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Autophagy-targeting modulation to promote peripheral nerve regeneration

Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia Deng Nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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Scalable synthesis of mesoporous FeS_(2) nanorods as highperformance anode materials for sodium-ion batteries

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Rare Metals 2022年第1期41卷 21-28页

作者： Hong-Yan Liang Zhi-Wen zhang Xiao-Bin zhong yao-Hui zhang Meng-yao Tang Shu-Xian Li Huan-Huan zhang Peng-Fei Hu Jun-Fei Liang School of Energy and Power Engineering North University of ChinaTaiyuan 030051China School of Chemistry Beihang UniversityBeijing 100191China

Sodium-ion batteries(SIBs),as highly promising alternatives to lithium-ion batteries(LIBs),can be widely used in a variety of next-generation energy storage ***,the current commercial graphite anodes of LIBs could not intercalate sodium ions to appreciable extent,and the electrochemical irreversibility hinders further *** for a suitable anode material is a critical issue for the successful development of ***,we report a convenient,fast,and large-scale preparation method of mesoporous FeS_(2) *** specially designed one-dimensional mesoporous structure of FeS_(2) takes full advantage of ultra-high strain relaxation as well as fast Na^(+)transport rate arising from microstructural *** a result,the mesoporous FeS_(2) nanorods exhibited excellent sodium storage *** discharge capacity was retained at 711.1 mAh·g^(-1) after 450 cycles at a current density of 1000 mA·g^(-1).The special microstructure and superior performance of mesoporous FeS_(2) nanorods represent a critical step for transition metal sulfides electrode materials toward practical SIBs application.

关键词： FeS_(2) critical relaxation

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The role of forest culture in green construction and management of forest parks:merging knowledge-attitude-practice and theory of planned behavior

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Journal of Forestry Research 2023年第3期34卷 841-852页

作者： yao Xu Zhiguang zhang College of Economics and Management Nanjing Forestry UniversityNanjing 210037People’s Republic of China System Engineering Institute for Environment and Development Nanjing Forestry UniversityNanjing 210037People’s Republic of China

As a cultural concept refl ecting the relationship between humans and forests,forest culture plays an active role in sustainable forest *** parks provide a wide range of ecosystem services essential for the sustainable development of society,and the relationships between forest culture,green construction and management of forest parks have practical signifi *** study aimed to understand the interaction and process of forest culture infl uencing green construction and management in forest parks with the models Knowledge-Attitude-Practice(KAP)and Theory of Planned Behavior(TPB)by proposing a theoretical *** hypotheses were tested using data collected from 193 forest park employees in Heilongjiang Province,*** results show that forest culture had a signifi cant infl uence on green construction and forest *** addition,subjective norm and perceived behavioral control directly impacted behavior in green construction and management of the forest park,whereas attitude did not have an *** norm had a direct eff ect on *** between constructs show that forest culture had an indirect eff ect on planning and construction,and on ecological and economic ***,it supported three of four hypotheses within the proposed model in determining the infl uence of forest culture on green construction and management.

关键词： Forest parks Forest culture Green construction and management Knowledge-attitudepractice Theory of planned behavior

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The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan zhang Yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

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Combined control of fast attitude maneuver and stabilization for large complex spacecraft

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Acta Mechanica Sinica 2013年第6期29卷 875-882页

作者： yao zhang Jing-Rui zhang School of Aerospace Engineering Beijing Institute of Technology

In remote sensing or laser communication space missions, spacecraft need fast maneuver and fast stabilization in order to accomplish agile imaging and attitude tracking tasks. However, fast attitude maneuvers can easily cause elastic deformations and vibrations in flexible appendages of the spacecraft. This paper focuses on this problem and deals with the combined control of fast attitude maneuver and sta- bilization for large complex spacecraft. The mathematical model of complex spacecraft with flexible appendages and momentum bias actuators on board is presented. Based on the plant model and combined with the feedback controller, modal parameters of the closed-loop system are calculated, and a multiple mode input shaper utilizing the modal information is designed to suppress vibrations. Aiming at reducing vibrations excited by attitude maneuver, a quintic polynomial form rotation path planning is proposed with constraints on the actuators and the angular velocity taken into account. Attitude maneuver simulation results of the control systems with input shaper or path planning in loop are sepa- rately analyzed, and based on the analysis, a combined control strategy is presented with both path planning and input shaper in loop. Simulation results show that the combined control strategy satisfies the complex spacecraft＇s require- ment of fast maneuver and stabilization with the actuators＇ torque limitation satisfied at the same time.

关键词： Attitude control Input shaping Path planning Vibration suppression

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Alloy-Electrode-Assisted High-Performance Enhancement-Type Neodymium-Doped Indium-Zinc-Oxide Thin-Film Transistors on Polyimide Flexible Substrate

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Research 2021年第1期2021卷 295-303页

作者： Kuankuan Lu Rihui yao Wei Xu Honglong Ning Xu zhang Guanguang zhang Yilin Li Jinyao zhong Yuexin Yang Junbiao Peng State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

Flexible thin-film transistors with high current-driven capability are of great significance for the next-generation new display *** effect of a Cu-Cr-Zr(CCZ)copper alloy source/drain(S/D)electrode on flexible amorphous neodymiumdoped indium-zinc-oxide thin-film transistors(NdIZO-TFTs)was *** with pure copper(Cu)and aluminum(Al)S/D electrodes,the CCZ S/D electrode changes the TFT working mode from depletion mode to enhancement mode,which is ascribed to the alloy-assisted interface layer besides work function matching.X-ray photoelectron spectroscopy(XPS)depth profile analysis was conducted to examine the chemical states of the contact interface,and the result suggested that chromium(Cr)oxide and zirconium(Zr)oxide aggregate at the interface between the S/D electrode and the active layer,acting as a potential barrier against residual free electron *** optimal NdIZO-TFT exhibited a desired performance with a saturation mobility(μsat)of 40.3 cm^(2)·V-1·s^(-1),an Ion/Ioff ratio of 1:24×10^(8),a subthreshold swing(SS)value of 0.12 V·decade^(-1),and a threshold voltage(Vth)of 0.83 *** work is anticipated to provide a novel approach to the realization of highperformance flexible NdIZO-TFTs working in enhancement mode.

关键词： interface electrode copper

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli zhang Tian Li Jie Miao Zhina zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Composition and structure of coatings on Ti-6Al-4V alloy by micro-plasma oxidation in NaAlO2 solution

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中国有色金属学会会刊：英文版 2004年第z1期14卷 162-165页

作者： yao zhong-ping JIANG Zhao-hua SUN Xue-tong WU Zheng-dong zhang Xue-lin Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 China

Compound ceramic coatings on Ti-6Al-4V alloy were prepared for different time by pulsed bi-polar micro-plasma oxidation (MPO) in NaAlO2 solution. The phase composition was studied by XRD. And the electrochemical impedance spectra (EIS) of the coatings were measured to study the structure of the coatings, combined with the surface morphology. Using the proper EIS interpreting software, the "equivalent circuit" of the coatings was established, and meanwhile fitting values of equivalent element were obtained. The results show that the coating is composed of Al2 TiO5, α-Al2O3 and rutile TiO2, of which Al2 TiO5 is the main crystalline. Increasing the MPO time, the contents of Al2TiO5, rutile TiO2 and α-Al2O3 in the surface of the coating increase. And the EIS analysis and the surface morphology of the coatings illustrates the double-layer structure of the coatings, and the outer layer is loosen and the inner layer is compact. With the increase of the oxidizing time, the surface coarse degree of the coatings and the porosity of the outer layer of the coating are increased while the compactness of the inner layer of the coating is improved.

关键词： micro-plasma oxidation ceramic coatings electrochemical impedance spectra Ti-6Al-4V alloy

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天然产物抗氧化活性评价方法研究进展

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广州化工 2017年第19期45卷 7-10页

作者：张雪苗婷婷陆炯汤同中张耀堂张春平段静雨徐州医科大学药学院江苏徐州221004

体内氧化应激是诱导多种慢性疾病发生发展的主要机制。目前,人工抗氧化剂大多存在毒性,因而人们越来越重视天然抗氧化剂的研究,目前多种抗氧化活性研究方法用于评价天然产物的抗氧化活性,由于抗氧化反应机理各有不同,研究者应采取多种... 详细信息

体内氧化应激是诱导多种慢性疾病发生发展的主要机制。目前,人工抗氧化剂大多存在毒性,因而人们越来越重视天然抗氧化剂的研究,目前多种抗氧化活性研究方法用于评价天然产物的抗氧化活性,由于抗氧化反应机理各有不同,研究者应采取多种抗氧化方法综合评价天然产物的抗氧化能力。该文旨在分类总结现有的抗氧化活性研究的方法,阐述其原理与特点,为天然产物抗氧化活性研究及相关领域的研究提供依据。

关键词：抗氧化活性天然产物体内外评价方法研究进展

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ECCENTRICITY CHANGE IN TUBE SINKING

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Acta Metallurgica Sinica(English Letters) 1991年第9期4卷 184-190页

作者： yao Ruohao zhong Jianhua HUANG Jianfang zhang Ruhua South Institute of Metallurgy,Ganzhou,Jiangxi,China South Inst of Metallurgy Jiangxi China

The rectification of eccentricity was revealed to be more effective in tube sinking than drawing with a *** ratio of thickness to diameter of tube blank on both sides of thick and thin wall seems to be the principal influential factor in rectifying *** greater the ini- tial outside diameter and the initial wall thickness difference are and the less the initial wall thickness of the tube blank is,the better the rectification is.

关键词： sinking tube eccentricity rectifying

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