existing knowledge about the factors influencing energy consumption in com-mercial buildings by considering the impact of the pandemic and furthermore contribute to the improvement of energy management in commercial buildings by providing directions for building energy efficiency approaches.

关键词： Commercial buildings Energy consumption Energy use intensity Impact of COVID-19 Influential factors

Experimental investigation of spectral evolution in flash radiation by hypervelocity impact on aluminum plates

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Defence Technology（防务技术） 2024年第7期37卷 96-110页

作者： Xing Chen Yonggang Lu Zhiwen Li zhonghua Cui Institute of Systems Engineering China Academy of Engineering PhysicsMianyang 621900SichuanChina Chongqing Qianwei Technology Group Co. LtdChongqing 401121China

In this study,a series of hypervelocity impact tests were carried out based on a two-stage light gas gun,and the sequence spectrum and radiation evolution data of the impact products under different impact conditions were *** diameter of the projectile is 3-5 mm,the impact velocity is 3.13-6.58 km/s,and the chamber pressure is 0.56-990 *** spectrum of ejected debris cloud in the 250-310 nm band were obtained using a transient spectral measurement system and a multi-channel radiometer measurement *** test results reveal that the flash radiation intensity increases as a power function with the kinetic energy of the ***,the peak value of the line spectrum decreases as the chamber vacuum degree increases,while the radiation width gradually *** line spectrum in the spectral characterization curve corresponds to the ejected debris clouds splitting phase,which does not produce significant line spectrum during material fragmentation and is dominated by the continuum spectrum produced by blackbody *** will appear one or three characteristic peaks in the flash radiation time curve,the first and second peaks correspond to the penetration phase and the third peak corresponds to the expansion phase of the ejected debris clouds on the time scale,the first and second peaks are more sensitive to the chamber vacuum degree,and when the pressure is higher than 99 Pa,the first and second characteristic peaks will *** radiant heat attenuation of the flash under different impact conditions is significantly different,the attenuation exponent has a power function relationship with the impact velocity and the chamber vacuum degree,while the attenuation exponent has a linear relationship with the diameter of the projectile,the specific expression of the attenuation exponent is obtained by *** findings from this research can serve as a valuable reference for remote diagnostic technologies based on flash radiation characte

关键词： Hypervelocity impact Flash radiation Evolution Spectral characteristics Damage evaluation

Double stabilizations and convergence analysis of a second-order linear numerical scheme for the nonlocal Cahn-Hilliard equation

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Science China Mathematics 2024年第1期67卷 187-210页

作者： Xiao Li zhonghua Qiao Cheng Wang Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong KongChina Department of Mathematics The University of MassachusettsNorth DartmouthMA 02747USA

In this paper,we study a second-order accurate and linear numerical scheme for the nonlocal CahnHilliard *** scheme is established by combining a modified Crank-Nicolson approximation and the Adams-Bashforth extrapolation for the temporal discretization,and by applying the Fourier spectral collocation to the spatial *** addition,two stabilization terms in different forms are added for the sake of the numerical *** conduct a complete convergence analysis by using the higher-order consistency estimate for the numerical scheme,combined with the rough error estimate and the refined *** regarding the numerical solution as a small perturbation of the exact solution,we are able to justify the discrete?^(∞)bound of the numerical solution,as a result of the rough error ***,the refined error estimate is derived to obtain the optimal rate of convergence,following the established?∞bound of the numerical ***,the energy stability is also rigorously proved with respect to a modified *** proposed scheme can be viewed as the generalization of the second-order scheme presented in an earlier work,and the energy stability estimate has greatly improved the corresponding result therein.

关键词： nonlocal Cahn-Hilliard equation second-order stabilized scheme higher-order consistency analysis rough and refined error estimate

Eutectic-derived synthesis of hierarchically nanoporous copper for electrochemical actuation and solar steam generation

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Nano Research 2024年第3期17卷 2011-2018页

作者： Qingguo Bai Yan Wang Fuquan Tan zhonghua Zhang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJingshi Road 17923Jinan 250061China School of Applied Physics and Materials Wuyi UniversityDongcheng Village 22Jiangmen 529020China School of Materials Science and Engineering University of JinanWest Road of Nan Xinzhuang 336Jinan 250022China

The utilization of nanoporous copper(np-Cu)as a metallic actuator has gained attention in recent years due to its cost-effectiveness in comparison to other precious *** this,the enhancement of np-Cu’s actuation performance remains a challenge due to limitations in its strain amplitude and actuation ***,np-Cu has been deemed as a promising material for solar absorption due to its localized surface plasmon resonance ***,practical applications such as solar steam generators(SSGs)utilizing np-Cu have yet to be *** this study,we present the development of hierarchically nanoporous copper(HNC)through the dealloying of a eutectic Al-Cu *** hierarchical structure of the HNC features a combination of ordered flat channels and randomly distributed continuous nanopores,which work in synergy to improve actuation *** ordered flat channels,with a sub-micron scale,facilitate rapid mass transport of electrolyte ions,while the nano-sized continuous pores,due to their large specific surface area,enhance the induced *** results indicate that the HNC exhibits improved actuation performance,with a two times increase in both strain amplitude and rate in comparison to other reported ***,the HNC,for the first time,showcases excellent solar steam generation capabilities,with an evaporation rate of 1.47 kg·m^(-2)·h^(-1) and a photothermal conversion efficiency of 92%under a light intensity of 1 kW·m^(-2),which rivals that of nanoporous gold and silver *** enhanced actuation performance and newly discovered solar steam generation properties of the HNC are attributed to its hierarchically porous structure.

关键词： eutectic alloy dealloying hierarchically nanoporous copper(HNC) actuation solar steam generation

Stability and variability of molecular subtypes:comparative analysis of primary and metastatic triple-negative breast cancer

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Cancer Biology & Medicine 2024年第9期21卷 784-798页

作者： Xiuzhi zhu Xiaohan Ying Yin Liu Yunyi Wang Li Chen Zhiming Shao Xi Jin Yizhou Jiang zhonghua Wang Key Laboratory of Breast Cancer in Shanghai Shanghai Institute of Infectious Disease and BiosecurityDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200000China Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200000China

Objective:Triple-negative breast cancer(TNBC)is a heterogeneous and aggressive *** our previous study classified primary TNBC into four subtypes,comprehensive longitudinal investigations are ***:We assembled a large-scale,real-world cohort comprised of 880 TNBC patients[465 early-stage TNBC(eTNBC)and 415 metastatic TNBC(mTNBC)patients]who were treated at Fudan University Shanghai Cancer *** longitudinal dynamics of TNBC subtypes during disease progression were elucidated in this patient *** analysis was performed to compare primary and metastatic lesions within specific TNBC ***:The recurrence and metastasis rates within 3 years after initial diagnosis in the eTNBC cohort were 10.1%(47/465).The median overall survival(OS)in the mTNBC cohort was 27.2 months[95%confidence interval(CI),24.4–30.2 months],which indicated a poor *** prognostic significance of the original molecular subtypes in both eTNBC and mTNBC patients was *** molecular subtypes were maintained in 77.5%of the patients throughout disease progression with the mesenchymal-like(MES)subtype demonstrating a tendency for subtype transition and brain ***,a precision treatment strategy based on the metastatic MES subtype of target lesions resulted in improved progression-free survival in the FUTURE ***:Our longitudinal study comprehensively revealed the clinical characteristics and survival of patients with the original TNBC subtypes and validated the consistency of most molecular subtypes throughout disease ***,we emphasize the major importance of repeat pathologic confirmation of the MES subtype.

关键词： Triple-negative breast cancer molecular subtype metastasis primary tumor overall survival