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Papillary fibroblast-recruiting injectable self-healing multifunctional hydrogels for wound regeneration

Nano Research 2023年第7期16卷 9792-9803页

作者： Yueyue Li Weifeng Zhong Junjie Wu Yuan Jia zhonghua chen Kaiwen Zhang Danyang Guo Yifei Fu Mengnan chen Weiwei chen Fan Tian Xia Li Hongji Zhang Xiaojin Zhou Feng-Lai Yuan Institute of Integrated Chinese and Western Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214000China The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214000China

The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound *** fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to *** fibroblasts play central regulatory roles in the regeneration of skin appendages during wound *** by the phenomenon where bait for grass carp can attract grouped grass carps to a fishing spot soon,“Grass Carp Fishing”multifunctional hydrogels,that is,codelivery of an antibody of leucine-rich repeats and immunoglobulin-like domains 1(Lrig1)on the surface of papillary fibroblasts and insulinlike growth factor 1(IGF1)with recruitment function,can recruit papillary *** the experiments,carboxymethyl chitosan showed positive effects in promoting cell proliferation and neovascularization,while dopamine-grafted gelatin was effective in stabilizing the structure and prolonging the degradation *** sustained release of Lrig1 antibodies and IGF1 from injectable self-healing multifunctional hydrogels persistently accelerated the migration and proliferation of Lrig1+*** in vivo results from a full-thickness cutaneous wound model showed that injectable self-healing multifunctional hydrogel accelerated wound healing and skin regeneration through the recruitment of Lrig1+papillary fibroblasts in wound *** findings reveal an injectable self-healing multifunctional hydrogel for regeneration,a promising approach to promoting skin wound healing.

关键词： wound healing regeneration papillary fibroblasts recruitment

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High Dose-Volume SBRT Following TACE Improves Clinical Outcomes of Patients with Unresectable Hepatocellular Carcinoma

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Journal of Cancer Therapy 2016年第2期7卷 152-161页

作者： Nanbao Zhong Guangming Lv zhonghua chen Tumor Radiotherapy Center Fuzhou General Hospital Fuzhou China

This study aimed to investigate the dose-volume effects of γ-ray stereotactic body radiotherapy (SBRT) on clinical outcomes of patients with huge-size (≥10 cm) unresectable hepatocellular carcinoma (HCC). A total of 59 patients with huge-size unresectable HCC were treated with SBRT following TACE between May 2006 and Dec. 2009. The analyzed parameters included fractional dose, marginal dose, maximal dose, and mean dose that the target received, as well as percentages of tumor volume encompassed by 60% (P60), 70% (P70), and 80% (P80) of isodose curves in entire tumor. The clinical outcomes included objective response rate (ORR), disease-free survival (DFS), overall survival (OS), and adverse event (AE). During median follow-up of 18.4 months, 81.4% of ORR (8.5% CR and 72.9% PR) was achieved, higher than 28.9% of ORR recently reported for TACE alone. 1- and 3-year DFS rates were 31.1% and 2.6% with median DFS of 8.7 months;1-, 3-, and 5-year OS rates were 46.5%, 13.7%, and 2.9%, with median OS of 11.8 months. P70 was the only factor significantly correlating to DFS (P = 0.009) and OS (P = 0.01). Neither severe radiation-related liver disease nor > grade 3 AE was observed. In conclusion, SBRT was a safe and effective option for treatment of huge-size unresectable HCC. P70 represented a parameter for predicting DFS and OS, and high dose-volume (e.g., P70) might be required to achieve improved clinical outcomes of patients with this type of HCC.

关键词： Stereotactic Body Radiotherapy Dose-Volume Parameter Disease-Free Survival Overall Survival Unresectable Hepatocellular Carcinoma

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Application Of CBERS Satellite Data for Ice Flood Monitoring Of The Yellow River

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Aerospace China 2006年第3期7卷 12-14页

作者： Yang zhonghua , chen Lin ,MaHaolu

The Yellow River, popularly known as China＇s Mother River, starts from the Qinghai-Tibet Plateau, flows through Qinghai, Sichun, Gansu, Ningxia, InnerMongolia, Shanxi, Shaanxi, Henan and Shandong provinces and autonomous regions, with a total length of 5,464 km, and finally empties itself into the Bohai Sea. It is the second largest fiver in China.

关键词：黄河洪水中国人造卫星

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From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： zhonghua Lu Jun Shen Xin Zhang Lingcong Chao Liang chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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WO_3 Anodic Oxide Film——*** and Auto-bleaching mechanism

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Chemical Research in Chinese Universities 1990年第4期6卷 320-326页

作者： Lin zhonghua, chen Kunyao, Zheng Zhizhen, chen Haiyi (Dept. of Chem. and Inst. of Phys. Chem. , Xiamen University, Xiamen)

Electrochromic and auto-bleaching processes at the WO2 anodic film in 0. 5 mol/L H2SO4 solution were investigated by cyclic voltammetry, a. c. impedance technique and photocurrent spectrometry. The colouration mechanism consists of hydrogen adsorption on the WO2 surface and the transport of H atoms in the WO, lattice. The bleaching process involves at least two steps: transport of interstitial H atoms and hydrogen desorption on the W surface, resulting in interstitial H+ ions; then extration of the H+ ions driven by the external electric field. The auto-bleaching arises from the hydroxylation due to both partial interstitial H atoms and a little of water contained in the film.

关键词： Electrochromism Tungsten trioxide film Tungsten electrode Anodic oxide film

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Establishment of Early Warning Diagnostic Systems of Chronic Allograft Nephropathy with Polypeptide or Protein Fingerprints in Urine

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器官移植内科学杂志 2007年第4期2卷 223-226页

作者： Li Tong Li Wang Saotang Zhou zhonghua chen Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University ofScience and Technology Wuhan 430030 China

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SEMICONDUCTING PROPERTIES OF In_2O_3 ANODIC FILM

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Chinese Chemical Letters 1990年第3期1卷 275-276页

作者： zhonghua LIN Haiyi chen Zhaowu TIAN NATIONAL LABORATORY OF PHYSICAL CHEMISTRY OF SOLID SURFACE XIAMEN UNIVERSITY,XIAMEN,361005

The good potentiality of the In_2O_3 anodic film as a photoanodic material has been *** anodic oxidation of In substrate in alkaline solution for obtaining In_2O_3 film has been developed and their semiconducting prop... 详细信息

关键词： In SEMICONDUCTING PROPERTIES OF In2O3 ANODIC FILM

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Research on Short-Term Load Forecasting Using K-means Clustering and CatBoost Integrating Time Series Features

Research on Short-Term Load Forecasting Using K-means Cluste...

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第三十九届中国控制会议

作者： chenrui Zhang zhonghua chen Jing Zhou College of Electrical Engineering Zhejiang University System Design Center Hangzhou Electric Power Design Institute Co.Ltd

Better understanding of the actual power consumption pattern of industrial customers is critical for improving load forecasting to enhance the operation and energy management of electric power systems. This paper introduced a hybrid model to forecast the short-term load function, which consists of K-means clustering and CatBoost model integrating time series features. K-means clustering is executed for partitioning industrial customers with similar load function into the same cluster. The improved CatBoost can be applied to forecast the load demand using small training dataset and overcome the local offset problem. The model is evaluated on the load data collected from Yangzhong High-tech Zone in China, and is compared with models based on Autoregressive Moving Average model, Long Short-Term Memory, Gradient Boosting Decision Tree and CatBoost, respectively. The results demonstrate that the proposed model outperforms all the other mentioned models.

关键词： K-means clustering CatBoost load forecasting time series

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Romidepsin(FK228) improves the survival of allogeneic skin grafts through downregulating the production of donor-specific antibody via suppressing the IRE1α-XBP1 pathway

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第5期23卷 392-406页

作者： Yuliang GUO Siyu SONG Xiaoxiao DU Li TIAN Man ZHANG Hongmin ZHOU zhonghua Klaus chen Sheng CHANG Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationNHC Key Laboratory of Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China Henan Key Laboratory of Digestive Organ Transplantation Open and Key Laboratory of Hepatobiliary&Pancreatic Surgery and Digestive Organ Transplantation at Henan UniversitiesZhengzhou Key Laboratory of Hepatobiliary&Pancreatic Diseases and Organ TransplantationDepartment of Hepatobiliary and Pancreatic Surgerythe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Antibody-mediated rejection(AMR)is one of the major causes of graft loss after ***,the regulation of B cell differentiation and the prevention of donor-specific antibody(DSA)production have gained increased attention in transplant ***,we established a secondary allogeneic in vivo skin transplant model to study the effects of romidepsin(FK228)on *** survival of grafted skins was monitored *** serum levels of DSA and the number of relevant immunocytes in the recipient spleens were evaluated by flow ***,we isolated and purified B cells from B6mouse spleens in vitro by magnetic bead *** B cells were cultured with interleukin-4(IL-4)and anti-clusters of differentiation 40(CD40)antibody with or without FK228 *** immunoglobulin G1(IgG1)and IgM levels in the supernatant were evaluated by enzyme-linked immunosorbent assay(ELISA).Quantitative reverse transcription-polymerase chain reaction(RT-q PCR)and western blotting were conducted to determine the corresponding levels of messenger RNA(mRNA)and protein expression in cultured cells and the recipient *** results showed that FK228 significantly improved the survival of allogeneic skin ***,FK228 inhibited DSA production in the serum along with the suppression of histone deacetylase 1(HADC1)and HDAC2 and the upregulation of the acetylation of histones H2A and *** also inhibited the differentiation of B cells to plasma cells,decreased the transcription of positive regulatory domain-containing 1(Prdm1)and X-box-binding protein 1(Xbp1),and decreased the expression of phosphorylated inositol-requiring enzyme 1α(p-IRE1α),XBP1,and B lymphocyte-induced maturation protein-1(Blimp-1).In conclusion,FK228 could decrease the production of antibodies by B cells via inhibition of the IRE1α-XBP1 signaling ***,FK228 is considered as a promising therapeutic agent for the clinical treatment of AMR.

关键词： Histone acetylation Romidepsin(FK228) Skin transplantation Donor-specific antibody Unfolded protein response

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界面张力特征对三元复合驱油效率影响的实验研究

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石油学报 2006年第5期27卷 96-98页

作者：李华斌陈中华西南石油大学油气藏地质及开发工程国家重点实验室四川成都610500 西南油气田分公司勘探开发研究院四川成都610041

分别采用了油水平衡界面张力和瞬时动态界面张力为1mN/m、0.1mN/m、0.01mN/m和0.001mN/m的4种体系进行了岩心驱油试验。结果表明,在大庆油田三元复合驱中,油水动态界面张力最低值是影响驱油效果的重要因素,而不是平衡界面张力。动态界... 详细信息

分别采用了油水平衡界面张力和瞬时动态界面张力为1mN/m、0.1mN/m、0.01mN/m和0.001mN/m的4种体系进行了岩心驱油试验。结果表明,在大庆油田三元复合驱中,油水动态界面张力最低值是影响驱油效果的重要因素,而不是平衡界面张力。动态界面张力最低值达到0.01mN/m时,体系的驱油效果与界面张力平衡值达到0.001mN/m时基本相同。因此,可以大幅度降低三元复合体系中碱的用量,甚至可以不用碱。此外,还可以降低对表面活性剂的苛刻要求,扩大表面活性剂的种类和范围。

关键词：三元复合驱表面活性剂平衡界面张力动态界面张力岩心驱油实验驱油效率

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