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Rapid Microwave-promoted Base-free Suzuki Coupling Reaction of Sodium Tetraphenylborate with Hypervalent Iodonium Salts in Water

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Chinese Chemical Letters 2006年第4期17卷 473-476页

作者： Jie YAN zhong shi zhou Min ZHU College of Chemical Engineering and Materials Sciences Zhejiang University of Technology Hangzhou 310032 College of Biological and Environmental Sciences Zhejiang Shuren University Hangzhou 310015

The palladium chloride-catalyzed Suzuki coupling reaction of sodium tetraphenylborate with hypervalent iodonium salts was achieved under microwave irradiation in water without base in excellent yield. A convenient and... 详细信息

关键词： Suzuki reaction sodium tetraphenylborate iodonium salt microwave irradiation

Microwave-assisted base-free synthesis of trans-cinnamic acids using hypervalent iodonium salts

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Chinese Chemical Letters 2007年第3期18卷 272-274页

作者： Min Zhu Chao Shentu zhong shi zhou College of Biological and Environmental Sciences Zhejiang Shuren University Hangzhou 310015 China

A fast and convenient base-free Heck reaction of acrylic acid with hypervalent iodonium salts was achieved under microwave irradiation in water, providing a simple method for the synthesis of trans-cinnanfic acids in ... 详细信息

关键词： Heck reaction Hypervalent iodonium salts Microwave irradiation trans-Cinnamic acids

A simple and convenient method for direct α-chlorination of ketones with ammonium chloride and Oxone~

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Chinese Chemical Letters 2012年第11期23卷 1213-1216页

作者： zhong shi zhou Li Li Xue Han He College of Biological and Environmental Sciences Zhejiang Shuren UniversityHangzhou 310015China Zhejiang Institute of Geology and Mineral Resource Laboratory Hangzhou 310007China

When ketones were treated with ammonium chloride and Oxone in MeOH at room temperature, a direct or-chlorination of ketones was occurred and a series of the corresponding α-chloroketones were obtained in moderate to good yields after 24 h. In this reaction, ammonium chloride was used as the source of chlorine and Oxone was used as an oxidant. This method was simple, convenient and providing a novel procedure for preparation of α-chloroketones.

关键词： Chlorination of ketone α-Chloroketone Synthesis

An Explicit Solution for a Series and Parallel Queue with Retrial,Losses,and Bernoulli Schedule

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Journal of the Operations Research Society of China 2016年第1期4卷 121-129页

作者： shi-zhong zhou Li-Wei Liu Jian-Jun Li Department of Statistics and Financial Mathematics School of ScienceNanjing University of Science and TechnologyNanjing 210094China

This paper deals with the series and parallel queueing system in which there are two servers whose service time follow two exponential *** arriving customer either enters into the tandem service with probability or joins the service of the single server with complementary *** assume that the customers of arriving at the first server who find the first server is busy join an orbit and retry to enter the server after some time and of arriving at the second server who find the second server is busy are *** this model,we obtain the explicit expressions of the joint stationary distribution between the number of customers in the orbit and the states of the servers.

关键词： Series and parallel queue Retrial Bernoulli schedule Explicit solution Hypergeometric function

Synthesis of p-nitrophenol under normal pressure with A-1 phase transfer catalysis

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Journal of Central South University of Technology 2001年第1期8卷 54-56页

作者： zhong shi an, OUYANG Xi, zhou Chun shan, CHENG Ben cheng (College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China) 1. College of Chemistry and Chemical Engineering Central South University 410083 Changsha China

p nitrophenol is synthesized using p nitrochlorobenzene and sodium hydroxide with phase transfer catalyst. Several reaction factors, such as catalyst type, the amounts of catalysts and sodium hydroxide, the concentration of sodium hydroxide solution as well as reaction time, affect greatly the yield of p nitrophenol. The optimum reaction conditions are as follows: A 1 used as phase transfer catalyst whose consumption is 6% (mole fraction) of p nitrochlorobenzene; the molar ratio of sodium hydroxide to p nitrochlorobenzene is 3:1; the concentration of sodium hydroxide solution is 50% (mass fraction). Nitrobenzene, whose molar amount is 2.45 times as much as that of p nitrochlorobenzene; reaction time is 7 h at 140 ℃ under normal pressure. The final yield of p nitrophenol is 83.6%.

关键词： phase transfer catalysis p nitrophenol synthesis

Upgrade and separation of Co from solution with low-grade Co

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Journal of Central South University of Technology 2001年第4期8卷 249-251页

作者： zhong shi an,zhou Chun shan,OU Yang xi,CHENG Ben cheng(College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China) 1. College of Chemistry and Chemical Engineering Central South University 410083 Changsha China

Upgrade and separation of Co from solution with low grade Co were studied. In the solution, the content of Co is about 1 g·L -1 , while that of Ni, Zn, Mn, Mg, Si and Ca is 0.145, 1.108, 0.119, 6.672, 0.026 and 0.200 g·L -1 , respectively. After absorbed with absorbent G-1, the content of Co in the solution is less than 1 mg·L -1 , the average loss rate of Co is 0.07%, while the average loss rate of Mg is 67.92%. It is demonstrated that the absorbent has selectivity to absorb Co. After the absorbent was eluted with HCl at room temperature, the solution with higher content of Co was obtained. Through being evaporated and concentrated, the contant of Co in the solution can be upgraded to 26.6 g·L -1 . At the same time, most of Si, Mg is removed, the total recovery of Co can reach as high as 98.7%. The content of Pb, Ni, Cu, Zn, Mn in the discharge solution is 1.00, 0.26, 0.21, 0.09, 0.15 mg·L -1 , respectively, and the discharge solution can reach the national discharge standard. CoCl 2 solid can be obtained and can reach chemical purity.

关键词： Co upgrade separation

PID1,a new tumor-promoting gene in insulin resistance mediated acceleration of hepatocellular carcinoma development and progression

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中国药理学与毒理学杂志 2017年第10期31卷 977-978页

作者： Ming XIANG Qian-qian XU Na XU zhong-shi zhou Ya-li TUO Cheng TIAN Department of Pharmacology School of PharmacyTongji Medical CollegeHuazhong University of Science and Technology

OBJECTIVE To investigate the effect of phosphotyrosine interaction domain containing 1(PID1,NYGGF4)on promotion of IR and HCC,and explore its underlying *** Lentivirus were used to mediate the knockdown of PID1 in HFD induced IR mouse model as well as ob/ob *** glucose and insulin tolerance were performed 4 weeks after lentivirus ***-based transfection was applied to inducethe liver specific overexpression of *** cytometry was exerted to detect the proportion and function of immune *** T-PCR and Western blot were used to detect the expression of downstream pathways of *** was used to determine the receptor of *** immunoprecipitation(ChI P)was operated to measure the modification of H3K4me3 of PID1 *** PID1 restriction improved insulin resistance,hyperglycemia and fatty ***,hepatic knockdown of PID1 attenuated liver xenografted tumor ***,PID1 liver-specific protooncogenes via hydrodynamics-based transfection established a primary hepatocellular carcinoma mouse model,induced an immunosuppressive environment,with the reduction of CD3^+,CD4^+,CD8^+T cel s,retarded maturation of dendritic cel s(DCs),pronounced differentiation of regulatory T cells(Tregs),and recruitment of *** addition,PID1 overexpression activated proliferation related genes,promoted anti-inflammatory genes,suppressed pro-inflammatory genes,induced glycolysis and lipid metabolism genes to facilitate tumorigenesis in ***,PID1 exerted its tumor-promoting function through binding to epidermal growth factor receptor(EGFR)and activation of downstream MAPK *** such,PID1 exist trimethylation of histone H3 at lysine 4(H3K4me3)modification and IR up-regulated the expression of PID1 by activation the H3K4me3 *** PID1 is a new gene that exerts both liver cancer-promoting and insulin resistance inducing *** accelerates liver cancer

关键词： PID1 insulin resistance hepatocellular carcinoma cancer promoting immunosuppression

Prognostic factors of fulminant hepatitis in pregnancy

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Chinese Medical Journal 2005年第20期118卷 1754-1757页

作者： LI Xiao-mao MA Lin YANG Yue-bo shi zhong-jie zhou Shui-sheng Department of Obstetrics and Gynecology Third Affiliated HospitalSun Yat-Sen University Guangzhou 510630 China

Fulminant hepatitis （FH） refers to liver diseases that have severe state and complicated manifestations. It will endanger patients＇lives and health largely. The incidence of fulminant hepatitis in pregnancy （FHP） is 66 times of patients not in pregnancy,1 which is more dangerous and is one of the major causes of maternal and perinatal death in China. In order to predict the prognoses of FHP and decrease maternal and perinatal death rate, we summarized clinical information of 25 cases of FHP admitted to our hospital and investigated into prognostic factors that influenced FHP.

关键词： fulminant hepatitis · pregnancy · prognosis

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng zhou Wei Yang Di Zhu Bi-Fei Wu Hai-Bin shi Sheng Liu Wei-zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis