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Journal of Geriatric Cardiology 2024年第5期21卷 550-576页

作者： zhong-hua sun Discipline of Medical Radiation Science Curtin Medical SchoolCurtin UniversityPerthAustralia Curtin Health Innovation Research Institute(CHIRI) Curtin UniversityPerth 6012Australia

Cardiovascular computed tomography angiography(CTA)is a widely used imaging modality in the diagnosis of cardiovascular *** in CT imaging technology have further advanced its applications from high diagnostic value to minimising radiation exposure to *** addition to the standard application of assessing vascular lumen changes,CTA-derived applications including 3D printed personalised models,3D visualisations such as virtual endoscopy,virtual reality,augmented reality and mixed reality,as well as CT-derived hemodynamic flow analysis and fractional flow reserve(FFRCT)greatly enhance the diagnostic performance of CTA in cardiovascular *** widespread application of artificial intelligence in medicine also significantly contributes to the clinical value of CTA in cardiovascular *** value of CTA has extended from the initial diagnosis to identification of vulnerable lesions,and prediction of disease extent,hence improving patient care and *** this review article,as an active researcher in cardiovascular imaging for more than 20 years,I will provide an overview of cardiovascular CTA in cardiovascular *** is expected that this review will provide readers with an update of CTA applications,from the initial lumen assessment to recent developments utilising latest novel imaging and visualisation *** will serve as a useful resource for researchers and clinicians to judiciously use the cardiovascular CT in clinical practice.

关键词： diagnosis cardiovascular prediction

Clinical outcomes of COVID-19 in elderly male patients

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Journal of Geriatric Cardiology 2020年第5期17卷 243-245页

作者： zhong-hua sun Department of Medical Radiation Sciences Curtin UniversityPerth6845Western AustraliaAustralia

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has spread throughout the world involving more than 200 countries with more than 3 million confirmed cases and over 200,000 deaths worldwide.[1]COVID-19 patients primarily present with respiratory symptoms showing abnormal lung changes on chest X-ray or computed tomography(CT)with typical imaging appearances of ground glass opacities and consolidation.

关键词： Clinical features COVID-19 Male patients

A head-to-head comparison of the coronary calcium score by computed tomography with myocardial perfusion imaging in predicting coronary artery disease

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Journal of Geriatric Cardiology 2012年第4期9卷 349-354页

作者： Mansour Almoudi zhong-hua sun Discipline of Medical Imaging Department of Imaging and Applied Physics Curtin University GPO Box U1987 Perth Western Australia 6845 Australia

Objectives The coronary artery calcium (CAC) score has been shown to predict future cardiac events. However the extent to which the added value of a CAC score to the diagnostic performance of myocardial perfusion imaging (MPI) by single photon emission computed tomography (SPECT) is unclear. The purpose of this study is to investigate the correlation between CAC score and SPECT in patients with suspected coronary artery disease. Methods A retrospective review of the CAC scores by use of the Agatston calcium scoring method and cardiac SPECT diagnostic reports was conducted in 48 patients, who underwent both coronary computed tomography (CT) and SPECT examinations due to suspected coronary artery disease. A Pearson correlation test was used to determine the relation between CAC scores and MPI-SPECT assessments with regard to the evaluation of the extent of disease. Results Forty-seven percent of the patients had CAC scores more than 100, while 42% of these patients demonstrated abnormal, or probably abnormal, MPI-SPECT. Of the 23% of patients with a zero CAC score, only 7% had normal MPI-SPECT findings. No significant correlation was found between the CAC scores and MPISPECT assessments (r value ranged from 0.012 to 0.080), regardless of the degree of coronary calcification. Conclusions There is a lack of correlation between the CAC scores and the MPI-SPECT findings in the assessment of the extent of coronary artery disease. CAC scores and MPI-SPECT should be considered complementary approaches in the evaluation of patientswith suspected coronary artery disease.

关键词： Coronary artery disease Coronary calcium score Coronary computed tomography Myocardial perfusion imaging

Inter-hospital transfers and door-to-balloon times for STEMI: a single centre cohort study

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Journal of Geriatric Cardiology 2020年第6期17卷 321-329页

作者： RenéForsyth zhong-hua sun Christopher Reid Rachael Moorin Department of Medical Radiation Sciences Curtin UniversityPerthAustralia School of Public Health NHMRC Centre of Research Excellence in Cardiovascular Outcomes ImprovementPerthAustralia Centre of Research Excellence in Therapeutics Monash UniversityMelbourneAustralia School of Public Health Curtin UniversityPerthAustralia School of Population and Global Health the University of Western AustraliaCrawleyAustralia

Background Key performance indices such as door-to-balloon times have long been recognized as quality metrics in reducing time to care for patients with acute coronary syndromes(ACS). In the situation where patients do not present to a facility capable of 24/7 percutaneous coronary interventions(PCI) delays in time to therapy can exceed the recommendation of 90 min or less. This study aimed to evaluate the impact of transfers on performance indices for patients diagnosed with ST-segment elevation myocardial infarction(STEMI). Methods Over a seven month collection period, all patients presenting with symptoms suggestive of ACS and admitted for PCI were studied. Patients were divided into dichotomous groups of direct presentations or transfers from a secondary non-PCI capable hospital with key times recorded, including symptom-onset, first hospital and PCI-capable hospital arrival and balloon inflation times to evaluate time of treatment for STEMI patients. Results Of the 87 patients diagnosed with STEMI, transferred patients experienced statistically significant delays in symptom-onset to the PCI-capable hospital(PCI-H) arrival(215 vs. 95 min, P < 0.001), symptom-onset to balloon inflation(225 vs. 160 min, P = 0.009) and first hospital arrival to balloon inflation times(106 vs. 56 min, P < 0.001). Only 28%(n = 9) of transferred patients underwent balloon inflation within 90 min from first hospital arrival, while 60%(n = 19) did within 120 min, although all received balloon inflation within 90 min from arrival at the PCI-H. After controlling for confounding factors of socio-economic status, presentation date/time and diagnostic category, transferred patients experienced an average 162% longer delays from symptom-onset to PCI-H door arrival, and 98% longer delays in symptom-onset to balloon inflation;compared to patients who present directly to the PCI-H. No statistically significant differences were noted between transferred and direct patients when measured from PCI-

关键词： Acute coronary syndrome Door-to-balloon times Inter-hospital transfers ST-segment elevation myocardial infarction

Abdominal aortic aneurysm： Treatment options, image visualizations and follow-up procedures

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Journal of Geriatric Cardiology 2012年第1期9卷 49-60页

作者： zhong-hua sun Discipline of Medical Imaging Department of lmaging and Applied Physics Curtin University Perth Western Australia 6845 Australia

Abdominal aortic aneurysm is a common vascular disease that affects elderly *** surgical repair is regarded as the gold standard technique for treatment of abdominal aortic aneurysm,however,endovaseular aneurysm repair has rapidly expanded since its first introduction in *** a less invasive technique,endovascular aneurysm repair has been confirmed to be an effective alternative to open surgical repair,especially in patients with co-morbid *** tomography （CT） angiography is currently the preferred imaging modality for both preoperative planning and post-operative follow-up.2D CT images are complemented by a number of 3D reconstructions which enhance the diagnostic applications of CT angiography in both planning and follow-up of endovascular *** has the disadvantage of high cummulative radiation dose,of particular concern in younger patients,since patients require regular imaging follow-ups after endovascular repair,thus,exposing patients to repeated radiation exposure for *** is a trend to change from CT to ultrasound surveillance of endovascular aneurysm *** image visualizations demonstrate excellent morphological assessment of aneurysm and stent-grafts,but fail to provide hemodynamic changes caused by the complex stent-graft device that is implanted into the *** article reviews the treatment options of abdominal aortic aneurysm,various image visualization tools,and follow-up procedures with use of different modalities including both imaging and computational fluid dynamics *** directions to improve treatment outcomes in the follow-up of endovascular aneurysm repair are outlined.

关键词： Abdominal aortic aneurysm Computed tomography Follow-up Stent graft Treatment Visualization.

Diagnostic value of18F-FDG PET in the assessment of myocardial viability in coronary artery disease：A comparative study with99mTc SPECT and echocar-diography

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Journal of Geriatric Cardiology 2014年第3期11卷 229-236页

作者： Mansour Al Moudi zhong-hua sun Department of Medical Imaging and Nuclear Medicine King Saud Medical City Riyadh Saudi Arabia Discipline of Medical Imaging Department of Imaging and Applied Physics Curtin University GP0 Box U1987 Perth Western Australia 6845 Australia

ObjectiveTo investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography （18F-FDG PET） in the as-sessment of myocardial viability in patients with known coronary artery disease （CAD） when compared to99mTc single photon emission computed tomography （SPECT） and echocardiography, with invasive coronary angiography as the gold *** patients with diagnosed CAD met the selection criteria, with 10 of them （9 men, mean age 59.5 ± 10.5 years） undergoing all of these imaging proce-dures consisting of SPECT and PET, echocardiography and invasive angiography. Diagnostic sensitivity of these less invasive modalities for detection of myocardial viability was compared to invasive coronary angiography. Inter- and intra-observer agreement was assessed for di-agnostic performance of SPECT and *** all patients with proven CAD, 50% had triple vessel disease. Diagnostic sensitivity of SPECT, PET and echocardiography was 90%, 100% and 80% at patient-based assessment, respectively. Excellent agreement was achieved between inter-observer and intra-observer agreement of the diagnostic value of SPECT and PET in myocardial viability （k= 0.9）. Conclusion18F-FDG PET has high diagnostic value in the assessment of myocardial viability in patients with known CAD when com-pared to SPECT and echocardiography. Further studies based on a large cohort with incorporation of18F-FDG PET into patient management are warranted.

关键词： Coronary artery disease Diagnostic value Positron emission tomography Single photon emission computed tomography Vi-ability

Multislice computed tomography angiography in the diagnosis of coronary artery disease

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Journal of Geriatric Cardiology 2011年第2期8卷 104-113页

作者： zhong-hua sun Yan Cao hua-Feng Li Discipline ofMedical Imaging Department oflmaging and Applied Physics Curtin University of Technology Perth Western Australia 6845 Australia Department of Medical Imaging Shandong Medical College Jinan 250012 Shandong Province China

Multislice CT angiography represents one of the most exciting technological revolutions in cardiac imaging and it has been increasingly used in the diagnosis of coronary artery disease. Rapid improvements in multislice CT scanners over the last decade have allowed this technique to become a potentially effective alternative to invasive coronary angiography in patients with suspected coronary artery disease. High diagnostic value has been achieved with multislice CT angiography with use of 64- and more slice CT scanners. In addition, multislice CT angiography shows accurate detection and analysis of coronary calcium, characterization of coronary plaques, as well as prediction of the disease progression and major cardiac events. Thus, patients can benefit from multislice CT angiography that provides a rapid and accurate diagnosis while avoiding unnecessary invasive coronary angiography procedures. The aim of this article is present an overview of the clinical applications of multislice CT angiography in coronary artery disease with a focus on the diagnostic accuracy of coronary artery disease; prognostic value of coronary artery disease with regard to the prediction of major cardiac events; detection and quantification of coronary calcium and characterization of coronary plaques. Limitations of multislice CT angiography in coronary artery disease are also briefly discussed, and future directions are highlighted.

关键词： coronary artery disease plaque diagnosis multislice computed tomography angiography

Molecular imaging of plaques in coronary arteries with PET and SPECT

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Journal of Geriatric Cardiology 2014年第3期11卷 259-273页

作者： zhong-hua sun Hairil Rashmizal Lei XU Discipline of Medical Imaging Department of Imaging and Applied Physics Curtin University Perth Western Australia 6845 Australia Department of Medical Imaging Faculty of Health Sciences University Technology MARA UiTM Selangor 42300 Malaysia Department of Radiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lu-men stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increas-ingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of positron emission tomography （PET） and single photon emission computed tomography （SPECT） has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging tech-niques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coro-nary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed.

关键词： Atherosclerotic plaque Coronary artery disease Single photon emission computed tomography Positron emission to-mography Vulnerability

Preparation and Properties of FeZrB Amorphous-Nanocrystalline Soft Magnetic Alloy

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Journal of Wuhan University of Technology(Materials Science) 2009年第5期24卷 747-749页

作者：华中 College of Physics Jilin Normal University

Fe68Zr20B12 amorphous alloy was prepared by mechanical alloying（MA） method and annealed at different temperatures. Microstructures and magnetic properties of Fe68Zr20B12 alloys as-milled and annealed at 693, 843, 943 and 993 K were studied. The raw powders（Fe, Zr, B） formed b. c. c. α-Fe solid solution at early stages of MA and then transformed into amorphous alloy. Grain size（D） of Fe68Zr20B12 alloys increases with increasing annealing temperature and keeps at nanometer level. The specific saturation magnetization（σs） increases with increasing annealing temperature from 300 K to 943 K, and then decreases with annealing temperature at 993 K because of the precipitation of Fe3B.

关键词： FeZrB amorphous-nanocrystalline alloy grain size specific saturation magnetization

Ultra-high-rate Bi anode encapsulated in 3D lignin-derived carbon framework for sodium-ion hybrid capacitors

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Rare Metals 2024年第3期43卷 1037-1047页

作者： Ze-hua Lin Xue-Qing Qiu Xi-Hong Zu Xiao-Shan Zhang Lei zhong Shi-Rong sun Shu-hua Hao Ying-Juan sun Wen-Li Zhang School of Chemical Engineering and Light Industry Guangdong University of Technology(GDUT)Guangzhou510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang515200China School of Advanced Manufacturing Institute of Green Chemistry and Advanced MaterialsGuangdong University of TechnologyJieyang515200China

Bismuth(Bi),as an alloy-based anode material,has attracted much atte ntion in the developme nt of sodiumion hybrid capacitors(SIHCs)due to its high theoretical ***,the volume expansion of the Bi-based anode during the sodiation/desodiation process results in limited rate *** the present work,a porous Bi-based composite was constructed by a one-step hydrothermal method,and Bi was encapsulated in ligninderived nitrogen-doped porous carbon(Bi@LNPC)after *** obtained Bi nanoparticles could effectively adapt to the strain and shorten the diffusion distance of Na^(+).In addition,porous carbon skeleton provides a rigid conductive network for electronic ***,the assembled sodium-ion half-cell with Bi@LNPC anode shows ultra-high-rate *** the current density was enhanced from 0.1 to 50 A·g^(-1),the specific capacity decreased slightly from 351.5 to 342.8 mAh·g^(-1).Even at an extremely high current density of 200 A·g^(-1),it retains 81.3%capacity retention when compared to a current density of 1 A·g^(-1).The SIHCs assembled by Bi@LNPC show a high energy density of 63 Wh·kg^(-1).This work provides an effective method for developing high-rate Bi anode materials for sodium-ion hybrid capacitors(SIHCs)and sodium-ion batteries(SIBs).

关键词： Bismuth Lignin Sodium-ion batteries Sodium-ion hybrid capacitors Rate Porous carbon