检索结果-南通市图书馆

Effect of superoxide dismutase and malondialdehyde metabolic changes on carcinogenesis of gastric carcinoma

World Journal of Gastroenterology 2005年第28期11卷 4305-4310页

作者： Shao-Hong wang Jin-Hui Shen Hou-Qiang Zhou Xiao-Yang Qiu yi-zhong wang Ke-yi Zhang Department of Pathology Central Hospital of Shantou City Shantou 515031 Guangdong Province China Department of Laboratory Central Hospital of Shantou City Shantou 515031 Guangdong Province China Department of Surgical Oncology Central Hospital of Shantou City Shantou 515031 Guangdong Province China

AIM： To investigate the relationship between the superoxide dismutase （SOD）, malondialdehyde （MDA） metabolic changes and the gastric carcinogenesis.METHODS： The SOD activity and MDA content were measured in the gastric tissues from the focus center, peripheral and far-end areas of gastric carcinoma （n = 52） arid gastric ulcer （n = 10）. All the tissues were subjected to routine histological examinations and classifications.RESULTS： The SOD activity was greatly reduced but the MDA content was markedly increased in the center areas of the non-mucous gastric carcinoma （non-MGC）; and the poorly differentiated gastric carcinoma varied. The SOD activity was gradually decreased and the MDA content was gradually increased in the tissues from the focus far-end, peripheral to center areas of non-MGC. Both of the SOD activity and the MDA content were significantly declined and were respectively at same low level in the tissues from the focus center, peripheral, and far-end area with the mucous gastric carcinoma （MGC）. In contrast to the gastric ulcer and grade I or II of non-MGC, the same level of the SOD activity and the MDA content were found in the focus center areas. Between non-MGC （groups A-D） and gastric ulcer （group F）, the differences of SOD activity and MDA content were very noticeable in the gastric tissues from the focus peripheral and far-end areas, in which the SOD activity showed noticeable increase and the MDA content showed noticeable decreasein the gastric ulcer.CONCLUSION： The active free radical reaction in the gastric tissues can induce the carcinogenesis of non-MGC. The utmost low ability of antioxidation in the gastric tissues can induce the carcinogenesis of MGC. The metabolic change of the free radicals centralized mostly in the center of ulcerated lesions only, which suggested the ability of antioxidation was declined only in these lesions. However, the metabolism of free radicals varied significantly and the ability of antioxidation declined not

关键词： Gastric carcinoma Free radical Superoxide dismutase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Formation of hierarchical Co-decorated Mo_(2)C hollow spheres for enhanced hydrogen evolution

引用

Rare Metals 2021年第10期40卷 2785-2792页

作者： yi-zhong wang yi-Ming Ding Cai-Hong Zhang Bo-Wen Xue Nian-Wu Li Le Yu State Key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

Water electrolysis has been regarded as a promising technology to produce clean hydrogen fuel with high purity. However, large-scale water electrolysis has been greatly hindered due to the lack of non-noble metal catalysts with high catalytic performance. Benefitting from unique hollow structures with large surface area and adjustable chemical compositions, hollow design plays an important role in improving the electrocatalytic performance for hydrogen evolution reaction(HER). Herein, we report an effective multi-step strategy to prepare hierarchical Co-decorated Mo_(2)C hollow spheres(CMCHSs) as electrocatalyst for HER. To be specific, the preparation process involves a metal-chelated polymerization and a subsequent surface modulation process. Owing to the unique hollow structure and incorporation of Co species,the as-prepared CMCHSs demonstrate largely enhanced HER performance with a low overpotential of 139 mV at the current density of 10 m A·cm^(-2) and good cycling durability in acid. The present research work highlights a new feasible strategy for the design of HER electrocatalyst via hollow designs and surface engineering.

关键词： Mo_(2)C Hollow design Surface modulation Hydrogen evolution reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

(-)-Epigallocatechin-3-gallate enhances poly I:C-induced interferon-λ1 production and inhibits hepatitis C virus replication in hepatocytes

引用

World Journal of Gastroenterology 2017年第32期23卷 5895-5903页

作者： yi-zhong wang Jie-Liang Li Xu wang Ting Zhang Wen-Zhe Ho Department of Infectious Diseases Shanghai Children’s Hospital Shanghai Jiao Tong University Department of Pathology and Laboratory Medicine Temple University Lewis Katz School of Medicine

AIM To investigate the effect of(-)-epigallocatechin-3-gallate(EGCG) on polyinosinic-polycytidylic acid(poly I:C)-triggered intracellular innate immunity against hepatitis C virus(HCV) in hepatocytes. METHODS A cell culture model of HCV infection was generated by infecting a hepatoma cell line, Huh7, with HCV JFH-1 strain(JFH-1-Huh7). Poly I:C with a high molecular weight and EGCG were used to stimulate the JFH-1-Huh7 cells. Real-time reverse transcription-polymerase chain reaction was used to detect the expression levels of intracellular m RNAs and of intracellular and extracellular HCV RNA. Enzyme-linked immunosorbent assay was used to evaluate the interferon(IFN)-λ1 protein level in the cell culture supernatant. Immunostaining was used to examine HCV core protein expression in Huh7 *** Our recent study showed that HCV replication could impair poly I:C-triggered intracellular innate immune responses in hepatocytes. In the current study, we showed that EGCG treatment significantly increased the poly I:C-induced expression of Toll-like receptor 3(TLR3), retinoic acid-inducible gene I, and IFN-λ1 in JFH-1-Huh7 cells. In addition, supplementation with EGCG increased the poly I:C-mediated antiviral activity in JFH-1-Huh7 cells at the intracellular and extracellular HCV RNA and protein levels. Further investigation of the mechanisms showed that EGCG treatment significantly enhanced the poly I:C-induced expression of IFN-regulatory factor 9 and several antiviral IFNstimulated genes, including ISG15, ISG56, myxovirus resistance A, and 2'-5'-oligoadenylate synthetase 1, which encode the key antiviral elements in the IFN signaling pathway. CONCLUSION Our observations provide experimental evidence that EGCG has the ability to enhance poly I:C-induced intracellular antiviral innate immunity against HCV replication in hepatocytes.

关键词： (-)-Epigallocatechin-3-gallate Toll-like receptor 3 Retinoic acid-inducible gene I IFN-λ1 Hepatitis C virus IFN-stimulated genes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of a portable multi-channel system for plant physiological signal recording

引用

Information Processing in Agriculture 2016年第2期3卷 124-132页

作者： Ting Li Zi-Yang wang Dong-Jie Zhao Lan Huang zhong-yi wang College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Modern Precision Agriculture System Integration Research Key Laboratory of Ministry of Education Beijing 100083China Key Laboratory of Agricultural Information Acquisition Technology(Beijing) Ministry of AgricultureBeijing 100083China

Bioelectrical signals can reflect physiological state of organs or tissues in plants and have a significant potential value in research of plant stress *** order to study the relationship between environment factors and electrical signals in plant,a portable multichannel physiological signal acquisition system which relevant in plant physiology research was *** parameters and electrical signals can be measured in different channels by the acquisition system simultaneously and the measurement data will be displayed in an embedded integrated touch screen which is the system processing *** system was validated to be stable and reliable after the calibration and repeated experiments of recording electrical signals in Helianthus annuus L.

关键词： Bioelectrical signals Acquisition system Multi-channel Portable device

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic scaling characteristics of single-phase natural circulation based on different strain transformations

引用

Nuclear Science and Techniques 2023年第9期34卷 128-141页

作者： Jia-Ning Xu Xiang-Bin Li zhong-yi wang Yu-Sheng Liu De-Chen Zhang Qiao Wu School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China Beijing Key Laboratory of Passive Safety Technology for Nuclear Energy Beijing 102206China China Institute of Nuclear Industry Strategy BeijingChina Nuclear and Radiation Safety Center MEEBeijing 100082China Department of Nuclear Engineering Oregon State UniversityCorvallisOR 97331USA

To understand the dynamical system scaling(DSS)analysis theory,the applicability of DSSβ-andω-strain transformation methods for the scaling analysis of complex loops was explored.A simplified model consisting of two loops was established based on the primary and secondary sides of a nuclear reactor,andβ-andω-strain transformation methods were used to ana-lyze the single-phase natural circulation in the primary *** comparison with the traditional method,simplified DSSβ-andω-strain methods were developed based on the standard scaling *** strain parameters in these four methods were modified to form multiple groups of scaled-down *** transient process of the natural circulation was simulated using the Relap5 code,and the variation in the dynamic flow characteristics with the strain numbers was obtained using different scaling *** results show that both the simplified and standard DSS methods can simulate the dynamic characteristics of natural circulation in the primary *** scaled-down cases in the simplified method exhibit the same geometric scaling and correspond to small core power *** contrast,different scaled-down cases in the standard DSS method correspond to different geometric scaling criteria and require more *** dynamic process of natural circula-tion can be simulated more accurately using the standard DSS method.

关键词： Dynamical system scaling analysis β-strain transformation ω-strain transformation Natural circulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The calibration model in potassium ion flux non-invasive measurement of plants in vivo in situ

引用

Information Processing in Agriculture 2016年第2期3卷 76-82页

作者： Lin Xue Dong-jie Zhao Zi-yang wang Xiao-dong wang Cheng wang Lan Huang zhong-yi wang College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China College of Information Technology Beijing Union UniversityBeijing 100101China Modern Precision Agriculture System Integration Research Key Laboratory of Ministry of Education Beijing 100083China Key Laboratory of Agricultural Information Acquisition Technology(Beijing) Ministry of AgricultureBeijing 100083China National Engineering Research Center for Information Technology in Agriculture Beijing 100097China

SIET(Self-referencing Ion Electrode Technique)provides a novel electrophysiological tool which can non-invasively measure the dynamic influxes and effluxes of ions caused by the diffusion along the concentration gradients in ***,in this technique ion fluxes are converted to voltage signals using an ion selective microelectrode at a small amplitude of lV,which is easy to be interfered by the ambient ***,effective solutions to the suppression of noise and calibration of ion flux measurement system are very important for this method.A K^+-selective microelectrode was constructed using liquid ion exchangers(LIX)to investigate ion transport over plant tissue.A standard concentration gradient which simulates plant living cells was produced by an electrode with a certain tip diameter,filled with a solution containing a known K+concentration in 100 mmol/*** ion diffusion simulation model was *** model evaluated the performance of ion flux measurement system in accuracy and reliability by comparing the consistency of the measured value and the predicted curve.K^+fluxes were measured within 25 min at each measuring point of distance 10,20,30,40,50,80,and 100 lm from the K+source,*** can be seen that the K^+fluxes changes little,which indicates that ion flux measurement system has a reliable *** study provides a theoretical basis for a new non-invasive ion flux measurement method creation and a new sensors design.

关键词： SIET Plant K^+flux Calibration In situ

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reliable calculations of nuclear binding energies by the Gaussian process of machine learning

引用

Nuclear Science and Techniques 2024年第6期35卷 130-144页

作者： Zi-yi Yuan Dong Bai Zhen wang zhong-Zhou Ren School of Physics Science and Engineering Tongji UniversityShanghai 200092China College of Science Hohai UniversityNanjing 211100China Key Laboratory of Advanced Micro-Structure Materials Ministry of EducationShanghai 200092China

Reliable calculations of nuclear binding energies are crucial for advancing the research of nuclear physics. Machine learning provides an innovative approach to exploring complex physical problems. In this study, the nuclear binding energies are modeled directly using a machine-learning method called the Gaussian process. First, the binding energies for 2238 nuclei with Z > 20 and N > 20 are calculated using the Gaussian process in a physically motivated feature space, yielding an average deviation of 0.046 MeV and a standard deviation of 0.066 MeV. The results show the good learning ability of the Gaussian process in the studies of binding energies. Then, the predictive power of the Gaussian process is studied by calculating the binding energies for 108 nuclei newly included in AME2020. The theoretical results are in good agreement with the experimental data, reflecting the good predictive power of the Gaussian process. Moreover, the α-decay energies for 1169 nuclei with 50 ≤ Z ≤ 110 are derived from the theoretical binding energies calculated using the Gaussian process. The average deviation and the standard deviation are, respectively, 0.047 MeV and 0.070 MeV. Noticeably, the calculated α-decay energies for the two new isotopes ^ (204 )Ac(Huang et al. Phys Lett B 834, 137484(2022)) and ^ (207) Th(Yang et al. Phys Rev C 105, L051302(2022)) agree well with the latest experimental data. These results demonstrate that the Gaussian process is reliable for the calculations of nuclear binding energies. Finally, the α-decay properties of some unknown actinide nuclei are predicted using the Gaussian process. The predicted results can be useful guides for future research on binding energies and α-decay properties.

关键词： Nuclear binding energies decay Machine learning Gaussian process

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Congenital hepatic fibrosis in a young boy with congenital hypothyroidism:A case report

引用

World Journal of Clinical Cases 2021年第6期9卷 1475-1482页

作者： Fang-Fei Xiao yi-zhong wang Fang Dong Xiao-Lu Li Ting Zhang Department of Gastroenterology Hepatology and NutritionShanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China

BACKGROUND Congenital hepatic fibrosis(CHF)is a rare autosomal recessive disorder characterized by variable degrees of periportal fibrosis and malformation of bile *** is generally accompanied by a variety of conditions or syndromes with other organ *** SUMMARY We report a 5-year-4-month-old Chinese boy with congenital hypothyroidism(CH)diagnosed with *** patient was diagnosed with CH by a newborn screening test and has since been taking *** has developed normally without neurocognitive *** liver function was observed in the patient at the age of 4 years and 11 mo,and elevated levels of liver function indices were persistent for 5 *** imaging indicated hepatosplenomegaly without narrowing of the portal vein but dilated splenic vein.A liver biopsy confirmed the pathological features of *** testing revealed two novel homozygous mutations,namely,c.2141-3T>C variant in PKHD1 related to CHF and c.2921G>A(p.R974H)in DUOX2 related to *** patient was treated with compound glycyrrhizin tablet,ursodeoxycholic acid,and levothyroxine after *** patient achieved a favorable clinical outcome during a follow-up period of over 2 *** Herein,we report the first case of a Chinese boy with comorbidity of CHF and CH,carrying both PKHD1 gene and DUOX2 gene novel *** biopsy and genetic testing should be considered for the diagnosis of coexistent liver disease in CH patients with unexplained abnormal liver function.

关键词： Congenital hepatic fibrosis Congenital hypothyroidism Liver biopsy PKHD1 DUOX2 Case report Genetic testing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel Mechanism,Drug Target and Therapy in Epilepsy

引用

Neuroscience Bulletin 2024年第5期40卷 561-563页

作者： Cenglin Xu yi wang zhong Chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China

Epilepsy,which is characterized by unprovoked seizures and has a prevalence of nearly 1%,is becoming one of the leading causes of disability and death globally[1].The exact mechanisms behind epilepsy are still unknown,which contributes to the inadequate efficacy of anti-seizure medications(ASMs)that mainly target membrane ion channels and neurotransmission[2].

关键词： epilepsy Therapy death

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sodium intake:a double-edged sword wielded by the brain

引用

Science China(Life Sciences) 2024年第7期67卷 1545-1547页

作者： Lingyu Xu Xiaolong Ma yi wang zhong Chen Key Laboratory of Neuropharmacology and Pharmaceutical Sciences Zheiiang Chinese Medical UniversityHangzhou 310053China Institute of Pharmacology&Toxicology College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China

Taste receptors on the tongue discriminate between five fundamental tastes:sour,sweet,bitter,salty,and umami(Chandrashekar et al.,2006).Typically,stimuli that evoke bitterness and acidity prompt aversive responses by animals,whereas sweet and umami flavors are appetitive and *** is unique in that it transitions from an appetitive to an aversive stimulus with increasing concentrations.

关键词： prompt sweet sword

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：