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The Application of Aspirin in Pregnancy-Related Complications

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Reproductive and Developmental Medicine 2020年第3期4卷 184-190页

作者： Lu-Yu Ruan Zhen-Zhen Lai hui-Li Yang Shao-Liang Yang Si-Yao Ha Jia-Wei Shi hui-hui shen Ming-Qing Li Laboratory for Reproductive Immunology Institute of Obstetrics and GynecologyHospital of Obstetrics and GynecologyFudan UniversityShanghai 200080China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Hospital of Obstetrics and GynecologyFudan UniversityShanghai 200011China NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research) Fudan UniversityShanghai 230032China

Aspirin,one of the most widely applied medicines,not only possesses the effects on reducing fever,anti-vascular hyperplasia,and anti-inflammation,but also has the capacity of preventing platelet *** far,it is acceptable to adopt aspirin,especially low-dose aspirin(LDA),to prevent pregnancy-related complications,such as pregnancy complicated by antiphospholipid syndrome,systemic lupus erythematosus,or preeclampsia;unexplained recurrent spontaneous abortion;fetal growth restriction;and preterm *** this article,we reviewed the possible mechanism of action and applications of aspirin in these pregnancy-related complications.

关键词： Abortion Antiphospholipid Antibodies Aspirin Fetal Growth Restriction Preeclampsia Pregnancy Preterm Birth Systemic Lupus Erythematosus

High expression of EPO gene using un-dhfr negative cell

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Chinese Science Bulletin 1998年第23期43卷 1996-2001页

作者： Zhenzhong Cui Pengpeng Liu Shunzhang Qi Heng shen China Agr Univ Coll Biol Sci Dept Biochem Beijing 100094 Peoples R China

Erythropoietin （EPO） genomic gene was cloned and its expression vector pOP13/EPO was constructed. CHOK12 cell was transfected by this vector using lipofectin method. A stable expression cell strain C10 cell with the EPO production at 160IU/d in 10\+6 cells were obtained at 400 μg/mL G418. Based on the C10 cell, another vector pHY/dhfr （dihydrofolate reductase） that carries a dhfr gene and a selecting marker of hygromycin B resistant gene was transferred to this cell. Several cell clones were obtained at 200 μg/mL hygromycin B. These cell clones that can express both EPO gene and exogenous dhfr gene were selected under the progressively increased concentration to 1 μmol methotrexate（MTX）. Some high EPO expression cell clones were obtained, the highest expression was 2 400 IU/d in 10\+6 cells, 15 times higher than that without MTX pressure. Then, a method of EPO high expression by using undhfr negative cell was primarily established. EPO bioactivity was found by using TF1 cell.

关键词： erythropoietin dihydrofolate reductase gene methotrexate un_dhfr negative cell cell expression.

An Efficient,Energy Stable Scheme for the Cahn-Hilliard-Brinkman System

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Communications in Computational Physics 2013年第4期13卷 929-957页

作者： Craig Collins Jie shen Steven M.Wise Department of Mathematics University of TennesseeKnoxvilleTN 37912USA Department of Mathematics Purdue UniversityWest LafayetteIN 47907USA

We present an unconditionally energy stable and uniquely solvable finite difference scheme for the Cahn-Hilliard-Brinkman(CHB)system,which is comprised of a Cahn-Hilliard-type diffusion equation and a generalized Brinkman equation modeling fluid *** CHB system is a generalization of the Cahn-Hilliard-Stokes model and describes two phase very viscous flows in porous *** scheme is based on a convex splitting of the discrete CH energy and is *** equations at the implicit time level are nonlinear,but we prove that they represent the gradient of a strictly convex functional and are therefore uniquely solvable,regardless of time step *** to energy stability,we show that the scheme is stable in the time and space discrete ℓ^(∞)(0,T;H_(h)^(1))and ℓ^(2)(0,T;H_(h)^(2))*** also present an efficient,practical nonlinear multigrid method–comprised of a standard FAS method for the Cahn-Hilliard part,and a method based on the Vanka smoothing strategy for the Brinkman part-for solving these *** particular,we provide evidence that the solver has nearly optimal complexity in typical *** solver is applied to simulate spinodal decomposition of a viscous fluid in a porous medium,as well as to the more general problems of buoyancy-and boundary-driven flows.

关键词： Cahn-Hilliard equation Stokes equations Brinkman equation finite difference methods nonlinear multigrid convex splitting energy stability

Geochemical characteristics of the oceanic islandtype volcanic rocks in the Chiang Mai zone,northern Thailand

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Chinese Journal Of Geochemistry 2009年第3期28卷 258-263页

作者： shen Shangyue FENG Qinglai ZHANG Zhibin CHONGPAN Chonglakmani China University ofGeosciences Wuhan 430074 China Institute of Regional Geology Yunnan Bureau of Geology and Mineral Resources Yuxi 653100 China Suranaree University of Technology Thailand

The oceanic island volcanic rocks in the Chiang Mai zone, northern Thailand, are usually covered by Lower Carboniferous and Upper Permian shallow-water carbonate rocks, with the Hawaii rocks and potash trachybasalt being the main rock types. The alkaline series is dominant with sub-alkaline series occurring in few cases. The geochemical characteristics are described as follows: the major chemical compositions are characterized by high TiO2, high P2O5 and medium K2O; the rare-earth elements are characterized by right-inclined strong LREE-enrichment patterns; the trace element patterns are of the upward-bulging K-Ti enrichment type; multi-component plots falling within the fields of oceanic island basalts and alkali basalts, belonging to the oceanic island-type volcanic rocks, which are similar to the equivalents in Deqin and Gengma (the Changning-Menglian zone) of Yunnan Province, China.

关键词：洋岛玄武岩地球化学特征火山岩区泰国稀土元素特征碱性玄武岩岩石类型二氧化钛

Laser melted oxide ceramics:Multiscale structural evolution with non-equilibrium features

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Journal of Materiomics 2019年第3期5卷 436-445页

作者： Lu Song Jing Ma Qinghua Zhang Zhijian shen State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China Department of Materials and Environmental Chemistry Arrhenius LaboratoryStockholm UniversityStockholm10691Sweden

Compared with the versatility in metal industry,application of laser on oxide ceramics is quite limited due to the intrinsic features of ceramics and limited understanding in laser-ceramic interaction mechanism,especially for high-energy laser that causes melting of *** this research,a study into general behaviors of several oxide ceramics melted by laser under inert atmosphere is *** factors in determining state transformation,chemical reduction and phase structure are summarized,with further investigation into the evolution in microstructure at multiscale and the corresponding novelty and *** is found that laser melting does show great potential in introducing deep reduction,unique microstructure,and notable increase in structure complexity and total entropy,and those features could contribute to some unconventional functional performance with brand-new structure-property relationship.

关键词： Laser Oxide ceramic Heterogeneity Defects Non-equilibrium

Numerical simulation on multiple pouring process for a 292 t steel ingot

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China Foundry 2014年第1期11卷 52-58页

作者： Tu Wutao Zhang Xiong shen Houfa Liu Baicheng Key Laboratory for Advanced Materials Processing Technology Ministry of Education School of Materials Science and Engineering Tsinghua University Sinotrans Ltd.

A ladle-tundish-mould transportation model considering the entire multiple pouring(MP) process is proposed. Numerical simulation is carried out to study the carbon distribution and variation in both the tundish and the mould for making a 292 t steel ingot. Firstly, the fluid flow as well as the heat and mass transfer of the molten steel in the tundish is simulated based on the multiphase transient turbulence model. Then, the carbon mixing in the mould is calculated by using the species concentration at the tundish outlet as the inlet condition during the teeming process. The results show a high concentration of carbon at the bottom and a low concentration of carbon at the top of the mould after a MP process with carbon content high in the first ladle and low in the last ladle. Such carbon concentration distribution would help reduce the negative segregation at the bottom and the positive segregation at the top of the solidified ingot.

关键词： multiple pouring transportation numerical simulation large steel ingot

Wide Speed Range Permanent Magnet Synchronous Generator Design for a DC Power System

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Chinese Journal of Electrical Engineering 2017年第1期3卷 33-41页

作者： Dongmin Miao Yves Mollet Johan Gyselinck Jianxin shen Department of Bio Electro And Mechanical SystemsUniversitéLibre de BruxellesBrussels1050Belgium Department of Electrical Engineering Zhejiang UniversityHangzhou310027China

A wide speed range permanent magnet synchronous generator(PMSG)system is studied in this paper,including the PMSG design and comparative study on control strategies with a pulse width modulation(PWM)rectifier,the purpose of which is to regulate the DC-link *** is of great importance to study the foregoing DC power system based on the PMSG and PWM rectifier,where vector control(VC)can be implemented and the corresponding field-weakening strategy can be realized by injecting a field-weakening current component without any auxiliary *** machine inductance is desired in order to limit the short-circuit current and the loaded voltage *** control strategies including VC,direct torque control(DTC)and direct voltage control(DVC)are studied and compared with both simulations and experiments.

关键词： Wide speed range permanent magnet synchronous generator PWM rectifier vector control field-weakening control direct torque control direct voltage control

Effects of inductive methods on dunging behavior of weaning pigs in slatted floor pens

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International Journal of Agricultural and Biological Engineering 2016年第4期9卷 192-198页

作者： Wang Yu Li Dapeng shen Xiong Shi Zhengxiang Key Laboratory of Agricultural Engineering in Structure and Environment Ministry of AgricultureBeijing 100083China College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China Tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin 300072China

The excreta of pig is generally utilized to induce pigs to excrete in particular area,which reduces the subsequent work required to clean *** paper discussed a new induction device design based on the biological characteristics of *** different induction materials in the devices,the frequency and location of the excretory behavior of pigs through five treatments and a control group were *** to the results,different induction methods had significant(p<0.05)effects on frequency and duration of excretory *** to the conventional induction method,the induction devices were significantly(p<0.05)more effective in training pigs to excrete in the assigned area,the most effective material used in the induction devices was *** the inductive feces had been preserved in the air for a longer time,the effect of inducing excretory behavior would have been more *** devices did not work to induce pigs to excrete in the induction area.

关键词： animal behavior weaning pigs slatted floor pen pig training excretory behavior inductive material

New advances in the neural correlates of insight: A decade in review of the insightful brain

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Chinese Science Bulletin 2013年第13期58卷 1497-1511页

作者： shen WangBing LUO Jing LIU Chang YUAN Yuan Laboratory of Cognitive Neuroscience and Department of Psychology Nanjing Normal University Key Laboratory of Cognition and Learning Capital Normal University Key Laboratory of Mental Health Chinese Academy of Sciences

The first neuroimaging study of real-time brain activity during insight problem solving was conducted almost ten years ago. Many subsequent studies have used high-resolution event-related potentials (ERPs) and event-related functional magnetic resonance imaging (fMRI) to investigate the temporal dynamics and neural correlates of insight. Recent results on the neural underpinnings of insight have led researchers to propose a neural framework referred to as the "insightful brain". This putative framework represents the neural basis of the cognitive and affective processes that are involved in insight. The insightful brain may involve numerous brain regions, including the lateral prefrontal cortex, cingulate cortex, hippocampus, superior temporal gyrus, fusiform gyrus, precuneus, cuneus, insula and cerebellum. Functional studies have demonstrated that the lateral prefrontal cortex is responsible for mental set shifting and breaking during insight problem solving. The cingulate cortex is involved in the cognitive conflict between new and old ideas and progress monitoring. The hippocampus, superior temporal gyrus and fusiform gyrus form an integrated functional network that specializes in the formation of novel and effective associations. The effective transformation of problem representations depends on a non-verbal visuospatial information-processing network that comprises the precuneus and cuneus. The insula reflects cognitive flexibility and the emotional experience that is associated with insight. The cortical control of finger movements relies on the cerebellum.

关键词：大脑活动神经事件相关电位功能磁共振成像前额叶皮质审查额叶皮层空间信息处理