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Synthesis,Characterization and Biological Activities of Novel Acrylamide Compounds

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Chemical Research in Chinese Universities 2008年第5期24卷 575-578页

作者： XU Liang-zhong XU zhong-jie zhang Gong-sheng ZHOU Kai ZHAI Zhi-wei College of Chemistry and Molecule Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

With dimethomorph and flumorph as the leading compounds, four novel acrylamide compounds with two types of structure were designed and synthesized by means of the method of ＂me too chemistry＂. The target compounds were characterized by 1H NMR, IR, MS, and elemental analysis. The influences of solvent and raw material on the yield were investigated and optimum processing conditions were determined. The results of preliminary biological tests show that all those compounds exhibit certain antifungal activities.

关键词： Acrylamide derivatives Biological activity Process optimum

Recent Advances in Artificial Sensory Neurons: Biological Fundamentals, Devices, Applications, and Challenges

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NANO-MICRO LETTERS 2025年第1期17卷 1-49页

作者： zhong, Shuai Su, Lirou Xu, Mingkun Loke, Desmond Yu, Bin zhang, Yishu Zhao, Rong Guangdong Inst Intelligence Sci & Technol Zhuhai 519031 Hengqin Peoples R China Zhejiang Univ Coll Integrated Circuits Hangzhou 3112000 Peoples R China ZJU Hangzhou Global Sci & Technol Innovat Ctr Hangzhou 310027 Peoples R China Singapore Univ Technol & Design Dept Sci Math & Technol Singapore 487372 Singapore Tsinghua Univ Dept Precis Instruments Beijing 100084 Peoples R China Tsinghua Univ Ctr Brain Inspired Comp Res Beijing 100084 Peoples R China Tsinghua Univ IDG McGovern Inst Brain Res Beijing 100084 Peoples R China

Biological fundamentals and recent progress of artificial sensory neurons are systematically *** device, performance metrics, and potential applications of artificial sensory neurons are *** for the future development of artificial sensory neurons are discussed. Spike-based neural networks, which use spikes or action potentials to represent information, have gained a lot of attention because of their high energy efficiency and low power consumption. To fully leverage its advantages, converting the external analog signals to spikes is an essential prerequisite. Conventional approaches including analog-to-digital converters or ring oscillators, and sensors suffer from high power and area costs. Recent efforts are devoted to constructing artificial sensory neurons based on emerging devices inspired by the biological sensory system. They can simultaneously perform sensing and spike conversion, overcoming the deficiencies of traditional sensory systems. This review summarizes and benchmarks the recent progress of artificial sensory neurons. It starts with the presentation of various mechanisms of biological signal transduction, followed by the systematic introduction of the emerging devices employed for artificial sensory neurons. Furthermore, the implementations with different perceptual capabilities are briefly outlined and the key metrics and potential applications are also provided. Finally, we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： zhong-Liang Gong Hong-Jie zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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苦荞麦曲奇饼干的研制

食品科技 2003年第12期28卷 31-32页

作者：肖诗明吴中文张忠南京财经大学南京210003 西昌学院食品科学系西昌615013

用正交试验探讨苦荞麦曲奇饼干生产中苦荞粉用量、低筋面粉用量、糖浆水用量和奶油用量4因素对饼干比容及饼干品质的影响,从而确立了苦荞麦曲奇饼干生产的最佳工艺条件。

关键词：苦荞麦饼干正交试验

Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao zhang Yuqin Dong Jin zhong zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

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结直肠癌患者围术期感染的病原菌分布及耐药情况分析

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中华医院感染学杂志 2017年第7期27卷 1587-1589页

作者：何春华董来荣张斌忠冯联忠章波嘉兴市第二医院肿瘤外科浙江嘉兴314000

目的探讨医院结直肠癌围术期感染患者的病原菌分布及耐药情况,为临床治疗提供参考依据。方法选择医院2012年-2015年结直肠癌围术期医院感染患者115例为研究对象,收集患者的围术期感染情况、感染部位、病原菌分布及主要病原菌的药敏试验... 详细信息

目的探讨医院结直肠癌围术期感染患者的病原菌分布及耐药情况,为临床治疗提供参考依据。方法选择医院2012年-2015年结直肠癌围术期医院感染患者115例为研究对象,收集患者的围术期感染情况、感染部位、病原菌分布及主要病原菌的药敏试验结果等临床资料。结果 115例结直肠癌围术期医院感染患者中,以呼吸道感染为主,共38例占33.0%;共检出264株病原菌,以革兰阴性菌为主,共178株占67.4%;大肠埃希菌对美罗培南、厄他培南、亚胺培南和阿米卡星的敏感率较高,均>90.0%,鲍氏不动杆菌对哌拉西林、头孢吡肟、环丙沙星、头孢他啶耐药率均高,均>80.0%。结论结直肠癌患者围术期容易发生医院感染,以呼吸道感染最常见,其次为切口感染,结直肠癌围术期医院感染主要病原菌的耐药现象严重,尤其鲍氏不动杆菌。

关键词：结直肠癌医院感染病原菌耐药

Dual-Donor-Induced Crystallinity Modulation Enables 19.23% Efficiency Organic Solar Cells

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NANO-MICRO LETTERS 2025年第1期17卷 1-13页

作者： Liang, Anhai Sun, Yuqing Chung, Sein Shin, Jiyeong Sun, Kangbo Zhu, Chaofeng Zhao, Jingjing Zhao, Zhenmin zhong, Yufei zhang, Guangye Cho, Kilwon Kan, Zhipeng Guangxi Univ Inst Sci & Technol Carbon Peak & Neutral Ctr Nanoenergy Res Sch Phys Sci & Technol Nanning 530004 Peoples R China Pohang Univ Sci & Technol Dept Chem Engn Pohang 37673 South Korea Shenzhen Technol Univ Coll New Mat & New Energies Shenzhen 518118 Peoples R China NingboTech Univ Zhejiang Engn Res Ctr Fabricat & Applicat Adv Phot Sch Mat Sci & Engn Ningbo 315100 Peoples R China State Key Lab Featured Met Mat & Life Cycle Safety Nanning 530004 Peoples R China

By modulating the crystalline properties of the active layer with dual donors, the efficiency of organic solar cells reaches 19.23%.The introduction of PTzBI-dF suppresses the accumulation of traps and charge recombination, allowing ternary devices to maintain 82% of their initial power conversion efficiency (PCE) after illumination for 800 *** dual-donor strategy for modulating the crystallinity of the active layer is applicable to a variety of Y6 derivatives, and the increase in PCE exceeds 1%. Trap-assisted charge recombination is one of the primary limitations of restricting the performance of organic solar cells. However, effectively reducing the presence of traps in the photoactive layer remains challenging. Herein, wide bandgap polymer donor PTzBI-dF is demonstrated as an effective modulator for enhancing the crystallinity of the bulk heterojunction active layers composed of D18 derivatives blended with Y6, leading to dense and ordered molecular packings, and thus, improves photoluminescence quenching properties. As a result, the photovoltaic devices exhibit reduced trap-assisted charge recombination losses, achieving an optimized power conversion efficiency of over 19%. Besides the efficiency enhancement, the devices comprised of PTzBI-dF as a third component simultaneously attain decreased current leakage, improved charge carrier mobilities, and suppressed bimolecular charge recombination, leading to reduced energy losses. The advanced crystalline structures induced by PTzBI-dF and its characteristics, such as well-aligned energy level, and complementary absorption spectra, are ascribed to the promising performance improvements. Our findings suggest that donor phase engineering is a feasible approach to tuning the molecular packings in the active layer, providing guidelines for designing effective morphology modulators for high-performance organic solar cells.

关键词： Trap-assisted charge recombination Photoluminescence Miscibility Current leakage Power conversion efficiency

Functional Interaction of a Novel Protein with Cavl.3 Calcium Channel

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Functional Interaction of a Novel Protein with Cavl.3 Calciu...