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Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 48-55页

作者： Yeming Wang Li Guo Guohui Fan Yang Han Qiao Zhang Lili Ren Hui Zhang Geng Wang Xueyang Zhang Tingxuan Huang Weiyang Wang Lan Chen Lixue Huang Xiaoying Gu Xinming Wang Jingchuan zhong Ying Wang Hui Li Jiapei Yu Zhibo Liu Chaolin Huang Bin cao Jianwei Wang National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesChina-Japan Friendship HospitalBeijing 100029China National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100029China School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeState Key Laboratory of Respiratory Health and MultimorbidityKey Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College)Ministry of EducationBeijing 100730China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical research and Data managementCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Jin Yin-tan Hospital WuhanHubei 430023China Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology and Clinical Immunology Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Ministry of Science&TechnologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(PUMCH)Key Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospsitalInstitute of Respiratory MedicineChinese

Background:The impact of corticosteroids on humoral responses in coronavirus disease 2019(COVID-19)sur-vivors during the acute phase and subsequent 6-month period remains *** study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-19 survivors 6 months after infection ***:We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2020,which involved adults hospitalized with severe COVID-19(LOTUS,ChiCTR2000029308).Anti-body samples were collected from 192 patients during hospitalization,and kinetic antibodies were monitored at all available time points after ***,plasma samples were collected from 101 COVID-19 survivors for comprehensive humoral immune measurement at the half-year follow-up *** main focus was comparing the humoral responses between patients treated with systemic corticosteroid therapy and the non-corticosteroid ***:From illness onset to day 30,the median antibody titre areas under the receiver operating characteristic curve(AUCs)of nucleoprotein(N),spike protein(S),and receptor-binding domain(RBD)immunoglobulin G(IgG)were significantly lower in the corticosteroids *** AUCs of N-,S-,and RBD-IgM as well as neutralizing antibodies(NAbs)were numerically lower in the corticosteroids group compared with the non-corticosteroid ***,peak titres of N,S,RBD-IgM and-IgG and NAbs were not influenced by *** 6-month follow-up,we observed a delayed decline for most binding antibodies,except N-IgM(𝛽−0.05,95%CI[−0.10,0.00])in the corticosteroids group,though not reaching statistical *** significant difference was observed for ***,for the half-year seropositive rate,corticosteroids significantly accelerated the decay of IgA and IgM but made no difference to N-,S-,and RBD-IgG or ***,corticosteroids group showed a trend towards d

关键词： COVID-19 Corticosteroid Immunity Antibody Humoral response

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基于多因子多模式集成的中长期径流预测模型

水科学进展 2024年第3期35卷 408-419页

作者：陈娟徐琦曹端祥李国智钟平安河海大学水文水资源学院江苏南京210029

提高中长期径流预测精度对于水资源调度等具有重要意义和应用价值。基于国家气候中心的130项气候因子,采用皮尔逊相关系数、最大信息系数、方差增量指标筛选主要预测因子,建立基于DS(Dempster-Shafer)证据理论的多因子综合方法;采用随... 详细信息

提高中长期径流预测精度对于水资源调度等具有重要意义和应用价值。基于国家气候中心的130项气候因子,采用皮尔逊相关系数、最大信息系数、方差增量指标筛选主要预测因子,建立基于DS(Dempster-Shafer)证据理论的多因子综合方法;采用随机森林、BP神经网络和贝叶斯网络等建立基于水文-气象因子遥相关的中长期径流预测模型,构建基于DS证据理论的预测结果集成模型。以三峡水库为对象开展实例研究,结果表明:引入遥相关因子能有效提高预测精度;基于DS证据理论的多因子综合方法能筛选出综合性更强、稳定性更优的因子,弥补单一筛选方法的不足;基于DS证据理论的多因子多模式集成方法在径流预测精度上优于单一方法单一模型,确定性系数提高到0.823,平均相对误差降低到23.2%。

关键词：中长期径流预测 DS证据理论随机森林贝叶斯网络 BP神经网络遥相关

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深部煤层CO_(2)地质封存量化评估及案例研究

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煤炭科学技术 2024年第S01期52卷 288-298页

作者：刘操赵春辉钟福平秦书杰韦沧龙河南理工大学安全科学与工程学院河南焦作454003 河南理工大学河南省瓦斯地质与瓦斯治理重点实验室-省部共建国家重点实验室培育基地河南焦作454000 全国煤炭行业瓦斯地质与瓦斯防治工程研究中心河南焦作454003

地质封存CO_(2)作为理想的减碳技术,有望成为缓解温室效应的重要手段,因此量化评估深部煤层CO_(2)地质封存潜力与研究超临界CO_(2)与深部煤岩之间相互作用成为了“双碳”背景下的研究热点。以焦作矿区九里山煤样为试验研究对象,分析了... 详细信息

地质封存CO_(2)作为理想的减碳技术,有望成为缓解温室效应的重要手段,因此量化评估深部煤层CO_(2)地质封存潜力与研究超临界CO_(2)与深部煤岩之间相互作用成为了“双碳”背景下的研究热点。以焦作矿区九里山煤样为试验研究对象,分析了深部煤层超临界CO_(2)吸附与封存机理,分别开展了35和45℃下煤样的CO_(2)等温吸附试验,解释并校正了CO_(2)吸附等温线高压异常下拐现象,得到了不同温度下煤样的CO_(2)实际吸附量。提出了一种新方法计算CO_(2)地质封存量,能够校正吸附相体积造成的封存量计算误差,并能精确评估不同埋深煤层CO_(2)理论和有效封存量。研究结果表明:①当高压吸附饱和时,煤样表面所有的吸附位被完全占据,此时吸附相体积和密度不再发生改变,吸附量应趋于稳定,但实验室测得的吸附量却在高压饱和阶段随压力增大而减小,这并不符合Langmuir吸附原理,因此必须对实验室测试的吸附等温线进行校正,才能应用于深部煤层CO_(2)封存量评估;②煤中CO_(2)封存量主要由吸附和游离封存量组成,吸附封存量需要采用吸附相密度和Gibbs吸附量进行反算,游离封存量则需要掌握煤中游离相占据的孔隙体积,它只能根据煤中孔隙总体积减去吸附相体积进行计算,因此,吸附相是精确评估吸附和游离封存量的决定性因素;③采用修正的煤层CO_(2)地质封存量化方法,以焦作修武研究区800~2000 m深部煤层为例,得出其单位质量煤中CO_(2)理论封存量为1.52~2.16 mmol/g,CO_(2)有效封存总量为11.19×10^(9)m^(3),换算为封存总质量为21.97 Mt。本研究案例不仅校正了吸附试验数据的物质平衡错误,而且考虑了吸附相占据孔隙空间对游离封存量的影响,这对深部煤层CO_(2)地质封存量精准评估具有重要的应用意义。

关键词： CO_(2)地质封存深部煤层 CO_(2)吸附试验吸附相评估方法

煤中超临界CO_(2)解吸滞后机理及其对地质封存启示

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煤炭学报 2024年第7期49卷 3154-3166页

作者：刘操闫江伟赵春辉钟福平贾天让刘小磊张航河南理工大学安全科学与工程学院河南焦作454003 河南理工大学河南省瓦斯地质与瓦斯治理重点实验室−省部共建国家重点实验室培育基地河南焦作454000 全国煤炭行业瓦斯地质与瓦斯防治工程研究中心河南焦作454003 中原经济区煤层(页岩)气河南省协同创新中心河南焦作454000 煤炭安全生产与清洁高效利用省部共建协同创新中心河南焦作454000

将CO_(2)注入不可采煤层地质封存既是降低温室气体效应最理想选择之一,也是煤炭工业降低CO_(2)排放、实现低碳化可持续发展的必由之路,然而,煤层CO_(2)地质封存悬而未决的关键问题是:“注入煤层中的CO_(2)到底能否长期停留而安全封存?... 详细信息

将CO_(2)注入不可采煤层地质封存既是降低温室气体效应最理想选择之一,也是煤炭工业降低CO_(2)排放、实现低碳化可持续发展的必由之路,然而,煤层CO_(2)地质封存悬而未决的关键问题是:“注入煤层中的CO_(2)到底能否长期停留而安全封存?”。鉴于此,在弄清煤体CO_(2)解吸滞后规律的基础上,揭示超临界CO_(2)解吸滞后机理,建立煤层CO_(2)地质封存量化模型,探讨利用解吸滞后实现煤层CO_(2)长期安全封存。研究表明:煤中超临界态CO_(2)解吸滞后程度大于亚临界态CO_(2),在超临界阶段,吸附与解吸等温线形成近似“平行线”的稳定滞后特征;解吸滞后的本质原因是煤中微纳米级亲水性孔隙形成弯液面、产生强大毛细压力、渗吸液态水、截断并固定超临界CO_(2)流体、最终形成了CO_(2)残余封存,例如,煤中直径40~10 nm圆柱形无机孔隙可产生7.30~29.12 MPa毛细压力,足以封堵超临界态CO_(2);以九里山煤样解吸等温线数据为例,采用基于煤层CO_(2)解吸滞后的地质封存量化模型,评估出900~1500 m深部二1煤层封存总量稳定在35~37 m^(3)/t,其中,吸附封存约占80%,残余封存约占15%,而结构封存仅占5%;解吸滞后启示应尽可能采取措施提高煤层残余封存CO_(2)比例,原因是毛细堵塞的残余封存CO_(2)较围岩密封的游离和吸附CO_(2)更安全且没有泄露风险,煤层灰分、水分、孔隙尺寸和形貌等物性参数是影响残余封存效率的主要因素。

关键词： CO_(2)地质封存超临界CO_(2) 解吸滞后残余封存毛细压力地质封存量化模型

AIEgen configuration transition and aggregation enable dual prompt emission for single-component nondoped white OLEDs

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Aggregate

Aggregate 2024年第1期5卷 292-298页

作者： Jiasen Zhang Qiang Wei Wei Li Hao Chen Xiangyu Zhu Yongqi Bai Nannan Fei Liang cao Zujin Zhao Anjun Qin Ben zhong Tang Ziyi Ge Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingP.R.China Center for Aggregation-Induced Emission State Key Laboratory of Luminescent Materials and Devices South China University of Technology GuangzhouGuangzhouChina Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhenChina

The dual emission(DE)feature in materials holds great potential to revolutionize the development of one-component system white organic lightemitting diodes(WOLEDs).However,the reported DE materials remain scarce owing to the formidable challenge of breaking Kasha’s rule and managing the intricate energy/charge transfer ***,we have introduced a groundbreaking DE AIEgen,2CzAn-TPE,which possesses a simple structure and undergoes Z-to-E isomerization and exhibits yellow and red fluorescence powders for pre-and post-sublimation,*** relatively lower potential energy,Z-conformation((Z)-1,2-diphenyl-1,2-bis(4-(10-(9-phenyl-9H-carbazol-3-yl)anthracen-9-yl)phenyl)ethene)of 2CzAn-TPE can be readily transformed into E-conformation((E)-1,2-diphenyl-1,2-bis(4-(10-(9-phenyl-9Hcarbazol-3-yl)anthracen-9-yl)phenyl)ethene)via vacuum *** utilization of X-ray diffraction and grazing-incidence-wide-angle X-ray scattering techniques confirms the structural transformation,while the crystallographic analysis reveals the establishment of numerous intermolecular CH⋅⋅⋅πinteractions between the tetraphenylethene(TPE)moiety and both the anthracene and carbazole *** allows a densely packed molecular arrangement,thereby offering propitious conditions for excimer generation in the E-conformation aggregated *** utilizing the sublimated 2CzAn-TPE as an emitter,a nondoped one-component WOLED was prepared,exhibiting an exceptionally high external quantum efficiency(EQE)of 5.0%,which represents one of the highest performances among all *** research introduces a novel,simple,and efficient approach to realize highly efficient one-molecule WOLEDs.

关键词： aggregation-induced emission dual emission isomerization white OLED

Selective sintering of magnesia-calcia materials by utilizing hot spots during induction sintering process

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Journal of Iron and Steel Research International 2024年第8期31卷 1914-1922页

作者： Yun-jie Dong Zhou-fu Wang Hao Liu Yan Ma Xi-tang Wang Nian Yi zhong-feng Xia Yu-xuan Zhu Cheng-ji Deng Ling Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 110325LiaoningChina

Magnesia-calcia refractories are widely used in the production process of clean steel due to their excellent high-tem-perature stability,slag resistance and ability to purify molten ***,there are still problems such as difficult sintering and easy ***-calcia materials with various calcium oxide contents were prepared by using induction sintering,and the sintering property combined with the hydration resistance of the materials was *** experimental results showed that the magnesia-calcia materials prepared under induction field had higher density,microhardness and hydration *** particular,the relative density of induction sintered magnesia-calcia materials with 50 mo1%cao was greater than 98%,and the average grain size of cao was 4.56μm,which was much larger than that of traditional sintered *** order to clarify the densification and microstructure evolution mechanism of the magnesia-calcia materials,the changes in temperature and magnetic field throughout the sintering process were analyzed by using finite element *** results showed that the larger heating rate and higher sintering temperature under the induction sintering mode were beneficial to the rapid *** addition,the hot spots generated within the material due to the difference in high-temperature electric conductivity between MgO and cao were the critical factor to realize selective sintering in MgO-cao system,which provides a novel pathway to solve the problem of difficult sintering and control the microstructure of high-temperature composite material used in the field of high-purity steel smelting.

关键词： Magnesia-calcia material Induction sintering Hot spot Selective sintering Density Microstructure control Hydration resistance

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软体机械手关键技术研究进展

科技导报 2024年第8期42卷 48-62页

作者：付敏王鹏王成梦曹众陈见坤东北林业大学机电工程学院哈尔滨150040

软体机械手具有良好的环境适应性、灵活性和人机交互性,可应用于作物采摘、水下探索、医疗康复、野外救援、物品分拣等众多领域。综述了软体机械手的驱动方式、制造技术、构型,以及建模与控制方法等关键技术进展,分析了其目前存在的问... 详细信息

软体机械手具有良好的环境适应性、灵活性和人机交互性,可应用于作物采摘、水下探索、医疗康复、野外救援、物品分拣等众多领域。综述了软体机械手的驱动方式、制造技术、构型,以及建模与控制方法等关键技术进展,分析了其目前存在的问题与难点,提出了未来软体机械手探索方向:制作材料智能化、提高控制精确度、探究新型驱动方式、仿生设计构型。

关键词：软体机械手驱动构型制造技术建模与控制

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空气分级技术及设备研究进展

化学工业与工程 2024年第04期41卷 117-130页

作者：付敏曹众陈效庆高泽飞战明宇东北林业大学机电工程学院

空气分级机是通过空气流场对不同粒径大小的颗粒进行分离的设备，广泛应用于选矿、食品加工、精细化工、生物制药和固体废弃物回收等领域，对控制粉体原料的品质有重要作用。总结了静态空气分级机和动态空气分级机的研究进展，主要包括... 详细信息

空气分级机是通过空气流场对不同粒径大小的颗粒进行分离的设备，广泛应用于选矿、食品加工、精细化工、生物制药和固体废弃物回收等领域，对控制粉体原料的品质有重要作用。总结了静态空气分级机和动态空气分级机的研究进展，主要包括垂直流型和水平流型重力式分级机、离心式分级机、动态分级机的分类以及转笼、导风叶片和物料分散机构等关键部件、工艺参数和内部流场的研究现状，指出存在的问题并展望未来发展方向，以期为空气分级技术及设备的研究提供参考。未来空气分级机的研究可重点关注分级室内颗粒运动学、动力学分析、分级机内部流场定量表征以及整体结构与工艺参数优化。

关键词：分级技术重力式分级离心式分级动态空气分级涡流场

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具有自驱动有源缓冲器的GaN基高效准谐振反激式功率变换器

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半导体技术 2024年第3期49卷 263-271页

作者：王忠曹通王福学边国辉无锡职业技术学院汽车与交通学院江苏无锡214121 江南大学理学院江苏无锡214122 河北东森电子科技有限公司石家庄050200

提出了一种具有自驱动有源缓冲器的GaN基高效准谐振(QR)反激式功率变换器,以解决准谐振反激式功率变换器中开关管关断时电压过高的问题。电路以GaN高电子迁移率晶体管(HEMT)器件为主开关管和同步整流器开关管,自驱动有源缓冲器由钳位电... 详细信息

提出了一种具有自驱动有源缓冲器的GaN基高效准谐振(QR)反激式功率变换器,以解决准谐振反激式功率变换器中开关管关断时电压过高的问题。电路以GaN高电子迁移率晶体管(HEMT)器件为主开关管和同步整流器开关管,自驱动有源缓冲器由钳位电容和有源开关管组成。该变换器在主开关管关断期间将开关管的电压浪涌钳位为恒定电压,由于有源开关管驱动信号由变压器的次级侧电流控制,因此不需要单独的控制电路。为验证所提出的变换器和控制电路的有效性,搭建了一个60 W的AC-DC功率变换器,测试结果表明,主开关管的最大电压浪涌约为450 V,具有高达91.6%的能量转换效率。

关键词：反激式变换器电压浪涌自驱动有源缓冲器 GaN高电子迁移率晶体管(HEMT) DC-DC