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Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy

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Chinese Chemical Letters 2024年第10期35卷 348-352页

作者： Lin Li Bingjun Sun jin Sun Lin chen zhonggui He Department of Pharmacy Women and Children's Hospital of Chongqing Medical University/Chongqing Health Center for Women and ChildrenChongqing 401147China Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

Chemotherapy has been recommended as the standard protocol for triple-negative breast cancer(TNBC)at the advanced ***,the current treatment is unsatisfactory due to inefficient drug accumulation and rapid ***,rational design of advanced drug delivery systems that can induce multiple cell death pathways is a promising strategy to combat *** is a powerful non-apoptotic cell death modality,showing potential in tumor ***,we propose a binary prodrug nanoassemblies that combines chemotherapy with ferroptosis for TNBC *** this system,paclitaxel is linked with paracetamol(ferroptosis activator)by a disulfide linkage to construct self-assembly ***,2-distearoyl-sn-glycerol-3-phosphoethanolamine-N-methyl(polyethylene glycol)-2000-tyrosine(DSPE-PEG2k-tyrosine)is applied for large neutral amino acid transporter 1(LAT1)targeting,which is highly expressed in *** prodrug nanoassemblies exhibit good stability and a glutathione(GSH)-responsive release ***,the LAT1-targeted nanoassemblies show stronger cytotoxicity,higher cellular uptake,and more obvious ferroptosis activation than non-decorated *** a TNBC mice model,the prodrug nanoassemblies demonstrate strong anti-tumor *** application of ferroptosis-assisting chemotherapy may provide a promising strategy for TNBC therapy.

关键词： Prodrug nanoassemblies Paclitaxel Ferroptosis LAT1 Triple-negative breast cancer

PHOTOREFLECTANCE STUDY OF GaAs/AlGaAs MULTI-QUANTUM WELLS

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Chinese Physics Letters 1987年第10期4卷 477-479页

作者： TANG Yinsheng JIANG Desheng ZHUANG Weihua chen zhonggui Institute of Semiconductors Academia SinicaBeijing University of Science and Technology of China Hefei

Using photoreflectance(PR)at room temperature,we have studied GaAs/AlGaAs multi-quantum wells(MQWs)grown by molecular beam *** shows that the modulation mechanism of PR of MQWs is Stark shift of the subbands produced by photo-injection of carriers,which has first derivative functional *** fitting the experimental spectra,an unusual transition coming from the interfaces in MQWs was observed.

关键词： GaAs/AlGaAs reflectance quantum

GNSS Coverage Performance for Medium-High Earth Orbital Satellites

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GNSS Coverage Performance for Medium-High Earth Orbital Sate...

Solar Radiation Pressure Modeling and Application of BDS Satellites

第26届中国控制与决策会议

作者： Zhao Xiaofang Wang Haihong Wu Xiangjun Wang Jie chen zhonggui Institute of Spacecraft System Engineering CAST

ISBN: (纸本)9781479937097

With the launching activities of spacecrafts,there come the increased demands of autonomous navigation of those medium-high Earth orbital *** the application of satellite navigation system is mainly on LEO satellite,its application on the medium-high Earth orbital satellites has to be further *** navigation of GEO satellites is essentially one kind of parameter estimation and in this paper the feasibility of GEO satellites’ navigation based on GNSS was *** this article the coverage analysis was done to answering the feasibility of the application of GNSS for those ***,the observation geometry of GEO satellites based on GNSS was also *** results could be a reference for those high orbit satellites’ navigation based on satellite navigation system.

关键词： GNSS Medium-high Earth orbital satellite Navigation estimation Coverage GDOP

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Journal of Geodesy and Geoinformation Science 2020年第2期3卷 45-52页

作者： Qiuli chen Hui YANG zhonggui chen Haihong WANG chen WANG Beijing Institute of Engineering Spacecraft System Beijing 100094China GNSS Research Center Wuhan UniversityWuhan 430079China

Solar radiation pressure(SRP)model is the basis of high precise orbit determination and positioning of navigation *** present,it is common to see the study of SRP model of BDS ***,the establishment and application of a comprehensive analytical SRP model based on satellite physical parameters are *** from other conservative forces and non-conservative forces,SRP is closely related to the satellite’s physical parameters and in-orbit *** the basis of the physical mechanism of solar radiation,BDS satellite physical parameters,in-orbit attitude control mode,and so on,a comprehensive analytical model has been studied in this *** on precise ephemeris and satellite laser ranging(SLR)data,the precision of a comprehensive analytical model has been *** the precision of orbit determination is at the decimeter level using this comprehensive analytical SRP *** to the satellite conservation theorem of angular momentum and change of in-orbit telemetry parameters,the difference between a comprehensive analytical model and the actual in-orbit interference force has been analyzed and *** addition of empirical items on the comprehensive analytical model has been *** validations demonstrated that the orbit precision of BDS C08 and C10 can be achieved at 0.078 m and 0.084 m *** with using the improved CODE empirical model,precision orbit accuracy of them has increased by 0.021 m and 0.045 m respectively.

关键词： BDS satellite solar radiation pressure comprehensive analytical model experience correction item precise orbit determination

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基于局部单射的平面形状插值形变

计算机辅助设计与图形学学报 2016年第12期28卷 2060-2066页

作者：齐飞陈中贵厦门大学信息科学与技术学院厦门361005

在只给出用简单多边形表示的两输入形状的情况下,实现一种简单易用、自然高效的形状插值方法.首先利用基于形状感知的特征匹配算法生成源形状和目标形状之间的匹配;之后在源形状上构造三角剖分,并通过求解映射到目标形状上的尽量刚体的... 详细信息

在只给出用简单多边形表示的两输入形状的情况下,实现一种简单易用、自然高效的形状插值方法.首先利用基于形状感知的特征匹配算法生成源形状和目标形状之间的匹配;之后在源形状上构造三角剖分,并通过求解映射到目标形状上的尽量刚体的局部单射得到同构三角剖分;最后利用扭曲有界的插值方法得到中间序列.实验结果表明,该方法构造的形变结果能较好地体现源形状和目标形状的特征对应信息,形变过程自然,扭曲较小.

关键词：特征匹配同构剖分三角网格插值形变

Experimental Demonstration of　Heterostructure　Intervalley Transferred Electron Effect

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固体电子学研究与进展 1993年第1期 6-8页

作者： Xue Fangshi, Deng Yanmao, Zhang Chongren(Nanjing Electronic Devices Institute ,210016)chen zhonggui(National Key Lab for Semiconductor Superlattices, Beijing.100083)

Precis: Since negative differential resistance in the double barrier heterostructure was originally proposed and demonstrated by chang, Tsu ,and Esaki, there has been extensive investigations aimed at exploiting the resonant tunneling phenomena through heterostructure quantum well and corresponding device application. Among these works only direct gap/direct gap (D/D) heterostructures have been considered. However GaAs/AlAs direct gap/indirect gap (D/I) quantum well has attracted extensive interest in recent years. F-X mixing inside these D/I quantum wells has been investigated by many authors. The resonant tunneling in GaAs/AlAs quantum well has been reported by Mendez et al.

关键词： Heterostructure Intervalley Transferred Electron Effect. Direct Gap/Indirect Gap Heterostructure High Efficiency High Power Quantum Well Tunneling Intervalley Transferred Electron Device

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导航卫星测距码的优选方法

中国空间科学技术 2006年第2期26卷 1-9页

作者：帅平曲广吉陈忠贵中国空间技术研究院北京100094

传统的选择民用测距码可选择组合码的范围较小,难于获得足够多的卫星地址码数和良好互相关性能。文中提出的n级线性移位寄存器的m序列及其优选对的全域搜索算法和导航卫星测距码的生成方案,能够获得所有可能的码序列组合,优选的Gold码... 详细信息

传统的选择民用测距码可选择组合码的范围较小,难于获得足够多的卫星地址码数和良好互相关性能。文中提出的n级线性移位寄存器的m序列及其优选对的全域搜索算法和导航卫星测距码的生成方案,能够获得所有可能的码序列组合,优选的Gold码族能够产生足够数量的、具有良好互相关性能的测距码序列。通过对比分析优选测距码与GPS C/A码的可分配码数量、自相关及互相关函数特性,初步说明优选测距码的优越性及其优选算法的可行性。

关键词：导航卫星伪随机噪声码优选法

Modeling and Simulation of the Passive Regional Satellite Navigation System

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Modeling and Simulation of the Passive Regional Satellite Na...

Spacecrafts Navigation Signal Research Based on GNSS Constellation

2012年计算机应用与系统建模国际会议

作者： chen zhonggui Zhang Zhi Liao Ying Su Tianxiang College of Aerospace and Material Engineering National University of Defense Technology

The passive regional satellite navigation system (PRSNS) becomes a significant topic for civil and military services due to the limit of outlays and geography factors. The research on the modeling and simulation (M&S) of PRSNS is to study the key technology and operation principle. The paper discussed how to build up the simulation system of PRSNS. The system included satellite constellation, tracking station, data processing center (DPC), feeding station, users’ application, information management, surveillance and visualization, etc. And the system is divided into two major logical parts and three physical layers to reduce the dependence among the components in order to quicken the programming process. As an example, a simulation system of PRSNS is constructed, which adopts a satellite constellation that is composed of geostationary earth orbit (GEO) satellites, inclined geosynchronous orbit (IGSO) satellites and median earth orbit (MEO) satellites and covers the Pacific-Asia, Indian Ocean and Middle East. The efficiency of the simulation system and the feasibility of PRSNS are verified by simulated static positioning and dynamic navigating.

关键词： Satellite navigation system Modeling and simulation (M&S) Satellite constellation

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Spacecrafts Navigation Signal Research Based on GNSS Constel...