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Enhanced breakdown strength of BaTiO_(3)-based multilayer ceramic capacitor by structural optimization

Rare Metals 2023年第8期42卷 2552-2561页

作者： Qian Liu Hua Hao Qing-Hu Guo zhong-hui shen Jian Wang Ming-He Cao zhong-Hua Yao Han-Xing Liu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Material Science and EngineeringWuhan University of TechnologyWuhan 430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528220China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China International School of Material Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center of Smart Materials and DevicesWuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Material Science and EngineeringWuhan University of TechnologyWuhan 430070China

0.5 wt%Nb_(2)O_(5)doped 0.12BiAlO_(3)-0.88BaTiO_(3)(12BA5N)multilayer ceramic capacitor(MLCC-1)was prepared,which satisfied EIA X7R specification(where X is the minimum temperature,R is the percentage of capacitance variation limit)at 1 *** distribution of internal electric field under breakdown voltage was simulated by finite element method(FEM),indicating that the electric field strength increased significantly at the terminal of internal *** areas may become the headstream of breakdown for MLCC-1 due to the shape *** order to improve the breakdown performance of MLCC-1,it was optimized by 12BA5N+2G green sheets(prepared by 12BA5N ceramic powder with 2 wt%B-Al-Si glass additive),then MLCC-2 was obtained which satisfied EIA X8R *** BDS rose from 20 to29.4 kV·mm^(-1),and the electric field distribution of dielectric layer was also analyzed by ***,it was also found that the grain size and the dielectric constants of"core"and"shell"parts for the 12BA5N+2G dielectric layer both contributed to the enhanced BDS of MLCC-2according to the simulation results from FEM.

关键词： Multilayer ceramic capacitor(MLCC) Breakdown strength(BDS) Simulation Grain size Dielectric constant

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High-throughput data-driven interface design of high-energy-density polymer nanocomposites

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Journal of Materiomics 2020年第3期6卷 573-581页

作者： zhong-hui shen Yang shen Xiao-Xing Cheng Han-Xing Liu Long-Qing Chen Ce-Wen Nan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center of Smart Materials and DevicesWuhan University of TechnologyWuhan430070China School of Materials Science and Engineering State Key Lab of New Ceramics and Fine ProcessingTsinghua UniversityBeijing100084China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States

Understanding the interface effect in dielectric nanocomposites is crucial to the enhancement of their *** this work,a data-driven interface design strategy based on high-throughput phase-field simulations is developed to study the interface effect and then optimize the permittivity and breakdown strength of ***,we use two microscopic features that are closely related to the macroscopic dielectric properties,the thickness and permittivity of the interface phases,to evaluate the role of interfaces in experimental configuration,and thus provide quantitative design schemes for the interfacial *** the polyvinyl difluoride(PVDF)-BaTiO_(3) nanocomposite as an example,the calculation results demonstrate that the interfacial polarization could account for up to 83.6% of the increase in the experimentally measured effective permittivity of the *** on the interface optimized strategy,a maximum enhancement of ~156% in the energy density could be achieved by introducing an interface phase with d/r=0.55 and ε_(interface)/ε_(filler)=0:036,compared to the pristine ***,the present work not only provides fundamental understanding of the interface effect in dielectric nanocomposites,but also establishes a powerful data-driven interface design framework for such materials that could also be easily generalized and applied to study interface issues in other functional nanocomposites,such as solid electrolytes and thermoelectrics.

关键词： Interface Polymer nanocomposites Energy storage Data-driven Phase-field simulation

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Designing polymer nanocomposites with high energy density using machine learning

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npj Computational Materials 2021年第1期7卷 999-1007页

作者： zhong-hui shen Zhi-Wei Bao Xiao-Xing Cheng Bao-Wen Li Han-Xing Liu Yang shen Long-Qing Chen Xiao-Guang Li Ce-Wen Nan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center of Smart Materials and DevicesWuhan University of TechnologyWuhanChina International School of Materials Science and Engineering Wuhan University of TechnologyWuhanChina Hefei National Laboratory for Physical Sciences at the Microscale Department of Physics and CAS Key Laboratory of Strongly-Coupled Quantum Matter Physics University of Science and Technology of China HefeiChina Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPAUnited States School of Materials Science and Engineering State Key Lab of New Ceramics and Fine ProcessingTsinghua UniversityBeijingChina

Addressing microstructure-property relations of polymer nanocomposites is vital for designing advanced dielectrics for electrostatic energy ***,we develop an integrated phase-field model to simulate the dielectric response,charge transport,and breakdown process of polymer ***,based on 6615 high-throughput calculation results,a machine learning strategy is schemed to evaluate the capability of energy *** find that parallel perovskite nanosheets prefer to block and then drive charges to migrate along with the interfaces in x-y plane,which could significantly improve the breakdown strength of polymer *** verify our predictions,we fabricate a polymer nanocomposite P(VDF-HFP)/Ca_(2)Nb_(3)O_(10),whose highest discharged energy density almost doubles to 35.9 J cm^(−3) compared with the pristine polymer,mainly benefit from the improved breakdown strength of 853 MVm^(−1).This work opens a horizon to exploit the great potential of 2D perovskite nanosheets for a wide range of applications of flexible dielectrics with the requirement of high voltage endurance.

关键词： polymer energy perovskite

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Machine learning in energy storage materials

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Interdisciplinary Materials 2022年第2期1卷 175-195页

作者： zhong-hui shen Han-Xing Liu Yang shen Jia-Mian Hu Long-Qing Chen Ce-Wen Nan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center of Smart Materials and DevicesWuhan University of TechnologyWuhanChina International School of Materials Science and Engineering Wuhan University of TechnologyWuhanChina State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijingChina Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWisconsinUSA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA

With its extremely strong capability of data analysis,machine learning has shown versatile potential in the revolution of the materials research ***,taking dielectric capacitors and lithium‐ion batteries as two representa-tive examples,we review substantial advances of machine learning in the research and development of energy storage ***,a thorough discussion of the machine learning framework in materials science is ***,we summarize the applications of machine learning from three aspects,including discovering and designing novel materials,enriching theoretical simulations,and assisting experimentation and ***,a brief outlook is highlighted to spark more insights on the innovative implementation of machine learning in materials science.

关键词： dielectric capacitor energy storage lithiumion battery machine learning

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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： shengyang Zhou Ting Li Wei Zhang Jian Wu hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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AF-1 Inhibits Macrophage VEGF Expression through PLA2-Independent Mechanism

AF-1 Inhibits Macrophage VEGF Expression through PLA2-Indepe...

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湖南省生理科学会2006年度学术年会

作者： Li Chen,Han Jian-zhong,Liu hui-Jun,shen L,Liu Yong,Shi Xiao-juan,Liu Wei,Feng Dan-Dan, Luo Zi-Qiang~(**) Department of Physiology,Xiangya School of Medicine,Central South University Changsha 410078,PR.China

＜正＞VEGF production has been associated with cell proliferation,vascular permeability,and angiogenesis related to pulmonary *** previous findings indicated that lung tissue proliferation activity and inflammatory response were augmented in bleomycin lung after Clara cell *** a further approach to gain insight of Clara cell secretory protein（CCSP） associated with fibrogenesis,the present study investigated the effect of AF-1,equivalent to the carboxyl-terminal part ofα-helix three in CCSP and generally characterized as a PLA2 inhibitor,on VEGF protein levels using

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Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie shen Jinxing Lu Chuqiang Huang Zhuoyuan Chen Feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

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Numerical Simulation of Sloshing Using the MPS-FSI Method with Large Eddy Simulation

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China Ocean Engineering 2018年第3期32卷 278-287页

作者： YANG Chao ZHANG Huai-xin SU hui-lin shen zhong-xiang State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai Jiao Tong UniversityShanghai 200240China PLA Army Engineering University Nanjing 210007China School of Naval Architecture and Ocean Engineering Dalian Maritime UniversityDalian 116026China

A numerical model has been developed to study sloshing of turbulent flow in a tank with elastic baffles. The Moving-Particle Semi-implicit method(MPS) is a kind of meshless Lagrangian calculation method. The large eddy simulation(LES) approach is employed to model the turbulence by using the Smagorinsky Sub-Particle Scale(SPS)closure model. This paper uses MPS-FSI method with LES to simulate the interaction between free surface flow and a thin elastic baffle in sloshing. Then, the numerical model is validated, and the numerical solution has good agreement with experimental data for sloshing in a tank with elastic baffles. Furthermore, under external excitations,the MPS is applied to viscous laminar flow and turbulent flow, with both the deformation of elastic baffles and the wave height of the free surface are compared with each other. Besides, the impact pressure with/without baffles and wave height of free surface are investigated and discussed in detail. Finally, preliminary simulations are carried out in the damage problem of elastic baffles, taking the advantage of the MPS-FSI method in computations of the fluid–structure interaction with large deformation.

关键词： moving particle semi-implicit method(MPS) fluid–structure interaction(FSI) large eddy simulation(LES) meshless sloshing

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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