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Defence Technology（防务技术） 2020年第1期16卷 88-95页

作者： Song Cai Chen-lei Huang Kun liu zhong-xin li Zhi-lin Wu School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina

The cartridge case headspace is the axial clearance between the cartridge and bolt of an automatic weapon,and influences the reliability and security of the ***,theoretical and numerical studies were conducted to analyze the dynamic response of cartridge cases during internal impact considering the initial radial clearances between the cartridge case and chamber.A theoretical model was proposed to predict the cartridge case headspace considering both the deformation and movement of the cartridge case and confirmed by the results of nonlinear finite element *** differences between the results of the conventional static model and the dynamic model were then comprehensively *** effects of the angle between the cartridge and chamber,the cartridge case material,and the intermal impact pressure on the predicted headspace value were also *** dynamic response of the cartridge case predicted by the dynamic model was more accurate than that predicted by the conventional static *** internal impact pressure,pressure change rate,and cartridge material were all found to affect the predicted headspace.

关键词： Cartridge case headspace Radial clearance Thick-walled cylinder Dynamic response

Strain concentration caused by the closed end contributes to cartridge case failure at the bottom

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Defence Technology（防务技术） 2020年第6期16卷 1151-1159页

作者： Song Cai Jie Feng Hui Xu Kun liu zhong-xin li Zhi-lin Wu School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094JiangsuChina

Ruptures at the bottom of cartridges are a common cause of failure of ammunitions,which directly threatens the safety of weapons and *** on plastic tube theory,this study analyses the radial and axial deformation of a cartridge,considering the radial constraint of the closed end at the bottom of the *** to the influence of the closed end,the bottom of a cartridge does not establish complete contact with the *** to strain concentration in the non-contact area,this area is more amenable to the occurrence of cartridge *** theory predicts the location of the fracture more accurately than the traditional *** maximum axial deformation of a cartridge comprises bending and friction *** maximum strain at the bottom of the cartridge increased by 135%owing to the introduction of bending strain caused by the closed *** strain distribution of a cartridge was measured using digital image correlation technology,and the measured result was consistent with the predicted results of the bending deformation theory and rupture *** effects of wall thickness,radial clearance,friction coefficient,and axial clearance on the axial deformation of the cylinder were *** the wall thickness and reducing radial clearance were found to reduce bending deformation;furthermore,lubrication and reduction in axial clearance reduce frictional deformation,which in turn reduce cartridge rupture.

关键词： Closed end Cartridge case failures Strain concentration Bending deformation

An experiment evaluating how the tiny mass eccentricities in spinstabilized projectiles affect the position of impact points

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Defence Technology（防务技术） 2021年第3期17卷 948-960页

作者： Chuan-lin Chen Hui Xu Chen-lei Huang zhong-xin li Zhi-lin Wu School of Mechanical Engineering Nanjing University of Science and TechnologyNanjingJiangsu210094China

This study investigates and quantifies some possible sources affecting the position of impact points of small caliber spin-stabilized projectiles(such as 12.7 mm bullets).A comparative experiment utilizing the control variable method was designed to figure out the influence of tiny eccentric centroids on the *** study critically analyzes data obtained from characteristic parameter measurements and precision *** also combines Sobol’s algorithm with an artificial intelligence algorithmdAdaptive Neuro-Fuzzy Inference Systems(ANFIS)ein order to conduct global sensitivity analysis and determine which parameters were most *** results indicate that the impact points of projectiles with an entry angle of 0°deflected to the left to that of projectiles with an entry angle of 90°.The difference of the mean coordinates of impact points was about 12.61 cm at a target range of 200 *** analysis indicated that the entry *** initial position of mass eccentricityehad a notable *** global sensitivity analysis,the significance of the effect of mass eccentricity was confirmed again and the most influential factors were determined to be the axial moment and transverse moment of inertia(Izz Iyy),the mass of a projectile(m),the distance between nose and center of mass along the symmetry axis for a projectile(Lm),and the eccentric distance of the centroid(Lr).The results imply that the control scheme by means of modifying mass center(moving mass or mass eccentricity)is promising for designing small-caliber spin-stabilized projectiles.

关键词： Tiny mass eccentricity Small-caliber projectile Bullet Artificial intelligence algorithm Global sensitivity analyses Precision trials ANFIS Sobol’s algorithm

Delamination process in cross-ply UHMWPE laminates under ballistic penetration

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Defence Technology（防务技术） 2021年第1期17卷 278-286页

作者： Gen-lin Mo Qian-wen Ma Yong-xi Jin Wen-min Yan zhong-xin li Zhi-lin Wu Institute of Advanced Manufacturing Jiangsu UniversityZhenjiang212013China Key Laboratory of Transient Shock Beijing102202China Zhenjiang Hospital of Traditional Chinese Medicine 212013China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China

Cross-ply unidirectional laminates made of ultra-high molecular weight polyethylene fibers are widely used as components of bullet-proof *** simulate the delamination process of the material under penetration,we constructed a numerical mechanical model,which was validated by tests using 7.6239 mm rifle bullets penetrating laminates of different *** results show that the delamination region is essentially *** simulated delamination region is in good agreement with the experimental *** is found that the delamination region increases with the compression modulus along the fiber *** delamination region increases when the shear strength between the fabric layers decreases;However,it is little influenced by the normal *** delamination region of the front face of the laminate is little influenced by the failure strain of the material and the initial velocity of the *** delamination region of the back face increases with the failure strain and decreases with the initial velocity.

关键词： proof process modulus

Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota

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World Journal of Gastroenterology 2020年第48期26卷 7633-7651页

作者： Yang li zhong-xin li Chen-Yang Xie Jing Fan Ji Lv xin-Jian Xu Jian Lv Wen-Tao Kuai Yi-Tao Jia Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Oncology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Second Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Surgery The First Hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina Department of Thoracic Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Emergency Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND We previously showed,using the Traditional Chinese Medicine System Pharmacology Database,that Gegen Qinlian decoction(GQD)had a direct antitumor effect,and was combined with programmed cell death protein(PD)-1 inhibitors to treat microsatellite stable(MSS)tumor-bearing ***,the effect of GQD on patients with colorectal cancer(CRC)is not *** To determine the therapeutic mechanism of GQD in improving immune function,reducing inflammation and protecting intestinal barrier *** Seventy patients with CRC were included in this study:37 in the control group and 33 in the treatment *** proportions of CD4+T,CD8+T,natural killer(NK),NKT and T regulatory cells were measured by flow *** of the cytokines tumor necrosis factor(TNF)-α,interferon(IFN)-γ,interleukin(IL)-2,IL-6,IL-10 and serotonin(5-hydroxytryptamine;5-HT)in serum were assessed by enzyme-linked immunosorbent assay(EliSA).The expression of zonula occludens(ZO)-1,occludin,nuclear factor(NF)-κB and TNF-αin tumor and normal tissues was measured by *** composition of gut microbiota from patients in the treatment group was assessed using 16S rDNA *** There were no adverse events in the treatment *** proportion of CD4+T cells and NKT cells in the post-treatment group was significantly higher than that in the pre-treatment and control groups(P<0.05).The level of TNF-αin the posttreatment group was significantly lower than that in the pre-treatment and control groups(P<0.05).The concentration of 5-HT in the post-treatment group was significantly lower than that in the pre-treatment group(P<0.05).The expression of ZO-1 and occludin in tumor tissues in the treatment group was significantly higher than that in the control group(P<0.05).The expression of ZO-1 in normal tissues of the treatment group was significantly higher than that in the control group(P=0.010).Compared with the control group,expression of NF-κB and TNF-αin tumor tis

关键词： Colorectal cancer Gegen Qinlian decoction Immunity Inflammation Intestinal barrier function Gut microbiota

Study on the occurrence and influencing factors of gastrointestinal symptoms in hemodialysis patients with uremia

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2157-2166页

作者： Dan Yuan Xiao-Qi Wang Feng Shao Jing-Jing Zhou zhong-xin li Department of Nephrology Beijing Luhe Hospital Affiliated to Capital Medical UniversityBeijing 101100China

BACKGROUND Gastrointestinal symptoms are common in patients with uremia undergoing hemodialysis,and these symptoms seriously affect patients'*** To assess the occurrence and factors influencing gastrointestinal symptoms in patients with uremia undergoing *** We retrospectively selected 98 patients with uremia who underwent regular hemo-dialysis treatment in the blood purification center of our hospital from December 2022 to December *** gastrointestinal symptoms and scores of each dimension were evaluated using the Gastrointestinal Symptom Grading Scale(GSRS).Patients were divided into gastrointestinal symptoms and no gastrointestinal symptom groups according to whether they had gastrointestinal *** factors that may affect gastrointestinal symptoms were identified by single-factor *** logistic regression analysis was performed to identify independent risk factors for gastrointestinal *** Gastrointestinal symptoms included indigestion,constipation,reflux,diarrhea,abdominal pain,and eating disorders,and the total average GSRS score was 1.35±*** study showed that age,number of tablets,dialysis time,glucocorticoid,parathyroid hormone(PTH),combined diabetes mellitus and C-reactive protein(CRP)were independent risk factors for gastrointestinal symptoms in patients with uremia undergoing hemodialysis,whereas body mass index(BMI),hemoglobin(Hb),and urea clearance index were independent protective factors(Plinically related factors influencing the occurrence of gastrointestinal symptoms,and targeted prevention can be perform

关键词： Uremic hemodialysis Gastrointestinal symptoms Influencing factors Blood pressure dialysis Chronic renal failure

Bladder perforation injury after percutaneous peritoneal dialysis catheterization:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7054-7059页

作者： Chun-Xia Shi zhong-xin li Hai-Tao Sun Wu-Qing Sun Yu Ji Shu-Jing Jia Department of Nephrology Beijing Luhe Hospital Affiliated to Capital Medical UniversityBeijing 101149China Department of Medicine Beijing Shuangqiao HospitalBeijing 100121China

BACKGROUND Insertion of a catheter into the bladder is a rare complication of peritoneal dialysis(PD),and is mainly related to surgical *** paper reports a case of bladder perforation that was caused by percutaneous PD *** SUMMARY A 64-year-old man underwent percutaneous PD catheterization for end-stage renal *** the second day after the operation,urgent urination and gross hematuria *** showed the presence of red and white blood *** anti-infective treatment was *** the third day after the operation,urgent urination occurred during PD *** showed that the PD catheter was located in the bladder,and subsequent computed tomography(CT)showed that the PD catheter moved through the anterior wall into the *** PD catheter was withdrawn from the bladder and catheterization was *** CT on the fourth day after the operation showed that the PD catheter was removed from the bladder,but there was poor catheter *** PD catheter was removed and the patient was changed to *** cystography showed that the bladder healed well and the patient was discharged 14 d after the *** Bladder perforation injury should be considered and treated timeously in case of bladder irritation during and after percutaneous PD *** use of Doppler ultrasound and other related technologies may reduce the incidence of such complications.

关键词： Bladder perforation Peritoneal dialysis Percutaneous peritoneal dialysis catheterization Peritoneal dialysis catheter dysfunction Case report

Waist subcutaneous soft tissue metastasis of rectal mucinous adenocarcinoma: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2412-2419页

作者： Zi-xing Gong Guo-Lei li Wen-Min Dong Zhao Xu Rui li Wen-Xia Lv Jing Yang zhong-xin li Wei xing Department of General Surgery Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Department of Medical Imaging Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Department of Pathology Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Department of Gastroendoscopy Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Gastrointestinal Disease Diagnosis and Treatment Center The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Rectal mucinous adenocarcinoma(MAC)is a rare pathological type of rectal can-cer with unique pathological features and a poor *** is difficult to diag-nose and treat early because of the lack of specific manifestations in some aspects of the *** common metastatic organs of rectal cancer are the liver and lung;however,rectal carcinoma with metastasis to subcutaneous soft tissue is a rare *** SUMMARY In this report,the clinical data,diagnosis and treatment process,and postope-rative pathological features of a patient with left waist subcutaneous soft tissue masses were retrospectively *** patient underwent surgical treatment after admission and recovered well after *** final pathological diagnosis was rectal MAC with left waist subcutaneous soft tissue *** Subcutaneous soft tissue metastasis of rectal MAC is rare,and it can suggest that the tumor is disseminated,and it can appear even earlier than the primary ma-lignant tumor,which is occult and leads to a missed diagnosis and misdiagnosis *** a subcutaneous soft tissue mass of unknown origin appears in a patient with rectal cancer,a ma-lignant tumor should be considered.

关键词： Colorectal cancer Rectal mucinous adenocarcinoma Cancer metastasis Subcutaneous soft tissue Hematogenous Case report

Microstructure and properties of novel quinary multi-principal element alloys with refractory elements

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China Foundry 2015年第5期12卷 319-325页

作者： Na-na Guo liang Wang Yan-qing Su liang-shun Luo xin-zhong li Jing-jie Guo Heng-zhi Fu National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and Engineering Harbin Institute of Technology

Five equiatomic alloys(Ti Zr Hf VNb, Ti Zr Hf VTa, Ti Zr Nb Mo V, Ti Zr Hf Mo V and Zr Nb Mo Hf V) composed of five elements with high melting temperature, respectively were prepared by arc-melting to develop a novel high temperature alloy. The five alloys exhibit different dendritic and interdendritic morphologies. The Ti Zr Hf VNb, Ti Zr Hf VTa and Ti Zr Nb Mo V alloys formed disordered solid solution phases with body-centered cubic structure, and exhibited high compressive strength and good plasticity. The Ti Zr Hf Mo V and Zr Nb Mo Hf V alloys are composed with Laves phase(Hf Mo2) and disordered solid solution phases with body-centered cubic structure. The Ti Zr Hf Mo V and Zr Nb Mo Hf V alloys are harder and more brittle than the other three alloys due to the existence of hard and brittle Laves phases. At high temperatures, the strength decreases to below 300 MPa for the Ti Zr Hf VNb and Ti Zr Hf Mo V alloys. Solution strengthening is the primary strengthening mechanism of the Ti Zr Hf VNb, Ti Zr Hf VTa and Ti Zr Nb Mo V alloys, and brittle Laves phase is the main cause for the low ductility of the Ti Zr Hf Mo V and Zr Nb Mo Hf V alloys.

关键词： high temperature alloys high-entropy alloy crystal structure and microstructure hardness compressive property

Effects on Proliferation and Migration of the Human Colon Carcinoma Cell line SW620 by Silencing of Hepatocyte Growth Factor Expression

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Clinical oncology and cancer researeh 2010年第5期7卷 277-283页

作者： Yi-tao JIA Lei ZHANG Yan li Ya-di WANG Wei GUO Lei CAO zhong-xin li 3rd Department of Oncology Hebei ProvincialPepeol's Hospital Shijiazhuang 050051 HebeiProvince China. Department of Histology and Embryology Hebei Medical University Shijiazhuang050017 Hebei Province China Department of Radiotherapy Hebei Medical University Fourth Hospital Shijiazhuang050011 Hebei Province China. 2nd Department of Surgery Hebei Medical University Foruth Hospital Shijiazhuang050011 Hebei Province China.

OBJECTIVE Hepatocyte growth factor （HGF） expression is closely related to the progression and poor prognosis of colorectal cancer patients. In this study, we investigated the effects on proliferation and migration of the human colon carcinoma cell line SW620 by silencing HGF expression. METHODS HGF was silenced using specific HGF a/f3 siRNA. The proliferation, migration, cell cycle and ultrastructure of SW620 cells were examined. RESULTS The transfection efficiency was 70%-80%. The expression rate of HGF in the experimental group was significantly lower than that in the negative and blank control groups （P 〈 0.05）. The proliferation inhibition rate in the experimental group at 24, 48, 72 and 96 h after transfection was 14.2%, 50.2%, 39.5% and 23.2%, respectively. The migratory ability of cells in the experimental group was significantly inhibited compared with that in the negative control or blank control groups （58.2% vs. 2.1% or 0%, P 〈 0.05）. CONCLUSION The application of RNA interference to silence the expression of HGF in the colon carcinoma cell line SW620 effectively inhibits the proliferation and migration of tumor cells.

关键词： RNA interference HGF protein human cellular proliferation cell movement colorectal neoplasms.