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Etomidate vs propofol in coronary heart disease patients undergoing major noncardiac surgery:A randomized clinical trial

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World Journal of Clinical Cases 2021年第6期9卷 1293-1303页

作者： zhong-liang dai Xing-Tao Cai Wen-Li Gao Miao Lin Juan Lin Yuan-Xu Jiang Xin Jiang Department of Anesthesiology The First Affiliated Hospital of Southern UniversityThe Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Geriatrics The First Affiliated Hospital of Southern UniversityThe Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina

BACKGROUND The ideal depth of general anesthesia should achieve the required levels of hypnosis,analgesia,and muscle relaxation while minimizing physiologic responses to *** choice of anesthetic strategy in patients with coronary heart disease(CHD)undergoing major noncardiac surgery is becoming an increasingly important issue as the population *** is because general anesthesia is associated with a risk of perioperative cardiac complications and death,and this risk is much higher in people with *** To compare hemodynamic function and cardiovascular event rate between etomidate-and propofol-based anesthesia in patients with *** This prospective study enrolled consecutive patients(American Society of Anesthesiologists grade II/III)with stable CHD(New York Heart Association class I/II)undergoing major noncardiac *** patients were randomly allocated to receive either etomidate/remifentanil-based or propofol/remifentanil-based general *** was performed using a computer-generated random number table and sequentially numbered,opaque,sealed *** was maintained until the patient had arrived in the operating theater,at which point the consulting anesthetist opened the *** patients,data collectors,and data analyzers were blinded to the type of anesthesia *** primary endpoints were the occurrence of cardiovascular events(bradycardia,tachycardia,hypotension,ST-T segment changes,and ventricular premature beats)during anesthesia and cardiac troponin I level at 24 *** secondary endpoints were hemodynamic parameters,bispectral index,and use of vasopressors during *** The final analysis included 40 patients in each of the propofol and etomidate *** incidences of bradycardia,hypotension,ST-T segment changes,and ventricular premature beats during anesthesia were significantly higher in the propofol group than in the etomidate group(P<0.05 for all).The incidence of tachycardia

关键词： Etomidate Propofol General anesthesia Coronary heart disease Hemodynamic Cardiovascular events

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Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells

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Current Medical Science 2023年第6期43卷 1096-1106页

作者： Shang-wen PAN Li-sha HU Han WANG Rui-ting LI Ya-jun HE You SHANG zhong-liang dai Li-xin CHEN Wei XIONG Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Qingdao Women and Children’s HospitalQingdao UniversityQingdao266034China Department of Anesthesiology The Second Clinical Medical College(Shenzhen People’s Hospital)Jinan UniversityShenzhen518020China Department of Pharmacology Medical CollegeJinan UniversityGuangzhou510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou510632China

Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral *** is a catabolic process responsible for maintaining cellular *** recent years,autophagy has been demonstrated to play an important role in *** D1(RvD1)is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving ***,whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further *** present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding *** Mouse microglial cells(BV-2)were cultured,treated with RvD1,and examined by Western blotting,confocal immunofluorescence microscopy,transmission electron microscopy,and flow *** RvD1 promoted autophagy in both BV-2 cells and mouse primary microglia by favoring the maturation of autophagosomes and their fusion with ***,RvD1 had no significant effect on the activation of mammalian target of rapamycin(mTOR)***,RvD1-induced mTOR-independent autophagy was confirmed by observing reduced cytoplasmic calcium levels and suppressed calcium/calmodulin-dependent protein kinase II(CaMK II)***,by downregulating ATG5,the increased phagocytic activity induced by RvD1 was demonstrated to be tightly controlled by ATG5-dependent *** The present work identified a previously unreported mechanism responsible for the role of RvD1 in microglial autophagy,highlighting its therapeutic potential against neuroinflammation.

关键词： resolvin D1 microglia mTOR-independent autophagy ATG5-dependent autophagy phagocytosis

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Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang dai Guoyao Yue Yiman Zhang Lulu Li zhong-Zhen Yu Peng Min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge dai Li Rongrong zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin dai Xuefeng Liu Xin Ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

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SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang Hu Jiao dai Baigen Cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

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A Preliminary Study on the Soft–Sediment Deformation Structures in the Late Quaternary Lacustrine Sediments at Tashkorgan, Northeastern Pamir, China

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Acta Geologica Sinica(English Edition) 2018年第4期92卷 1574-1591页

作者： liang Lianji dai Fuchu JIANG Hanchao zhong Ning College of Architecture and Civil Engineering Beijing University of Technology State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake Administration

This study identified soft-sediment deformation structures （SSDS） of seismic origin from lacustrine sediments in the late Quaternary paleo-dammed lake at Tashkorgan, northeastern Pamir. The observed deformation structures include sand dykes, liquefied diapir and convolute structures, gravity induced SSDS, and thixotropic pillar and tabular structures. We conducted a preliminary study on the morphology, formation and trigger mechanisms of pillar and tabular structures formed by liquefaction of underlying coarse sand and thixotropy of the upper silty clay. The regional tectonic setting and distribution of lacustrine strata indicate that the most probable trigger for the SSDS in lacustrine sediments was seismic activity, with an approximate earthquake magnitude of M〉6.0; the potential seismogenic fault is the southern part of the Kongur normal fault extensional system. AMS ^4C dating results indicate that the SSDS were formed by seismic events occurring between 26050±100 yrBP and 22710±80 yrBP, implying intense fault activity in this region during the late Pleistocene. This study provides new evidence for understanding tectonic activity and regional geodynamics in western China.

关键词： soft-sediment deformation structures lacustrine sediment Pamir liquefaction thixotropy paleo-seismicity

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Multi-stream signals separation based on space-time-isomeric (SPATIO) array using metasurface antennas

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Science China(Information Sciences) 2024年第2期67卷 181-200页

作者： Yangming LOU liang JIN Huiming WANG Zhou zhong Junyan dai PLA Strategic Support Force Information Engineering University School of Information and Communications Engineering Xi'an Jiaotong University 3. State Key Laboratory of Millimeter WavesSoutheast University

In spatial domain signal processing, it is necessary to equip more antennas at the receiver to improve spatial demultiplexing capability. However, increasing the number of antennas under restricted space will reduce antenna spacing and raise the channel correlation, making the number of signal streams spatially demultiplexed much smaller than that of antennas. This paper proposes a method to design a space-timeisomeric(SPATIO) array based on metasurface antennas under wireless multipath conditions. Each antenna in this array has a different pattern and varies independently with time, reducing the channel correlation by superposing multipath at distinct positions and moments. Based on the SPATIO array, we present an array parameter design scheme based on infinity norm minimization, which can maximize the received energy of each stream while separating multi-stream received signals. Simulation results illustrate the performance of the SPATIO array for multi-stream signal reception. Compared with conventional multiple-input multipleoutput arrays, the proposed array can reduce the bit error rate by one order of magnitude under the same simulation conditions.

关键词： multiple-input multiple-output metasurface antenna space-time-isomeric array multipath channel degree of freedom

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Irritable bowel syndrome and functional constipation management with integrative medicine: A systematic review

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World Journal of Clinical Cases 2019年第21期7卷 3486-3504页

作者： liang dai Linda LD zhong Guang Ji Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina

BACKGROUND Irritable bowel syndrome(IBS)and functional constipation(FC)are two commonly encountered functional gastrointestinal disorders in clinical practice and are usually managed with Western medicines in cooperation with traditional Chinese medicine(TCM)*** clinical practice guidelines(CPGs)have been developed to assist clinicians with their decisions,there are still gaps in management with regard to integrative medicine(IM)*** To comprehensively review the currently available CPGs and to provide a reference for addressing the gaps in IBS and FC *** We searched mainstream English and Chinese databases and collected data from January 1990 to January *** search was additionally enriched by manual searches and the use of publicly available *** on the development method,the guidelines were classified into evidence-based(EB)guidelines,consensus-based(CB)guidelines,and consensus-based guidelines with no comprehensive consideration of the EB(CB-EB)*** regard to the recommendations,the strength of the interventions was uniformly converted to a 4-point grading *** Thirty CPGs met the inclusion criteria and were captured as data extraction *** Western medicine(WM)CPGs were developed as EB *** TCM CPGs and most IM CPGs were identified as CB *** the 2011 IBS and IM CPG was a CB-EB set of *** and peppermint oil for pain,loperamide for diarrhea,and linaclotide for constipation polyethylene glycol and lactulose as osmotic laxatives,bisacodyl and sodium picosulfate as stimulant laxatives,lubiprostone and linaclotide as prosecretory agents,and prucalopride were strongly recommended or recommended in *** interventions were suggested based on pattern differentiation,while the recommendation level was considered to be weak or *** WM CPGs generally provide a comprehensive management algorithm,although there are still s

关键词： Irritable bowel disease Functional constipation Clinical practice guideline Integrative medicine Systematic review

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