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粉土地基中劲性复合桩抗压承载特性与荷载传递机制研究

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岩土力学 2024年第2期45卷 511-524页

作者：文磊刘钟马晓华张振浙江坤德创新岩土工程有限公司浙江宁波315100 坤德智慧岩土技术研究院浙江宁波315100 同济大学地下建筑与工程系上海200092

劲性复合桩(stiffened deep cement mixing pile,简称SDCM桩)兼具高强度芯桩的轴向荷载传递能力与搅拌桩较高的桩侧摩阻力优势,施工效率高、性价比高,在土木建筑领域中得到推广应用。然而,由于其荷载传递机制尚缺乏统一认识,现有计算方... 详细信息

劲性复合桩(stiffened deep cement mixing pile,简称SDCM桩)兼具高强度芯桩的轴向荷载传递能力与搅拌桩较高的桩侧摩阻力优势,施工效率高、性价比高,在土木建筑领域中得到推广应用。然而,由于其荷载传递机制尚缺乏统一认识,现有计算方法与实测承载力差异较大。基于此,开展了粉土地基中SDCM桩现场足尺试验,研究了其抗压承载特性与荷载传递机制。搅拌桩固化剂采用普通水泥和GS固化剂(gypsum-slag soil hardening agent)。依据实测荷载-位移曲线分析了单桩抗压极限承载力及不同固化剂的影响,并通过现场桩身取芯及芯样无侧限抗压试验分析了现场施工水泥土与室内试样强度的差异。建立了考虑芯桩-水泥土、水泥土-土体接触面的三维弹塑性有限元模型,分析了竖向下压荷载条件下桩身轴力、接触面的剪切应力分布规律,探讨了SDCM桩的荷载传递机制与承载力提高原因。研究结果表明:粉土地基中SDCM桩抗压承载力大于纯搅拌桩和单独芯桩抗压承载力之和的1.5倍;在端阻力发挥作用后,桩底水泥土由于轴向受压变形,芯桩-水泥土之间的剪切变形会大幅增加,该位置易产生剪切破坏。水泥土固化后与地基土接触面性能的改善是SDCM桩相对传统灌注桩具有更高的承载力的主要原因。

关键词：劲性复合桩粉土地基抗压承载力现场试验数值模拟

已有消费量、支付意愿与消费者言行差异——边际效用和边际替代率递减规律的再审视

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农业技术经济 2024年第8期 72-87页

作者：王琳钟甫宁刘华南京农业大学经济管理学院南京210095

如何解释消费者陈述性偏好(言)与显示性偏好(行)之间的差异,既是重要的现实问题,也是前沿的学术问题。本文基于陈述性偏好测度方法应用和逻辑推论问题,着重考察边际效用递减规律和边际替代率递减规律的作用,探讨已有消费量与消费者支付... 详细信息

如何解释消费者陈述性偏好(言)与显示性偏好(行)之间的差异,既是重要的现实问题,也是前沿的学术问题。本文基于陈述性偏好测度方法应用和逻辑推论问题,着重考察边际效用递减规律和边际替代率递减规律的作用,探讨已有消费量与消费者支付意愿之间的关系,并以转基因食用油为研究对象,进一步分析在已有消费量的情形下,对消费者言行差异的影响和改进程度。结果表明,支付意愿并非固定不变,其受商品本身和替代品已有消费量的影响;在食用油支出占比高的情况下,转基因食用油已有消费量越多,消费者对转基因食用油的支付意愿越低,非转基因食用油已有消费量越多,消费者对转基因食用油的支付意愿反而越高。进一步研究发现,控制已有消费量的影响,在一定程度上可以缩小消费者言行差异问题。因此,在预测支付意愿和购买行为的调查中,增加对已有消费量的关注,可以修正陈述性偏好推论消费者行为时的应用范畴和逻辑演绎错误,有效减少消费者言行差异,提高预测效率。

关键词：消费者言行差异支付意愿已有消费量边际效用递减规律边际替代率递减规律

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本体·认识·价值:关于共同富裕的哲学阐释

学海 2024年第5期 188-196页

作者：钟清莲刘华扬州大学马克思主义学院江苏扬州225009

共同富裕作为社会主义的本质要求,既是一种“经济活动”,也是一种“哲学追求”。从本体论视角来看,共同富裕是人民群众通过人类劳动创造自在财富的社会实践活动。其中,现实的人、人类劳动、自在财富共同构建了解释“共同富裕”何以存在... 详细信息

共同富裕作为社会主义的本质要求,既是一种“经济活动”,也是一种“哲学追求”。从本体论视角来看,共同富裕是人民群众通过人类劳动创造自在财富的社会实践活动。其中,现实的人、人类劳动、自在财富共同构建了解释“共同富裕”何以存在的逻辑演绎体系,以纯粹原理的形式表达了对人类自我意识不断觉醒、人类生活达到应然秩序的内在向往。从认识论视角看,共同富裕是人民群众在社会主义现代化建设的具体实践中形成的关于社会主义发展之本质规律的理性认识,既包含对社会生活“富裕”的基本共识,也包括对社会财富“共同”的美好期许。从价值观视角来看,共同富裕作为衡量人类文明进步的重要尺度,是实现全人类解放的阶段性目标,充分彰显其关于实现人的自由全面发展的价值规范。

关键词：共同富裕本体活动理性认识价值规范

Single-center retrospective study of the diagnostic value of doubleballoon enteroscopy in Meckel’s diverticulum with bleeding

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1043-1054页

作者： Tian He Chao Yang Jing Wang Ji-Sheng zhong Ai-hua Li Ya-Jing Yin Li-Ling Luo Chun-Mei Rao Nian-Fen Mao Qiang Guo Zan Zuo Wen Zhang Ping Wan Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceThe Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Medicine Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina School of Medicine Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina Department of Gastroenterology Qujing Hospital of Traditional Chinese MedicineQujing 655000Yunnan ProvinceChina Department of Gastroenterology Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina

BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract ***,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula *** To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with *** The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of ***(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 *** incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)was30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before *** endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal u

关键词： Meckel’s diverticulum with bleeding Double-balloon colonoscopy 99mTc-pertechnetate scanning Capsule endoscopy Ectopic gastric mucosa

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： huang Chen Rui-Ying Jiang Zhan hua Xiao-Wei Wang Xiao-Li Shi Ye Wang Qian-Qian Feng Jie Luo Wu Ning Yan-Fen Shi Da-Kui Zhang Bei Wang Jian-Zheng Jie Ding-Rong zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the China-Japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II *** This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis

Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping huang Zhi-Hui Lin Yi-Juan Liu Shao-Wei Lin Yan-Feng Shao Feng Qiu Qing-Wu Qiu Zhang-Kun Xu Jin-Xian Chen Liang-Huo Chen Zhen-Qun Lin Wen-hua Dai Ming-Qing Zhang Qi Jiang zhong-Qin Xiao Xian-Xing Cheng Xiang-Fei Zhang Wen-Bin You Wei Chen Long-Qin Li Wei-Xing Lin Yong-Fu Wang Fu-Jin Lai Long-Qun Chen zhong-hua huang Wen-Qi Zheng Jin-Qi Wei Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina Department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 23 centers in Fujian,China(May 2021-April 2022).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** In the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 23 among 28 cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2%[95%confidence interval(95%CI):71.4%-86.8%],93.2%(86.6%-96.7%),92.2%(85.3%-96.0%)in the intention-to-treat(ITT)analysis,and 80.9%(95%CI:71.7%-87.5%),94.0%(87.5%-97.2%),and 93.9%(87.4%-97.2%)in the per-protocol *** ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.022 and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(25.27%and 13.73%vs 37.62%,respectively;P<0.001).CONCLUSION VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

A pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2679-2693页

作者： Junzhi Yi Hui Zhang Fangyuan Bao Zhichu Chen Yuliang zhong Tianning Ye Xuri Chen Jingyi Qian Mengya Tian Min Zhu Zhi Peng Zongyou Pan Jianyou Li Zihao Hu Weiliang Shen Jiaqi Xu Xianzhu Zhang Youzhi Cai Mengjie Wu hua Liu Jing Zhou Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesHangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang ProvinceLife Sciences InstituteZhejiang UniversityHangzhouChina Department of Orthopedics Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

The knee joint has long been considered a closed *** pathological effects of joint diseases on distant organs have not been ***,our clinical data showed that post-traumatic joint damage,combined with joint bleeding(hemarthrosis),exhibits a worse liver function compared with healthy *** mouse model,hemarthrosis induces both cartilage degeneration and remote liver ***,we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4^(+)T cells in peripheral blood and *** of CD4^(+)T cells reverses hemarthrosis-induced liver *** of cartilage matrix induced by hemarthrosis upregulates serological type Ⅱ collagen(COL Ⅱ),which activates CD4^(+)T *** application of a COL Ⅱ antibody blocks the ***,bulk RNAseq and single-cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood ***-articular application of Akt activator blocks the cartilage degeneration and thus protects against the liver impairment in mouse and pig *** together,our study revealed a pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells,which refreshes the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related disease.

关键词： degeneration damage inhibited

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肺癌第9版TNM分期解读

中华肿瘤杂志 2024年第3期46卷 206-210页

作者：张波方文涛钟华上海市胸科医院、上海交通大学医学院附属胸科医院呼吸与危重症医学科上海200030 上海市胸科医院、上海交通大学医学院附属胸科医院胸外科上海200030

流行病学数据显示,肺癌发病率位居恶性肿瘤第2位,死亡率位居恶性肿瘤第1位,2020年约180万例患者死于肺癌。对于晚期肺癌患者,驱动基因的发现及相应靶向药物的应用不仅改善了患者生活质量,同时提高了患者的生存时间。免疫检查点抑制剂的... 详细信息

流行病学数据显示,肺癌发病率位居恶性肿瘤第2位,死亡率位居恶性肿瘤第1位,2020年约180万例患者死于肺癌。对于晚期肺癌患者,驱动基因的发现及相应靶向药物的应用不仅改善了患者生活质量,同时提高了患者的生存时间。免疫检查点抑制剂的应用则革新了驱动基因突变阴性患者的治疗策略。TNM分期是包括肺癌在内的实体瘤应用最为广泛的分期系统,统一的分期方法不仅为国际间的学术交流提供了共同的学术语言,同时也为疾病的预后判断及后续治疗决策制定提供了重要的工具。随着对肺癌预后因素的深入认识及研究数据的不断积累和成熟,肺癌TNM分期不断更新。2023年9月在新加坡举行的世界肺癌大会上,第9版TNM分期向全球公布并预计在2024年1月正式采用。本文就肺癌TNM分期的历史沿革、数据来源、第9版分期的主要变化及局限性进行讨论。

关键词：肺肿瘤 TNM分期国际肺癌研究协会

Chinese expert consensus on immunotherapy for advanced non-small cell lung cancer with oncogenic driver mutations(2023 edition)

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Chinese Medical Journal 2024年第9期137卷 1016-1018页

作者： The Society of Cancer Precision Medicine of Chinese Anti-Cancer Association The Lung Cancer Expert Group of Chinese Medical Association Publishing House Baohui Han hua zhong 不详 Department of Respiratory Medicine Shanghai Chest HospitalSchool of MedicineShanghai JiaoTong UniversityShanghai 20030China Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine

Non-small cell lung cancer(NSCLC)with oncogenic driver mutations was previously deemed“forbidden territory”for immunotherapy.[1]With the continuous generation of evidence,immunotherapy is expected to bring hope for such NSCLC with oncogenic driver mutations after acquired tyrosine kinase inhibitor(TKI)***,given the intricate interplay between driven mutations,targeted therapy,and immune microenvironment,the efcacy of immunotherapy in advanced NSCLC patients with diverse oncogenic driver mutations remains a topic of ongoing *** this context,Chinese Expert Consensus on Immunotherapy for Advanced NSCLC with Oncogenic Driver Mutations(2022 edition)wasrst launched in 2022 by the Society of Cancer Precision Medicine of Chinese Anti-Cancer Association and the Lung Cancer Expert Group of Chinese Medical Journals,aiming to provide standardized treatment guidance for clinical practice.

关键词： immunotherapy cancer lung